{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T11:42:30Z","timestamp":1789990950166,"version":"4.0.1"},"reference-count":71,"publisher":"Rockefeller University Press","issue":"10","funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003141","name":"Consejo Nacional de Ciencia y Tecnologia","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003141","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["rupress.org"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2016,9,19]]},"abstract":"<jats:p>Atopic dermatitis (AD) is a Th2-dominated inflammatory skin disease characterized by epidermal thickening. Serum levels of IL-22, a cytokine known to induce keratinocyte proliferation, are elevated in AD, and Th22 cells infiltrate AD skin lesions. We show that application of antigen to mouse skin subjected to tape stripping, a surrogate for scratching, induces an IL-22 response that drives epidermal hyperplasia and keratinocyte proliferation in a mouse model of skin inflammation that shares many features of AD. DC-derived IL-23 is known to act on CD4+ T cells to induce IL-22 production. However, the mechanisms that drive IL-23 production by skin DCs in response to cutaneous sensitization are not well understood. We demonstrate that IL-23 released by keratinocytes in response to endogenous TLR4 ligands causes skin DCs, which selectively express IL-23R, to up-regulate their endogenous IL-23 production and drive an IL-22 response in naive CD4+ T cells that mediates epidermal thickening. We also show that IL-23 is released in human skin after scratching and polarizes human skin DCs to drive an IL-22 response, supporting the utility of IL-23 and IL-22 blockade in AD.<\/jats:p>","DOI":"10.1084\/jem.20150376","type":"journal-article","created":{"date-parts":[[2016,8,22]],"date-time":"2016-08-22T14:07:31Z","timestamp":1471874851000},"page":"2147-2166","update-policy":"https:\/\/doi.org\/10.1084\/jem.crossmarkpolicy","source":"Crossref","is-referenced-by-count":98,"title":["IL-23 induced in keratinocytes by endogenous TLR4 ligands polarizes dendritic cells to drive IL-22 responses to skin immunization"],"prefix":"10.1084","volume":"213","author":[{"given":"Juhan","family":"Yoon","sequence":"first","affiliation":[{"name":"Division of Immunology, Children\u2019s Hospital and Department of Pediatrics, Harvard Medical School, Boston, MA 02115 1"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7394-4457","authenticated-orcid":false,"given":"Juan Manuel","family":"Leyva-Castillo","sequence":"additional","affiliation":[{"name":"Division of Immunology, Children\u2019s Hospital and Department of Pediatrics, Harvard Medical School, Boston, MA 02115 1"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7762-4848","authenticated-orcid":false,"given":"Guoxing","family":"Wang","sequence":"additional","affiliation":[{"name":"Division of Immunology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02115 2"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8005-4831","authenticated-orcid":false,"given":"Claire","family":"Galand","sequence":"additional","affiliation":[{"name":"Division of Immunology, Children\u2019s Hospital and Department of Pediatrics, Harvard Medical School, Boston, MA 02115 1"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michiko K.","family":"Oyoshi","sequence":"additional","affiliation":[{"name":"Division of Immunology, Children\u2019s Hospital and Department of Pediatrics, Harvard Medical School, Boston, MA 02115 1"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2045-298X","authenticated-orcid":false,"given":"Lalit","family":"Kumar","sequence":"additional","affiliation":[{"name":"Division of Immunology, Children\u2019s Hospital and Department of Pediatrics, Harvard Medical School, Boston, MA 02115 1"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sabine","family":"Hoff","sequence":"additional","affiliation":[{"name":"Division of Immunology, Children\u2019s Hospital and Department of Pediatrics, Harvard Medical School, Boston, MA 02115 