{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T21:53:58Z","timestamp":1791410038529,"version":"4.3.3"},"reference-count":55,"publisher":"Rockefeller University Press","issue":"6","content-domain":{"domain":["rupress.org"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2012,6,4]]},"abstract":"<jats:p>Langerhans cells (LCs) are the dendritic cells (DCs) of the epidermis, forming one of the first hematopoietic lines of defense against skin pathogens. In contrast to other DCs, LCs arise from hematopoietic precursors that seed the skin before birth. However, the origin of these embryonic precursors remains unclear. Using in vivo lineage tracing, we identify a first wave of yolk sac (YS)\u2013derived primitive myeloid progenitors that seed the skin before the onset of fetal liver hematopoiesis. YS progenitors migrate to the embryo proper, including the prospective skin, where they give rise to LC precursors, and the brain rudiment, where they give rise to microglial cells. However, in contrast to microglia, which remain of YS origin throughout life, YS-derived LC precursors are largely replaced by fetal liver monocytes during late embryogenesis. Consequently, adult LCs derive predominantly from fetal liver monocyte-derived cells with a minor contribution of YS-derived cells. Altogether, we establish that adult LCs have a dual origin, bridging early embryonic and late fetal myeloid development.<\/jats:p>","DOI":"10.1084\/jem.20120340","type":"journal-article","created":{"date-parts":[[2012,5,8]],"date-time":"2012-05-08T02:55:26Z","timestamp":1336445726000},"page":"1167-1181","update-policy":"https:\/\/doi.org\/10.1084\/jem.crossmarkpolicy","source":"Crossref","is-referenced-by-count":788,"title":["Adult Langerhans cells derive predominantly from embryonic fetal liver monocytes with a minor contribution of yolk sac\u2013derived macrophages"],"prefix":"10.1084","volume":"209","author":[{"given":"Guillaume","family":"Hoeffel","sequence":"first","affiliation":[{"name":"Singapore Immunology Network, Agency for Science, Technology and Research (A*STAR), Immunos Building #3-4, BIOPOLIS, 138648, Singapore 1"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yilin","family":"Wang","sequence":"additional","affiliation":[{"name":"Singapore Immunology Network, Agency for Science, Technology and Research (A*STAR), Immunos Building #3-4, BIOPOLIS, 138648, Singapore 1"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Melanie","family":"Greter","sequence":"additional","affiliation":[{"name":"Department of Gene and Cell Medicine 2 and 3"},{"name":"The Immunology Institute, Mount Sinai School of Medicine, New York, NY 10029 2 and 3"},{"name":"Department of Gene and Cell Medicine 2 and 3"},{"name":"The Immunology Institute, Mount Sinai School of Medicine, New York, NY 10029 2 and 3"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter","family":"See","sequence":"additional","affiliation":[{"name":"Singapore Immunology Network, Agency for Science, Technology and Research (A*STAR), Immunos Building #3-4, BIOPOLIS, 138648, Singapore 1"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pearline","family":"Teo","sequence":"additional","affiliation":[{"name":"Singapore Immunology Network, Agency for Science, Technology and Research (A*STAR), Immunos Building #3-4, BIOPOLIS, 138648, Singapore 1"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Benoit","family":"Malleret","sequence":"additional","affiliation":[{"name":"Singapore Immunology Network, Agency for Science, Technology and Research (A*STAR), Immunos Building #3-4, BIOPOLIS, 138648, Singapore 1"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maryl\u00e8ne","family":"Leboeuf","sequence":"additional","affiliation":[{"name":"Department of Gene and Cell Medicine 2 and 3"},{"name":"The Immunology Institute, Mount Sinai School of Medicine, New York, NY 10029 2 and 3"},{"name":"Department of Gene and Cell Medicine 2 and 3"},{"name":"The Immunology Institute, Mount Sinai School of Medicine, New York, NY 10029 2 and 3"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Donovan","family":"Low","sequence":"additional","affiliation":[{"name":"Singapore Immunology Network, Agency for Science, Technology and Research (A*STAR), Immunos Building #3-4, BIOPOLIS, 138648, Singapore 1"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guillaume","family":"Oller","sequence":"additional","affiliation":[{"name":"Singapore Immunology Network, Agency for Science, Technology and Research (A*STAR), Immunos Building #3-4, BIOPOLIS, 138648, Singapore 1"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francisca","family":"Almeida","sequence":"additional","affiliation":[{"name":"Singapore Immunology Network, Agency for Science, Technology and Research (A*STAR), Immunos Building #3-4, BIOPOLIS, 138648, Singapore 1"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sharon H.Y.","family":"Choy","sequence":"additional","affiliation":[{"name":"Biological Resource Centre, A*STAR, #07-01 Centros, 138668, Singapore 4"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marcos","family":"Grisotto","sequence":"additional","affiliation":[{"name":"Centro Universit\u00e1rio do Maranh\u00e3o \u2013 UNICEUMA, S\u00e3o Luis, MA, Brazil 5"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laurent","family":"Renia","sequence":"additional","affiliation":[{"name":"Singapore Immunology Network, Agency for Science, Technology and Research (A*STAR), Immunos Building #3-4, BIOPOLIS, 138648, Singapore 1"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Simon J.","family":"Conway","sequence":"additional","affiliation":[{"name":"Herman B Wells Center for Pediatric Research, Indiana University School of Medicine, Indianapolis, IN 46202 6"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E. 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