{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T16:19:54Z","timestamp":1791217194393,"version":"4.1.0"},"reference-count":49,"publisher":"Rockefeller University Press","issue":"9","content-domain":{"domain":["rupress.org"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2014,8,25]]},"abstract":"<jats:p>Secretion of the immunosuppressive cytokine interleukin (IL) 10 by effector T cells is an essential mechanism of self-limitation during infection. However, the transcriptional regulation of IL-10 expression in proinflammatory T helper (Th) 1 cells is insufficiently understood. We report a crucial role for the transcriptional regulator Blimp-1, induced by IL-12 in a STAT4-dependent manner, in controlling IL-10 expression in Th1 cells. Blimp-1 deficiency led to excessive inflammation during Toxoplasma gondii infection with increased mortality. IL-10 production from Th1 cells was strictly dependent on Blimp-1 but was further enhanced by the synergistic function of c-Maf, a transcriptional regulator of IL-10 induced by multiple factors, such as the Notch pathway. We found Blimp-1 expression, which was also broadly induced by IL-27 in effector T cells, to be antagonized by transforming growth factor (TGF) \u03b2. While effectively blocking IL-10 production from Th1 cells, TGF-\u03b2 shifted IL-10 regulation from a Blimp-1\u2013dependent to a Blimp-1\u2013independent pathway in IL-27\u2013induced Tr1 (T regulatory 1) cells. Our findings further illustrate how IL-10 regulation in Th cells relies on several transcriptional programs that integrate various signals from the environment to fine-tune expression of this critical immunosuppressive cytokine.<\/jats:p>","DOI":"10.1084\/jem.20131548","type":"journal-article","created":{"date-parts":[[2014,7,30]],"date-time":"2014-07-30T00:50:29Z","timestamp":1406681429000},"page":"1807-1819","update-policy":"https:\/\/doi.org\/10.1084\/jem.crossmarkpolicy","source":"Crossref","is-referenced-by-count":178,"title":["Role of Blimp-1 in programing Th effector cells into IL-10 producers"],"prefix":"10.1084","volume":"211","author":[{"given":"Christian","family":"Neumann","sequence":"first","affiliation":[{"name":"German Rheumatism Research Centre Berlin, an Institute of the Leibniz-Association, 10117 Berlin, Germany 1"},{"name":"Department of Rheumatology and Clinical Immunology 2 , 3 , and 4"},{"name":"Medical Clinic I, Gastroenterology 2 , 3 , and 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