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Using homologous recombination, we replaced the first coding exon of Zbtb46 with GFP to inactivate the locus while allowing detection of Zbtb46 expression. GFP expression in Zbtb46gfp\/+ mice recapitulated the cDC-specific expression of the native locus, being restricted to cDC precursors (pre-cDCs) and lymphoid organ\u2013 and tissue-resident cDCs. GFP+ pre-cDCs had restricted developmental potential, generating cDCs but not pDCs, monocytes, or macrophages. Outside the immune system, Zbtb46 was expressed in committed erythroid progenitors and endothelial cell populations. Zbtb46 overexpression in bone marrow progenitor cells inhibited granulocyte potential and promoted cDC development, and although cDCs developed in Zbtb46gfp\/gfp (Zbtb46 deficient) mice, they maintained expression of granulocyte colony-stimulating factor and leukemia inhibitory factor receptors, which are normally down-regulated in cDCs. Thus, Zbtb46 may help enforce cDC identity by restricting responsiveness to non-DC growth factors and may serve as a useful marker to identify rare cDC progenitors and distinguish between cDCs and other mononuclear phagocyte lineages.<\/jats:p>","DOI":"10.1084\/jem.20120030","type":"journal-article","created":{"date-parts":[[2012,5,21]],"date-time":"2012-05-21T22:51:23Z","timestamp":1337640683000},"page":"1135-1152","update-policy":"https:\/\/doi.org\/10.1084\/jem.crossmarkpolicy","source":"Crossref","is-referenced-by-count":633,"title":["<i>Zbtb46<\/i>\n                    expression distinguishes classical dendritic cells and their committed progenitors from other immune lineages"],"prefix":"10.1084","volume":"209","author":[{"given":"Ansuman T.","family":"Satpathy","sequence":"first","affiliation":[{"name":"Department of Pathology and Immunology 1 and 2"},{"name":"Howard Hughes Medical Institute, School of Medicine, Washington University in St. Louis, St. Louis, MO 63110 1 and 2"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wumesh","family":"KC","sequence":"additional","affiliation":[{"name":"Department of Pathology and Immunology 1 and 2"},{"name":"Howard Hughes Medical Institute, School of Medicine, Washington University in St. Louis, St. Louis, MO 63110 1 and 2"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J\u00f6rn C.","family":"Albring","sequence":"additional","affiliation":[{"name":"Department of Pathology and Immunology 1 and 2"},{"name":"Howard Hughes Medical Institute, School of Medicine, Washington University in St. Louis, St. Louis, MO 63110 1 and 2"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brian T.","family":"Edelson","sequence":"additional","affiliation":[{"name":"Department of Pathology and Immunology 1 and 2"},{"name":"Howard Hughes Medical Institute, School of Medicine, Washington University in St. Louis, St. Louis, MO 63110 1 and 2"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicole M.","family":"Kretzer","sequence":"additional","affiliation":[{"name":"Department of Pathology and Immunology 1 and 2"},{"name":"Howard Hughes Medical Institute, School of Medicine, Washington University in St. Louis, St. Louis, MO 63110 1 and 2"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Deepta","family":"Bhattacharya","sequence":"additional","affiliation":[{"name":"Department of Pathology and Immunology 1 and 2"},{"name":"Howard Hughes Medical Institute, School of Medicine, Washington University in St. Louis, St. Louis, MO 63110 1 and 2"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Theresa L.","family":"Murphy","sequence":"additional","affiliation":[{"name":"Department of Pathology and Immunology 1 and 2"},{"name":"Howard Hughes Medical Institute, School of Medicine, Washington University in St. Louis, St. Louis, MO 63110 1 and 2"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kenneth M.","family":"Murphy","sequence":"additional","affiliation":[{"name":"Department of Pathology and Immunology 1 and 2"},{"name":"Howard Hughes Medical Institute, School of Medicine, Washington University in St. Louis, St. Louis, MO 63110 1 and 2"},{"name":"Department of Pathology and Immunology 1 and 2"},{"name":"Howard Hughes Medical Institute, School of Medicine, Washington University in St. Louis, St. Louis, MO 63110 1 and 2"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"291","published-online":{"date-parts":[[2012,5,21]]},"reference":[{"key":"2023072602561142600_bib1","doi-asserted-by":"publisher","first-page":"193","DOI":"10.1038\/35004599","article-title":"A clonogenic common myeloid progenitor that gives rise to all myeloid lineages","volume":"404","author":"Akashi","year":"2000","journal-title":"Nature."},{"key":"2023072602561142600_bib2","doi-asserted-by":"publisher","first-page":"85","DOI":"10.1016\/j.immuni.2010.12.011","article-title":"CD169-positive macrophages dominate antitumor immunity by crosspresenting dead cell-associated antigens","volume":"34","author":"Asano","year":"2011","journal-title":"Immunity."},{"key":"2023072602561142600_bib3","doi-asserted-by":"publisher","first-page":"14745","DOI":"10.1073\/pnas.1001562107","article-title":"CX3CR1+ CD8alpha+ dendritic cells are a steady-state population related to plasmacytoid dendritic cells","volume":"107","author":"Bar-On","year":"2010","journal-title":"Proc. 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