{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,4]],"date-time":"2026-11-04T05:39:11Z","timestamp":1793770751489,"version":"4.6.1"},"reference-count":56,"publisher":"Rockefeller University Press","issue":"12","content-domain":{"domain":["rupress.org"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2015,11,16]]},"abstract":"<jats:p>ZEB2 is a multi-zinc-finger transcription factor known to play a significant role in early neurogenesis and in epithelial-mesenchymal transition\u2013dependent tumor metastasis. Although the function of ZEB2 in T lymphocytes is unknown, activity of the closely related family member ZEB1 has been implicated in lymphocyte development. Here, we find that ZEB2 expression is up-regulated by activated T cells, specifically in the KLRG1hi effector CD8+ T cell subset. Loss of ZEB2 expression results in a significant loss of antigen-specific CD8+ T cells after primary and secondary infection with a severe impairment in the generation of the KLRG1hi effector memory cell population. We show that ZEB2, which can bind DNA at tandem, consensus E-box sites, regulates gene expression of several E-protein targets and may directly repress Il7r and Il2 in CD8+ T cells responding to infection. Furthermore, we find that T-bet binds to highly conserved T-box sites in the Zeb2 gene and that T-bet and ZEB2 regulate similar gene expression programs in effector T cells, suggesting that T-bet acts upstream and through regulation of ZEB2. Collectively, we place ZEB2 in a larger transcriptional network that is responsible for the balance between terminal differentiation and formation of memory CD8+ T cells.<\/jats:p>","DOI":"10.1084\/jem.20150194","type":"journal-article","created":{"date-parts":[[2015,10,27]],"date-time":"2015-10-27T01:55:20Z","timestamp":1445910920000},"page":"2027-2039","update-policy":"https:\/\/doi.org\/10.1084\/jem.crossmarkpolicy","source":"Crossref","is-referenced-by-count":266,"title":["Transcriptional repressor ZEB2 promotes terminal differentiation of CD8+ effector and memory T cell populations during infection"],"prefix":"10.1084","volume":"212","author":[{"given":"Kyla D.","family":"Omilusik","sequence":"first","affiliation":[{"name":"Division of Biological Sciences, University of California, San Diego, La Jolla, CA 92093 1"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J. 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