{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,26]],"date-time":"2026-02-26T20:29:39Z","timestamp":1772137779408,"version":"3.50.1"},"reference-count":26,"publisher":"Rockefeller University Press","issue":"6","content-domain":{"domain":["rupress.org"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2012,6,4]]},"abstract":"<jats:p>Systemic lupus erythematosus (SLE), a disease of women during childbearing years, is characterized by the production of double-stranded DNA antibodies. A subset of these antibodies, present in 40% of patients, cross-reacts with the NR2A and NR2B subunits of the N-methyl-d-aspartate receptor (NMDAR). In this study, we show that, in mouse models, these antibodies cause a loss of female fetus viability by inducing apoptosis of NR2A-expressing neurons within the brainstem late in fetal development; gender specificity derives from a time-dependent increased expression of NR2A in female brainstem or increased vulnerability of female fetal neurons to signaling through NR2A-containing NMDARs. This paradigm is consistent with available data on the sex ratio of live births of women with SLE. It represents a novel mechanism by which maternal autoantibodies can severely affect fetal health in a gender-specific fashion and raises the question of how many maternal antibodies affect brain development or exhibit gender-specific fetal effects.<\/jats:p>","DOI":"10.1084\/jem.20111986","type":"journal-article","created":{"date-parts":[[2012,5,8]],"date-time":"2012-05-08T02:55:26Z","timestamp":1336445726000},"page":"1083-1089","update-policy":"https:\/\/doi.org\/10.1084\/jem.crossmarkpolicy","source":"Crossref","is-referenced-by-count":40,"title":["Female mouse fetal loss mediated by maternal autoantibody"],"prefix":"10.1084","volume":"209","author":[{"given":"Li","family":"Wang","sequence":"first","affiliation":[{"name":"Center for Autoimmune and Musculoskeletal Diseases 1 ; 2 ; and 3"},{"name":"Laboratory of Immune and Neural Networks, Center for Biomedical Science 1 ; 2 ; and 3"},{"name":"Laboratory of Functional Neuropathology; The Feinstein Institute for Medical Research, North Shore\u2013Long Island Jewish Health System, Manhasset, NY 11030 1 ; 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