1"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5288-9786","authenticated-orcid":false,"given":"Rui","family":"He","sequence":"additional","affiliation":[{"name":"Division of Immunology, Children\u2019s Hospital and Department of Pediatrics, Harvard Medical School, Boston, MA 02115 1"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexander","family":"Chervonsky","sequence":"additional","affiliation":[{"name":"Department of Pathology, University of Chicago, Chicago, IL 60637 6"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joost J.","family":"Oppenheim","sequence":"additional","affiliation":[{"name":"Laboratory of Molecular Immunoregulation, National Cancer Institute, Frederick, MD 21702 7"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7177-2110","authenticated-orcid":false,"given":"Vijay K.","family":"Kuchroo","sequence":"additional","affiliation":[{"name":"Center for Neurological Diseases, Brigham and Women\u2019s Hospital, Harvard Medical School, Boston, MA 02115 4"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0696-4401","authenticated-orcid":false,"given":"Marcel R.M.","family":"van den Brink","sequence":"additional","affiliation":[{"name":"Department of Immunology and Medicine, Memorial Sloan-Kettering Cancer Center, New York, NY 10065 8"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2663-383X","authenticated-orcid":false,"given":"Rene De Waal","family":"Malefyt","sequence":"additional","affiliation":[{"name":"Merck Research Laboratories, Palo Alto, CA 94304 9"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7177-7763","authenticated-orcid":false,"given":"Philippe A.","family":"Tessier","sequence":"additional","affiliation":[{"name":"Centre de Recherche du Centre Hospitalier de l\u2019Universit\u00e9 Laval, Sainte-Foy, Quebec QC G1V 4G2, Canada 10"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0911-9310","authenticated-orcid":false,"given":"Robert","family":"Fuhlbrigge","sequence":"additional","affiliation":[{"name":"Division of Immunology, Children\u2019s Hospital and Department of Pediatrics, Harvard Medical School, Boston, MA 02115 1"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philip","family":"Rosenstiel","sequence":"additional","affiliation":[{"name":"Institute of Clinical Molecular Biology, Christian-Albrechts-University of Kiel, 24105 Kiel, Germany 11"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6233-7029","authenticated-orcid":false,"given":"Cox","family":"Terhorst","sequence":"additional","affiliation":[{"name":"Division of Immunology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02115 2"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3909-1160","authenticated-orcid":false,"given":"George","family":"Murphy","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Harvard Medical School, Boston, MA 02115 3"},{"name":"Division of Dermatopathology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115 5"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6019-3751","authenticated-orcid":false,"given":"Raif S.","family":"Geha","sequence":"additional","affiliation":[{"name":"Division of Immunology, Children\u2019s Hospital and Department of Pediatrics, Harvard Medical School, Boston, MA 02115 1"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"291","published-online":{"date-parts":[[2016,8,22]]},"reference":[{"key":"2023072603160339700_bib1","doi-asserted-by":"publisher","first-page":"1118","DOI":"10.1189\/jlb.0704385","article-title":"Differential macrophage expression of IL-12 and IL-23 upon innate immune activation defines rat autoimmune susceptibility","volume":"76","author":"Andersson","year":"2004","journal-title":"J. Leukoc. Biol."},{"key":"2023072603160339700_bib2","doi-asserted-by":"publisher","first-page":"275","DOI":"10.1038\/nm1710","article-title":"IL-22 mediates mucosal host defense against Gram-negative bacterial pneumonia","volume":"14","author":"Aujla","year":"2008","journal-title":"Nat.                        Med."},{"key":"2023072603160339700_bib3","doi-asserted-by":"publisher","first-page":"5904","DOI":"10.4049\/jimmunol.0900732","article-title":"Cutting edge: IL-23 receptor gfp reporter mice reveal distinct populations of IL-17-producing cells","volume":"182","author":"Awasthi","year":"2009","journal-title":"J. Immunol."