{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,3]],"date-time":"2026-10-03T09:11:30Z","timestamp":1791018690961,"version":"4.1.0"},"reference-count":60,"publisher":"Rockefeller University Press","issue":"11","content-domain":{"domain":["rupress.org"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2011,10,24]]},"abstract":"<jats:p>In humans, DOCK8 immunodeficiency syndrome is characterized by severe cutaneous viral infections. Thus, CD8 T cell function may be compromised in the absence of DOCK8. In this study, by analyzing mutant mice and humans, we demonstrate a critical, intrinsic role for DOCK8 in peripheral CD8 T cell survival and function. DOCK8 mutation selectively diminished the abundance of circulating naive CD8 T cells in both species, and in DOCK8-deficient humans, most CD8 T cells displayed an exhausted CD45RA+CCR7\u2212 phenotype. Analyses in mice revealed the CD8 T cell abnormalities to be cell autonomous and primarily postthymic. DOCK8 mutant naive CD8 T cells had a shorter lifespan and, upon encounter with antigen on dendritic cells, exhibited poor LFA-1 synaptic polarization and a delay in the first cell division. Although DOCK8 mutant T cells underwent near-normal primary clonal expansion after primary infection with recombinant influenza virus in vivo, they showed greatly reduced memory cell persistence and recall. These findings highlight a key role for DOCK8 in the survival and function of human and mouse CD8 T cells.<\/jats:p>","DOI":"10.1084\/jem.20110345","type":"journal-article","created":{"date-parts":[[2011,10,18]],"date-time":"2011-10-18T04:51:02Z","timestamp":1318913462000},"page":"2305-2320","update-policy":"https:\/\/doi.org\/10.1084\/jem.crossmarkpolicy","source":"Crossref","is-referenced-by-count":186,"title":["DOCK8 deficiency impairs CD8 T cell survival and function in humans and mice"],"prefix":"10.1084","volume":"208","author":[{"given":"Katrina L.","family":"Randall","sequence":"first","affiliation":[{"name":"Department of Immunology, The John Curtin School of Medical Research 1 and 2"},{"name":"Australian National University Medical School, Australian National University, Canberra, Australian Capital Territory 0200, Australia 1 and 2"},{"name":"Department of Immunology, The John Curtin School of Medical Research 1 and 2"},{"name":"Australian National University Medical School, 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