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Blimp-1 represses PD-1 through a feed-forward repressive circuit by regulating PD-1 directly and by repressing NFATc1 expression, an activator of PD-1 expression. Blimp-1 binding induces a repressive chromatin structure at the PD-1 locus, leading to the eviction of NFATc1 from its site. These data place Blimp-1 at an important phase of the CD8 T cell effector response and provide a molecular mechanism for its repression of PD-1.<\/jats:p>","DOI":"10.1084\/jem.20130208","type":"journal-article","created":{"date-parts":[[2014,3,4]],"date-time":"2014-03-04T00:19:49Z","timestamp":1393892389000},"page":"515-527","update-policy":"https:\/\/doi.org\/10.1084\/jem.crossmarkpolicy","source":"Crossref","is-referenced-by-count":151,"title":["Blimp-1 represses CD8 T cell expression of PD-1 using a feed-forward transcriptional circuit during acute viral infection"],"prefix":"10.1084","volume":"211","author":[{"given":"Peiyuan","family":"Lu","sequence":"first","affiliation":[{"name":"Department of Microbiology and Immunology and Emory Vaccine Center, Emory University School of Medicine, Atlanta, GA 30322"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Benjamin A.","family":"Youngblood","sequence":"additional","affiliation":[{"name":"Department of Microbiology and Immunology and Emory Vaccine Center, Emory University School of Medicine, Atlanta, GA 30322"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James W.","family":"Austin","sequence":"additional","affiliation":[{"name":"Department of Microbiology and Immunology and Emory Vaccine Center, Emory University School of Medicine, Atlanta, GA 30322"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ata Ur","family":"Rasheed Mohammed","sequence":"additional","affiliation":[{"name":"Department of Microbiology and Immunology and Emory Vaccine Center, Emory University School of Medicine, Atlanta, GA 30322"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Royce","family":"Butler","sequence":"additional","affiliation":[{"name":"Department of Microbiology and Immunology and Emory Vaccine Center, Emory University School of Medicine, Atlanta, GA 30322"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rafi","family":"Ahmed","sequence":"additional","affiliation":[{"name":"Department of Microbiology and Immunology and Emory Vaccine Center, Emory University School of Medicine, Atlanta, GA 30322"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeremy M.","family":"Boss","sequence":"additional","affiliation":[{"name":"Department of Microbiology and Immunology and Emory Vaccine Center, Emory University School of Medicine, Atlanta, GA 30322"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"291","published-online":{"date-parts":[[2014,3,3]]},"reference":[{"key":"2023072602144040500_bib1","doi-asserted-by":"publisher","first-page":"4565","DOI":"10.1073\/pnas.0610335104","article-title":"Impaired NFAT nuclear translocation results in split exhaustion of virus-specific CD8+ T cell functions during chronic viral infection","volume":"104","author":"Agnellini","year":"2007","journal-title":"Proc. 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