{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T20:23:35Z","timestamp":1791318215136,"version":"4.3.1"},"reference-count":81,"publisher":"Rockefeller University Press","issue":"11","content-domain":{"domain":["rupress.org"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2013,10,21]]},"abstract":"<jats:p>Progression and disease relapse of chronic myeloid leukemia (CML) depends on leukemia-initiating cells (LIC) that resist treatment. Using mouse genetics and a BCR-ABL model of CML, we observed cross talk between Wnt\/\u03b2-catenin signaling and the interferon-regulatory factor 8 (Irf8). In normal hematopoiesis, activation of \u03b2-catenin results in up-regulation of Irf8, which in turn limits oncogenic \u03b2-catenin functions. Self-renewal and myeloproliferation become dependent on \u03b2-catenin in Irf8-deficient animals that develop a CML-like disease. Combined Irf8 deletion and constitutive \u03b2-catenin activation result in progression of CML into fatal blast crisis, elevated leukemic potential of BCR-ABL\u2013induced LICs, and Imatinib resistance. Interestingly, activated \u03b2-catenin enhances a preexisting Irf8-deficient gene signature, identifying \u03b2-catenin as an amplifier of progression-specific gene regulation in the shift of CML to blast crisis. Collectively, our data uncover Irf8 as a roadblock for \u03b2-catenin\u2013driven leukemia and imply both factors as targets in combinatorial therapy.<\/jats:p>","DOI":"10.1084\/jem.20130706","type":"journal-article","created":{"date-parts":[[2013,10,7]],"date-time":"2013-10-07T23:05:56Z","timestamp":1381187156000},"page":"2239-2256","update-policy":"https:\/\/doi.org\/10.1084\/jem.crossmarkpolicy","source":"Crossref","is-referenced-by-count":49,"title":["Cross talk between Wnt\/\u03b2-catenin and\n                    <i>Irf8<\/i>\n                    in leukemia progression and drug resistance"],"prefix":"10.1084","volume":"210","author":[{"given":"Marina","family":"Scheller","sequence":"first","affiliation":[{"name":"Max Delbr\u00fcck Center for Molecular Medicine, 13125 Berlin, Germany 1"},{"name":"Berlin-Brandenburg Center for Regenerative Therapies, Charit\u00e9-Universit\u00e4tsmedizin Berlin, 13353 Berlin, Germany 2"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J\u00f6rg","family":"Sch\u00f6nheit","sequence":"additional","affiliation":[{"name":"Max Delbr\u00fcck Center for Molecular Medicine, 13125 Berlin, Germany 1"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karin","family":"Zimmermann","sequence":"additional","affiliation":[{"name":"Institute for Computer Science, Humboldt-University of Berlin, 10099 Berlin, Germany 3"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ulf","family":"Leser","sequence":"additional","affiliation":[{"name":"Institute for Computer Science, Humboldt-University of Berlin, 10099 Berlin, Germany 3"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Frank","family":"Rosenbauer","sequence":"additional","affiliation":[{"name":"Institute of Molecular Tumor Biology, Medical Faculty of the University of Muenster, 48149 Muenster, Germany 4"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Achim","family":"Leutz","sequence":"additional","affiliation":[{"name":"Max Delbr\u00fcck Center for Molecular Medicine, 13125 Berlin, Germany 1"},{"name":"Berlin-Brandenburg Center for Regenerative Therapies, Charit\u00e9-Universit\u00e4tsmedizin Berlin, 13353 Berlin, Germany 2"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"291","published-online":{"date-parts":[[2013,10,7]]},"reference":[{"key":"2023072603074201100_bib1","doi-asserted-by":"publisher","first-page":"e13186","DOI":"10.1371\/journal.pone.0013186","article-title":"Chronic myeloid leukemia patients sensitive and resistant to imatinib treatment show different metabolic responses","volume":"5","author":"A","year":"2010","journal-title":"PLoS ONE."