},{"key":"2023072603160339700_bib4","doi-asserted-by":"publisher","first-page":"933","DOI":"10.1016\/j.jaci.2013.05.012","article-title":"IL-33 is more potent than IL-25 in provoking IL-13-producing nuocytes (type 2 innate lymphoid cells) and airway contraction","volume":"132","author":"Barlow","year":"2013","journal-title":"J. Allergy Clin. Immunol."},{"key":"2023072603160339700_bib5","doi-asserted-by":"publisher","first-page":"1483","DOI":"10.1056\/NEJMra074081","article-title":"Atopic dermatitis","volume":"358","author":"Bieber","year":"2008","journal-title":"N.                        Engl. J. Med."},{"key":"2023072603160339700_bib6","doi-asserted-by":"publisher","first-page":"3695","DOI":"10.4049\/jimmunol.174.6.3695","article-title":"IL-22 inhibits epidermal differentiation and induces proinflammatory gene expression and migration of human keratinocytes","volume":"174","author":"Boniface","year":"2005","journal-title":"J. Immunol."},{"key":"2023072603160339700_bib7","doi-asserted-by":"publisher","first-page":"e12955","DOI":"10.1371\/journal.pone.0012955","article-title":"Generation of IL-23 producing dendritic cells (DCs) by airborne fungi regulates fungal pathogenicity via the induction of T(H)-17 responses","volume":"5","author":"Chamilos","year":"2010","journal-title":"PLoS One."},{"key":"2023072603160339700_bib8","doi-asserted-by":"publisher","first-page":"2577","DOI":"10.1084\/jem.20060244","article-title":"IL-23 stimulates epidermal hyperplasia via TNF and IL-20R2-dependent mechanisms with implications for psoriasis pathogenesis","volume":"203","author":"Chan","year":"2006","journal-title":"J. Exp. Med."},{"key":"2023072603160339700_bib9","doi-asserted-by":"publisher","first-page":"91","DOI":"10.1126\/science.1218004","article-title":"Interleukin-22 drives endogenous thymic regeneration in mice","volume":"336","author":"Dudakov","year":"2012","journal-title":"Science."},{"key":"2023072603160339700_bib10","doi-asserted-by":"publisher","first-page":"857","DOI":"10.1038\/ni.1767","article-title":"Production of interleukin 22 but not interleukin 17 by a subset of human skin-homing memory T                        cells","volume":"10","author":"Duhen","year":"2009","journal-title":"Nat. Immunol."},{"key":"2023072603160339700_bib11","doi-asserted-by":"publisher","first-page":"313","DOI":"10.1016\/j.clim.2008.09.019","article-title":"IL-17 producing CD4+ T cells mediate accelerated ischemia\/reperfusion-induced injury in autoimmunity-prone mice","volume":"130","author":"Edgerton","year":"2009","journal-title":"Clin. Immunol."},{"key":"2023072603160339700_bib12","doi-asserted-by":"publisher","first-page":"1645","DOI":"10.1084\/jem.20021340","article-title":"Lipopolysaccharide-enhanced, toll-like receptor 4-dependent T helper cell type 2 responses to inhaled antigen","volume":"196","author":"Eisenbarth","year":"2002","journal-title":"J. Exp. Med."},{"key":"2023072603160339700_bib13","doi-asserted-by":"publisher","first-page":"967","DOI":"10.1038\/nature09447","article-title":"Generation of pathogenic T(H)17 cells in the absence of TGF-\u03b2 signalling","volume":"467","author":"Ghoreschi","year":"2010","journal-title":"Nature."},{"key":"2023072603160339700_bib14","doi-asserted-by":"publisher","first-page":"1344","DOI":"10.1016\/j.jaci.2012.07.012","article-title":"Progressive activation of T(H)2\/T(H)22 cytokines and selective epidermal proteins characterizes acute and chronic atopic dermatitis","volume":"130","author":"Gittler","year":"2012","journal-title":"J. Allergy Clin.                        Immunol."},{"key":"2023072603160339700_bib15","doi-asserted-by":"publisher","first-page":"e17171","DOI":"10.1371\/journal.pone.0017171","article-title":"IL-22 production is regulated by IL-23 during Listeria monocytogenes infection but is not required for bacterial clearance or tissue protection","volume":"6","author":"Graham","year":"2011","journal-title":"PLoS One."