{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T00:07:31Z","timestamp":1791418051150,"version":"4.3.3"},"reference-count":25,"publisher":"Rockefeller University Press","issue":"4","content-domain":{"domain":["rupress.org"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2012,4,9]]},"abstract":"<jats:p>Dendritic cells (DCs) initiate adaptive immune responses in lymph nodes (LNs). In mice, LN DCs can be divided into resident and tissue-derived populations, the latter of which migrate from the peripheral tissues. In humans, different subsets of DCs have been identified in the blood, spleen, and skin, but less is known about populations of resident and migratory tissue-derived DCs in LNs. We have analyzed DCs in human LNs and identified two populations of resident DCs that are present in all LNs analyzed, as well as in the spleen and tonsil, and correspond to the two known blood DC subtypes. We also identify three main populations of skin-derived migratory DCs that are present only in skin-draining LNs and correspond to the DC subsets found in the skin. Resident DCs subsets induce both Th1 and Th2 cytokines in naive allogeneic T lymphocytes, whereas the corresponding blood subsets failed to induce efficient Th2 polarization. LN-resident DCs also cross-present antigen without in vitro activation, whereas blood DCs fail to do so. Among migratory DCs, one subset was poor at both CD4+ and CD8+ T cell activation, whereas the other subsets induced only Th2 polarization. We conclude that in humans, skin-draining LNs host both resident and migratory DC subsets with distinct functional abilities.<\/jats:p>","DOI":"10.1084\/jem.20111457","type":"journal-article","created":{"date-parts":[[2012,3,20]],"date-time":"2012-03-20T04:34:41Z","timestamp":1332218081000},"page":"653-660","update-policy":"https:\/\/doi.org\/10.1084\/jem.crossmarkpolicy","source":"Crossref","is-referenced-by-count":333,"title":["Characterization of resident and migratory dendritic cells in human lymph nodes"],"prefix":"10.1084","volume":"209","author":[{"given":"Elodie","family":"Segura","sequence":"first","affiliation":[{"name":"Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale Unit\u00e9 932, 75005 Paris, France 1"},{"name":"Centre de Recherche 2 , 3 , and 4"},{"name":"Laboratoire d\u2019Immunologie Clinique 2 , 3 , and 4"},{"name":"D\u00e9partement de Biologie des Tumeurs, Institut Curie, 75005 Paris, France 2 , 3 , and 4"},{"name":"CBT507 Institut Gustave Roussy\u2013Curie (Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale Centre d\u2019Investigation Clinique), 75005 Paris, France 5"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jenny","family":"Valladeau-Guilemond","sequence":"additional","affiliation":[{"name":"Le Centre de Recherche en Canc\u00e9rologie de Lyon, Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale Unit\u00e9 1052, Centre National de la Recherche Scientifique 5286, Centre L\u00e9on B\u00e9rard, 69008 Lyon, France 6"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marie-H\u00e9l\u00e8ne","family":"Donnadieu","sequence":"additional","affiliation":[{"name":"Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale Unit\u00e9 932, 75005 Paris, France 1"},{"name":"Centre de Recherche 2 , 3 , and 4"},{"name":"Laboratoire d\u2019Immunologie Clinique 2 , 3 , and 4"},{"name":"D\u00e9partement de Biologie des Tumeurs, Institut Curie, 75005 Paris, France 2 , 3 , and 4"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xavier","family":"Sastre-Garau","sequence":"additional","affiliation":[{"name":"Centre de Recherche 2 , 3 , and 4"},{"name":"Laboratoire d\u2019Immunologie Clinique 2 , 3 , and 4"},{"name":"D\u00e9partement de Biologie des Tumeurs, Institut Curie, 75005 Paris, France 2 , 3 , and 4"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vassili","family":"Soumelis","sequence":"additional","affiliation":[{"name":"Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale Unit\u00e9 932, 75005 Paris, France 1"},{"name":"Centre de Recherche 2 , 3 , and 4"},{"name":"Laboratoire d\u2019Immunologie Clinique 2 , 3 , and 4"},{"name":"D\u00e9partement de Biologie des Tumeurs, Institut Curie, 75005 Paris, France 2 , 3 , and 4"},{"name":"CBT507 Institut Gustave Roussy\u2013Curie (Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale Centre d\u2019Investigation Clinique), 75005 Paris, France 5"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sebastian","family":"Amigorena","sequence":"additional","affiliation":[{"name":"Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale Unit\u00e9 932, 75005 Paris, France 1"},{"name":"Centre de Recherche 2 , 3 , and 4"},{"name":"Laboratoire d\u2019Immunologie Clinique 2 , 3 , and 4"},{"name":"D\u00e9partement de Biologie des Tumeurs, Institut Curie, 75005 Paris, France 2 , 3 , and 4"},{"name":"CBT507 Institut Gustave Roussy\u2013Curie (Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale Centre d\u2019Investigation Clinique), 75005 Paris, France 5"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"291","published-online":{"date-parts":[[2012,3,19]]},"reference":[{"key":"2023072601131776000_bib1","doi-asserted-by":"publisher","first-page":"1257","DOI":"10.1182\/blood-2008-06-165266","article-title":"Distinctive localization of antigen-presenting cells in human lymph nodes","volume":"113","author":"Angel","year":"2009","journal-title":"Blood."},{"key":"2023072601131776000_bib2","doi-asserted-by":"publisher","first-page":"1273","DOI":"10.1084\/jem.20100348","article-title":"Superior antigen cross-presentation and XCR1 expression define human CD11c+CD141+ cells as homologues of mouse CD8+ dendritic cells","volume":"207","author":"Bachem","year":"2010","journal-title":"J. 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