},{"key":"2023072603074201100_bib2","doi-asserted-by":"publisher","first-page":"3797","DOI":"10.1093\/emboj\/16.13.3797","article-title":"beta-catenin is a target for the ubiquitin-proteasome pathway","volume":"16","author":"Aberle","year":"1997","journal-title":"EMBO J."},{"key":"2023072603074201100_bib3","doi-asserted-by":"publisher","first-page":"3925","DOI":"10.1073\/pnas.0900189106","article-title":"Glycogen synthase kinase 3beta missplicing contributes to leukemia stem cell generation","volume":"106","author":"Abrahamsson","year":"2009","journal-title":"Proc. Natl. Acad. Sci. USA."},{"key":"2023072603074201100_bib4","doi-asserted-by":"publisher","first-page":"599","DOI":"10.1016\/j.immuni.2005.10.009","article-title":"Constitutively active beta-catenin confers multilineage differentiation potential on lymphoid and myeloid progenitors","volume":"23","author":"Baba","year":"2005","journal-title":"Immunity."},{"key":"2023072603074201100_bib5","doi-asserted-by":"publisher","first-page":"277","DOI":"10.1038\/306277a0","article-title":"Translocation of c-ab1 oncogene correlates with the presence of a Philadelphia chromosome in chronic myelocytic leukaemia","volume":"306","author":"Bartram","year":"1983","journal-title":"Nature."},{"key":"2023072603074201100_bib6","doi-asserted-by":"publisher","first-page":"730","DOI":"10.1038\/nm0797-730","article-title":"Human acute myeloid leukemia is organized as a hierarchy that originates from a primitive hematopoietic cell","volume":"3","author":"Bonnet","year":"1997","journal-title":"Nat. Med."},{"key":"2023072603074201100_bib7","doi-asserted-by":"publisher","first-page":"2420","DOI":"10.1038\/sj.leu.2404917","article-title":"Marrow fibrosis and its relevance during imatinib treatment of chronic myeloid leukemia","volume":"21","author":"Buesche","year":"2007","journal-title":"Leukemia."},{"key":"2023072603074201100_bib8","doi-asserted-by":"publisher","first-page":"3480","DOI":"10.1182\/blood-2003-08-2970","article-title":"Interferon consensus sequence binding protein (ICSBP; IRF-8) antagonizes BCR\/ABL and down-regulates bcl-2","volume":"103","author":"Burchert","year":"2004","journal-title":"Blood."},{"key":"2023072603074201100_bib9","doi-asserted-by":"publisher","first-page":"221","DOI":"10.1084\/jem.20031615","article-title":"\u03b2-catenin is dispensable for hematopoiesis and lymphopoiesis","volume":"199","author":"Cobas","year":"2004","journal-title":"J. Exp. Med."},{"key":"2023072603074201100_bib10","doi-asserted-by":"publisher","first-page":"303","DOI":"10.1186\/1471-2407-12-303","article-title":"Wnt\/\u03b2-catenin pathway regulates ABCB1 transcription in chronic myeloid leukemia","volume":"12","author":"Corr\u00eaa","year":"2012","journal-title":"BMC Cancer."},{"key":"2023072603074201100_bib11","doi-asserted-by":"publisher","first-page":"15","DOI":"10.1016\/j.canlet.2012.08.006","article-title":"Selective elimination of leukemia stem cells: Hitting a moving target","volume":"338","author":"Crews","year":"2013","journal-title":"Cancer Lett."},{"key":"2023072603074201100_bib12","doi-asserted-by":"publisher","first-page":"6144","DOI":"10.1182\/blood-2010-07-296954","article-title":"Polymorphisms in the multidrug resistance gene MDR1 (ABCB1) predict for molecular resistance in patients with newly diagnosed chronic myeloid leukemia receiving high-dose imatinib","volume":"116","author":"Deenik","year":"2010","journal-title":"Blood."},{"key":"2023072603074201100_bib13","doi-asserted-by":"publisher","first-page":"3491","DOI":"10.1182\/blood.V97.11.3491","article-title":"Expression of interferon consensus sequence binding protein induces potent immunity against BCR\/ABL-induced leukemia","volume":"97","author":"Deng","year":"2001","journal-title":"Blood."