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More importantly, the memory cells that are formed do not respond properly to antigen reencounter. In vitro, both proteins are required to maintain a poised state at the Il2 target locus in resting but previously stimulated CD4+ T cells. OCA-B is also required for the robust reexpression of multiple other genes including Ifng. ChIPseq identifies \u223c50 differentially expressed direct Oct1 and OCA-B targets. We identify an underlying mechanism involving OCA-B recruitment of the histone lysine demethylase Jmjd1a to targets such as Il2, Ifng, and Zbtb32. The findings pinpoint Oct1 and OCA-B as central mediators of CD4+ T cell memory.<\/jats:p>","DOI":"10.1084\/jem.20150363","type":"journal-article","created":{"date-parts":[[2015,10,20]],"date-time":"2015-10-20T08:28:03Z","timestamp":1445329683000},"page":"2115-2131","update-policy":"https:\/\/doi.org\/10.1084\/jem.crossmarkpolicy","source":"Crossref","is-referenced-by-count":61,"title":["Oct1 and OCA-B are selectively required for CD4 memory T cell function"],"prefix":"10.1084","volume":"212","author":[{"given":"Arvind","family":"Shakya","sequence":"first","affiliation":[{"name":"Department of Pathology, University of Utah School of Medicine, Salt Lake City, UT 84112 1"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alon","family":"Goren","sequence":"additional","affiliation":[{"name":"Broad Technology Labs, The Broad Institute of MIT and Harvard, Cambridge, MA 02142 2"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alex","family":"Shalek","sequence":"additional","affiliation":[{"name":"Department of Chemistry and Chemical Biology, Harvard University, Cambridge, MA 02138 3"},{"name":"Department of Physics, Harvard University, Cambridge, MA 02138 4"},{"name":"The Broad Institute of MIT and Harvard, Cambridge, MA 02142\u200b 8"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cody N.","family":"German","sequence":"additional","affiliation":[{"name":"Department of Pathology, University of Utah School of Medicine, Salt Lake City, UT 84112 1"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeremy","family":"Snook","sequence":"additional","affiliation":[{"name":"Department of Pathology, University of Utah School of Medicine, Salt Lake City, UT 84112 1"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vijay K.","family":"Kuchroo","sequence":"additional","affiliation":[{"name":"Ann Romney Center for Neurologic Diseases, Brigham and Women\u2019s Hospital, Harvard Medical School, Boston, MA 02115 5"},{"name":"The Broad Institute of MIT and Harvard, Cambridge, MA 02142\u200b 8"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nir","family":"Yosef","sequence":"additional","affiliation":[{"name":"Ann Romney Center for Neurologic Diseases, Brigham and Women\u2019s Hospital, Harvard Medical School, Boston, MA 02115 5"},{"name":"The Broad Institute of MIT and Harvard, Cambridge, MA 02142\u200b 8"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raymond C.","family":"Chan","sequence":"additional","affiliation":[{"name":"Department of Human Genetics, University of Michigan, Ann Arbor, MI 48109 6"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aviv","family":"Regev","sequence":"additional","affiliation":[{"name":"Howard Hughes Medical Institute, Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 02139 7"},{"name":"The Broad Institute of MIT and Harvard, Cambridge, MA 02142\u200b 8"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthew A.","family":"Williams","sequence":"additional","affiliation":[{"name":"Department of Pathology, University of Utah School of Medicine, Salt Lake City, UT 84112 1"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dean","family":"Tantin","sequence":"additional","affiliation":[{"name":"Department of Pathology, University of Utah School of Medicine, Salt Lake City, UT 84112 1"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"291","published-online":{"date-parts":[[2015,10,19]]},"reference":[{"key":"2023072602351544300_bib1","doi-asserted-by":"publisher","first-page":"1549","DOI":"10.1073\/pnas.1017340108","article-title":"T-cell receptor ligation induces distinct signaling pathways in naive vs. antigen-experienced T cells","volume":"108","author":"Adachi","year":"2011","journal-title":"Proc. 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