{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T23:44:33Z","timestamp":1791330273066,"version":"4.3.1"},"reference-count":58,"publisher":"Rockefeller University Press","issue":"3","content-domain":{"domain":["rupress.org"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2012,3,12]]},"abstract":"<jats:p>Formation of the hematopoietic stem cell (HSC) niche in bone marrow (BM) is tightly associated with endochondral ossification, but little is known about the mechanisms involved. We used the oc\/oc mouse, a mouse model with impaired endochondral ossification caused by a loss of osteoclast (OCL) activity, to investigate the role of osteoblasts (OBLs) and OCLs in the HSC niche formation. The absence of OCL activity resulted in a defective HSC niche associated with an increased proportion of mesenchymal progenitors but reduced osteoblastic differentiation, leading to impaired HSC homing to the BM. Restoration of OCL activity reversed the defect in HSC niche formation. Our data demonstrate that OBLs are required for establishing HSC niches and that osteoblastic development is induced by OCLs. These findings broaden our knowledge of the HSC niche formation, which is critical for understanding normal and pathological hematopoiesis.<\/jats:p>","DOI":"10.1084\/jem.20110994","type":"journal-article","created":{"date-parts":[[2012,2,20]],"date-time":"2012-02-20T21:19:28Z","timestamp":1329772768000},"page":"537-549","update-policy":"https:\/\/doi.org\/10.1084\/jem.crossmarkpolicy","source":"Crossref","is-referenced-by-count":205,"title":["Osteoclasts promote the formation of hematopoietic stem cell niches in the bone marrow"],"prefix":"10.1084","volume":"209","author":[{"given":"Anna","family":"Mansour","sequence":"first","affiliation":[{"name":"Universit\u00e9 de Nice Sophia Antipolis, 06000 Nice, France 1"},{"name":"Centre National de la Recherche Scientifique, UMR 6235, Facult\u00e9 de M\u00e9decine, 06100 Nice, France 2"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Grazia","family":"Abou-Ezzi","sequence":"additional","affiliation":[{"name":"Universit\u00e9 de Nice Sophia Antipolis, 06000 Nice, France 1"},{"name":"Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale, UMR 576, H\u00f4pital de l\u2019Archet, 06202 Nice, France 3"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ewa","family":"Sitnicka","sequence":"additional","affiliation":[{"name":"Hematopoietic Stem Cell Laboratory, Lund Research Center for Stem Cell Biology and Cell Therapy, Lund University, 22184 Lund, Sweden 4"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sten Eirik","family":"W. 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