},{"key":"2023072603074201100_bib14","doi-asserted-by":"publisher","first-page":"494","DOI":"10.1038\/sj.leu.2404549","article-title":"Molecular signature of CD34(+) hematopoietic stem and progenitor cells of patients with CML in chronic phase","volume":"21","author":"Diaz-Blanco","year":"2007","journal-title":"Leukemia."},{"key":"2023072603074201100_bib15","doi-asserted-by":"crossref","first-page":"2272","DOI":"10.1182\/blood.V91.7.2272","article-title":"Systemic overexpression of BCL-2 in the hematopoietic system protects transgenic mice from the consequences of lethal irradiation","volume":"91","author":"Domen","year":"1998","journal-title":"Blood."},{"key":"2023072603074201100_bib16","doi-asserted-by":"publisher","first-page":"2408","DOI":"10.1056\/NEJMoa062867","article-title":"Five-year follow-up of patients receiving imatinib for chronic myeloid leukemia","volume":"355","author":"Druker","year":"2006","journal-title":"N. Engl. J. Med."},{"key":"2023072603074201100_bib17","doi-asserted-by":"publisher","first-page":"384","DOI":"10.1038\/nature09883","article-title":"BCL6 enables Ph+ acute lymphoblastic leukaemia cells to survive BCR-ABL1 kinase inhibition","volume":"473","author":"Duy","year":"2011","journal-title":"Nature."},{"key":"2023072603074201100_bib18","doi-asserted-by":"publisher","first-page":"1086","DOI":"10.1038\/nm.2415","article-title":"Stem cell gene expression programs influence clinical outcome in human leukemia","volume":"17","author":"Eppert","year":"2011","journal-title":"Nat. Med."},{"key":"2023072603074201100_bib19","doi-asserted-by":"publisher","first-page":"151","DOI":"10.1007\/978-1-62703-128-8_10","article-title":"Isolation and characterization of mouse side population cells","volume":"946","author":"Ergen","year":"2013","journal-title":"Methods Mol. Biol."},{"key":"2023072603074201100_bib20","doi-asserted-by":"publisher","first-page":"12532","DOI":"10.1073\/pnas.1209815109","article-title":"\u03b2-Arrestin2 mediates the initiation and progression of myeloid leukemia","volume":"109","author":"Fereshteh","year":"2012","journal-title":"Proc. Natl. Acad. Sci. USA."},{"key":"2023072603074201100_bib21","doi-asserted-by":"publisher","first-page":"55","DOI":"10.1038\/35094067","article-title":"APC, signal transduction and genetic instability in colorectal cancer","volume":"1","author":"Fodde","year":"2001","journal-title":"Nat. Rev. Cancer."},{"key":"2023072603074201100_bib22","doi-asserted-by":"publisher","first-page":"411","DOI":"10.1084\/jem.190.3.411","article-title":"Regulation of apoptosis in myeloid cells by interferon consensus sequence-binding protein","volume":"190","author":"Gabriele","year":"1999","journal-title":"J. Exp. Med."},{"key":"2023072603074201100_bib23","doi-asserted-by":"publisher","first-page":"136","DOI":"10.1016\/j.stem.2011.01.007","article-title":"Critical appraisal of the side population assay in stem cell and cancer stem cell research","volume":"8","author":"Golebiewska","year":"2011","journal-title":"Cell Stem Cell."},{"key":"2023072603074201100_bib24","doi-asserted-by":"publisher","first-page":"876","DOI":"10.1126\/science.1062538","article-title":"Clinical resistance to STI-571 cancer therapy caused by BCR-ABL gene mutation or amplification","volume":"293","author":"Gorre","year":"2001","journal-title":"Science."},{"key":"2023072603074201100_bib25","doi-asserted-by":"publisher","first-page":"1191","DOI":"10.1016\/j.exphem.2006.04.020","article-title":"Retroviral integration site analysis identifies ICSBP as a collaborating tumor suppressor gene in NUP98-TOP1-induced leukemia","volume":"34","author":"Gurevich","year":"2006","journal-title":"Exp. Hematol."