{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T13:25:27Z","timestamp":1790256327343,"version":"4.1.0"},"reference-count":59,"publisher":"Rockefeller University Press","issue":"1","content-domain":{"domain":["rupress.org"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2016,1,11]]},"abstract":"<jats:p>CD8\u03b1+ and CD103+ dendritic cells (DCs) play a central role in the development of type 1 immune responses. However, their role in type 2 immunity remains unclear. We examined this issue using Batf3\u2212\/\u2212 mice, in which both of these DC subsets are missing. We found that Th2 cell responses, and related events such as eosinophilia, alternative macrophage activation, and immunoglobulin class switching to IgG1, were enhanced in Batf3\u2212\/\u2212 mice responding to helminth parasites. This had beneficial or detrimental consequences depending on the context. For example, Batf3 deficiency converted a normally chronic intestinal infection with Heligmosomoides polygyrus into an infection that was rapidly controlled. However, liver fibrosis, an IL-13\u2013mediated pathological consequence of wound healing in chronic schistosomiasis, was exacerbated in Batf3\u2212\/\u2212 mice infected with Schistosoma mansoni. Mechanistically, steady-state production of IL-12 by migratory CD103+ DCs, independent of signals from commensals or TLR-initiated events, was necessary and sufficient to exert the suppressive effects on Th2 response development. These findings identify a previously unrecognized role for migratory CD103+ DCs in antagonizing type 2 immune responses.<\/jats:p>","DOI":"10.1084\/jem.20150235","type":"journal-article","created":{"date-parts":[[2015,12,29]],"date-time":"2015-12-29T03:03:05Z","timestamp":1451358185000},"page":"35-51","update-policy":"https:\/\/doi.org\/10.1084\/jem.crossmarkpolicy","source":"Crossref","is-referenced-by-count":108,"title":["Migratory CD103+ dendritic cells suppress helminth-driven type 2 immunity through constitutive expression of IL-12"],"prefix":"10.1084","volume":"213","author":[{"given":"Bart","family":"Everts","sequence":"first","affiliation":[{"name":"Department of Pathology and Immunology, Washington University School of Medicine, St. Louis, MO 63110 1"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roxane","family":"Tussiwand","sequence":"additional","affiliation":[{"name":"Department of Pathology and Immunology, Washington University School of Medicine, St. Louis, MO 63110 1"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leentje","family":"Dreesen","sequence":"additional","affiliation":[{"name":"Department of Pathology and Immunology, Washington University School of Medicine, St. Louis, MO 63110 1"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Keke C.","family":"Fairfax","sequence":"additional","affiliation":[{"name":"Department of Pathology and Immunology, Washington University School of Medicine, St. Louis, MO 63110 1"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stanley Ching-Cheng","family":"Huang","sequence":"additional","affiliation":[{"name":"Department of Pathology and Immunology, Washington University School of Medicine, St. Louis, MO 63110 1"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amber M.","family":"Smith","sequence":"additional","affiliation":[{"name":"Department of Pathology and Immunology, Washington University School of Medicine, St. Louis, MO 63110 1"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christina M.","family":"O\u2019Neill","sequence":"additional","affiliation":[{"name":"Department of Pathology and Immunology, Washington University School of Medicine, St. Louis, MO 63110 1"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wing Y.","family":"Lam","sequence":"additional","affiliation":[{"name":"Department of Pathology and Immunology, Washington University School of Medicine, St. Louis, MO 63110 1"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brian T.","family":"Edelson","sequence":"additional","affiliation":[{"name":"Department of Pathology and Immunology, Washington University School of Medicine, St. Louis, MO 63110 1"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"suffix":"Jr.","given":"Joseph