},{"key":"2023072603160339700_bib16","doi-asserted-by":"publisher","first-page":"2921","DOI":"10.1084\/jem.20101102","article-title":"Plasmacytoid dendritic cells sense skin injury and promote wound healing through type I interferons","volume":"207","author":"Gregorio","year":"2010","journal-title":"J. Exp. Med."},{"key":"2023072603160339700_bib17","doi-asserted-by":"publisher","first-page":"2931","DOI":"10.1084\/jem.20101048","article-title":"Autoimmune skin inflammation is dependent on plasmacytoid dendritic cell activation by nucleic acids via TLR7 and TLR9","volume":"207","author":"Guiducci","year":"2010","journal-title":"J. Exp. Med."},{"key":"2023072603160339700_bib18","doi-asserted-by":"publisher","first-page":"7420","DOI":"10.4049\/jimmunol.181.10.7420","article-title":"Low expression of the IL-23\/Th17 pathway in atopic dermatitis compared to psoriasis","volume":"181","author":"Guttman-Yassky","year":"2008","journal-title":"J.                        Immunol."},{"key":"2023072603160339700_bib19","doi-asserted-by":"publisher","first-page":"339","DOI":"10.1016\/j.immuni.2012.05.028","article-title":"Interleukin-22 protects intestinal stem cells from immune-mediated tissue damage and regulates sensitivity to graft versus host disease","volume":"37","author":"Hanash","year":"2012","journal-title":"Immunity."},{"key":"2023072603160339700_bib20","doi-asserted-by":"publisher","first-page":"620","DOI":"10.1016\/j.immuni.2014.09.010","article-title":"Interleukin-22 regulates the complement system to promote resistance against pathobionts after pathogen-induced intestinal damage","volume":"41","author":"Hasegawa","year":"2014","journal-title":"Immunity."},{"key":"2023072603160339700_bib21","doi-asserted-by":"publisher","first-page":"78","DOI":"10.1016\/j.jdermsci.2010.08.013","article-title":"Significant correlation of serum IL-22 levels with CCL17 levels in atopic dermatitis","volume":"61","author":"Hayashida","year":"2011","journal-title":"J. Dermatol.                        Sci."},{"key":"2023072603160339700_bib22","doi-asserted-by":"publisher","first-page":"15817","DOI":"10.1073\/pnas.0706942104","article-title":"Epicutaneous antigen exposure induces a Th17 response that drives airway inflammation after inhalation challenge","volume":"104","author":"He","year":"2007","journal-title":"Proc. Natl. Acad. Sci. USA."},{"key":"2023072603160339700_bib23","doi-asserted-by":"publisher","first-page":"1068","DOI":"10.4049\/jimmunol.178.2.1068","article-title":"Innate immune responses to endosymbiotic Wolbachia bacteria in Brugia malayi and Onchocerca volvulus are dependent on TLR2, TLR6, MyD88, and Mal, but not TLR4, TRIF, or TRAM","volume":"178","author":"Hise","year":"2007","journal-title":"J. Immunol."},{"key":"2023072603160339700_bib24","doi-asserted-by":"publisher","first-page":"178","DOI":"10.1016\/j.jaci.2006.03.047","article-title":"Cytokines and chemokines orchestrate atopic skin inflammation","volume":"118","author":"Homey","year":"2006","journal-title":"J. Allergy Clin.                        Immunol."},{"key":"2023072603160339700_bib25","doi-asserted-by":"publisher","first-page":"341","DOI":"10.1016\/j.immuni.2006.02.006","article-title":"Cytokine milieu of atopic dermatitis skin subverts the innate immune response to vaccinia virus","volume":"24","author":"Howell","year":"2006","journal-title":"Immunity"},{"key":"2023072603160339700_bib26","doi-asserted-by":"publisher","first-page":"47","DOI":"10.1172\/JCI32310","article-title":"IL-21R is essential for epicutaneous sensitization and allergic skin inflammation in humans and mice","volume":"119","author":"Jin","year":"2009","journal-title":"J. Clin. Invest."},{"key":"2023072603160339700_bib27","doi-asserted-by":"publisher","first-page":"436","DOI":"10.1016\/j.imbio.2011.10.010","article-title":"Increased serum human \u03b2-defensin-2 levels in atopic dermatitis: relationship to IL-22 and oncostatin M","volume":"217","author":"Kanda","year":"2012","journal-title":"Immunobiology."},{"key":"2023072603160339700_bib28","doi-asserted-by":"publisher","first-page":"1626","DOI":"10.1016\/j.jaci.2014.03.003","article-title":"Cyclosporine in patients with atopic dermatitis modulates activated inflammatory pathways and reverses epidermal pathology","volume":"133","author":"Khattri","year":"2014","journal-title":"J. Allergy Clin. Immunol."