{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T21:21:26Z","timestamp":1792790486190,"version":"4.5.0"},"reference-count":42,"publisher":"Rockefeller University Press","issue":"4","content-domain":{"domain":["rupress.org"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2014,4,7]]},"abstract":"<jats:p>Retention of lymphocytes in the intestinal mucosa requires specialized chemokine receptors and adhesion molecules. We find that both CD4+CD8+ and CD4+ T cells in the intestinal epithelium, as well as CD8+ T cells in the intestinal mucosa and mesenteric lymph nodes, express the cell adhesion molecule class I\u2013restricted T cell\u2013associated molecule (Crtam) upon activation, whereas the ligand of Crtam, cell adhesion molecule 1 (Cadm1), is expressed on gut CD103+DCs. Lack of Crtam\u2013Cadm1 interactions in Crtam\u2212\/\u2212 and Cadm1\u2212\/\u2212 mice results in loss of CD4+CD8+ T cells, which arise from mucosal CD4+ T cells that acquire a CD8 lineage expression profile. After acute oral infection with Toxoplasma gondii, both WT and Crtam\u2212\/\u2212 mice mounted a robust TH1 response, but markedly fewer TH17 cells were present in the intestinal mucosa of Crtam\u2212\/\u2212 mice. The almost exclusive TH1 response in Crtam\u2212\/\u2212 mice resulted in more efficient control of intestinal T. gondii infection. Thus, Crtam\u2013Cadm1 interactions have a major impact on the residency and maintenance of CD4+CD8+ T cells in the gut mucosa in the steady state. During pathogenic infection, Crtam\u2013Cadm1 interactions regulate the dynamic equilibrium between newly formed CD4+ T cells and their retention in the gut, thereby shaping representation of disparate CD4+ T cell subsets and the overall quality of the CD4+ T cell response.<\/jats:p>","DOI":"10.1084\/jem.20130904","type":"journal-article","created":{"date-parts":[[2014,4,1]],"date-time":"2014-04-01T01:27:25Z","timestamp":1396315645000},"page":"623-633","update-policy":"https:\/\/doi.org\/10.1084\/jem.crossmarkpolicy","source":"Crossref","is-referenced-by-count":59,"title":["CRTAM controls residency of gut CD4+CD8+ T cells in the steady state and maintenance of gut CD4+ Th17 during parasitic infection"],"prefix":"10.1084","volume":"211","author":[{"given":"Victor S.","family":"Cortez","sequence":"first","affiliation":[{"name":"Department of Pathology and Immunology 1 , 2 , 3 , and 4"},{"name":"Department of Internal Medicine 1 , 2 , 3 , and 4"},{"name":"Department of Molecular 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