{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T17:16:38Z","timestamp":1790270198620,"version":"4.1.0"},"reference-count":38,"publisher":"Rockefeller University Press","issue":"3","content-domain":{"domain":["rupress.org"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2014,3,10]]},"abstract":"<jats:p>Pharmacological targeting of metabolic processes in cancer must overcome redundancy in biosynthetic pathways. Deoxycytidine (dC) triphosphate (dCTP) can be produced both by the de novo pathway (DNP) and by the nucleoside salvage pathway (NSP). However, the role of the NSP in dCTP production and DNA synthesis in cancer cells is currently not well understood. We show that acute lymphoblastic leukemia (ALL) cells avoid lethal replication stress after thymidine (dT)-induced inhibition of DNP dCTP synthesis by switching to NSP-mediated dCTP production. The metabolic switch in dCTP production triggered by DNP inhibition is accompanied by NSP up-regulation and can be prevented using DI-39, a new high-affinity small-molecule inhibitor of the NSP rate-limiting enzyme dC kinase (dCK). Positron emission tomography (PET) imaging was useful for following both the duration and degree of dCK inhibition by DI-39 treatment in vivo, thus providing a companion pharmacodynamic biomarker. Pharmacological co-targeting of the DNP with dT and the NSP with DI-39 was efficacious against ALL models in mice, without detectable host toxicity. These findings advance our understanding of nucleotide metabolism in leukemic cells, and identify dCTP biosynthesis as a potential new therapeutic target for metabolic interventions in ALL and possibly other hematological malignancies.<\/jats:p>","DOI":"10.1084\/jem.20131738","type":"journal-article","created":{"date-parts":[[2014,2,25]],"date-time":"2014-02-25T06:11:11Z","timestamp":1393308671000},"page":"473-486","update-policy":"https:\/\/doi.org\/10.1084\/jem.crossmarkpolicy","source":"Crossref","is-referenced-by-count":42,"title":["Co-targeting of convergent nucleotide biosynthetic pathways for leukemia eradication"],"prefix":"10.1084","volume":"211","author":[{"given":"David A.","family":"Nathanson","sequence":"first","affiliation":[{"name":"Department of Molecular and Medical Pharmacology 1 ; 2 ; 3 ; 4 ; 5 ; and 6"},{"name":"Ahmanson Translational Imaging Division 1 ; 2 ; 3 ; 4 ; 5 ; and 6"},{"name":"Department of Biomathematics 1 ; 2 ; 3 ; 4 ; 5 ; and 6"},{"name":"The Pasarow Mass Spectrometry Laboratory, Department of Psychiatry and Biobehavioral Sciences and the Semel Institute for Neuroscience and Human Behavior 1 ; 2 ; 3 ; 4 ; 5 ; and 6"},{"name":"Department of Biological Chemistry 1 ; 2 ; 3 ; 4 ; 5 ; and 6"},{"name":"Department of Chemistry and Biochemistry, University of California, Los Angeles, Los Angeles, CA 90095 1 ; 2 ; 3 ; 4 ; 5 ; and 6"},{"name":"Department of Molecular and Medical Pharmacology 1 ; 2 ; 3 ; 4 ; 5 ; and 6"},{"name":"Ahmanson Translational Imaging Division 1 ; 2 ; 3 ; 4 ; 5 ; and 6"},{"name":"Department of Biomathematics 1 ; 2 ; 3 ; 4 ; 5 ; and 6"},{"name":"The Pasarow Mass Spectrometry Laboratory, Department of Psychiatry and Biobehavioral Sciences and the Semel Institute for Neuroscience and Human Behavior 1 ; 2 ; 3 ; 4 ; 5 ; and 6"},{"name":"Department of Biological Chemistry 1 ; 2 ; 3 ; 4 ; 5 ; and 6"},{"name":"Department of Chemistry and Biochemistry, University of California, Los Angeles, Los Angeles, CA 90095 1 ; 2 ; 3 ; 4 ; 5 ; and 6"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amanda L.","family":"Armijo","sequence":"additional","affiliation":[{"name":"Department of Molecular and Medical Pharmacology 1 ; 2 ; 3 ; 4 ; 5 ; and 6"},{"name":"Ahmanson Translational Imaging Division 1 ; 2 ; 3 ; 4 ; 5 ; and 6"},{"name":"Department of Biomathematics 1 ; 2 ; 3 ; 4 ; 5 ; and 6"},{"name":"The Pasarow Mass Spectrometry Laboratory, Department of Psychiatry and Biobehavioral Sciences and the Semel Institute for Neuroscience and Human Behavior 1 ; 2 ; 3 ; 4 ; 5 ; and 6"},{"name":"Department of Biological Chemistry 1 ; 2 ; 3 ; 4 ; 5 ; and 6"},{"name":"Department of Chemistry and Biochemistry, University of California, Los Angeles, Los Angeles, CA 90095 1 ; 2 ; 3 ; 4 ; 5 ; and 6"},{"name":"Department of Molecular and Medical Pharmacology 1 ; 2 ; 3 ; 4 ; 5 ; and 6"},{"name":"Ahmanson Translational Imaging Division 1 ; 2 ; 3 ; 4 ; 5 ; and 6"},{"name":"Department of Biomathematics 1 ; 2 ; 3 ; 4 ; 5 ; and 6"},{"name":"The Pasarow Mass Spectrometry Laboratory, Department of Psychiatry and Biobehavioral Sciences and the Semel Institute for Neuroscience and Human Behavior 1 ; 2 ; 3 ; 4 ; 5 ; and 6"},{"name":"Department of Biological Chemistry 1 ; 2 ; 3 ; 4 ; 5 ; and 6"},{"name":"Department of Chemistry and Biochemistry, University of California, Los Angeles, Los Angeles, CA 90095 1 ; 2 ; 3 ; 4 ; 5 ; and 6"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michelle","family":"Tom","sequence":"additional","affiliation":[{"name":"Department of Molecular and Medical Pharmacology 1 ; 2 ; 3 ; 4 ; 5 ; and 6"},{"name":"Ahmanson Translational Imaging Division 1 ; 2 ; 3 ; 4 ; 5 ; and 6"},{"name":"Department of Biomathematics 1 ; 2 ; 3 ; 4 ; 5 ; and 6"},{"name":"The Pasarow Mass Spectrometry Laboratory, Department of Psychiatry and Biobehavioral Sciences and the Semel Institute for Neuroscience and Human Behavior 1 ; 2 ; 3 ; 4 ; 5 ; and 6"},{"name":"Department of Biological Chemistry 1 ; 2 ; 3 ; 4 ; 5 ; and 6"},{"name":"Department of Chemistry and Biochemistry, University of California, Los Angeles, Los Angeles, CA 90095 1 ; 2 ; 3 ; 4 ; 5 ; and 6"},{"name":"Department of Molecular and Medical Pharmacology 1 ; 2 ; 3 ; 4 ; 5 ; and 6"},{"name":"Ahmanson Translational Imaging Division 1 ; 2 ; 3 ; 4 ; 5 ; and 6"},{"name":"Department of Biomathematics 1 ; 2 ; 3 ; 4 ; 5 ; and 6"},{"name":"The Pasarow Mass Spectrometry Laboratory, Department of Psychiatry and