{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T00:28:48Z","timestamp":1791419328095,"version":"4.3.3"},"reference-count":46,"publisher":"Rockefeller University Press","issue":"9","content-domain":{"domain":["rupress.org"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2012,8,27]]},"abstract":"<jats:p>Apoptosis-inducing factor (Aif) is a mitochondrial flavoprotein that regulates cell metabolism and survival in many tissues. We report that aif-hypomorphic harlequin (Hq) mice show thymic hypocellularity and a cell-autonomous thymocyte developmental block associated with apoptosis at the \u03b2-selection stage, independent of T cell receptor \u03b2 recombination. No abnormalities are observed in the B cell lineage. Transgenes encoding wild-type or DNA-binding\u2013deficient mutant Aif rectify the thymic defect, but a transgene encoding oxidoreductase activity\u2013deficient mutant Aif does not. The Hq thymic block is reversed in vivo by antioxidant treatment, and Hq T but not B lineage cells show enhanced oxidative stress. Thus, Aif, a ubiquitous protein, serves a lineage-specific nonredundant antiapoptotic role in the T cell lineage by regulating reactive oxygen species during thymic \u03b2-selection.<\/jats:p>","DOI":"10.1084\/jem.20110306","type":"journal-article","created":{"date-parts":[[2012,8,6]],"date-time":"2012-08-06T22:12:55Z","timestamp":1344291175000},"page":"1641-1653","update-policy":"https:\/\/doi.org\/10.1084\/jem.crossmarkpolicy","source":"Crossref","is-referenced-by-count":22,"title":["A role for apoptosis-inducing factor in T cell development"],"prefix":"10.1084","volume":"209","author":[{"given":"Hridesh","family":"Banerjee","sequence":"first","affiliation":[{"name":"National Institute of Immunology, New Delhi 110067, India 1"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abhishek","family":"Das","sequence":"additional","affiliation":[{"name":"National Institute of Immunology, New Delhi 110067, India 1"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Smita","family":"Srivastava","sequence":"additional","affiliation":[{"name":"National Institute of Immunology, New Delhi 110067, India 1"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hamid R.","family":"Mattoo","sequence":"additional","affiliation":[{"name":"National Institute of Immunology, New Delhi 110067, India 1"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Krishnamurthy","family":"Thyagarajan","sequence":"additional","affiliation":[{"name":"National Institute of Immunology, New Delhi 110067, India 1"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jasneet Kaur","family":"Khalsa","sequence":"additional","affiliation":[{"name":"National Institute of Immunology, New Delhi 110067, India 1"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shalini","family":"Tanwar","sequence":"additional","affiliation":[{"name":"National Institute of Immunology, New Delhi 110067, India 1"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Deepika Sharma","family":"Das","sequence":"additional","affiliation":[{"name":"National Institute of Immunology, New Delhi 110067, India 1"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Subeer S.","family":"Majumdar","sequence":"additional","affiliation":[{"name":"National Institute of Immunology, New Delhi 110067, India 1"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna","family":"George","sequence":"additional","affiliation":[{"name":"National Institute of Immunology, New Delhi 110067, India 1"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vineeta","family":"Bal","sequence":"additional","affiliation":[{"name":"National Institute of Immunology, New Delhi 110067, India 1"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeannine M.","family":"Durdik","sequence":"additional","affiliation":[{"name":"Department of Biological Sciences, University of Arkansas, Fayetteville, AR 72701 2"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Satyajit","family":"Rath","sequence":"additional","affiliation":[{"name":"National Institute of Immunology, New Delhi 110067, India 1"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"291","published-online":{"date-parts":[[2012,8,6]]},"reference":[{"key":"2023072601155294400_bib1","doi-asserted-by":"publisher","first-page":"371","DOI":"10.1023\/A:1011390103783","article-title":"Caspase-independent apoptotic pathways in T lymphocytes: a minireview","volume":"6","author":"Bid\u00e8re","year":"2001","journal-title":"Apoptosis."},{"key":"2023072601155294400_bib2","doi-asserted-by":"publisher","first-page":"4727","DOI":"10.1242\/jcs.00210","article-title":"Apoptosis-inducing factor (AIF): key to the conserved caspase-independent pathways of cell death?","volume":"115","author":"Cand\u00e9","year":"2002","journal-title":"J. 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