{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T00:39:42Z","timestamp":1791247182901,"version":"4.1.0"},"reference-count":58,"publisher":"Rockefeller University Press","issue":"10","content-domain":{"domain":["rupress.org"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2014,9,22]]},"abstract":"<jats:p>Germinal centers (GCs) are the sites where memory B cells and plasma cells producing high-affinity antibodies are generated during T cell\u2013dependent immune responses. The molecular control of GC B cell maintenance and differentiation remains incompletely understood. Activation of the NF-\u03baB signaling pathway has been implicated; however, the distinct roles of the individual NF-\u03baB transcription factor subunits are unknown. We report that GC B cell\u2013specific deletion of the NF-\u03baB subunits c-REL or RELA, which are both activated by the canonical NF-\u03baB pathway, abolished the generation of high-affinity B cells via different mechanisms acting at distinct stages during the GC reaction. c-REL deficiency led to the collapse of established GCs immediately after the formation of dark and light zones at day 7 of the GC reaction and was associated with the failure to activate a metabolic program that promotes cell growth. Conversely, RELA was dispensable for GC maintenance but essential for the development of GC-derived plasma cells due to impaired up-regulation of BLIMP1. These results indicate that activation of the canonical NF-\u03baB pathway in GC B cells controls GC maintenance and differentiation through distinct transcription factor subunits. Our findings have implications for the role of NF-\u03baB in GC lymphomagenesis.<\/jats:p>","DOI":"10.1084\/jem.20132613","type":"journal-article","created":{"date-parts":[[2014,9,2]],"date-time":"2014-09-02T00:19:08Z","timestamp":1409617148000},"page":"2103-2118","update-policy":"https:\/\/doi.org\/10.1084\/jem.crossmarkpolicy","source":"Crossref","is-referenced-by-count":242,"title":["Germinal center B cell maintenance and differentiation are controlled by distinct NF-\u03baB transcription factor subunits"],"prefix":"10.1084","volume":"211","author":[{"given":"Nicole","family":"Heise","sequence":"first","affiliation":[{"name":"Herbert Irving Comprehensive Cancer Center 1 , 2 , and 3"},{"name":"Department of Pathology and Cell Biology 1 , 2 , and 3"},{"name":"Department of Microbiology and Immunology, Columbia University, New York, NY 10032 1 , 2 , and 3"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nilushi S.","family":"De 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