Biobehavioral Sciences and the Semel Institute for Neuroscience and Human Behavior 1 ; 2 ; 3 ; 4 ; 5 ; and 6"},{"name":"Department of Biological Chemistry 1 ; 2 ; 3 ; 4 ; 5 ; and 6"},{"name":"Department of Chemistry and Biochemistry, University of California, Los Angeles, Los Angeles, CA 90095 1 ; 2 ; 3 ; 4 ; 5 ; and 6"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zheng","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Molecular and Medical Pharmacology 1 ; 2 ; 3 ; 4 ; 5 ; and 6"},{"name":"Ahmanson Translational Imaging Division 1 ; 2 ; 3 ; 4 ; 5 ; and 6"},{"name":"Department of Biomathematics 1 ; 2 ; 3 ; 4 ; 5 ; and 6"},{"name":"The Pasarow Mass Spectrometry Laboratory, Department of Psychiatry and Biobehavioral Sciences and the Semel Institute for Neuroscience and Human Behavior 1 ; 2 ; 3 ; 4 ; 5 ; and 6"},{"name":"Department of Biological Chemistry 1 ; 2 ; 3 ; 4 ; 5 ; and 6"},{"name":"Department of Chemistry and Biochemistry, University of California, Los Angeles, Los Angeles, CA 90095 1 ; 2 ; 3 ; 4 ; 5 ; and 6"},{"name":"Department of Molecular and Medical Pharmacology 1 ; 2 ; 3 ; 4 ; 5 ; and 6"},{"name":"Ahmanson Translational Imaging Division 1 ; 2 ; 3 ; 4 ; 5 ; and 6"},{"name":"Department of Biomathematics 1 ; 2 ; 3 ; 4 ; 5 ; and 6"},{"name":"The Pasarow Mass Spectrometry Laboratory, Department of Psychiatry and Biobehavioral Sciences and the Semel Institute for Neuroscience and Human Behavior 1 ; 2 ; 3 ; 4 ; 5 ; and 6"},{"name":"Department of Biological Chemistry 1 ; 2 ; 3 ; 4 ; 5 ; and 6"},{"name":"Department of Chemistry and Biochemistry, University of California, Los Angeles, Los Angeles, CA 90095 1 ; 2 ; 3 ; 4 ; 5 ; and 6"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elizabeth","family":"Dimitrova","sequence":"additional","affiliation":[{"name":"Department of Molecular and Medical Pharmacology 1 ; 2 ; 3 ; 4 ; 5 ; and 6"},{"name":"Ahmanson Translational Imaging Division 1 ; 2 ; 3 ; 4 ; 5 ; and 6"},{"name":"Department of Biomathematics 1 ; 2 ; 3 ; 4 ; 5 ; and 6"},{"name":"The Pasarow Mass Spectrometry Laboratory, Department of Psychiatry and Biobehavioral Sciences and the Semel Institute for Neuroscience and Human Behavior 1 ; 2 ; 3 ; 4 ; 5 ; and 6"},{"name":"Department of Biological Chemistry 1 ; 2 ; 3 ; 4 ; 5 ; and 6"},{"name":"Department of Chemistry and Biochemistry, University of California, Los Angeles, Los Angeles, CA 90095 1 ; 2 ; 3 ; 4 ; 5 ; and 6"},{"name":"Department of Molecular and Medical Pharmacology 1 ; 2 ; 3 ; 4 ; 5 ; and 6"},{"name":"Ahmanson Translational Imaging Division 1 ; 2 ; 3 ; 4 ; 5 ; and 6"},{"name":"Department of Biomathematics 1 ; 2 ; 3 ; 4 ; 5 ; and 6"},{"name":"The Pasarow Mass Spectrometry Laboratory, Department of Psychiatry and Biobehavioral Sciences and the Semel Institute for Neuroscience and Human Behavior 1 ; 2 ; 3 ; 4 ; 5 ; and 6"},{"name":"Department of Biological Chemistry 1 ; 2 ; 3 ; 4 ; 5 ; and 6"},{"name":"Department of Chemistry and Biochemistry, University of California, Los Angeles, Los Angeles, CA 90095 1 ; 2 ; 3 ; 4 ; 5 ; and 6"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wayne R.","family":"Austin","sequence":"additional","affiliation":[{"name":"Department of Molecular and Medical Pharmacology 1 ; 2 ; 3 ; 4 ; 5 ; and 6"},{"name":"Ahmanson Translational Imaging Division 1 ; 2 ; 3 ; 4 ; 5 ; and 6"},{"name":"Department of Biomathematics 1 ; 2 ; 3 ; 4 ; 5 ; and 6"},{"name":"The Pasarow Mass Spectrometry Laboratory, Department of Psychiatry and Biobehavioral Sciences and the Semel Institute for Neuroscience and Human Behavior 1 ; 2 ; 3 ; 4 ; 5 ; and 6"},{"name":"Department of Biological Chemistry 1 ; 2 ; 3 ; 4 ; 5 ; and 6"},{"name":"Department of Chemistry and Biochemistry, University of California, Los Angeles, Los Angeles, CA 90095 1 ; 2 ; 3 ; 4 ; 5 ; and 6"},{"name":"Department of Molecular and Medical Pharmacology 1 ; 2 ; 3 ; 4 ; 5 ; and 6"},{"name":"Ahmanson Translational Imaging Division 1 ; 2 ; 3 ; 4 ; 5 ; and 6"},{"name":"Department of Biomathematics 1 ; 2 ; 3 ; 4 ; 5 ; and 6"},{"name":"The Pasarow Mass Spectrometry Laboratory, Department of Psychiatry and Biobehavioral Sciences and the Semel Institute for Neuroscience and Human Behavior 1 ; 2 ; 3 ; 4 ; 5 ; and 6"},{"name":"Department of Biological Chemistry 1 ; 2 ; 3 ; 4 ; 5 ; and 6"},{"name":"Department of Chemistry and Biochemistry, University of California, Los Angeles, Los Angeles, CA 90095 1 ; 2 ; 3 ; 4 ; 5 ; and 6"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julian","family":"Nomme","sequence":"additional","affiliation":[{"name":"Department of Biochemistry and Molecular Genetics, University of Illinois at Chicago, Chicago, IL 60607 7"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dean O.","family":"Campbell","sequence":"additional","affiliation":[{"name":"Department of Molecular and Medical Pharmacology 1 ; 2 ; 3 ; 4 ; 5 ; and 6"},{"name":"Ahmanson Translational Imaging Division 1 ; 2 ; 3 ; 4 ; 5 ; and 6"},{"name":"Department of Biomathematics 1 ; 2 ; 3 ; 4 ; 5 ; and 6"},{"name":"The Pasarow Mass Spectrometry Laboratory, Department of Psychiatry and Biobehavioral Sciences and the Semel Institute for Neuroscience and Human Behavior 1 ; 2 ; 3 ; 4 ; 5 ; and 6"},{"name":"Department of Biological Chemistry 1 ; 2 ; 3 ; 4 ; 5 ; and 6"},{"name":"Department of Chemistry and Biochemistry, University of California, Los Angeles, Los Angeles, CA 90095 1 ; 2 ; 3 ; 4 ; 5 ; and 6"},{"name":"Department of Molecular and Medical Pharmacology 1 ; 2 ; 3 ; 4 ; 5 ; and 6"},{"name":"Ahmanson Translational Imaging Division 1 ; 2 ; 3 ; 4 ; 5 ; and 6"},{"name":"Department of Biomathematics 1 ; 2 ; 3 ; 4 ; 5 ; and 6"},{"name":"The Pasarow Mass Spectrometry Laboratory, Department of Psychiatry and Biobehavioral Sciences and the Semel Institute for Neuroscience and Human Behavior 1 ; 2 ; 3 ; 4 ; 5 ; and 6"},{"name":"Department of Biological Chemistry 1 ; 2 ; 3 ; 4 ; 5 ; and 6"},{"name":"Department of Chemistry and Biochemistry, University of California, Los Angeles, Los Angeles, CA 90095 1 ; 2 ; 3 ; 4 ; 5 ; and 6"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lisa","family":"Ta","sequence":"additional","affiliation":[{"name":"Department of Molecular and Medical Pharmacology 1 ; 2 ; 3 ; 4 ; 5 ; and 6"},{"name":"Ahmanson Translational Imaging Division 1 ; 2 ; 3 ; 4 ; 5 ; and 6"},{"name":"Department of Biomathematics 1 ; 2 ; 3 ; 4 ; 5 ; and 6"},{"name":"The Pasarow Mass Spectrometry Laboratory, Department of Psychiatry and Biobehavioral Sciences and the Semel Institute for Neuroscience and Human Behavior 1 ; 2 ; 3 ; 4 ; 5 ; and 6"},{"name":"Department of Biological Chemistry 1 ; 2 ; 3 ; 4 ; 5 ; and 6"},{"name":"Department of Chemistry and Biochemistry, University of California, Los Angeles, Los Angeles, CA 90095 1 ; 2 ; 3 ; 4 ; 5 ; and 6"},{"name":"Department of Molecular and Medical Pharmacology 1 ; 2 ; 3 ; 4 ; 5 ; and 6"},{"name":"Ahmanson Translational Imaging Division 1 ; 2 ; 3 ; 4 ; 5 ; and 6"},{"name":"Department of Biomathematics 1 ; 2 ; 3 ; 4 ; 5 ; and 6"},{"name":"The Pasarow Mass Spectrometry Laboratory, Department of Psychiatry and Biobehavioral Sciences and the Semel Institute for Neuroscience and Human Behavior 1 ; 2 ; 3 ; 4 ; 5 ; and 6"},{"name":"Department of Biological Chemistry 1 ; 2 ; 3 ; 4 ; 5 ; and 6"},{"name":"Department of Chemistry and Biochemistry, University of California, Los Angeles, Los Angeles, CA 90095 1 ; 2 ; 3 ; 4 ; 5 ; and 6"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thuc M.","family":"Le","sequence":"additional","affiliation":[{"name":"Department of Molecular and Medical Pharmacology 1 ; 2 ; 3 ; 4 ; 5 ; and 6"},{"name":"Ahmanson Translational Imaging Division 1 ; 2 ; 3 ; 4 ; 5 ; and 6"},{"name":"Department of Biomathematics 1 ; 2 ; 3 ; 4 ; 5 ; and 6"},{"name":"The Pasarow Mass Spectrometry Laboratory, Department of Psychiatry and Biobehavioral Sciences and the Semel Institute for Neuroscience and Human Behavior 1 ; 2 ; 3 ; 4 ; 5 ; and 6"},{"name":"Department of Biological Chemistry 1 ; 2 ; 3 ; 4 ; 5 ; and 6"},{"name":"Department of Chemistry and Biochemistry, University of California, Los Angeles, Los Angeles, CA 90095 1 ; 2 ; 3 ; 4 ; 5 ; and 6"},{"name":"Department of Molecular and Medical Pharmacology 1 ; 2 ; 3 ; 4 ; 5 ; and 6"},{"name":"Ahmanson Translational Imaging Division 1 ; 2 ; 3 ; 4 ; 5 ; and 6"},{"name":"Department of Biomathematics 1 ; 2 ; 3 ; 4 ; 5 ; and 6"},{"name":"The Pasarow Mass Spectrometry Laboratory, Department of Psychiatry and Biobehavioral Sciences and the Semel Institute for Neuroscience and Human Behavior 1 ; 2 ; 3 ; 4 ; 5 ; and 6"},{"name":"Department of Biological Chemistry 1 ; 2 ; 3 ; 4 ; 5 ; and 6"},{"name":"Department of Chemistry and Biochemistry, University of California, Los Angeles, Los Angeles, CA 90095 1 ; 2 ; 3 ; 4 ; 5 ; and 6"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jason T.","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Molecular and Medical Pharmacology 1 ; 2 ; 3 ; 4 ; 5 ; and 6"},{"name":"Ahmanson Translational Imaging Division 1 ; 2 ; 3 ; 4 ; 5 ; and 6"},{"name":"Department of Biomathematics 1 ; 2 ; 3 ; 4 ; 5 ; and 6"},{"name":"The Pasarow Mass Spectrometry Laboratory, Department of Psychiatry and Biobehavioral Sciences and the Semel Institute for Neuroscience and Human Behavior 1 ; 2 ; 3 ; 4 ; 5 ; and 6"},{"name":"Department of Biological Chemistry 1 ; 2 ; 3 ; 4 ; 5 ; and 6"},{"name":"Department of Chemistry and Biochemistry, University of California, Los Angeles, Los Angeles, CA 90095 1 ; 2 ; 3 ; 4 ; 5 ; and 6"},{"name":"Department of Molecular and Medical Pharmacology 1 ; 2 ; 3 ; 4 ; 5 ; and 6"},{"name":"Ahmanson Translational Imaging Division 1 ; 2 ; 3 ; 4 ; 5 ; and 6"},{"name":"Department of Biomathematics 1 ; 2 ; 3 ; 4 ; 5 ; and 6"},{"name":"The Pasarow Mass Spectrometry Laboratory, Department of Psychiatry and Biobehavioral Sciences and the Semel Institute for Neuroscience and Human Behavior 1 ; 2 ; 3 ; 4 ; 5 ; and 6"},{"name":"Department of Biological Chemistry 1 ; 2 ; 3 ; 4 ; 5 ; and 6"},{"name":"Department of Chemistry and Biochemistry, University of California, Los Angeles, Los Angeles, CA 90095 1 ; 2 ; 3 ; 4 ; 5 ; and 6"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ryan","family":"Darvish","sequence":"additional","affiliation":[{"name":"Department of Molecular and Medical Pharmacology 1 ; 2 ; 3 ; 4 ; 5 ; and 6"},{"name":"Ahmanson Translational Imaging Division 1 ; 2 ; 3 ; 4 ; 5 ; and 6"},{"name":"Department of Biomathematics 1 ; 2 ; 3 ; 4 ; 5 ; and 6"},{"name":"The Pasarow Mass Spectrometry Laboratory, Department of Psychiatry and Biobehavioral Sciences and the Semel Institute for Neuroscience and Human Behavior 1 ; 2 ; 3 ; 4 ; 5 ; and 6"},{"name":"Department of Biological Chemistry 1 ; 2 ; 3 ; 4 ; 5 ; and 6"},{"name":"Department of Chemistry and Biochemistry, University of California, Los Angeles, Los Angeles, CA 90095 1 ; 2 ; 3 ; 4 ; 5 ; and 6"},{"name":"Department of Molecular and Medical Pharmacology 1 ; 2 ; 3 ; 4 ; 5 ; and 6"},{"name":"Ahmanson Translational Imaging Division 1 ; 2 ; 3 ; 4 ; 5 ; and 6"},{"name":"Department of Biomathematics 1 ; 2 ; 3 ; 4 ; 5 ; and 6"},{"name":"The Pasarow Mass Spectrometry Laboratory, Department of Psychiatry and Biobehavioral Sciences and the Semel Institute for Neuroscience and Human Behavior 1 ; 2 ; 3 ; 4 ; 5 ; and 6"},{"name":"Department of Biological Chemistry 1 ; 2 ; 3 ; 4 ; 5 ; and 6"},{"name":"Department of Chemistry and Biochemistry, University of California, Los Angeles, Los Angeles, CA 90095 1 ; 2 ; 3 ; 4 ; 5 ; and 6"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ari","family":"Gordin","sequence":"additional","affiliation":[{"name":"Department of Molecular and Medical Pharmacology 1 ; 2 ; 3 ; 4 ; 5 ; and 6"},{"name":"Ahmanson Translational Imaging Division 1 ; 2 ; 