},{"key":"2023072603074201100_bib26","doi-asserted-by":"publisher","first-page":"1149","DOI":"10.1128\/MCB.20.4.1149-1161.2000","article-title":"Expression of interferon consensus sequence binding protein (ICSBP) is downregulated in Bcr-Abl-induced murine chronic myelogenous leukemia-like disease, and forced coexpression of ICSBP inhibits Bcr-Abl-induced myeloproliferative disorder","volume":"20","author":"Hao","year":"2000","journal-title":"Mol. Cell. Biol."},{"key":"2023072603074201100_bib27","doi-asserted-by":"publisher","first-page":"3865","DOI":"10.1038\/sj.onc.1211043","article-title":"Acceleration of chronic myeloproliferation by enforced expression of Meis1 or Meis3 in Icsbp-deficient bone marrow cells","volume":"27","author":"Hara","year":"2008","journal-title":"Oncogene."},{"key":"2023072603074201100_bib28","doi-asserted-by":"publisher","first-page":"5931","DOI":"10.1093\/emboj\/18.21.5931","article-title":"Intestinal polyposis in mice with a dominant stable mutation of the beta-catenin gene","volume":"18","author":"Harada","year":"1999","journal-title":"EMBO J."},{"key":"2023072603074201100_bib29","doi-asserted-by":"publisher","first-page":"412","DOI":"10.1016\/j.stem.2012.02.017","article-title":"Genetic and pharmacologic inhibition of \u03b2-catenin targets imatinib-resistant leukemia stem cells in CML","volume":"10","author":"Heidel","year":"2012","journal-title":"Cell Stem Cell."},{"key":"2023072603074201100_bib30","doi-asserted-by":"publisher","first-page":"307","DOI":"10.1016\/S0092-8674(00)81348-3","article-title":"Immunodeficiency and chronic myelogenous leukemia-like syndrome in mice with a targeted mutation of the ICSBP gene","volume":"87","author":"Holtschke","year":"1996","journal-title":"Cell."},{"key":"2023072603074201100_bib31","doi-asserted-by":"publisher","first-page":"109","DOI":"10.1038\/leu.2008.262","article-title":"beta-Catenin is essential for survival of leukemic stem cells insensitive to kinase inhibition in mice with BCR-ABL-induced chronic myeloid leukemia","volume":"23","author":"Hu","year":"2009","journal-title":"Leukemia."},{"key":"2023072603074201100_bib32","doi-asserted-by":"publisher","first-page":"4575","DOI":"10.1128\/MCB.01595-09","article-title":"Interferon consensus sequence binding protein (ICSBP) decreases beta-catenin activity in myeloid cells by repressing GAS2 transcription","volume":"30","author":"Huang","year":"2010","journal-title":"Mol. Cell. Biol."},{"key":"2023072603074201100_bib33","doi-asserted-by":"publisher","first-page":"533","DOI":"10.1016\/S0092-8674(01)00336-1","article-title":"beta-Catenin controls hair follicle morphogenesis and stem cell differentiation in the skin","volume":"105","author":"Huelsken","year":"2001","journal-title":"Cell."},{"key":"2023072603074201100_bib34","doi-asserted-by":"publisher","first-page":"2163","DOI":"10.1084\/jem.20110304","article-title":"BCL6-mediated repression of p53 is critical for leukemia stem cell survival in chronic myeloid leukemia","volume":"208","author":"Hurtz","year":"2011","journal-title":"J. Exp. Med."},{"key":"2023072603074201100_bib35","doi-asserted-by":"publisher","first-page":"6687","DOI":"10.1038\/sj.onc.1210754","article-title":"Hematopoietic developmental pathways: on cellular basis","volume":"26","author":"Iwasaki","year":"2007","journal-title":"Oncogene."},{"key":"2023072603074201100_bib36","doi-asserted-by":"publisher","first-page":"657","DOI":"10.1056\/NEJMoa040258","article-title":"Granulocyte-macrophage progenitors as candidate leukemic stem cells in blast-crisis CML","volume":"351","author":"Jamieson","year":"2004","journal-title":"N. Engl. J. Med."