F.","family":"Urban","sequence":"additional","affiliation":[{"name":"Diet, Genomics, and Immunology Laboratory, Beltsville Human Nutrition Research Center, Agriculture Research Service, US Department of Agriculture, Beltsville, MD 20705 3"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kenneth M.","family":"Murphy","sequence":"additional","affiliation":[{"name":"Department of Pathology and Immunology, Washington University School of Medicine, St. Louis, MO 63110 1"},{"name":"Howard Hughes Medical Institute, Washington University School of Medicine, St. Louis, MO 63110 2"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Edward J.","family":"Pearce","sequence":"additional","affiliation":[{"name":"Department of Pathology and Immunology, Washington University School of Medicine, St. Louis, MO 63110 1"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"291","published-online":{"date-parts":[[2015,12,28]]},"reference":[{"key":"2023072603221691000_bib1","doi-asserted-by":"publisher","first-page":"2821","DOI":"10.4049\/jimmunol.1302498","article-title":"Mechanistic target of rapamycin inhibition extends cellular lifespan in dendritic cells by preserving mitochondrial function","volume":"193","author":"Amiel","year":"2014","journal-title":"J. Immunol."},{"key":"2023072603221691000_bib2","doi-asserted-by":"publisher","first-page":"955","DOI":"10.1038\/nm1451","article-title":"Memory T(H)2 cells induce alternatively activated macrophages to mediate protection against nematode parasites","volume":"12","author":"Anthony","year":"2006","journal-title":"Nat. Med."},{"key":"2023072603221691000_bib3","doi-asserted-by":"publisher","first-page":"1422","DOI":"10.1002\/eji.201344242","article-title":"Cross-presenting dendritic cells are required for control of Leishmania major infection","volume":"44","author":"Ashok","year":"2014","journal-title":"Eur. J. Immunol."},{"key":"2023072603221691000_bib4","doi-asserted-by":"publisher","first-page":"352","DOI":"10.1016\/j.jhep.2012.03.023","article-title":"Two lymph nodes draining the mouse liver are the preferential site of DC migration and T cell activation","volume":"57","author":"Barbier","year":"2012","journal-title":"J. Hepatol."},{"key":"2023072603221691000_bib5","doi-asserted-by":"publisher","first-page":"693","DOI":"10.1172\/JCI200317464","article-title":"Constitutive p40 promoter activation and IL-23 production in the terminal ileum mediated by dendritic cells","volume":"112","author":"Becker","year":"2003","journal-title":"J. Clin. Invest."},{"key":"2023072603221691000_bib6","doi-asserted-by":"crossref","first-page":"1437","DOI":"10.4049\/jimmunol.114.5.1437","article-title":"Spontaneous modulation of granulomatous hypersensitivity in schistosomiasis mansoni","volume":"114","author":"Boros","year":"1975","journal-title":"J. Immunol."},{"key":"2023072603221691000_bib7","doi-asserted-by":"publisher","first-page":"777","DOI":"10.1172\/JCI7325","article-title":"An IL-13 inhibitor blocks the development of hepatic fibrosis during a T-helper type 2-dominated inflammatory response","volume":"104","author":"Chiaramonte","year":"1999","journal-title":"J. Clin. Invest."},{"key":"2023072603221691000_bib8","doi-asserted-by":"publisher","first-page":"1757","DOI":"10.1084\/jem.20070590","article-title":"A functionally specialized population of mucosal CD103+ DCs induces Foxp3+ regulatory T cells via a TGF-\u03b2 and retinoic acid-dependent mechanism","volume":"204","author":"Coombes","year":"2007","journal-title":"J. Exp. Med."},{"key":"2023072603221691000_bib9","doi-asserted-by":"publisher","first-page":"1104","DOI":"10.1002\/embj.201488027","article-title":"Dendritic cell maturation: functional specialization through signaling specificity and transcriptional programming","volume":"33","author":"Dalod","year":"2014","journal-title":"EMBO J."},{"key":"2023072603221691000_bib10","doi-asserted-by":"publisher","first-page":"1704","DOI":"10.4049\/jimmunol.168.4.1704","article-title":"Microbial compounds selectively induce Th1 cell-promoting or Th2 cell-promoting dendritic cells in vitro with diverse Th cell-polarizing signals","volume":"168","author":"de Jong","year":"2002","journal-title":"J. Immunol."