3 ; 4 ; 5 ; and 6"},{"name":"Department of Biomathematics 1 ; 2 ; 3 ; 4 ; 5 ; and 6"},{"name":"The Pasarow Mass Spectrometry Laboratory, Department of Psychiatry and Biobehavioral Sciences and the Semel Institute for Neuroscience and Human Behavior 1 ; 2 ; 3 ; 4 ; 5 ; and 6"},{"name":"Department of Biological Chemistry 1 ; 2 ; 3 ; 4 ; 5 ; and 6"},{"name":"Department of Chemistry and Biochemistry, University of California, Los Angeles, Los Angeles, CA 90095 1 ; 2 ; 3 ; 4 ; 5 ; and 6"},{"name":"Department of Molecular and Medical Pharmacology 1 ; 2 ; 3 ; 4 ; 5 ; and 6"},{"name":"Ahmanson Translational Imaging Division 1 ; 2 ; 3 ; 4 ; 5 ; and 6"},{"name":"Department of Biomathematics 1 ; 2 ; 3 ; 4 ; 5 ; and 6"},{"name":"The Pasarow Mass Spectrometry Laboratory, Department of Psychiatry and Biobehavioral Sciences and the Semel Institute for Neuroscience and Human Behavior 1 ; 2 ; 3 ; 4 ; 5 ; and 6"},{"name":"Department of Biological Chemistry 1 ; 2 ; 3 ; 4 ; 5 ; and 6"},{"name":"Department of Chemistry and Biochemistry, University of California, Los Angeles, Los Angeles, CA 90095 1 ; 2 ; 3 ; 4 ; 5 ; and 6"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liu","family":"Wei","sequence":"additional","affiliation":[{"name":"Department of Molecular and Medical Pharmacology 1 ; 2 ; 3 ; 4 ; 5 ; and 6"},{"name":"Ahmanson Translational Imaging Division 1 ; 2 ; 3 ; 4 ; 5 ; and 6"},{"name":"Department of Biomathematics 1 ; 2 ; 3 ; 4 ; 5 ; and 6"},{"name":"The Pasarow Mass Spectrometry Laboratory, Department of Psychiatry and Biobehavioral Sciences and the Semel Institute for Neuroscience and Human Behavior 1 ; 2 ; 3 ; 4 ; 5 ; and 6"},{"name":"Department of Biological Chemistry 1 ; 2 ; 3 ; 4 ; 5 ; and 6"},{"name":"Department of Chemistry and Biochemistry, University of California, Los Angeles, Los Angeles, CA 90095 1 ; 2 ; 3 ; 4 ; 5 ; and 6"},{"name":"Department of Molecular and Medical Pharmacology 1 ; 2 ; 3 ; 4 ; 5 ; and 6"},{"name":"Ahmanson Translational Imaging Division 1 ; 2 ; 3 ; 4 ; 5 ; and 6"},{"name":"Department of Biomathematics 1 ; 2 ; 3 ; 4 ; 5 ; and 6"},{"name":"The Pasarow Mass Spectrometry Laboratory, Department of Psychiatry and Biobehavioral Sciences and the Semel Institute for Neuroscience and Human Behavior 1 ; 2 ; 3 ; 4 ; 5 ; and 6"},{"name":"Department of Biological Chemistry 1 ; 2 ; 3 ; 4 ; 5 ; and 6"},{"name":"Department of Chemistry and Biochemistry, University of California, Los Angeles, Los Angeles, CA 90095 1 ; 2 ; 3 ; 4 ; 5 ; and 6"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hsiang-I","family":"Liao","sequence":"additional","affiliation":[{"name":"Department of Molecular and Medical Pharmacology 1 ; 2 ; 3 ; 4 ; 5 ; and 6"},{"name":"Ahmanson Translational Imaging Division 1 ; 2 ; 3 ; 4 ; 5 ; and 6"},{"name":"Department of Biomathematics 1 ; 2 ; 3 ; 4 ; 5 ; and 6"},{"name":"The Pasarow Mass Spectrometry Laboratory, Department of Psychiatry and Biobehavioral Sciences and the Semel Institute for Neuroscience and Human Behavior 1 ; 2 ; 3 ; 4 ; 5 ; and 6"},{"name":"Department of Biological Chemistry 1 ; 2 ; 3 ; 4 ; 5 ; and 6"},{"name":"Department of Chemistry and Biochemistry, University of California, Los Angeles, Los Angeles, CA 90095 1 ; 2 ; 3 ; 4 ; 5 ; and 6"},{"name":"Department of Molecular and Medical Pharmacology 1 ; 2 ; 3 ; 4 ; 5 ; and 6"},{"name":"Ahmanson Translational Imaging Division 1 ; 2 ; 3 ; 4 ; 5 ; and 6"},{"name":"Department of Biomathematics 1 ; 2 ; 3 ; 4 ; 5 ; and 6"},{"name":"The Pasarow Mass Spectrometry Laboratory, Department of Psychiatry and Biobehavioral Sciences and the Semel Institute for Neuroscience and Human Behavior 1 ; 2 ; 3 ; 4 ; 5 ; and 6"},{"name":"Department of Biological Chemistry 1 ; 2 ; 3 ; 4 ; 5 ; and 6"},{"name":"Department of Chemistry and Biochemistry, University of California, Los Angeles, Los Angeles, CA 90095 1 ; 2 ; 3 ; 4 ; 5 ; and 6"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Moses","family":"Wilks","sequence":"additional","affiliation":[{"name":"Department of Molecular and Medical Pharmacology 1 ; 2 ; 3 ; 4 ; 5 ; and 6"},{"name":"Ahmanson Translational Imaging Division 1 ; 2 ; 3 ; 4 ; 5 ; and 6"},{"name":"Department of Biomathematics 1 ; 2 ; 3 ; 4 ; 5 ; and 6"},{"name":"The Pasarow Mass Spectrometry Laboratory, Department of Psychiatry and Biobehavioral Sciences and the Semel Institute for Neuroscience and Human Behavior 1 ; 2 ; 3 ; 4 ; 5 ; and 6"},{"name":"Department of Biological Chemistry 1 ; 2 ; 3 ; 4 ; 5 ; and 6"},{"name":"Department of Chemistry and Biochemistry, University of California, Los Angeles, Los Angeles, CA 90095 1 ; 2 ; 3 ; 4 ; 5 ; and 6"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Colette","family":"Martin","sequence":"additional","affiliation":[{"name":"Department of Molecular and Medical Pharmacology 1 ; 2 ; 3 ; 4 ; 5 ; and 6"},{"name":"Ahmanson Translational Imaging Division 1 ; 2 ; 3 ; 4 ; 5 ; and 6"},{"name":"Department of Biomathematics 1 ; 2 ; 3 ; 4 ; 5 ; and 6"},{"name":"The Pasarow Mass Spectrometry Laboratory, Department of Psychiatry and Biobehavioral Sciences and the Semel Institute for Neuroscience and Human Behavior 1 ; 2 ; 3 ; 4 ; 5 ; and 6"},{"name":"Department of Biological Chemistry 1 ; 2 ; 3 ; 4 ; 5 ; and 6"},{"name":"Department of Chemistry and Biochemistry, University of California, Los Angeles, Los Angeles, CA 90095 1 ; 2 ; 3 ; 4 ; 5 ; and 6"},{"name":"Department of Molecular and Medical Pharmacology 1 ; 2 ; 3 ; 4 ; 5 ; and 6"},{"name":"Ahmanson Translational Imaging Division 1 ; 2 ; 3 ; 4 ; 5 ; and 6"},{"name":"Department of Biomathematics 1 ; 2 ; 3 ; 4 ; 5 ; and 6"},{"name":"The Pasarow Mass Spectrometry Laboratory, Department of Psychiatry and Biobehavioral Sciences and the Semel Institute for Neuroscience and Human Behavior 1 ; 2 ; 3 ; 4 ; 5 ; and 6"},{"name":"Department of Biological Chemistry 1 ; 2 ; 3 ; 4 ; 5 ; and 6"},{"name":"Department of Chemistry and