},{"key":"2023072603074201100_bib37","doi-asserted-by":"publisher","first-page":"142","DOI":"10.1182\/blood-2007-07-102558","article-title":"Long-term, multilineage hematopoiesis occurs in the combined absence of beta-catenin and gamma-catenin","volume":"111","author":"Jeannet","year":"2008","journal-title":"Blood."},{"key":"2023072603074201100_bib38","doi-asserted-by":"publisher","first-page":"1370","DOI":"10.1182\/blood-2006-02-003145","article-title":"Functional ABCG2 is overexpressed on primary CML CD34+ cells and is inhibited by imatinib mesylate","volume":"108","author":"Jordanides","year":"2006","journal-title":"Blood."},{"key":"2023072603074201100_bib39","doi-asserted-by":"publisher","first-page":"3509","DOI":"10.1091\/mbc.11.10.3509","article-title":"Overexpression of beta-catenin induces apoptosis independent of its transactivation function with LEF-1 or the involvement of major G1 cell cycle regulators","volume":"11","author":"Kim","year":"2000","journal-title":"Mol. Biol. Cell."},{"key":"2023072603074201100_bib40","doi-asserted-by":"publisher","first-page":"1048","DOI":"10.1038\/ni1381","article-title":"Activation of the canonical Wnt pathway leads to loss of hematopoietic stem cell repopulation and multilineage differentiation block","volume":"7","author":"Kirstetter","year":"2006","journal-title":"Nat. Immunol."},{"key":"2023072603074201100_bib41","doi-asserted-by":"publisher","first-page":"299","DOI":"10.1016\/j.ccr.2008.02.008","article-title":"Modeling of C\/EBPalpha mutant acute myeloid leukemia reveals a common expression signature of committed myeloid leukemia-initiating cells","volume":"13","author":"Kirstetter","year":"2008","journal-title":"Cancer Cell."},{"key":"2023072603074201100_bib42","doi-asserted-by":"publisher","first-page":"160","DOI":"10.1182\/blood-2007-07-099754","article-title":"Simultaneous loss of beta- and gamma-catenin does not perturb hematopoiesis or lymphopoiesis","volume":"111","author":"Koch","year":"2008","journal-title":"Blood."},{"key":"2023072603074201100_bib43","doi-asserted-by":"publisher","first-page":"2078","DOI":"10.3109\/10428190903296913","article-title":"Loss of Irf8 does not co-operate with overexpression of BCL-2 in the induction of leukemias in vivo","volume":"50","author":"Koenigsmann","year":"2009","journal-title":"Leuk. Lymphoma."},{"key":"2023072603074201100_bib44","doi-asserted-by":"publisher","first-page":"818","DOI":"10.1038\/nature04980","article-title":"Transformation from committed progenitor to leukaemia stem cell initiated by MLL-AF9","volume":"442","author":"Krivtsov","year":"2006","journal-title":"Nature."},{"key":"2023072603074201100_bib45","doi-asserted-by":"publisher","first-page":"2295","DOI":"10.1016\/j.molimm.2010.05.289","article-title":"The combination of gene perturbation assay and ChIP-chip reveals functional direct target genes for IRF8 in THP-1 cells","volume":"47","author":"Kubosaki","year":"2010","journal-title":"Mol. Immunol."},{"key":"2023072603074201100_bib46","doi-asserted-by":"publisher","first-page":"1427","DOI":"10.1126\/science.7660125","article-title":"Inducible gene targeting in mice","volume":"269","author":"K\u00fchn","year":"1995","journal-title":"Science."},{"key":"2023072603074201100_bib47","doi-asserted-by":"publisher","first-page":"2849","DOI":"10.1182\/blood-2011-03-345165","article-title":"Differential niche and Wnt requirements during acute myeloid leukemia progression","volume":"118","author":"Lane","year":"2011","journal-title":"Blood."},{"key":"2023072603074201100_bib48","doi-asserted-by":"publisher","first-page":"1399","DOI":"10.1084\/jem.189.9.1399","article-title":"The P190, P210, and P230 forms of the BCR\/ABL oncogene induce a similar chronic myeloid leukemia-like syndrome in mice but have different lymphoid leukemogenic activity","volume":"189","author":"Li","year":"1999","journal-title":"J. Exp. Med."