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The interaction caused DCs to produce IL-27, which in turn enhanced IFN-\u03b3 production by NK cells, forming a self-amplifying positive feedback loop. IL-10, produced by the interacting cells themselves, was able to limit this process. The NK-DC\u2013dependent IL-27 inhibited development of the adaptive pathogenic IL-17 response and induced IL-10\u2013producing Tr1-like cells, which ameliorated disease in an IL-10-dependent manner. Our data reveal that an early NK-DC interaction controls the adaptive Th17 response and limits tissue-specific autoimmunity through an innate IFN-\u03b3\u2013IL-27 axis.<\/jats:p>","DOI":"10.1084\/jem.20141678","type":"journal-article","created":{"date-parts":[[2015,9,7]],"date-time":"2015-09-07T21:49:48Z","timestamp":1441662588000},"page":"1739-1752","update-policy":"https:\/\/doi.org\/10.1084\/jem.crossmarkpolicy","source":"Crossref","is-referenced-by-count":78,"title":["NK-DC crosstalk controls the autopathogenic Th17 response through an innate IFN-\u03b3\u2013IL-27 axis"],"prefix":"10.1084","volume":"212","author":[{"given":"Wai Po","family":"Chong","sequence":"first","affiliation":[{"name":"Laboratory of Immunology, National Eye Institute 1 , 2"},{"name":"Lymphocyte Biology Section, Laboratory of Systems Biology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892 1 , 2"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicholas","family":"van Panhuys","sequence":"additional","affiliation":[{"name":"Laboratory of Immunology, National Eye Institute 1 , 2"},{"name":"Lymphocyte Biology Section, Laboratory of Systems Biology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892 1 , 2"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jun","family":"Chen","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Ophthalmology, Zhongshan Ophthalmical Center, Sun Yat-sen University, Guangzhou 510060, China 3"},{"name":"Laboratory of Immunology, National Eye Institute 1 , 2"},{"name":"Lymphocyte Biology Section, Laboratory of Systems Biology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892 1 , 2"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Phyllis B.","family":"Silver","sequence":"additional","affiliation":[{"name":"Laboratory of Immunology, National Eye Institute 1 , 2"},{"name":"Lymphocyte Biology Section, Laboratory of Systems Biology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892 1 , 2"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yingyos","family":"Jittayasothorn","sequence":"additional","affiliation":[{"name":"Laboratory of Immunology, National Eye Institute 1 , 2"},{"name":"Lymphocyte Biology Section, Laboratory of Systems Biology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892 1 , 2"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mary J.","family":"Mattapallil","sequence":"additional","affiliation":[{"name":"Laboratory of Immunology, National Eye Institute 1 , 2"},{"name":"Lymphocyte Biology Section, Laboratory of Systems Biology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892 1 , 2"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ronald N.","family":"Germain","sequence":"additional","affiliation":[{"name":"Laboratory of Immunology, National Eye Institute 1 , 2"},{"name":"Lymphocyte Biology Section, Laboratory of Systems Biology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892 1 , 2"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rachel R.","family":"Caspi","sequence":"additional","affiliation":[{"name":"Laboratory of Immunology, National Eye Institute 1 , 2"},{"name":"Lymphocyte Biology Section, Laboratory of Systems Biology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892 1 , 2"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"291","published-online":{"date-parts":[[2015,9,7]]},"reference":[{"key":"2023072602505498900_bib1","doi-asserted-by":"publisher","first-page":"443","DOI":"10.1007\/978-1-60761-720-4_22","article-title":"Rodent models of experimental autoimmune uveitis","volume":"900","author":"Agarwal","year":"2012","journal-title":"Methods Mol. 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