Biochemistry, University of California, Los Angeles, Los Angeles, CA 90095 1 ; 2 ; 3 ; 4 ; 5 ; and 6"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Saman","family":"Sadeghi","sequence":"additional","affiliation":[{"name":"Department of Molecular and Medical Pharmacology 1 ; 2 ; 3 ; 4 ; 5 ; and 6"},{"name":"Ahmanson Translational Imaging Division 1 ; 2 ; 3 ; 4 ; 5 ; and 6"},{"name":"Department of Biomathematics 1 ; 2 ; 3 ; 4 ; 5 ; and 6"},{"name":"The Pasarow Mass Spectrometry Laboratory, Department of Psychiatry and Biobehavioral Sciences and the Semel Institute for Neuroscience and Human Behavior 1 ; 2 ; 3 ; 4 ; 5 ; and 6"},{"name":"Department of Biological Chemistry 1 ; 2 ; 3 ; 4 ; 5 ; and 6"},{"name":"Department of Chemistry and Biochemistry, University of California, Los Angeles, Los Angeles, CA 90095 1 ; 2 ; 3 ; 4 ; 5 ; and 6"},{"name":"Department of Molecular and Medical Pharmacology 1 ; 2 ; 3 ; 4 ; 5 ; and 6"},{"name":"Ahmanson Translational Imaging Division 1 ; 2 ; 3 ; 4 ; 5 ; and 6"},{"name":"Department of Biomathematics 1 ; 2 ; 3 ; 4 ; 5 ; and 6"},{"name":"The Pasarow Mass Spectrometry Laboratory, Department of Psychiatry and Biobehavioral Sciences and the Semel Institute for Neuroscience and Human Behavior 1 ; 2 ; 3 ; 4 ; 5 ; and 6"},{"name":"Department of Biological Chemistry 1 ; 2 ; 3 ; 4 ; 5 ; and 6"},{"name":"Department of Chemistry and Biochemistry, University of California, Los Angeles, Los Angeles, CA 90095 1 ; 2 ; 3 ; 4 ; 5 ; and 6"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jennifer M.","family":"Murphy","sequence":"additional","affiliation":[{"name":"Department of Molecular and Medical Pharmacology 1 ; 2 ; 3 ; 4 ; 5 ; and 6"},{"name":"Ahmanson Translational Imaging Division 1 ; 2 ; 3 ; 4 ; 5 ; and 6"},{"name":"Department of Biomathematics 1 ; 2 ; 3 ; 4 ; 5 ; and 6"},{"name":"The Pasarow Mass Spectrometry Laboratory, Department of Psychiatry and Biobehavioral Sciences and the Semel Institute for Neuroscience and Human Behavior 1 ; 2 ; 3 ; 4 ; 5 ; and 6"},{"name":"Department of Biological Chemistry 1 ; 2 ; 3 ; 4 ; 5 ; and 6"},{"name":"Department of Chemistry and Biochemistry, University of California, Los Angeles, Los Angeles, CA 90095 1 ; 2 ; 3 ; 4 ; 5 ; and 6"},{"name":"Department of Molecular and Medical Pharmacology 1 ; 2 ; 3 ; 4 ; 5 ; and 6"},{"name":"Ahmanson Translational Imaging Division 1 ; 2 ; 3 ; 4 ; 5 ; and 6"},{"name":"Department of Biomathematics 1 ; 2 ; 3 ; 4 ; 5 ; and 6"},{"name":"The Pasarow Mass Spectrometry Laboratory, Department of Psychiatry and Biobehavioral Sciences and the Semel Institute for Neuroscience and Human Behavior 1 ; 2 ; 3 ; 4 ; 5 ; and 6"},{"name":"Department of Biological Chemistry 1 ; 2 ; 3 ; 4 ; 5 ; and 6"},{"name":"Department of Chemistry and Biochemistry, University of California, Los Angeles, Los Angeles, CA 90095 1 ; 2 ; 3 ; 4 ; 5 ; and 6"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nidal","family":"Boulos","sequence":"additional","affiliation":[{"name":"Department of Developmental Neurobiology, St. Jude Children\u2019s Research Hospital, Memphis, TN, 38105 8"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael E.","family":"Phelps","sequence":"additional","affiliation":[{"name":"Department of Molecular and Medical Pharmacology 1 ; 2 ; 3 ; 4 ; 5 ; and 6"},{"name":"Ahmanson Translational Imaging Division 1 ; 2 ; 3 ; 4 ; 5 ; and 6"},{"name":"Department of Biomathematics 1 ; 2 ; 3 ; 4 ; 5 ; and 6"},{"name":"The Pasarow Mass Spectrometry Laboratory, Department of Psychiatry and Biobehavioral Sciences and the Semel Institute for Neuroscience and Human Behavior 1 ; 2 ; 3 ; 4 ; 5 ; and 6"},{"name":"Department of Biological Chemistry 1 ; 2 ; 3 ; 4 ; 5 ; and 6"},{"name":"Department of Chemistry and Biochemistry, University of California, Los Angeles, Los Angeles, CA 90095 1 ; 2 ; 3 ; 4 ; 5 ; and 6"},{"name":"Department of Molecular and Medical Pharmacology 1 ; 2 ; 3 ; 4 ; 5 ; and 6"},{"name":"Ahmanson Translational Imaging Division 1 ; 2 ; 3 ; 4 ; 5 ; and 6"},{"name":"Department of Biomathematics 1 ; 2 ; 3 ; 4 ; 5 ; and 6"},{"name":"The Pasarow Mass Spectrometry Laboratory, Department of Psychiatry and Biobehavioral Sciences and the Semel Institute for Neuroscience and Human Behavior 1 ; 2 ; 3 ; 4 ; 5 ; and 6"},{"name":"Department of Biological Chemistry 1 ; 2 ; 3 ; 4 ; 5 ; and 6"},{"name":"Department of Chemistry and Biochemistry, University of California, Los Angeles, Los Angeles, CA 90095 1 ; 2 ; 3 ; 4 ; 5 ; and 6"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kym F.","family":"Faull","sequence":"additional","affiliation":[{"name":"Department of Molecular and Medical Pharmacology 1 ; 2 ; 3 ; 4 ; 5 ; and 6"},{"name":"Ahmanson Translational Imaging Division 1 ; 2 ; 3 ; 4 ; 5 ; and 6"},{"name":"Department of Biomathematics 1 ; 2 ; 3 ; 4 ; 5 ; and 6"},{"name":"The Pasarow Mass Spectrometry Laboratory, Department of Psychiatry and Biobehavioral Sciences and the Semel Institute for Neuroscience and Human Behavior 1 ; 2 ; 3 ; 4 ; 5 ; and 6"},{"name":"Department of Biological Chemistry 1 ; 2 ; 3 ; 4 ; 5 ; and 6"},{"name":"Department of Chemistry and Biochemistry, University of California, Los Angeles, Los Angeles, CA 90095 1 ; 2 ; 3 ; 4 ; 5 ; and 6"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Harvey R.","family":"Herschman","sequence":"additional","affiliation":[{"name":"Department of Molecular and Medical Pharmacology 1 ; 2 ; 3 ; 4 ; 5 ; and 6"},{"name":"Ahmanson Translational Imaging Division 1 ; 2 ; 3 ; 4 ; 5 ; and 6"},{"name":"Department of Biomathematics 1 ; 2 ; 3 ; 4 ; 5 ; and 6"},{"name":"The Pasarow Mass Spectrometry Laboratory, Department of Psychiatry and Biobehavioral Sciences and the Semel Institute for Neuroscience and Human Behavior 1 ; 2 ; 3 ; 4 ; 5 ; and 6"},{"name":"Department of Biological Chemistry 1 ; 2 ; 3 ; 4 ; 5 ; and 6"},{"name":"Department of Chemistry and Biochemistry, University