{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T01:44:35Z","timestamp":1791423875832,"version":"4.3.3"},"reference-count":55,"publisher":"Rockefeller University Press","issue":"2","content-domain":{"domain":["rupress.org"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2011,2,14]]},"abstract":"<jats:p>Dendritic cells (DCs) in the thymus (tDCs) are predominantly accumulated in the medulla and contribute to the establishment of self-tolerance. However, how the medullary accumulation of tDCs is regulated and involved in self-tolerance is unclear. We show that the chemokine receptor XCR1 is expressed by tDCs, whereas medullary thymic epithelial cells (mTECs) express the ligand XCL1. XCL1-deficient mice are defective in the medullary accumulation of tDCs and the thymic generation of naturally occurring regulatory T cells (nT reg cells). Thymocytes from XCL1-deficient mice elicit dacryoadenitis in nude mice. mTEC expression of XCL1, tDC medullary accumulation, and nT reg cell generation are diminished in Aire-deficient mice. These results indicate that the XCL1-mediated medullary accumulation of tDCs contributes to nT reg cell development and is regulated by Aire.<\/jats:p>","DOI":"10.1084\/jem.20102327","type":"journal-article","created":{"date-parts":[[2011,2,8]],"date-time":"2011-02-08T00:35:24Z","timestamp":1297125324000},"page":"383-394","update-policy":"https:\/\/doi.org\/10.1084\/jem.crossmarkpolicy","source":"Crossref","is-referenced-by-count":291,"title":["Aire-dependent production of XCL1 mediates medullary accumulation of thymic dendritic cells and contributes to regulatory T cell development"],"prefix":"10.1084","volume":"208","author":[{"given":"Yu","family":"Lei","sequence":"first","affiliation":[{"name":"Division of Experimental Immunology, Institute for Genome Research 1 , 2"},{"name":"Department of Oral Molecular Pathology, Institute of Health Biosciences, University of Tokushima, Tokushima 770-8503, Japan 1 , 2"},{"name":"Key Laboratory of Molecular Biology for Infectious Disease of the 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