{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T07:07:25Z","timestamp":1791270445742,"version":"4.1.0"},"reference-count":70,"publisher":"Rockefeller University Press","issue":"5","content-domain":{"domain":["rupress.org"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2014,5,5]]},"abstract":"<jats:p>Regulatory T (T reg) cells play an essential role in preventing autoimmunity but can also impair clearance of foreign pathogens. Paradoxically, signals known to promote T reg cell function are abundant during infection and could inappropriately enhance T reg cell activity. How T reg cell function is restrained during infection to allow the generation of effective antiviral responses remains largely unclear. We demonstrate that the potent antiviral type I interferons (IFNs) directly inhibit co-stimulation\u2013dependent T reg cell activation and proliferation, both in vitro and in vivo during acute infection with lymphocytic choriomeningitis virus (LCMV). Loss of the type I IFN receptor specifically in T reg cells results in functional impairment of virus-specific CD8+ and CD4+ T cells and inefficient viral clearance. Together, these data demonstrate that inhibition of T reg cells by IFNs is necessary for the generation of optimal antiviral T cell responses during acute LCMV infection.<\/jats:p>","DOI":"10.1084\/jem.20131556","type":"journal-article","created":{"date-parts":[[2014,4,8]],"date-time":"2014-04-08T01:58:45Z","timestamp":1396922325000},"page":"961-974","update-policy":"https:\/\/doi.org\/10.1084\/jem.crossmarkpolicy","source":"Crossref","is-referenced-by-count":162,"title":["Type I interferons directly inhibit regulatory T cells to allow optimal antiviral T cell responses during acute LCMV infection"],"prefix":"10.1084","volume":"211","author":[{"given":"Shivani","family":"Srivastava","sequence":"first","affiliation":[{"name":"Immunology Program, Benaroya Research Institute, Seattle, WA 98101 1"},{"name":"Department of Immunology, University of Washington School of Medicine, Seattle, WA 98195 2"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meghan A.","family":"Koch","sequence":"additional","affiliation":[{"name":"Immunology Program, Benaroya Research Institute, Seattle, WA 98101 1"},{"name":"Department of Immunology, University of Washington School of Medicine, Seattle, WA 98195 2"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marion","family":"Pepper","sequence":"additional","affiliation":[{"name":"Department of Immunology, University of Washington School of Medicine, Seattle, WA 98195 2"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel J.","family":"Campbell","sequence":"additional","affiliation":[{"name":"Immunology Program, Benaroya Research Institute, Seattle, WA 98101 1"},{"name":"Department of Immunology, University of Washington School of Medicine, Seattle, WA 98195 2"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"291","published-online":{"date-parts":[[2014,4,7]]},"reference":[{"key":"2023072602104849900_bib1","doi-asserted-by":"publisher","first-page":"521","DOI":"10.1084\/jem.160.2.521","article-title":"Selection of genetic variants of lymphocytic choriomeningitis virus in spleens of persistently infected mice. 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