},{"key":"2023072603160339700_bib29","doi-asserted-by":"publisher","first-page":"234","DOI":"10.1038\/nature06726","article-title":"UNC93B1 delivers nucleotide-sensing toll-like receptors to endolysosomes","volume":"452","author":"Kim","year":"2008","journal-title":"Nature."},{"key":"2023072603160339700_bib30","doi-asserted-by":"publisher","first-page":"8098","DOI":"10.4049\/jimmunol.179.12.8098","article-title":"IL-22 is expressed by Th17 cells in an IL-23-dependent fashion, but not required for the development of autoimmune encephalomyelitis","volume":"179","author":"Kreymborg","year":"2007","journal-title":"J. Immunol."},{"key":"2023072603160339700_bib31","doi-asserted-by":"publisher","first-page":"440","DOI":"10.1172\/JCI57416","article-title":"Epidermal barrier dysfunction and cutaneous sensitization in atopic diseases","volume":"122","author":"Kubo","year":"2012","journal-title":"J. Clin.                        Invest."},{"key":"2023072603160339700_bib32","doi-asserted-by":"publisher","first-page":"860","DOI":"10.1067\/mai.2000.106484","article-title":"Atopic dermatitis: new insights and opportunities for therapeutic intervention","volume":"105","author":"Leung","year":"2000","journal-title":"J.                        Allergy Clin. Immunol."},{"key":"2023072603160339700_bib33","doi-asserted-by":"publisher","first-page":"2847","DOI":"10.1038\/ncomms3847","article-title":"Skin thymic stromal lymphopoietin initiates Th2 responses through an orchestrated immune cascade","volume":"4","author":"Leyva-Castillo","year":"2013","journal-title":"Nat.                        Commun."},{"key":"2023072603160339700_bib34","doi-asserted-by":"publisher","first-page":"621","DOI":"10.1172\/JCI0214097","article-title":"CCR3 is essential for skin eosinophilia and airway hyperresponsiveness in a murine model of allergic skin inflammation","volume":"109","author":"Ma","year":"2002","journal-title":"J. Clin. Invest."},{"key":"2023072603160339700_bib35","doi-asserted-by":"publisher","first-page":"e62853","DOI":"10.1371\/journal.pone.0062853","article-title":"IL-22-producing ROR\u03b3t-dependent innate lymphoid cells play a novel protective role in murine acute hepatitis","volume":"8","author":"Matsumoto","year":"2013","journal-title":"PLoS One."},{"key":"2023072603160339700_bib36","doi-asserted-by":"publisher","first-page":"314","DOI":"10.1038\/ni.1698","article-title":"The interleukin 23 receptor is essential for the terminal differentiation of interleukin 17-producing effector T helper cells in vivo","volume":"10","author":"McGeachy","year":"2009","journal-title":"Nat. Immunol."},{"key":"2023072603160339700_bib37","doi-asserted-by":"publisher","first-page":"501","DOI":"10.1684\/ejd.2011.1335","article-title":"Effect of methotrexate on serum levels of IL-22 in patients with psoriasis","volume":"21","author":"Meephansan","year":"2011","journal-title":"Eur. J.                        Dermatol."},{"key":"2023072603160339700_bib38","doi-asserted-by":"publisher","first-page":"1117","DOI":"10.1084\/jem.20121588","article-title":"Retinoic acid expression associates with enhanced IL-22 production by \u03b3\u03b4 T cells and innate lymphoid cells and attenuation of intestinal inflammation","volume":"210","author":"Mielke","year":"2013","journal-title":"J.                        Exp. Med."},{"key":"2023072603160339700_bib39","doi-asserted-by":"publisher","first-page":"127","DOI":"10.1016\/S0140-6736(82)90379-8","article-title":"Basophils in allergen-induced patch test sites in atopic dermatitis","volume":"1","author":"Mitchell","year":"1982","journal-title":"Lancet."},{"key":"2023072603160339700_bib40","doi-asserted-by":"publisher","first-page":"1667","DOI":"10.1038\/sj.jid.5700739","article-title":"Filaggrin mutations in children with severe atopic dermatitis","volume":"127","author":"Morar","year":"2007","journal-title":"J. Invest.                        Dermatol."