{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T02:08:33Z","timestamp":1791079713396,"version":"4.1.0"},"reference-count":36,"publisher":"Rockefeller University Press","issue":"9","content-domain":{"domain":["rupress.org"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2013,8,26]]},"abstract":"<jats:p>Interleukin (IL) 12 and IL23 are two related heterodimeric cytokines produced by antigen-presenting cells. The balance between these two cytokines plays a crucial role in the control of Th1\/Th17 responses and autoimmune inflammation. Most studies focused on their transcriptional regulation. Herein, we explored the role of the adenine and uridine\u2013rich element (ARE)\u2013binding protein tristetraprolin (TTP) in influencing mRNA stability of IL12p35, IL12\/23p40, and IL23p19 subunits. LPS-stimulated bone marrow\u2013derived dendritic cells (BMDCs) from TTP\u2212\/\u2212 mice produced normal levels of IL12\/23p40. Production of IL12p70 was modestly increased in these conditions. In contrast, we observed a strong impact of TTP on IL23 production and IL23p19 mRNA stability through several AREs in the 3\u2032 untranslated region. TTP\u2212\/\u2212 mice spontaneously develop an inflammatory syndrome characterized by cachexia, myeloid hyperplasia, dermatitis, and erosive arthritis. We observed IL23p19 expression within skin lesions associated with exacerbated IL17A and IL22 production by infiltrating \u03b3\u03b4 T cells and draining lymph node CD4 T cells. We demonstrate that the clinical and immunological parameters associated with TTP deficiency were completely dependent on the IL23\u2013IL17A axis. We conclude that tight control of IL23 mRNA stability by TTP is critical to avoid severe inflammation.<\/jats:p>","DOI":"10.1084\/jem.20120707","type":"journal-article","created":{"date-parts":[[2013,8,13]],"date-time":"2013-08-13T03:19:13Z","timestamp":1376363953000},"page":"1675-1684","update-policy":"https:\/\/doi.org\/10.1084\/jem.crossmarkpolicy","source":"Crossref","is-referenced-by-count":92,"title":["Tristetraprolin regulation of interleukin 23 mRNA stability prevents a spontaneous inflammatory disease"],"prefix":"10.1084","volume":"210","author":[{"given":"C\u00e9line","family":"Molle","sequence":"first","affiliation":[{"name":"Institute for Medical Immunology (IMI) 1 , 2 , and 3"},{"name":"Laboratoire de Biologie Mol\u00e9culaire du G\u00e8ne 1 , 2 , and 3"},{"name":"Center for Microscopy and Molecular Imaging (CMMI), Universit\u00e9 Libre de Bruxelles, B-6041 Charleroi-Gosselies, Belgium 1 , 2 , and 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