},{"key":"2023072603221691000_bib11","first-page":"369","article-title":"Endogenous desensitization: changing host granulomatou response to schistosome eggs at different stages of infection with Schistosoma mansoni","volume":"52","author":"Domingo","year":"1968","journal-title":"Am. J. Pathol."},{"key":"2023072603221691000_bib12","doi-asserted-by":"publisher","first-page":"107","DOI":"10.1126\/science.1136080","article-title":"Differential antigen processing by dendritic cell subsets in vivo","volume":"315","author":"Dudziak","year":"2007","journal-title":"Science."},{"key":"2023072603221691000_bib13","doi-asserted-by":"publisher","first-page":"823","DOI":"10.1084\/jem.20091627","article-title":"Peripheral CD103+ dendritic cells form a unified subset developmentally related to CD8\u03b1+ conventional dendritic cells","volume":"207","author":"Edelson","year":"2010","journal-title":"J. Exp. Med."},{"key":"2023072603221691000_bib14","doi-asserted-by":"publisher","first-page":"1673","DOI":"10.1084\/jem.20082460","article-title":"Omega-1, a glycoprotein secreted by Schistosoma mansoni eggs, drives Th2 responses","volume":"206","author":"Everts","year":"2009","journal-title":"J. Exp. Med."},{"key":"2023072603221691000_bib15","doi-asserted-by":"publisher","first-page":"268","DOI":"10.1016\/j.drudis.2007.12.008","article-title":"Advances in measuring cellular bioenergetics using extracellular flux","volume":"13","author":"Ferrick","year":"2008","journal-title":"Drug Discov. Today."},{"key":"2023072603221691000_bib16","doi-asserted-by":"publisher","first-page":"1563","DOI":"10.1084\/jem.179.5.1563","article-title":"Effects of interleukin 12 on immune responses and host protection in mice infected with intestinal nematode parasites","volume":"179","author":"Finkelman","year":"1994","journal-title":"J. Exp. Med."},{"key":"2023072603221691000_bib17","doi-asserted-by":"publisher","first-page":"1874","DOI":"10.1002\/eji.200636751","article-title":"Expansion and activation of CD4+CD25+ regulatory T cells in Heligmosomoides polygyrus infection","volume":"37","author":"Finney","year":"2007","journal-title":"Eur. J. Immunol."},{"key":"2023072603221691000_bib18","doi-asserted-by":"publisher","first-page":"2005","DOI":"10.1084\/jem.20101159","article-title":"Host type I IFN signals are required for antitumor CD8+ T cell responses through CD8\u03b1+ dendritic cells","volume":"208","author":"Fuertes","year":"2011","journal-title":"J. Exp. Med."},{"key":"2023072603221691000_bib19","doi-asserted-by":"publisher","first-page":"722","DOI":"10.1016\/j.immuni.2013.08.028","article-title":"Control of T helper 2 responses by transcription factor IRF4-dependent dendritic cells","volume":"39","author":"Gao","year":"2013","journal-title":"Immunity."},{"key":"2023072603221691000_bib20","doi-asserted-by":"publisher","first-page":"991","DOI":"10.1084\/jem.20090303","article-title":"T follicular helper cells differentiate from Th2 cells in response to helminth antigens","volume":"206","author":"Glatman Zaretsky","year":"2009","journal-title":"J. Exp. Med."},{"key":"2023072603221691000_bib21","doi-asserted-by":"publisher","first-page":"127","DOI":"10.1056\/NEJMoa1100066","article-title":"IRF8 mutations and human dendritic-cell immunodeficiency","volume":"365","author":"Hambleton","year":"2011","journal-title":"N. Engl. J. Med."},{"key":"2023072603221691000_bib22","doi-asserted-by":"publisher","first-page":"1097","DOI":"10.1126\/science.1164206","article-title":"Batf3 deficiency reveals a critical role for CD8\u03b1+ dendritic cells in cytotoxic T cell immunity","volume":"322","author":"Hildner","year":"2008","journal-title":"Science."},{"key":"2023072603221691000_bib23","doi-asserted-by":"publisher","first-page":"547","DOI":"10.1126\/science.8097338","article-title":"Development of TH1 CD4+ T cells through IL-12 produced by Listeria-induced macrophages","volume":"260","author":"Hsieh","year":"1993","journal-title":"Science."