of California, Los Angeles, Los Angeles, CA 90095 1 ; 2 ; 3 ; 4 ; 5 ; and 6"},{"name":"Department of Molecular and Medical Pharmacology 1 ; 2 ; 3 ; 4 ; 5 ; and 6"},{"name":"Ahmanson Translational Imaging Division 1 ; 2 ; 3 ; 4 ; 5 ; and 6"},{"name":"Department of Biomathematics 1 ; 2 ; 3 ; 4 ; 5 ; and 6"},{"name":"The Pasarow Mass Spectrometry Laboratory, Department of Psychiatry and Biobehavioral Sciences and the Semel Institute for Neuroscience and Human Behavior 1 ; 2 ; 3 ; 4 ; 5 ; and 6"},{"name":"Department of Biological Chemistry 1 ; 2 ; 3 ; 4 ; 5 ; and 6"},{"name":"Department of Chemistry and Biochemistry, University of California, Los Angeles, Los Angeles, CA 90095 1 ; 2 ; 3 ; 4 ; 5 ; and 6"},{"name":"Department of Molecular and Medical Pharmacology 1 ; 2 ; 3 ; 4 ; 5 ; and 6"},{"name":"Ahmanson Translational Imaging Division 1 ; 2 ; 3 ; 4 ; 5 ; and 6"},{"name":"Department of Biomathematics 1 ; 2 ; 3 ; 4 ; 5 ; and 6"},{"name":"The Pasarow Mass Spectrometry Laboratory, Department of Psychiatry and Biobehavioral Sciences and the Semel Institute for Neuroscience and Human Behavior 1 ; 2 ; 3 ; 4 ; 5 ; and 6"},{"name":"Department of Biological Chemistry 1 ; 2 ; 3 ; 4 ; 5 ; and 6"},{"name":"Department of Chemistry and Biochemistry, University of California, Los Angeles, Los Angeles, CA 90095 1 ; 2 ; 3 ; 4 ; 5 ; and 6"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael E.","family":"Jung","sequence":"additional","affiliation":[{"name":"Department of Molecular and Medical Pharmacology 1 ; 2 ; 3 ; 4 ; 5 ; and 6"},{"name":"Ahmanson Translational Imaging Division 1 ; 2 ; 3 ; 4 ; 5 ; and 6"},{"name":"Department of Biomathematics 1 ; 2 ; 3 ; 4 ; 5 ; and 6"},{"name":"The Pasarow Mass Spectrometry Laboratory, Department of Psychiatry and Biobehavioral Sciences and the Semel Institute for Neuroscience and Human Behavior 1 ; 2 ; 3 ; 4 ; 5 ; and 6"},{"name":"Department of Biological Chemistry 1 ; 2 ; 3 ; 4 ; 5 ; and 6"},{"name":"Department of Chemistry and Biochemistry, University of California, Los Angeles, Los Angeles, CA 90095 1 ; 2 ; 3 ; 4 ; 5 ; and 6"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Johannes","family":"Czernin","sequence":"additional","affiliation":[{"name":"Department of Molecular and Medical Pharmacology 1 ; 2 ; 3 ; 4 ; 5 ; and 6"},{"name":"Ahmanson Translational Imaging Division 1 ; 2 ; 3 ; 4 ; 5 ; and 6"},{"name":"Department of Biomathematics 1 ; 2 ; 3 ; 4 ; 5 ; and 6"},{"name":"The Pasarow Mass Spectrometry Laboratory, Department of Psychiatry and Biobehavioral Sciences and the Semel Institute for Neuroscience and Human Behavior 1 ; 2 ; 3 ; 4 ; 5 ; and 6"},{"name":"Department of Biological Chemistry 1 ; 2 ; 3 ; 4 ; 5 ; and 6"},{"name":"Department of Chemistry and Biochemistry, University of California, Los Angeles, Los Angeles, CA 90095 1 ; 2 ; 3 ; 4 ; 5 ; and 6"},{"name":"Department of Molecular and Medical Pharmacology 1 ; 2 ; 3 ; 4 ; 5 ; and 6"},{"name":"Ahmanson Translational Imaging Division 1 ; 2 ; 3 ; 4 ; 5 ; and 6"},{"name":"Department of Biomathematics 1 ; 2 ; 3 ; 4 ; 5 ; and 6"},{"name":"The Pasarow Mass Spectrometry Laboratory, Department of Psychiatry and Biobehavioral Sciences and the Semel Institute for Neuroscience and Human Behavior 1 ; 2 ; 3 ; 4 ; 5 ; and 6"},{"name":"Department of Biological Chemistry 1 ; 2 ; 3 ; 4 ; 5 ; and 6"},{"name":"Department of Chemistry and Biochemistry, University of California, Los Angeles, Los Angeles, CA 90095 1 ; 2 ; 3 ; 4 ; 5 ; and 6"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arnon","family":"Lavie","sequence":"additional","affiliation":[{"name":"Department of Biochemistry and Molecular Genetics, University of Illinois at Chicago, Chicago, IL 60607 7"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Caius G.","family":"Radu","sequence":"additional","affiliation":[{"name":"Department of Molecular and Medical Pharmacology 1 ; 2 ; 3 ; 4 ; 5 ; and 6"},{"name":"Ahmanson Translational Imaging Division 1 ; 2 ; 3 ; 4 ; 5 ; and 6"},{"name":"Department of Biomathematics 1 ; 2 ; 3 ; 4 ; 5 ; and 6"},{"name":"The Pasarow Mass Spectrometry Laboratory, Department of Psychiatry and Biobehavioral Sciences and the Semel Institute for Neuroscience and Human Behavior 1 ; 2 ; 3 ; 4 ; 5 ; and 6"},{"name":"Department of Biological Chemistry 1 ; 2 ; 3 ; 4 ; 5 ; and 6"},{"name":"Department of Chemistry and Biochemistry, University of California, Los Angeles, Los Angeles, CA 90095 1 ; 2 ; 3 ; 4 ; 5 ; and 6"},{"name":"Department of Molecular and Medical Pharmacology 1 ; 2 ; 3 ; 4 ; 5 ; and 6"},{"name":"Ahmanson Translational Imaging Division 1 ; 2 ; 3 ; 4 ; 5 ; and 6"},{"name":"Department of Biomathematics 1 ; 2 ; 3 ; 4 ; 5 ; and 6"},{"name":"The Pasarow Mass Spectrometry Laboratory, Department of Psychiatry and Biobehavioral Sciences and the Semel Institute for Neuroscience and Human Behavior 1 ; 2 ; 3 ; 4 ; 5 ; and 6"},{"name":"Department of Biological Chemistry 1 ; 2 ; 3 ; 4 ; 5 ; and 6"},{"name":"Department of Chemistry and Biochemistry, University of California, Los Angeles, Los Angeles, CA 90095 1 ; 2 ; 3 ; 4 ; 5 ; and 6"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"291","published-online":{"date-parts":[[2014,2,24]]},"reference":[{"key":"2023072602073184800_bib1","doi-asserted-by":"publisher","first-page":"2215","DOI":"10.1084\/jem.20121061","article-title":"Nucleoside salvage pathway kinases regulate hematopoiesis by linking nucleotide metabolism with replication stress","volume":"209","author":"Austin","year":"2012","journal-title":"J. Exp. Med."},{"key":"2023072602073184800_bib2","doi-asserted-by":"publisher","first-page":"5","DOI":"10.1038\/nsmb.2220","article-title":"Thresholds of replication stress signaling in cancer development and treatment","volume":"19","author":"Bartek","year":"2012","journal-title":"Nat. Struct. Mol. Biol."