},{"key":"2023072603074201100_bib49","doi-asserted-by":"publisher","first-page":"345","DOI":"10.1016\/j.stem.2011.07.017","article-title":"Canonical wnt signaling regulates hematopoiesis in a dosage-dependent fashion","volume":"9","author":"Luis","year":"2011","journal-title":"Cell Stem Cell."},{"key":"2023072603074201100_bib50","doi-asserted-by":"publisher","first-page":"86","DOI":"10.1038\/leu.2011.260","article-title":"Signal transduction pathways regulating hematopoietic stem cell biology: introduction to a series of Spotlight Reviews","volume":"26","author":"Luis","year":"2012","journal-title":"Leukemia."},{"key":"2023072603074201100_bib51","doi-asserted-by":"publisher","first-page":"27","DOI":"10.1016\/j.stem.2008.12.004","article-title":"Wnt-related molecules and signaling pathway equilibrium in hematopoiesis","volume":"4","author":"Malhotra","year":"2009","journal-title":"Cell Stem Cell."},{"key":"2023072603074201100_bib52","doi-asserted-by":"publisher","first-page":"407","DOI":"10.1016\/j.immuni.2007.02.013","article-title":"Molecular evidence for hierarchical transcriptional lineage priming in fetal and adult stem cells and multipotent progenitors","volume":"26","author":"M\u00e5nsson","year":"2007","journal-title":"Immunity."},{"key":"2023072603074201100_bib53","doi-asserted-by":"publisher","first-page":"2890","DOI":"10.1128\/MCB.24.7.2890-2904.2004","article-title":"Translocation products in acute myeloid leukemia activate the Wnt signaling pathway in hematopoietic cells","volume":"24","author":"M\u00fcller-Tidow","year":"2004","journal-title":"Mol. Cell. Biol."},{"key":"2023072603074201100_bib54","doi-asserted-by":"publisher","first-page":"3813","DOI":"10.1182\/blood-2008-07-167189","article-title":"ICSBP-mediated immune protection against BCR-ABL-induced leukemia requires the CCL6 and CCL9 chemokines","volume":"113","author":"Nardi","year":"2009","journal-title":"Blood."},{"key":"2023072603074201100_bib55","first-page":"85","article-title":"Chromosome studies on normal and leukemic human leukocytes","volume":"25","author":"Nowell","year":"1960","journal-title":"J. Natl. Cancer Inst."},{"key":"2023072603074201100_bib56","doi-asserted-by":"publisher","first-page":"3292","DOI":"10.1182\/blood-2009-03-212969","article-title":"The derivation of diagnostic markers of chronic myeloid leukemia progression from microarray data","volume":"114","author":"Oehler","year":"2009","journal-title":"Blood."},{"key":"2023072603074201100_bib57","doi-asserted-by":"publisher","first-page":"2254","DOI":"10.1172\/JCI41246","article-title":"Chronic myeloid leukemia: mechanisms of blastic transformation","volume":"120","author":"Perrotti","year":"2010","journal-title":"J. Clin. Invest."},{"key":"2023072603074201100_bib58","doi-asserted-by":"publisher","first-page":"1928","DOI":"10.1101\/gad.17421911","article-title":"Cooperation between both Wnt\/beta-catenin and PTEN\/PI3K\/Akt signaling promotes primitive hematopoietic stem cell self-renewal and expansion","volume":"25","author":"Perry","year":"2011","journal-title":"Genes Dev."},{"key":"2023072603074201100_bib59","doi-asserted-by":"publisher","first-page":"915","DOI":"10.1038\/nrc2536","article-title":"Insulin and insulin-like growth factor signalling in neoplasia","volume":"8","author":"Pollak","year":"2008","journal-title":"Nat. Rev. Cancer."},{"key":"2023072603074201100_bib60","doi-asserted-by":"publisher","first-page":"2094","DOI":"10.1038\/sj.leu.2404859","article-title":"ATP-binding-cassette transporters in hematopoietic stem cells and their utility as therapeutical targets in acute and chronic myeloid leukemia","volume":"21","author":"Raaijmakers","year":"2007","journal-title":"Leukemia."