},{"key":"2023072603221691000_bib24","doi-asserted-by":"publisher","first-page":"846","DOI":"10.1038\/ni.2956","article-title":"Cell-intrinsic lysosomal lipolysis is essential for alternative activation of macrophages","volume":"15","author":"Huang","year":"2014","journal-title":"Nat. Immunol."},{"key":"2023072603221691000_bib25","doi-asserted-by":"publisher","first-page":"65","DOI":"10.1159\/000088881","article-title":"Mechanisms underlying helminth- induced Th2 polarization: default, negative or positive pathways?","volume":"90","author":"Jankovic","year":"2006","journal-title":"Chem. Immunol. Allergy."},{"key":"2023072603221691000_bib26","doi-asserted-by":"publisher","first-page":"25","DOI":"10.4049\/jimmunol.1300193","article-title":"Cutting edge: inhaled antigen upregulates retinaldehyde dehydrogenase in lung CD103+ but not plasmacytoid dendritic cells to induce Foxp3 de novo in CD4+ T cells and promote airway tolerance","volume":"191","author":"Khare","year":"2013","journal-title":"J. Immunol."},{"key":"2023072603221691000_bib27","doi-asserted-by":"publisher","first-page":"1001","DOI":"10.1084\/jem.20090313","article-title":"IL-4-producing CD4+ T cells in reactive lymph nodes during helminth infection are T follicular helper cells","volume":"206","author":"King","year":"2009","journal-title":"J. Exp. Med."},{"key":"2023072603221691000_bib28","doi-asserted-by":"publisher","first-page":"733","DOI":"10.1016\/j.immuni.2013.08.029","article-title":"CD301b+ dermal dendritic cells drive T helper 2 cell-mediated immunity","volume":"39","author":"Kumamoto","year":"2013","journal-title":"Immunity."},{"key":"2023072603221691000_bib29","doi-asserted-by":"publisher","first-page":"55609","DOI":"10.1074\/jbc.M406565200","article-title":"Synergistic activation of interleukin-12 p35 gene transcription by interferon regulatory factor-1 and interferon consensus sequence-binding protein","volume":"279","author":"Liu","year":"2004","journal-title":"J. Biol. Chem."},{"key":"2023072603221691000_bib30","doi-asserted-by":"publisher","first-page":"1982","DOI":"10.4049\/jimmunol.167.4.1982","article-title":"CD8\u2212 dendritic cell activation status plays an integral role in influencing Th2 response development","volume":"167","author":"MacDonald","year":"2001","journal-title":"J. Immunol."},{"key":"2023072603221691000_bib31","doi-asserted-by":"publisher","first-page":"1199","DOI":"10.1084\/jem.177.4.1199","article-title":"Natural killer cell stimulatory factor (interleukin 12 [IL-12]) induces T helper type 1 (Th1)-specific immune responses and inhibits the development of IL-4-producing Th cells","volume":"177","author":"Manetti","year":"1993","journal-title":"J. Exp. Med."},{"key":"2023072603221691000_bib32","doi-asserted-by":"publisher","first-page":"249","DOI":"10.1016\/j.immuni.2011.08.008","article-title":"CD8\u03b1+ dendritic cells are the critical source of interleukin-12 that controls acute infection by Toxoplasma gondii tachyzoites","volume":"35","author":"Mashayekhi","year":"2011","journal-title":"Immunity."},{"key":"2023072603221691000_bib33","doi-asserted-by":"publisher","first-page":"13968","DOI":"10.1073\/pnas.0906367106","article-title":"Helminth products bypass the need for TSLP in Th2 immune responses by directly modulating dendritic cell function","volume":"106","author":"Massacand","year":"2009","journal-title":"Proc. Natl. Acad. Sci. USA."},{"key":"2023072603221691000_bib34","doi-asserted-by":"publisher","first-page":"3142","DOI":"10.1073\/pnas.92.8.3142","article-title":"Switch from a type 2 to a type 1 T helper cell response and cure of established Leishmania major infection in mice is induced by combined therapy with interleukin 12 and Pentostam","volume":"92","author":"Nabors","year":"1995","journal-title":"Proc. Natl. Acad. Sci. USA."},{"key":"2023072603221691000_bib35","doi-asserted-by":"publisher","first-page":"53","DOI":"10.1038\/mi.2011.47","article-title":"Pulmonary CD103+ dendritic cells prime Th2 responses to inhaled allergens","volume":"5","author":"Nakano","year":"2012","journal-title":"Mucosal Immunol."},{"key":"2023072603221691000_bib36","doi-asserted-by":"crossref","first-page":"1707","DOI":"10.4049\/jimmunol.153.4.1707","article-title":"IL-12 inhibits Th2 cytokine responses induced by eggs of Schistosoma mansoni","volume":"153","author":"Oswald","year":"1994","journal-title":"J. Immunol."