{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,23]],"date-time":"2026-08-23T14:55:33Z","timestamp":1787496933786,"version":"build-2736575974"},"reference-count":84,"publisher":"Rockefeller University Press","issue":"10","content-domain":{"domain":["rupress.org"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2011,9,26]]},"abstract":"<jats:p>Artery wall remodeling, a major feature of diseases such as hypertension, restenosis, atherosclerosis, and aneurysm, involves changes in the tunica media mass that reduce or increase the vessel lumen. The identification of molecules involved in vessel remodeling could aid the development of improved treatments for these pathologies. Angiotensin II (AngII) is a key effector of aortic wall remodeling that contributes to aneurysm formation and restenosis through incompletely defined signaling pathways. We show that AngII induces vascular smooth muscle cell (VSMC) migration and vessel remodeling in mouse models of restenosis and aneurysm. These effects were prevented by pharmacological inhibition of calcineurin (CN) or lentiviral delivery of CN-inhibitory peptides. Whole-genome analysis revealed &amp;gt;1,500 AngII-regulated genes in VSMCs, with just 11 of them requiring CN activation. Of these, the most sensitive to CN activation was regulator of CN 1 (Rcan1). Rcan1 was strongly activated by AngII in vitro and in vivo and was required for AngII-induced VSMC migration. Remarkably, Rcan1\u2212\/\u2212 mice were resistant to AngII-induced aneurysm and restenosis. Our results indicate that aneurysm formation and restenosis share mechanistic elements and identify Rcan1 as a potential therapeutic target for prevention of aneurysm and restenosis progression.<\/jats:p>","DOI":"10.1084\/jem.20110503","type":"journal-article","created":{"date-parts":[[2011,9,20]],"date-time":"2011-09-20T04:12:57Z","timestamp":1316491977000},"page":"2125-2139","update-policy":"https:\/\/doi.org\/10.1084\/jem.crossmarkpolicy","source":"Crossref","is-referenced-by-count":61,"title":["Regulator of calcineurin 1 mediates pathological vascular wall remodeling"],"prefix":"10.1084","volume":"208","author":[{"given":"Vanesa","family":"Esteban","sequence":"first","affiliation":[{"name":"Department of Vascular Biology and Inflammation, Centro Nacional de Investigaciones Cardiovasculares (CNIC), E-28029 Madrid, Spain 1"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nerea","family":"M\u00e9ndez-Barbero","sequence":"additional","affiliation":[{"name":"Department of Vascular Biology and Inflammation, Centro Nacional de Investigaciones Cardiovasculares (CNIC), E-28029 Madrid, Spain 1"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luis","family":"Jes\u00fas Jim\u00e9nez-Borreguero","sequence":"additional","affiliation":[{"name":"Department of Atherotrombosis and Imaging, CNIC and Hospital de la Princesa, E-28029 Madrid, Spain 2"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Merc\u00e8","family":"Roqu\u00e9","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Institut del T\u00f2rax, Institut d\u2019Investigacions Biom\u00e8diques Agust\u00ed Pi Sunyer, Hospital Cl\u00ednic, 08036 Barcelona, Spain 3"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura","family":"Novens\u00e1","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Institut del T\u00f2rax, Institut d\u2019Investigacions Biom\u00e8diques Agust\u00ed Pi Sunyer, Hospital Cl\u00ednic, 08036 Barcelona, Spain 3"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ana","family":"Bel\u00e9n Garc\u00eda-Redondo","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, Facultad de Medicina, Universidad Aut\u00f3noma de Madrid, E-28029 Madrid, Spain 4"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mercedes","family":"Salaices","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, Facultad de Medicina, Universidad Aut\u00f3noma de Madrid, E-28029 Madrid, Spain 4"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luis","family":"Vila","sequence":"additional","affiliation":[{"name":"Laboratory of Angiology, Vascular Biology and Inflammation, Institute of Biomedical Research (II-B Sant Pau), E-08025 Barcelona, Spain 5"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mar\u00eda L.","family":"Arbon\u00e9s","sequence":"additional","affiliation":[{"name":"Instituto de Biolog\u00eda Molecular de Barcelona, CSIC, Parc Cient\u00edfic de Barcelona, and Centro de Investigaciones Biom\u00e9dicas en Red de Enfermedades Raras (CIBERER), E-08028, Barcelona, Spain 6"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miguel R.","family":"Campanero","sequence":"additional","affiliation":[{"name":"Department of Cancer Biology, Instituto de Investigaciones Biomedicas Alberto Sols, CSIC-UAM, E-28029 Madrid, Spain 7"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juan Miguel","family":"Redondo","sequence":"additional","affiliation":[{"name":"Department of Vascular Biology and Inflammation, Centro Nacional de Investigaciones Cardiovasculares (CNIC), E-28029 Madrid, Spain 1"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"291","published-online":{"date-parts":[[2011,9,19]]},"reference":[{"key":"2023072522180236600_bib1","doi-asserted-by":"publisher","first-page":"7717","DOI":"10.1074\/jbc.M510775200","article-title":"Protein kinase-mediated regulation of calcineurin through the phosphorylation of modulatory calcineurin-interacting protein 1","volume":"281","author":"Abbasi","year":"2006","journal-title":"J. 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