},{"key":"2023072603074201100_bib61","doi-asserted-by":"publisher","first-page":"2794","DOI":"10.1073\/pnas.0510423103","article-title":"Gene expression changes associated with progression and response in chronic myeloid leukemia","volume":"103","author":"Radich","year":"2006","journal-title":"Proc. Natl. Acad. Sci. USA."},{"key":"2023072603074201100_bib62","doi-asserted-by":"publisher","first-page":"409","DOI":"10.1038\/nature01593","article-title":"A role for Wnt signalling in self-renewal of haematopoietic stem cells","volume":"423","author":"Reya","year":"2003","journal-title":"Nature."},{"key":"2023072603074201100_bib63","doi-asserted-by":"publisher","first-page":"105","DOI":"10.1038\/nri2024","article-title":"Transcription factors in myeloid development: balancing differentiation with transformation","volume":"7","author":"Rosenbauer","year":"2007","journal-title":"Nat. Rev. Immunol."},{"key":"2023072603074201100_bib64","doi-asserted-by":"publisher","first-page":"27","DOI":"10.1038\/ng1679","article-title":"Lymphoid cell growth and transformation are suppressed by a key regulatory element of the gene encoding PU.1","volume":"38","author":"Rosenbauer","year":"2006","journal-title":"Nat. Genet."},{"key":"2023072603074201100_bib65","doi-asserted-by":"crossref","first-page":"3764","DOI":"10.1182\/blood.V94.11.3764","article-title":"Altered development and cytokine responses of myeloid progenitors in the absence of transcription factor, interferon consensus sequence binding protein","volume":"94","author":"Scheller","year":"1999","journal-title":"Blood."},{"key":"2023072603074201100_bib66","doi-asserted-by":"publisher","first-page":"1037","DOI":"10.1038\/ni1387","article-title":"Hematopoietic stem cell and multilineage defects generated by constitutive beta-catenin activation","volume":"7","author":"Scheller","year":"2006","journal-title":"Nat. Immunol."},{"key":"2023072603074201100_bib67","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1182\/blood.V91.1.22","article-title":"Lack of interferon consensus sequence binding protein (ICSBP) transcripts in human myeloid leukemias","volume":"91","author":"Schmidt","year":"1998","journal-title":"Blood."},{"key":"2023072603074201100_bib68","doi-asserted-by":"publisher","first-page":"3648","DOI":"10.1182\/blood.V97.11.3648","article-title":"Expression of nuclear transcription factor interferon consensus sequence binding protein in chronic myeloid leukemia correlates with pretreatment risk features and cytogenetic response to interferon-alpha","volume":"97","author":"Schmidt","year":"2001","journal-title":"Blood."},{"key":"2023072603074201100_bib69","doi-asserted-by":"publisher","first-page":"1227","DOI":"10.1084\/jem.20020824","article-title":"AML1-ETO inhibits maturation of multiple lymphohematopoietic lineages and induces myeloblast transformation in synergy with ICSBP deficiency","volume":"196","author":"Schwieger","year":"2002","journal-title":"J. Exp. Med."},{"key":"2023072603074201100_bib70","doi-asserted-by":"publisher","first-page":"399","DOI":"10.1126\/science.1099480","article-title":"Overriding imatinib resistance with a novel ABL kinase inhibitor","volume":"305","author":"Shah","year":"2004","journal-title":"Science."},{"key":"2023072603074201100_bib71","doi-asserted-by":"publisher","first-page":"5522","DOI":"10.1073\/pnas.96.10.5522","article-title":"The cyclin D1 gene is a target of the beta-catenin\/LEF-1 pathway","volume":"96","author":"Shtutman","year":"1999","journal-title":"Proc. Natl. Acad. Sci. USA."},{"key":"2023072603074201100_bib72","doi-asserted-by":"publisher","first-page":"1395","DOI":"10.1038\/bjc.2012.81","article-title":"Impact of mutant \u03b2-catenin on ABCB1 expression and therapy response in colon cancer cells","volume":"106","author":"Stein","year":"2012","journal-title":"Br. J. Cancer."