},{"key":"2023072603221691000_bib37","doi-asserted-by":"publisher","first-page":"499","DOI":"10.1038\/nri843","article-title":"The immunobiology of schistosomiasis","volume":"2","author":"Pearce","year":"2002","journal-title":"Nat. Rev. Immunol."},{"key":"2023072603221691000_bib38","doi-asserted-by":"publisher","first-page":"159","DOI":"10.1084\/jem.173.1.159","article-title":"Downregulation of Th1 cytokine production accompanies induction of Th2 responses by a parasitic helminth, Schistosoma mansoni","volume":"173","author":"Pearce","year":"1991","journal-title":"J. Exp. Med."},{"key":"2023072603221691000_bib39","doi-asserted-by":"publisher","first-page":"322","DOI":"10.1016\/j.immuni.2012.10.016","article-title":"Conventional and monocyte-derived CD11b+ dendritic cells initiate and maintain T helper 2 cell-mediated immunity to house dust mite allergen","volume":"38","author":"Plantinga","year":"2013","journal-title":"Immunity."},{"key":"2023072603221691000_bib40","doi-asserted-by":"publisher","first-page":"1618","DOI":"10.4049\/jimmunol.177.3.1618","article-title":"Visualization of IL-12\/23p40 in vivo reveals immunostimulatory dendritic cell migrants that promote Th1 differentiation","volume":"177","author":"Reinhardt","year":"2006","journal-title":"J. Immunol."},{"key":"2023072603221691000_bib41","doi-asserted-by":"publisher","first-page":"829","DOI":"10.1007\/s00281-012-0347-3","article-title":"Immunity to the model intestinal helminth parasite Heligmosomoides polygyrus","volume":"34","author":"Reynolds","year":"2012","journal-title":"Semin. Immunopathol."},{"key":"2023072603221691000_bib42","doi-asserted-by":"publisher","first-page":"1145","DOI":"10.1038\/ni.2467","article-title":"Re(de)fining the dendritic cell lineage","volume":"13","author":"Satpathy","year":"2012","journal-title":"Nat. Immunol."},{"key":"2023072603221691000_bib43","doi-asserted-by":"publisher","first-page":"937","DOI":"10.1038\/ni.2679","article-title":"Notch2-dependent classical dendritic cells orchestrate intestinal immunity to attaching-and-effacing bacterial pathogens","volume":"14","author":"Satpathy","year":"2013","journal-title":"Nat. Immunol."},{"key":"2023072603221691000_bib44","doi-asserted-by":"publisher","first-page":"970","DOI":"10.1016\/j.immuni.2013.04.011","article-title":"IRF4 transcription factor-dependent CD11b+ dendritic cells in human and mouse control mucosal IL-17 cytokine responses","volume":"38","author":"Schlitzer","year":"2013","journal-title":"Immunity."},{"key":"2023072603221691000_bib45","doi-asserted-by":"publisher","first-page":"1775","DOI":"10.1084\/jem.20070602","article-title":"Small intestine lamina propria dendritic cells promote de novo generation of Foxp3 T reg cells via retinoic acid","volume":"204","author":"Sun","year":"2007","journal-title":"J. Exp. Med."},{"key":"2023072603221691000_bib46","doi-asserted-by":"publisher","first-page":"5839","DOI":"10.4049\/jimmunol.176.10.5839","article-title":"Regulatory T cell responses develop in parallel to Th responses and control the magnitude and phenotype of the Th effector population","volume":"176","author":"Taylor","year":"2006","journal-title":"J. Immunol."},{"key":"2023072603221691000_bib47","doi-asserted-by":"publisher","first-page":"1019","DOI":"10.1172\/JCI36534","article-title":"Th2 cell hyporesponsiveness during chronic murine schistosomiasis is cell intrinsic and linked to GRAIL expression","volume":"119","author":"Taylor","year":"2009","journal-title":"J. Clin. Invest."},{"key":"2023072603221691000_bib48","doi-asserted-by":"publisher","first-page":"502","DOI":"10.1038\/nature11531","article-title":"Compensatory dendritic cell development mediated by BATF-IRF interactions","volume":"490","author":"Tussiwand","year":"2012","journal-title":"Nature."},{"key":"2023072603221691000_bib49","doi-asserted-by":"publisher","first-page":"916","DOI":"10.1016\/j.immuni.2015.04.017","article-title":"Klf4 expression in conventional dendritic cells is required for T helper 2 cell responses","volume":"42","author":"Tussiwand","year":"2015","journal-title":"Immunity."