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The Notch ligand DLL4 is abundantly expressed on bone marrow Ocn+ cells, and selective depletion of DLL4 from these cells recapitulated the thymopoietic abnormality. These data indicate that specific mesenchymal cells in bone marrow provide key molecular drivers enforcing thymus-seeding progenitor generation and thereby directly link skeletal biology to the production of T cell\u2013based adaptive immunity.<\/jats:p>","DOI":"10.1084\/jem.20141843","type":"journal-article","created":{"date-parts":[[2015,4,27]],"date-time":"2015-04-27T21:31:40Z","timestamp":1430170300000},"page":"759-774","update-policy":"https:\/\/doi.org\/10.1084\/jem.crossmarkpolicy","source":"Crossref","is-referenced-by-count":166,"title":["Specific bone cells produce DLL4 to generate thymus-seeding progenitors from bone marrow"],"prefix":"10.1084","volume":"212","author":[{"given":"Vionnie W.C.","family":"Yu","sequence":"first","affiliation":[{"name":"Center for Regenerative Medicine, Massachusetts General Hospital, Boston, MA 02215 1"},{"name":"Harvard Stem Cell Institute, Cambridge, MA 02215 2"},{"name":"Department of Stem Cell and Regenerative Biology, Harvard University, 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