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Such severe immune deficiency is caused by multiple and profound B cell abnormalities, including early blocks during B cell development; impaired antigen-driven BCR signaling and actin remodeling; defective antigen presentation and in vivo interaction with T cells; and a severe B cell\u2013intrinsic block in plasma cell differentiation. Thus, our study presents a new perspective on Cdc42 as key regulator of B cell physiology.<\/jats:p>","DOI":"10.1084\/jem.20141143","type":"journal-article","created":{"date-parts":[[2014,12,30]],"date-time":"2014-12-30T08:07:07Z","timestamp":1419926827000},"page":"53-72","update-policy":"https:\/\/doi.org\/10.1084\/jem.crossmarkpolicy","source":"Crossref","is-referenced-by-count":80,"title":["Cdc42 is a key regulator of B cell differentiation and is required for antiviral humoral immunity"],"prefix":"10.1084","volume":"212","author":[{"given":"Marianne","family":"Burbage","sequence":"first","affiliation":[{"name":"Lymphocyte Interaction Laboratory 1 , 2"},{"name":"Electron Microscopy Unit, London Research Institute, Cancer Research UK, London WC2A 3LY, England, UK 1 , 2"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Selina J.","family":"Keppler","sequence":"additional","affiliation":[{"name":"Lymphocyte Interaction Laboratory 1 , 2"},{"name":"Electron Microscopy Unit, London Research Institute, Cancer Research UK, London WC2A 3LY, England, UK 1 , 2"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesca","family":"Gasparrini","sequence":"additional","affiliation":[{"name":"Lymphocyte Interaction Laboratory 1 , 2"},{"name":"Electron Microscopy Unit, London Research Institute, Cancer Research UK, London WC2A 3LY, England, UK 1 , 2"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nuria","family":"Mart\u00ednez-Mart\u00edn","sequence":"additional","affiliation":[{"name":"Lymphocyte Interaction Laboratory 1 , 2"},{"name":"Electron Microscopy Unit, London Research Institute, Cancer Research UK, London WC2A 3LY, England, UK 1 , 2"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mauro","family":"Gaya","sequence":"additional","affiliation":[{"name":"Lymphocyte Interaction Laboratory 1 , 2"},{"name":"Electron Microscopy Unit, London Research Institute, Cancer Research UK, London WC2A 3LY, England, UK 1 , 2"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christoph","family":"Feest","sequence":"additional","affiliation":[{"name":"Lymphocyte Interaction Laboratory 1 , 2"},{"name":"Electron Microscopy Unit, London Research Institute, Cancer Research UK, London WC2A 3LY, England, UK 1 , 2"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marie-Charlotte","family":"Domart","sequence":"additional","affiliation":[{"name":"Lymphocyte Interaction Laboratory 1 , 2"},{"name":"Electron Microscopy Unit, London Research Institute, Cancer Research UK, London WC2A 3LY, England, UK 1 , 2"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cord","family":"Brakebusch","sequence":"additional","affiliation":[{"name":"Biomedical Institute, Biotech Research and Innovation Centre, University of Copenhagen, 2100 Copenhagen, Denmark 3"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lucy","family":"Collinson","sequence":"additional","affiliation":[{"name":"Lymphocyte Interaction Laboratory 1 , 2"},{"name":"Electron Microscopy Unit, London Research Institute, Cancer Research UK, London WC2A 3LY, England, UK 1 , 2"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andreas","family":"Bruckbauer","sequence":"additional","affiliation":[{"name":"Lymphocyte Interaction Laboratory 1 , 2"},{"name":"Electron Microscopy Unit, London Research Institute, Cancer Research UK, London WC2A 3LY, England, UK 1 , 2"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Facundo D.","family":"Batista","sequence":"additional","affiliation":[{"name":"Lymphocyte Interaction Laboratory 1 , 2"},{"name":"Electron Microscopy Unit, London Research Institute, Cancer Research UK, London WC2A 3LY, England, UK 1 , 2"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"291","published-online":{"date-parts":[[2014,12,29]]},"reference":[{"key":"2023072602470139000_bib1","doi-asserted-by":"publisher","first-page":"113","DOI":"10.1038\/369113a0","article-title":"Transient accumulation of new class II MHC molecules in a novel endocytic compartment in B lymphocytes","volume":"369","author":"Amigorena","year":"1994","journal-title":"Nature."},{"key":"2023072602470139000_bib2","doi-asserted-by":"publisher","first-page":"88","DOI":"10.1016\/j.immuni.2007.12.003","article-title":"Activation of the small GTPase Rac2 via the B cell receptor regulates B cell adhesion and immunological-synapse formation","volume":"28","author":"Arana","year":"2008","journal-title":"Immunity."},{"key":"2023072602470139000_bib3","doi-asserted-by":"publisher","first-page":"70","DOI":"10.1016\/S0960-9822(02)00423-2","article-title":"Two GTPases, Cdc42 and Rac, bind directly to a protein implicated in the immunodeficiency disorder Wiskott-Aldrich syndrome","volume":"6","author":"Aspenstr\u00f6m","year":"1996","journal-title":"Curr. 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