},{"key":"2023072603221691000_bib50","doi-asserted-by":"publisher","first-page":"271","DOI":"10.4049\/jimmunol.165.1.271","article-title":"An IFN-\u03b3-inducible transcription factor, IFN consensus sequence binding protein (ICSBP), stimulates IL-12 p40 expression in macrophages","volume":"165","author":"Wang","year":"2000","journal-title":"J. Immunol."},{"key":"2023072603221691000_bib51","doi-asserted-by":"publisher","first-page":"1199","DOI":"10.1084\/jem.20042572","article-title":"Suppression of allergic airway inflammation by helminth-induced regulatory T cells","volume":"202","author":"Wilson","year":"2005","journal-title":"J. Exp. Med."},{"key":"2023072603221691000_bib52","doi-asserted-by":"publisher","first-page":"2187","DOI":"10.1182\/blood-2003-02-0513","article-title":"Most lymphoid organ dendritic cell types are phenotypically and functionally immature","volume":"102","author":"Wilson","year":"2003","journal-title":"Blood."},{"key":"2023072603221691000_bib53","doi-asserted-by":"publisher","first-page":"200","DOI":"10.1038\/sj.icb.7100125","article-title":"Normal proportion and expression of maturation markers in migratory dendritic cells in the absence of germs or Toll-like receptor signaling","volume":"86","author":"Wilson","year":"2008","journal-title":"Immunol. Cell Biol."},{"key":"2023072603221691000_bib54","doi-asserted-by":"publisher","first-page":"199","DOI":"10.1002\/path.2277","article-title":"Cellular and molecular mechanisms of fibrosis","volume":"214","author":"Wynn","year":"2008","journal-title":"J. Pathol."},{"key":"2023072603221691000_bib55","doi-asserted-by":"publisher","first-page":"1551","DOI":"10.1084\/jem.179.5.1551","article-title":"Endogenous interleukin 12 (IL-12) regulates granuloma formation induced by eggs of Schistosoma mansoni and exogenous IL-12 both inhibits and prophylactically immunizes against egg pathology","volume":"179","author":"Wynn","year":"1994","journal-title":"J. Exp. Med."},{"key":"2023072603221691000_bib56","doi-asserted-by":"publisher","first-page":"6923","DOI":"10.4049\/jimmunol.181.10.6923","article-title":"CD8+ CD205+ splenic dendritic cells are specialized to induce Foxp3+ regulatory T cells","volume":"181","author":"Yamazaki","year":"2008","journal-title":"J. Immunol."},{"key":"2023072603221691000_bib57","doi-asserted-by":"publisher","first-page":"1626","DOI":"10.1126\/science.1109893","article-title":"TLR11 activation of dendritic cells by a protozoan profilin-like protein","volume":"308","author":"Yarovinsky","year":"2005","journal-title":"Science."},{"key":"2023072603221691000_bib58","doi-asserted-by":"publisher","first-page":"1615","DOI":"10.1172\/JCI60644","article-title":"The dendritic cell receptor DNGR-1 controls endocytic handling of necrotic cell antigens to favor cross-priming of CTLs in virus-infected mice","volume":"122","author":"Zelenay","year":"2012","journal-title":"J. Clin. Invest."},{"key":"2023072603221691000_bib59","doi-asserted-by":"publisher","first-page":"496","DOI":"10.4049\/jimmunol.1303138","article-title":"GM-CSF-licensed CD11b+ lung dendritic cells orchestrate Th2 immunity to Blomia tropicalis","volume":"193","author":"Zhou","year":"2014","journal-title":"J. Immunol."}],"container-title":["Journal of Experimental Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/rupress.org\/jem\/article-pdf\/213\/1\/35\/1755203\/jem_20150235.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/rupress.org\/jem\/article-pdf\/213\/1\/35\/1755203\/jem_20150235.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,7,26]],"date-time":"2023-07-26T03:23:21Z","timestamp":1690341801000},"score":1,"resource":{"primary":{"URL":"https:\/\/rupress.org\/jem\/article\/213\/1\/35\/41889\/Migratory-CD103-dendritic-cells-suppress-helminth"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,12,28]]},"references-count":59,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2016,1,11]]}},"URL":"https:\/\/doi.org\/10.1084\/jem.20150235","relation":{},"ISSN":["0022-1007","1540-9538"],"issn-type":[{"value":"0022-1007","type":"print"},{"value":"1540-9538","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,12,28]]}}}