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We now report that the nuclear Jun activation domain\u2013binding protein 1 (Jab1) may transduce laminin211 signals to regulate Schwann cell number and differentiation during axonal sorting. Mice with inactivation of Jab1 in Schwann cells develop a dysmyelinating neuropathy with axonal sorting defects. Loss of Jab1 increases p27 levels in Schwann cells, which causes defective cell cycle progression and aberrant differentiation. Genetic down-regulation of p27 levels in Jab1-null mice restores Schwann cell number, differentiation, and axonal sorting and rescues the dysmyelinating neuropathy. Thus, Jab1 constitutes a regulatory molecule that integrates laminin211 signals in Schwann cells to govern cell cycle, cell number, and differentiation. Finally, Jab1 may constitute a key molecule in the pathogenesis of dysmyelinating neuropathies.<\/jats:p>","DOI":"10.1084\/jem.20130720","type":"journal-article","created":{"date-parts":[[2013,12,17]],"date-time":"2013-12-17T04:52:00Z","timestamp":1387255920000},"page":"29-43","update-policy":"https:\/\/doi.org\/10.1084\/jem.crossmarkpolicy","source":"Crossref","is-referenced-by-count":40,"title":["Jab1 regulates Schwann cell proliferation and axonal sorting through p27"],"prefix":"10.1084","volume":"211","author":[{"given":"Emanuela","family":"Porrello","sequence":"first","affiliation":[{"name":"Institute of Experimental Neurology (INSPE), Division of Neuroscience 1 ; 2 ; and 3"},{"name":"Department of Neurology 1 ; 2 ; and 3"},{"name":"Division of Immunology, Transplantation, and Infectious Disease; San Raffaele Scientific Institute, 20132 Milan, Italy 1 ; 2 ; and 3"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cristina","family":"Rivellini","sequence":"additional","affiliation":[{"name":"Institute of Experimental Neurology (INSPE), Division of Neuroscience 1 ; 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