},{"key":"2023072602073184800_bib3","doi-asserted-by":"publisher","first-page":"3585","DOI":"10.1182\/blood-2010-08-301267","article-title":"Chemotherapeutic agents circumvent emergence of dasatinib-resistant BCR-ABL kinase mutations in a precise mouse model of Philadelphia chromosome-positive acute lymphoblastic leukemia","volume":"117","author":"Boulos","year":"2011","journal-title":"Blood."},{"key":"2023072602073184800_bib4","first-page":"818","article-title":"Clinical phase I-II and pharmacokinetic study of high-dose thymidine given by continuous intravenous infusion","volume":"40","author":"Chiuten","year":"1980","journal-title":"Cancer Res."},{"key":"2023072602073184800_bib5","doi-asserted-by":"publisher","first-page":"3831","DOI":"10.1016\/j.jchromb.2009.09.030","article-title":"Simultaneous analysis of eight nucleoside triphosphates in cell lines by liquid chromatography coupled with tandem mass spectrometry","volume":"877","author":"Cohen","year":"2009","journal-title":"J. Chromatogr. B Analyt. Technol. Biomed. Life Sci."},{"key":"2023072602073184800_bib6","doi-asserted-by":"publisher","first-page":"2031","DOI":"10.1016\/S0006-2952(03)00182-5","article-title":"Activation of deoxycytidine kinase by gamma-irradiation and inactivation by hyperosmotic shock in human lymphocytes","volume":"65","author":"Csapo","year":"2003","journal-title":"Biochem. Pharmacol."},{"key":"2023072602073184800_bib7","doi-asserted-by":"crossref","first-page":"9359","DOI":"10.1016\/S0021-9258(18)60539-3","article-title":"Kinetic properties and inhibition of human T lymphoblast deoxycytidine kinase","volume":"264","author":"Datta","year":"1989","journal-title":"J. Biol. Chem."},{"key":"2023072602073184800_bib8","doi-asserted-by":"publisher","first-page":"543","DOI":"10.1038\/nature09339","article-title":"Translating cancer research into targeted therapeutics","volume":"467","author":"de Bono","year":"2010","journal-title":"Nature."},{"key":"2023072602073184800_bib9","doi-asserted-by":"publisher","first-page":"123","DOI":"10.1056\/NEJMoa0900212","article-title":"Inhibition of poly(ADP-ribose) polymerase in tumors from BRCA mutation carriers","volume":"361","author":"Fong","year":"2009","journal-title":"N. Engl. J. Med."},{"key":"2023072602073184800_bib10","doi-asserted-by":"publisher","first-page":"646","DOI":"10.1016\/j.cell.2011.02.013","article-title":"Hallmarks of cancer: the next generation","volume":"144","author":"Hanahan","year":"2011","journal-title":"Cell."},{"key":"2023072602073184800_bib11","doi-asserted-by":"publisher","first-page":"6314","DOI":"10.1073\/pnas.0802080105","article-title":"DNA synthesis from unbalanced nucleotide pools causes limited DNA damage that triggers ATR-CHK1-dependent p53 activation","volume":"105","author":"Hastak","year":"2008","journal-title":"Proc. Natl. Acad. Sci. USA."},{"key":"2023072602073184800_bib12","doi-asserted-by":"publisher","first-page":"1040","DOI":"10.1126\/science.1218595","article-title":"Metabolite profiling identifies a key role for glycine in rapid cancer cell proliferation","volume":"336","author":"Jain","year":"2012","journal-title":"Science."},{"key":"2023072602073184800_bib13","doi-asserted-by":"publisher","first-page":"5614","DOI":"10.1158\/1078-0432.CCR-04-0506","article-title":"Characterization of a gemcitabine-resistant murine leukemic cell line: reversion of in vitro resistance by a mononucleotide prodrug","volume":"10","author":"Jordheim","year":"2004","journal-title":"Clin. Cancer Res."},{"key":"2023072602073184800_bib14","doi-asserted-by":"publisher","first-page":"9114","DOI":"10.1021\/ac202220b","article-title":"Liquid chromatography-high resolution mass spectrometry analysis of fatty acid metabolism","volume":"83","author":"Kamphorst","year":"2011","journal-title":"Anal. Chem."},{"key":"2023072602073184800_bib15","first-page":"580","article-title":"High-dose thymidine infusions in patients with leukemia and lymphoma","volume":"55","author":"Kufe","year":"1980","journal-title":"Blood."},{"key":"2023072602073184800_bib16","doi-asserted-by":"publisher","first-page":"1513","DOI":"10.1002\/1097-0142(19811001)48:7&lt;1513::AID-CNCR2820480705&gt;3.0.CO;2-Q","article-title":"Effect of high-dose thymidine infusions in patients with mycosis fungoides","volume":"48","author":"Kufe","year":"1981","journal-title":"Cancer."},{"key":"2023072602073184800_bib17","doi-asserted-by":"publisher","first-page":"823","DOI":"10.1016\/j.cell.2009.02.024","article-title":"Principles of cancer therapy: oncogene and non-oncogene addiction","volume":"136","author":"Luo","year":"2009","journal-title":"Cell."},{"key":"2023072602073184800_bib18","doi-asserted-by":"publisher","first-page":"542","DOI":"10.1038\/nature11743","article-title":"Serine starvation induces stress and p53-dependent metabolic remodelling in cancer cells","volume":"493","author":"Maddocks","year":"2013","journal-title":"Nature."},{"key":"2023072602073184800_bib19","doi-asserted-by":"publisher","first-page":"1160","DOI":"10.1126\/science.1140321","article-title":"ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage","volume":"316","author":"Matsuoka","year":"2007","journal-title":"Science."},{"key":"2023072602073184800_bib20","doi-asserted-by":"publisher","first-page":"6696","DOI":"10.1021\/jm400457y","article-title":"Development of new deoxycytidine kinase inhibitors and noninvasive in vivo evaluation using positron emission tomography","volume":"56","author":"Murphy","year":"2013","journal-title":"J. Med. Chem."},{"key":"2023072602073184800_bib21","doi-asserted-by":"publisher","first-page":"68","DOI":"10.1107\/S1399004713025030","article-title":"Structural characterization of new deoxycytidine kinase inhibitors rationalizes the affinity-determining moieties of the molecules","volume":"70","author":"Nomme","year":"2014","journal-title":"Acta Crystallogr. D Biol. Crystallogr."