{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T05:11:01Z","timestamp":1791263461003,"version":"4.1.0"},"reference-count":77,"publisher":"Rockefeller University Press","issue":"12","content-domain":{"domain":["rupress.org"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2011,11,21]]},"abstract":"<jats:p>Transfusion-related acute lung injury (TRALI), a form of noncardiogenic pulmonary edema that develops during or within 6 h after a blood transfusion, is the most frequent cause of transfusion-associated death in the United States. Because development of TRALI is associated with donor antibodies (Abs) reactive with recipient major histocompatibility complex (MHC), a mouse model has been studied in which TRALI-like disease is caused by injecting mice with anti\u2013MHC class I monoclonal Ab (mAb). Previous publications with this model have concluded that disease is caused by FcR-dependent activation of neutrophils and platelets, with production of reactive oxygen species that damage pulmonary vascular endothelium. In this study, we confirm the role of reactive oxygen species in the pathogenesis of this mouse model of TRALI and show ultrastructural evidence of pulmonary vascular injury within 5 min of anti\u2013MHC class I mAb injection. However, we demonstrate that disease induction in this model involves macrophages rather than neutrophils or platelets, activation of complement and production of C5a rather than activation of Fc\u03b3RI, Fc\u03b3RIII, or Fc\u03b3RIV, and binding of anti\u2013MHC class I mAb to non-BM\u2013derived cells such as pulmonary vascular endothelium. These observations have important implications for the prevention and treatment of TRALI.<\/jats:p>","DOI":"10.1084\/jem.20110159","type":"journal-article","created":{"date-parts":[[2011,10,25]],"date-time":"2011-10-25T01:50:00Z","timestamp":1319507400000},"page":"2525-2544","update-policy":"https:\/\/doi.org\/10.1084\/jem.crossmarkpolicy","source":"Crossref","is-referenced-by-count":101,"title":["MHC class I\u2013specific antibody binding to nonhematopoietic cells drives complement activation to induce transfusion-related acute lung injury in mice"],"prefix":"10.1084","volume":"208","author":[{"given":"Richard T.","family":"Strait","sequence":"first","affiliation":[{"name":"Division of Emergency Medicine 1 , 2 , 3 , and 4"},{"name":"Division of Pathology 1 , 2 , 3 , and 4"},{"name":"Division of Molecular Immunology 1 , 2 , 3 , and 4"},{"name":"Division of Immunobiology, Cincinnati Children\u2019s Hospital Medical Center, Cincinnati, OH 45229 1 , 2 , 3 , and 4"},{"name":"Department of 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