},{"key":"2023072603074201100_bib73","doi-asserted-by":"publisher","first-page":"4547","DOI":"10.1182\/blood-2003-01-0291","article-title":"ICSBP\/IRF-8 inhibits mitogenic activity of p210 Bcr\/Abl in differentiating myeloid progenitor cells","volume":"102","author":"Tamura","year":"2003","journal-title":"Blood."},{"key":"2023072603074201100_bib74","doi-asserted-by":"publisher","first-page":"1938","DOI":"10.1182\/blood-2005-01-0080","article-title":"Identification of target genes and a unique cis element regulated by IRF-8 in developing macrophages","volume":"106","author":"Tamura","year":"2005","journal-title":"Blood."},{"key":"2023072603074201100_bib75","doi-asserted-by":"publisher","first-page":"1650","DOI":"10.1126\/science.1186624","article-title":"The Wnt\/beta-catenin pathway is required for the development of leukemia stem cells in AML","volume":"327","author":"Wang","year":"2010","journal-title":"Science."},{"key":"2023072603074201100_bib76","doi-asserted-by":"publisher","first-page":"606","DOI":"10.1016\/j.ccr.2010.10.032","article-title":"\u03b2-Catenin mediates the establishment and drug resistance of MLL leukemic stem cells","volume":"18","author":"Yeung","year":"2010","journal-title":"Cancer Cell."},{"key":"2023072603074201100_bib77","doi-asserted-by":"publisher","first-page":"3642","DOI":"10.1200\/JCO.2008.19.4076","article-title":"Predictors of primary imatinib resistance in chronic myelogenous leukemia are distinct from those in secondary imatinib resistance","volume":"27","author":"Zhang","year":"2009","journal-title":"J. Clin. Oncol."},{"key":"2023072603074201100_bib78","doi-asserted-by":"publisher","first-page":"528","DOI":"10.1016\/j.ccr.2007.11.003","article-title":"Loss of beta-catenin impairs the renewal of normal and CML stem cells in vivo","volume":"12","author":"Zhao","year":"2007","journal-title":"Cancer Cell."},{"key":"2023072603074201100_bib79","doi-asserted-by":"publisher","first-page":"2962","DOI":"10.1038\/onc.2010.67","article-title":"Imatinib resistance associated with BCR-ABL upregulation is dependent on HIF-1alpha-induced metabolic reprograming","volume":"29","author":"Zhao","year":"2010","journal-title":"Oncogene."},{"key":"2023072603074201100_bib80","doi-asserted-by":"publisher","first-page":"1028","DOI":"10.1038\/sj.leu.2404227","article-title":"Gene expression profiling of CD34+ cells identifies a molecular signature of chronic myeloid leukemia blast crisis","volume":"20","author":"Zheng","year":"2006","journal-title":"Leukemia."},{"key":"2023072603074201100_bib81","doi-asserted-by":"publisher","first-page":"1028","DOI":"10.1038\/nm0901-1028","article-title":"The ABC transporter Bcrp1\/ABCG2 is expressed in a wide variety of stem cells and is a molecular determinant of the side-population phenotype","volume":"7","author":"Zhou","year":"2001","journal-title":"Nat. Med."}],"container-title":["Journal of Experimental Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/rupress.org\/jem\/article-pdf\/210\/11\/2239\/1754005\/jem_20130706.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/rupress.org\/jem\/article-pdf\/210\/11\/2239\/1754005\/jem_20130706.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,7,25]],"date-time":"2023-07-25T23:08:41Z","timestamp":1690326521000},"score":1,"resource":{"primary":{"URL":"https:\/\/rupress.org\/jem\/article\/210\/11\/2239\/41553\/Cross-talk-between-Wnt-catenin-and-Irf8-in"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,10,7]]},"references-count":81,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2013,10,21]]}},"URL":"https:\/\/doi.org\/10.1084\/jem.20130706","relation":{},"ISSN":["1540-9538","0022-1007"],"issn-type":[{"value":"1540-9538","type":"electronic"},{"value":"0022-1007","type":"print"}],"subject":[],"published":{"date-parts":[[2013,10,7]]}}}