},{"key":"2023072602073184800_bib22","first-page":"3911","article-title":"Role of thymidine in biochemical modulation: a review","volume":"47","author":"O\u2019Dwyer","year":"1987","journal-title":"Cancer Res."},{"key":"2023072602073184800_bib23","doi-asserted-by":"publisher","first-page":"1382","DOI":"10.1248\/bpb.19.1382","article-title":"Increased deoxycytidine kinase activity by etoposide in L1210 murine leukemic cells","volume":"19","author":"Ooi","year":"1996","journal-title":"Biol. Pharm. Bull."},{"key":"2023072602073184800_bib24","doi-asserted-by":"publisher","first-page":"783","DOI":"10.1038\/nm1724","article-title":"Molecular imaging of lymphoid organs and immune activation by positron emission tomography with a new [18F]-labeled 2\u2032-deoxycytidine analog","volume":"14","author":"Radu","year":"2008","journal-title":"Nat. Med."},{"key":"2023072602073184800_bib25","doi-asserted-by":"publisher","first-page":"349","DOI":"10.1146\/annurev.bi.57.070188.002025","article-title":"Interactions between deoxyribonucleotide and DNA synthesis","volume":"57","author":"Reichard","year":"1988","journal-title":"Annu. Rev. Biochem."},{"key":"2023072602073184800_bib26","doi-asserted-by":"publisher","first-page":"241","DOI":"10.1172\/JCI58928","article-title":"Oncogenic stress sensitizes murine cancers to hypomorphic suppression of ATR","volume":"122","author":"Schoppy","year":"2012","journal-title":"J. Clin. Invest."},{"key":"2023072602073184800_bib27","doi-asserted-by":"publisher","first-page":"711","DOI":"10.1007\/s00259-010-1666-z","article-title":"Human biodistribution and radiation dosimetry of novel PET probes targeting the deoxyribonucleoside salvage pathway","volume":"38","author":"Schwarzenberg","year":"2011","journal-title":"Eur. J. Nucl. Med. Mol. Imaging."},{"key":"2023072602073184800_bib28","doi-asserted-by":"publisher","first-page":"1334","DOI":"10.1038\/3337","article-title":"Imaging proliferation in vivo with [F-18]FLT and positron emission tomography","volume":"4","author":"Shields","year":"1998","journal-title":"Nat. Med."},{"key":"2023072602073184800_bib29","doi-asserted-by":"publisher","first-page":"1092","DOI":"10.2967\/jnumed.109.073361","article-title":"Novel PET probes specific for deoxycytidine kinase","volume":"51","author":"Shu","year":"2010","journal-title":"J. Nucl. Med."},{"key":"2023072602073184800_bib30","doi-asserted-by":"publisher","first-page":"30","DOI":"10.1177\/0192623307310945","article-title":"Cyclodextrins","volume":"36","author":"Stella","year":"2008","journal-title":"Toxicol. Pathol."},{"key":"2023072602073184800_bib31","doi-asserted-by":"publisher","first-page":"582","DOI":"10.1038\/nprot.2009.28","article-title":"Gaussia luciferase reporter assay for monitoring biological processes in culture and in vivo","volume":"4","author":"Tannous","year":"2009","journal-title":"Nat. Protoc."},{"key":"2023072602073184800_bib32","doi-asserted-by":"publisher","first-page":"5551","DOI":"10.1073\/pnas.0913900107","article-title":"Requirement for deoxycytidine kinase in T and B lymphocyte development","volume":"107","author":"Toy","year":"2010","journal-title":"Proc. Natl. Acad. Sci. USA."},{"key":"2023072602073184800_bib33","doi-asserted-by":"publisher","first-page":"671","DOI":"10.1038\/nrd3504","article-title":"Targeting cancer metabolism: a therapeutic window opens","volume":"10","author":"Vander Heiden","year":"2011","journal-title":"Nat. Rev. Drug Discov."},{"key":"2023072602073184800_bib34","doi-asserted-by":"publisher","first-page":"519","DOI":"10.1085\/jgp.8.6.519","article-title":"The metabolism of tumors in the body","volume":"8","author":"Warburg","year":"1927","journal-title":"J. Gen. Physiol."},{"key":"2023072602073184800_bib35","doi-asserted-by":"publisher","first-page":"6688","DOI":"10.1073\/pnas.0602030103","article-title":"Arf gene loss enhances oncogenicity and limits imatinib response in mouse models of Bcr-Abl-induced acute lymphoblastic leukemia","volume":"103","author":"Williams","year":"2006","journal-title":"Proc. Natl. Acad. Sci. USA."},{"key":"2023072602073184800_bib36","doi-asserted-by":"crossref","first-page":"631","DOI":"10.1074\/jbc.270.2.631","article-title":"Functional compartmentation of dCTP pools. Preferential utilization of salvaged deoxycytidine for DNA repair in human lymphoblasts","volume":"270","author":"Xu","year":"1995","journal-title":"J. Biol. Chem."},{"key":"2023072602073184800_bib37","doi-asserted-by":"publisher","first-page":"9621","DOI":"10.1093\/nar\/gks707","article-title":"Deoxycytidine kinase regulates the G2\/M checkpoint through interaction with cyclin-dependent kinase 1 in response to DNA damage","volume":"40","author":"Yang","year":"2012","journal-title":"Nucleic Acids Res."},{"key":"2023072602073184800_bib38","doi-asserted-by":"publisher","first-page":"72","DOI":"10.1177\/1087057109353604","article-title":"Novel potent inhibitors of deoxycytidine kinase identified and compared by multiple assays","volume":"15","author":"Yu","year":"2010","journal-title":"J. Biomol. Screen."}],"container-title":["Journal of Experimental Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/rupress.org\/jem\/article-pdf\/211\/3\/473\/1749755\/jem_20131738.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/rupress.org\/jem\/article-pdf\/211\/3\/473\/1749755\/jem_20131738.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,7,26]],"date-time":"2023-07-26T02:08:07Z","timestamp":1690337287000},"score":1,"resource":{"primary":{"URL":"https:\/\/rupress.org\/jem\/article\/211\/3\/473\/41650\/Co-targeting-of-convergent-nucleotide-biosynthetic"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,2,24]]},"references-count":38,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2014,3,10]]}},"URL":"https:\/\/doi.org\/10.1084\/jem.20131738","relation":{},"ISSN":["1540-9538","0022-1007"],"issn-type":[{"value":"1540-9538","type":"electronic"},{"value":"0022-1007","type":"print"}],"subject":[],"published":{"date-parts":[[2014,2,24]]}}}