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We further show that activated B-RAF signaling enables robust regenerative growth of sensory axons into the spinal cord after a dorsal root crush as well as substantial axon regrowth in the crush-lesioned optic nerve. Finally, the combination of B-RAF gain-of-function and PTEN loss-of-function promotes optic nerve axon extension beyond what would be predicted for a simple additive effect. We conclude that cell-intrinsic RAF signaling is a crucial pathway promoting developmental and regenerative axon growth in the peripheral and central nervous systems.<\/jats:p>","DOI":"10.1084\/jem.20131780","type":"journal-article","created":{"date-parts":[[2014,4,15]],"date-time":"2014-04-15T03:28:16Z","timestamp":1397532496000},"page":"801-814","update-policy":"https:\/\/doi.org\/10.1084\/jem.crossmarkpolicy","source":"Crossref","is-referenced-by-count":92,"title":["B-RAF kinase drives developmental axon growth and promotes axon regeneration in the injured mature CNS"],"prefix":"10.1084","volume":"211","author":[{"given":"Kevin J.","family":"O\u2019Donovan","sequence":"first","affiliation":[{"name":"Burke Medical Research Institute, Weill Cornell Medical College of Cornell University, White Plains, NY 10605 1"},{"name":"Brain and Mind Research Institute, Weill Cornell Medical College of Cornell University, New York, NY 10065 2"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kaijie","family":"Ma","sequence":"additional","affiliation":[{"name":"Burke Medical Research Institute, Weill Cornell Medical College of Cornell University, White Plains, NY 10605 1"},{"name":"Brain and Mind Research Institute, Weill Cornell Medical College of Cornell University, New York, NY 10065 2"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hengchang","family":"Guo","sequence":"additional","affiliation":[{"name":"Burke Medical Research Institute, Weill Cornell Medical College of Cornell University, White Plains, NY 10605 1"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chen","family":"Wang","sequence":"additional","affiliation":[{"name":"F.M. 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