{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T03:53:36Z","timestamp":1791345216333,"version":"4.3.1"},"reference-count":32,"publisher":"Rockefeller University Press","issue":"6","content-domain":{"domain":["rupress.org"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2014,6,2]]},"abstract":"<jats:p>Resolution of inflammation is now recognized as a biosynthetically active process involving pro-resolving mediators. Here, we show in zymosan-initiated peritoneal inflammation that the vagus nerve regulates local expression of netrin-1, an axonal guidance molecule that activates resolution, and that vagotomy reduced local pro-resolving mediators, thereby delaying resolution. In netrin-1+\/\u2212 mice, resolvin D1 (RvD1) was less effective in reducing neutrophil influx promoting resolution of peritonitis compared with Ntn1+\/+. Netrin-1 shortened the resolution interval, decreasing exudate neutrophils, reducing proinflammatory mediators, and stimulating the production of resolvins, protectins, and lipoxins. Human monocytes incubated with netrin-1 produced proresolving mediators, including resolvins and lipoxins. Netrin-1 and RvD1 displayed bidirectional activation in that they stimulated each other\u2019s expression and enhanced efferocytosis. These results indicate that the vagus nerve regulates both netrin-1 and pro-resolving lipid mediators, which act in a bidirectional fashion to stimulate resolution, and provide evidence for a novel mechanism for local neuronal control of resolution.<\/jats:p>","DOI":"10.1084\/jem.20132103","type":"journal-article","created":{"date-parts":[[2014,5,27]],"date-time":"2014-05-27T02:50:26Z","timestamp":1401159026000},"page":"1037-1048","update-policy":"https:\/\/doi.org\/10.1084\/jem.crossmarkpolicy","source":"Crossref","is-referenced-by-count":170,"title":["Vagus nerve controls resolution and pro-resolving mediators of inflammation"],"prefix":"10.1084","volume":"211","author":[{"given":"Valbona","family":"Mirakaj","sequence":"first","affiliation":[{"name":"Center for Experimental Therapeutics and Reperfusion Injury, Harvard Institutes of Medicine, Department of Anesthesiology, Perioperative and Pain Medicine, Brigham and Women\u2019s Hospital and Harvard Medical School, Boston, MA 02115 1"},{"name":"Clinic of Anesthesiology and Intensive Care Medicine, University Hospital T\u00fcbingen, Eberhard-Karls University, 72076 T\u00fcbingen, Germany 2"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jesmond","family":"Dalli","sequence":"additional","affiliation":[{"name":"Center for Experimental Therapeutics and Reperfusion Injury, Harvard Institutes of Medicine, Department of Anesthesiology, Perioperative and Pain Medicine, Brigham and Women\u2019s Hospital and Harvard Medical School, Boston, MA 02115 1"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tiago","family":"Granja","sequence":"additional","affiliation":[{"name":"Clinic of Anesthesiology and Intensive Care Medicine, University Hospital T\u00fcbingen, Eberhard-Karls University, 72076 T\u00fcbingen, Germany 2"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter","family":"Rosenberger","sequence":"additional","affiliation":[{"name":"Clinic of Anesthesiology and Intensive Care Medicine, University Hospital T\u00fcbingen, Eberhard-Karls University, 72076 T\u00fcbingen, Germany 2"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Charles N.","family":"Serhan","sequence":"additional","affiliation":[{"name":"Center for Experimental Therapeutics and Reperfusion Injury, Harvard Institutes of Medicine, Department of Anesthesiology, Perioperative and Pain Medicine, Brigham and Women\u2019s Hospital and Harvard Medical School, Boston, MA 02115 1"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"291","published-online":{"date-parts":[[2014,5,26]]},"reference":[{"key":"2023072602170117800_bib1","doi-asserted-by":"publisher","first-page":"695","DOI":"10.1136\/gutjnl-2011-300012","article-title":"Neuronal guidance molecule netrin-1 attenuates inflammatory cell trafficking during acute experimental colitis","volume":"61","author":"Aherne","year":"2012","journal-title":"Gut."},{"key":"2023072602170117800_bib2","doi-asserted-by":"crossref","first-page":"G635","DOI":"10.1152\/ajpgi.2001.281.3.G635","article-title":"Persistent epithelial dysfunction and bacterial translocation after resolution of intestinal inflammation","volume":"281","author":"Asfaha","year":"2001","journal-title":"Am. 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