{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T18:29:00Z","timestamp":1791311340339,"version":"4.3.1"},"reference-count":59,"publisher":"Rockefeller University Press","issue":"2","content-domain":{"domain":["rupress.org"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2014,2,10]]},"abstract":"<jats:p>Group 3 innate lymphoid cells (ILC3) include IL-22\u2013producing NKp46+ cells and IL-17A\/IL-22\u2013producing CD4+ lymphoid tissue inducerlike cells that express ROR\u03b3t and are implicated in protective immunity at mucosal surfaces. Whereas the transcription factor Gata3 is essential for T cell and ILC2 development from hematopoietic stem cells (HSCs) and for IL-5 and IL-13 production by T cells and ILC2, the role for Gata3 in the generation or function of other ILC subsets is not known. We found that abundant GATA-3 protein is expressed in mucosa-associated ILC3 subsets with levels intermediate between mature B cells and ILC2. Chimeric mice generated with Gata3-deficient fetal liver hematopoietic precursors lack all intestinal ROR\u03b3t+ ILC3 subsets, and these mice show defective production of IL-22 early after infection with the intestinal pathogen Citrobacter rodentium, leading to impaired survival. Further analyses demonstrated that ILC3 development requires cell-intrinsic Gata3 expression in fetal liver hematopoietic precursors. Our results demonstrate that Gata3 plays a generalized role in ILC lineage determination and is critical for the development of gut ROR\u03b3t+ ILC3 subsets that maintain mucosal barrier homeostasis. These results further extend the paradigm of Gata3-dependent regulation of diversified innate ILC and adaptive T cell subsets.<\/jats:p>","DOI":"10.1084\/jem.20131038","type":"journal-article","created":{"date-parts":[[2014,1,13]],"date-time":"2014-01-13T23:54:38Z","timestamp":1389657278000},"page":"199-208","update-policy":"https:\/\/doi.org\/10.1084\/jem.crossmarkpolicy","source":"Crossref","is-referenced-by-count":214,"title":["<i>Gata3<\/i>\n                    drives development of ROR\u03b3t+ group 3 innate lymphoid cells"],"prefix":"10.1084","volume":"211","author":[{"given":"Nicolas","family":"Serafini","sequence":"first","affiliation":[{"name":"Innate Immunity Unit, Institut Pasteur, 25 rue du Docteur Roux, 75724 Paris, France 1"},{"name":"INSERM U668, 75724 Paris, France 2"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roel G.J.","family":"Klein Wolterink","sequence":"additional","affiliation":[{"name":"Innate Immunity Unit, Institut Pasteur, 25 rue du Docteur Roux, 75724 Paris, France 1"},{"name":"INSERM U668, 75724 Paris, France 2"},{"name":"Department of Pulmonary Medicine, Erasmus MC Rotterdam, 3000CA Rotterdam, Netherlands 3"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Naoko","family":"Satoh-Takayama","sequence":"additional","affiliation":[{"name":"Innate Immunity Unit, Institut Pasteur, 25 rue du Docteur Roux, 75724 Paris, France 1"},{"name":"INSERM U668, 75724 Paris, France 2"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Xu","sequence":"additional","affiliation":[{"name":"Innate Immunity Unit, Institut Pasteur, 25 rue du Docteur Roux, 75724 Paris, France 1"},{"name":"INSERM U668, 75724 Paris, France 2"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christian A.J.","family":"Vosshenrich","sequence":"additional","affiliation":[{"name":"Innate Immunity Unit, Institut Pasteur, 25 rue du Docteur Roux, 75724 Paris, France 1"},{"name":"INSERM U668, 75724 Paris, France 2"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rudi W.","family":"Hendriks","sequence":"additional","affiliation":[{"name":"Department of Pulmonary Medicine, Erasmus MC Rotterdam, 3000CA Rotterdam, Netherlands 3"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James P.","family":"Di Santo","sequence":"additional","affiliation":[{"name":"Innate Immunity Unit, Institut Pasteur, 25 rue du Docteur Roux, 75724 Paris, France 1"},{"name":"INSERM U668, 75724 Paris, France 2"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"291","published-online":{"date-parts":[[2014,1,13]]},"reference":[{"key":"2023072602135960800_bib1","doi-asserted-by":"publisher","first-page":"607","DOI":"10.1146\/annurev.immunol.23.021704.115821","article-title":"Regulation of Th2 differentiation and Il4 locus accessibility","volume":"24","author":"Ansel","year":"2006","journal-title":"Annu. 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