{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,3]],"date-time":"2026-11-03T21:43:14Z","timestamp":1793742194347,"version":"4.6.1"},"reference-count":41,"publisher":"Rockefeller University Press","issue":"13","content-domain":{"domain":["rupress.org"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2013,12,16]]},"abstract":"<jats:p>Studies on the role of the RNA receptor TLR8 in inflammation have been limited by its different function in human versus rodents. We have generated multiple lines of transgenic mice expressing different levels of human TLR8. The high copy number chimeras were unable to pass germline; developed severe inflammation targeting the pancreas, salivary glands, and joints; and the severity of the specific phenotypes closely correlated with the huTLR8 expression levels. Mice with relatively low expression levels survived and bred successfully but had increased susceptibility to collagen-induced arthritis, and the levels of huTLR8 correlated with proinflammatory cytokines in the joints of the animals. At the cellular level, huTLR8 signaling exerted a DC-intrinsic effect leading to up-regulation of co-stimulatory molecules and subsequent T cell activation. A pathogenic role for TLR8 in human diseases was suggested by its increased expression in patients with systemic arthritis and the correlation of TLR8 expression with the elevation of IL-1\u03b2 levels and disease status. We found that the consequence of self-recognition via TLR8 results in a constellation of diseases, strikingly distinct from those related to TLR7 signaling, and points to specific inflammatory diseases that may benefit from inhibition of TLR8 in humans.<\/jats:p>","DOI":"10.1084\/jem.20131044","type":"journal-article","created":{"date-parts":[[2013,11,26]],"date-time":"2013-11-26T03:41:08Z","timestamp":1385437268000},"page":"2903-2919","update-policy":"https:\/\/doi.org\/10.1084\/jem.crossmarkpolicy","source":"Crossref","is-referenced-by-count":201,"title":["RNA recognition by human TLR8 can lead to autoimmune inflammation"],"prefix":"10.1084","volume":"210","author":[{"given":"Cristiana","family":"Guiducci","sequence":"first","affiliation":[{"name":"Dynavax Technologies Corporation, Berkeley, CA 94710 1"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mei","family":"Gong","sequence":"additional","affiliation":[{"name":"Dynavax Technologies Corporation, Berkeley, CA 94710 1"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alma-Martina","family":"Cepika","sequence":"additional","affiliation":[{"name":"Baylor Institute for Immunology Research, Dallas, TX 75204 2"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhaohui","family":"Xu","sequence":"additional","affiliation":[{"name":"Baylor Institute for Immunology Research, Dallas, TX 75204 2"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claudio","family":"Tripodo","sequence":"additional","affiliation":[{"name":"Department of Human Pathology, Tumor Immunology Section, University of Palermo School of Medicine, 90128 Palermo, Italy 3"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lynda","family":"Bennett","sequence":"additional","affiliation":[{"name":"Baylor Institute for Immunology Research, Dallas, TX 75204 2"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chad","family":"Crain","sequence":"additional","affiliation":[{"name":"Dynavax Technologies Corporation, Berkeley, CA 94710 1"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pierre","family":"Quartier","sequence":"additional","affiliation":[{"name":"Hematology-Immunology-Rheumatology Unit, AP-HP, Necker Enfants Malades Hospital, 75015 Paris, France 4"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John J.","family":"Cush","sequence":"additional","affiliation":[{"name":"Baylor Institute for Immunology Research, Dallas, TX 75204 2"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Virginia","family":"Pascual","sequence":"additional","affiliation":[{"name":"Baylor Institute for Immunology Research, Dallas, TX 75204 2"},{"name":"Texas Scottish Rite Hospital, Dallas, TX 75219 5"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert L.","family":"Coffman","sequence":"additional","affiliation":[{"name":"Dynavax Technologies Corporation, Berkeley, CA 94710 1"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Franck J.","family":"Barrat","sequence":"additional","affiliation":[{"name":"Dynavax Technologies Corporation, Berkeley, CA 94710 1"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"291","published-online":{"date-parts":[[2013,11,25]]},"reference":[{"key":"2023072601131729100_bib1","doi-asserted-by":"publisher","first-page":"6824","DOI":"10.4049\/jimmunol.0803001","article-title":"Selection of molecular structure and delivery of RNA oligonucleotides to activate TLR7 versus TLR8 and to induce high amounts of IL-12p70 in primary human monocytes","volume":"182","author":"Ablasser","year":"2009","journal-title":"J. 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