{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T07:36:19Z","timestamp":1791272179188,"version":"4.1.0"},"reference-count":85,"publisher":"Rockefeller University Press","issue":"10","content-domain":{"domain":["rupress.org"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2013,9,23]]},"abstract":"<jats:p>Neurons are postmitotic and thus irreplaceable cells of the central nervous system (CNS). Accordingly, CNS inflammation with resulting neuronal damage can have devastating consequences. We investigated molecular mediators and structural consequences of CD8+ T lymphocyte (CTL) attack on neurons in vivo. In a viral encephalitis model in mice, disease depended on CTL-derived interferon-\u03b3 (IFN-\u03b3) and neuronal IFN-\u03b3 signaling. Downstream STAT1 phosphorylation and nuclear translocation in neurons were associated with dendrite and synapse loss (deafferentation). Analogous molecular and structural alterations were also found in human Rasmussen encephalitis, a CTL-mediated human autoimmune disorder of the CNS. Importantly, therapeutic intervention by IFN-\u03b3 blocking antibody prevented neuronal deafferentation and clinical disease without reducing CTL responses or CNS infiltration. These findings identify neuronal IFN-\u03b3 signaling as a novel target for neuroprotective interventions in CTL-mediated CNS disease.<\/jats:p>","DOI":"10.1084\/jem.20122143","type":"journal-article","created":{"date-parts":[[2013,9,3]],"date-time":"2013-09-03T00:38:46Z","timestamp":1378168726000},"page":"2087-2103","update-policy":"https:\/\/doi.org\/10.1084\/jem.crossmarkpolicy","source":"Crossref","is-referenced-by-count":85,"title":["Neuroprotective intervention by interferon-\u03b3 blockade prevents CD8+ T cell\u2013mediated dendrite and synapse loss"],"prefix":"10.1084","volume":"210","author":[{"given":"Mario","family":"Kreutzfeldt","sequence":"first","affiliation":[{"name":"Department of Pathology and Immunology 1 and 2"},{"name":"World Health Organization Collaborating Centre for Vaccine Immunology, University of Geneva, 1211 Geneva, Switzerland 1 and 2"},{"name":"Division of Clinical Pathology, Geneva University Hospital, 1211 Geneva, Switzerland 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