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Inflammation was also associated with deficient trophoblast invasion and SA remodeling, as well as with altered uteroplacental hemodynamics and placental nitrosative stress. Moreover, inflammation increased maternal mean arterial pressure (MAP) and was associated with renal structural alterations and proteinuria characteristic of PE. Finally, transdermal administration of the nitric oxide (NO) mimetic glyceryl trinitrate prevented altered uteroplacental perfusion, LPS-induced inflammation, placental nitrosative stress, renal structural and functional alterations, increase in MAP, and FGR. These findings demonstrate that maternal inflammation can lead to severe pregnancy complications via a mechanism that involves increased maternal levels of TNF. Our study provides a rationale for the use of antiinflammatory agents or NO-mimetics in the treatment and\/or prevention of inflammation-associated pregnancy complications.<\/jats:p>","DOI":"10.1084\/jem.20130295","type":"journal-article","created":{"date-parts":[[2014,1,7]],"date-time":"2014-01-07T04:15:02Z","timestamp":1389068102000},"page":"165-179","update-policy":"https:\/\/doi.org\/10.1084\/jem.crossmarkpolicy","source":"Crossref","is-referenced-by-count":307,"title":["Inflammation in rat pregnancy inhibits spiral artery remodeling leading to fetal growth restriction and features of preeclampsia"],"prefix":"10.1084","volume":"211","author":[{"given":"Tiziana","family":"Cotechini","sequence":"first","affiliation":[{"name":"Department of Biomedical and Molecular Sciences, Queen\u2019s University, Kingston, Ontario, Canada K7L 3N6"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria","family":"Komisarenko","sequence":"additional","affiliation":[{"name":"Department of Biomedical and Molecular Sciences, Queen\u2019s University, Kingston, Ontario, Canada K7L 3N6"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arissa","family":"Sperou","sequence":"additional","affiliation":[{"name":"Department of Biomedical and Molecular Sciences, Queen\u2019s University, Kingston, Ontario, Canada K7L 3N6"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shannyn","family":"Macdonald-Goodfellow","sequence":"additional","affiliation":[{"name":"Department of Biomedical and Molecular Sciences, Queen\u2019s University, Kingston, Ontario, Canada K7L 3N6"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael A.","family":"Adams","sequence":"additional","affiliation":[{"name":"Department of Biomedical and Molecular Sciences, Queen\u2019s University, Kingston, Ontario, Canada K7L 3N6"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Charles H.","family":"Graham","sequence":"additional","affiliation":[{"name":"Department of Biomedical and Molecular Sciences, Queen\u2019s University, Kingston, Ontario, Canada K7L 3N6"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"291","published-online":{"date-parts":[[2014,1,6]]},"reference":[{"key":"2023072602134833000_bib1","doi-asserted-by":"publisher","first-page":"162","DOI":"10.1002\/uog.1902","article-title":"Reference ranges for serial measurements of blood velocity and pulsatility index at the intra-abdominal portion, and fetal and placental ends of the umbilical artery","volume":"26","author":"Acharya","year":"2005","journal-title":"Ultrasound Obstet. 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