{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T09:07:22Z","timestamp":1790759242247,"version":"4.1.0"},"reference-count":78,"publisher":"Rockefeller University Press","issue":"13","content-domain":{"domain":["rupress.org"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2014,12,15]]},"abstract":"<jats:p>DOCK8 mutations result in an inherited combined immunodeficiency characterized by increased susceptibility to skin and other infections. We show that when DOCK8-deficient T and NK cells migrate through confined spaces, they develop cell shape and nuclear deformation abnormalities that do not impair chemotaxis but contribute to a distinct form of catastrophic cell death we term cytothripsis. Such defects arise during lymphocyte migration in collagen-dense tissues when DOCK8, through CDC42 and p21-activated kinase (PAK), is unavailable to coordinate cytoskeletal structures. Cytothripsis of DOCK8-deficient cells prevents the generation of long-lived skin-resident memory CD8 T cells, which in turn impairs control of herpesvirus skin infections. Our results establish that DOCK8-regulated shape integrity of lymphocytes prevents cytothripsis and promotes antiviral immunity in the skin.<\/jats:p>","DOI":"10.1084\/jem.20141307","type":"journal-article","created":{"date-parts":[[2014,11,24]],"date-time":"2014-11-24T22:25:00Z","timestamp":1416867900000},"page":"2549-2566","update-policy":"https:\/\/doi.org\/10.1084\/jem.crossmarkpolicy","source":"Crossref","is-referenced-by-count":177,"title":["DOCK8 regulates lymphocyte shape integrity for skin antiviral immunity"],"prefix":"10.1084","volume":"211","author":[{"given":"Qian","family":"Zhang","sequence":"first","affiliation":[{"name":"Laboratory of Host Defenses 1 , 2 , 3 , and 4"},{"name":"Laboratory of Systems Biology 1 , 2 , 3 , and 4"},{"name":"Laboratory of Immunology 1 , 2 , 3 , and 4"},{"name":"Laboratory of Clinical Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892 1 , 2 , 3 , and 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