},{"key":"2023072603160339700_bib41","doi-asserted-by":"publisher","first-page":"1244","DOI":"10.1016\/j.jaci.2009.03.041","article-title":"IL-22-producing \u201cT22\u201d T cells account for upregulated IL-22 in atopic dermatitis despite reduced IL-17-producing TH17 T cells","volume":"123","author":"Nograles","year":"2009","journal-title":"J. Allergy Clin.                        Immunol."},{"key":"2023072603160339700_bib42","doi-asserted-by":"publisher","first-page":"715","DOI":"10.1016\/S1074-7613(00)00070-4","article-title":"Novel p19 protein engages IL-12p40 to form a                        cytokine, IL-23, with biological activities similar as well as distinct from IL-12","volume":"13","author":"Oppmann","year":"2000","journal-title":"Immunity."},{"key":"2023072603160339700_bib43","doi-asserted-by":"publisher","first-page":"976","DOI":"10.1016\/j.jaci.2010.08.041","article-title":"Mechanical injury polarizes skin dendritic cells to elicit a                        TH2 response by inducing cutaneous thymic stromal lymphopoietin expression","volume":"126","author":"Oyoshi","year":"2010","journal-title":"J. Allergy Clin. Immunol."},{"key":"2023072603160339700_bib44","doi-asserted-by":"publisher","first-page":"1465","DOI":"10.1084\/jem.20082683","article-title":"STAT3 links IL-22 signaling in intestinal epithelial cells to mucosal wound healing","volume":"206","author":"Pickert","year":"2009","journal-title":"J. Exp.                        Med."},{"key":"2023072603160339700_bib45","doi-asserted-by":"publisher","first-page":"1908","DOI":"10.4049\/jimmunol.176.3.1908","article-title":"In vitro and in situ expression of IL-23 by keratinocytes in healthy skin and psoriasis lesions: enhanced expression in psoriatic skin","volume":"176","author":"Piskin","year":"2006","journal-title":"J. Immunol."},{"key":"2023072603160339700_bib46","doi-asserted-by":"publisher","first-page":"5167","DOI":"10.4049\/jimmunol.180.8.5167","article-title":"Cutting edge: NKT cells constitutively express IL-23 receptor and RORgammat and rapidly produce IL-17 upon receptor ligation in an IL-6-independent fashion","volume":"180","author":"Rachitskaya","year":"2008","journal-title":"J.                        Immunol."},{"key":"2023072603160339700_bib47","doi-asserted-by":"publisher","first-page":"1332","DOI":"10.1002\/hep.20184","article-title":"Interleukin 22 (IL-22) plays a protective role in T                        cell-mediated murine hepatitis: IL-22 is a survival factor for hepatocytes via STAT3 activation","volume":"39","author":"Radaeva","year":"2004","journal-title":"Hepatology."},{"key":"2023072603160339700_bib48","doi-asserted-by":"publisher","first-page":"157","DOI":"10.1038\/nature13199","article-title":"Nociceptive sensory neurons drive interleukin-23-mediated psoriasiform skin inflammation","volume":"510","author":"Riol-Blanco","year":"2014","journal-title":"Nature."},{"key":"2023072603160339700_bib49","doi-asserted-by":"publisher","first-page":"1495","DOI":"10.4049\/jimmunol.1001001","article-title":"IL-23-mediated psoriasis-like epidermal hyperplasia is dependent on IL-17A","volume":"186","author":"Rizzo","year":"2011","journal-title":"J.                        Immunol."},{"key":"2023072603160339700_bib50","doi-asserted-by":"publisher","first-page":"116","DOI":"10.1111\/imr.12027","article-title":"IL-22, not simply a Th17 cytokine","volume":"252","author":"Rutz","year":"2013","journal-title":"Immunol. Rev."},{"key":"2023072603160339700_bib51","doi-asserted-by":"publisher","first-page":"2229","DOI":"10.4049\/jimmunol.178.4.2229","article-title":"The effects of IL-20 subfamily cytokines on reconstituted human epidermis suggest potential roles in cutaneous innate defense and pathogenic adaptive immunity in psoriasis","volume":"178","author":"Sa","year":"2007","journal-title":"J. Immunol."},{"key":"2023072603160339700_bib52","doi-asserted-by":"publisher","first-page":"958","DOI":"10.1016\/j.immuni.2008.11.001","article-title":"Microbial flora drives interleukin 22 production in intestinal NKp46+ cells that provide innate mucosal immune defense","volume":"29","author":"Satoh-Takayama","year":"2008","journal-title":"Immunity."},{"key":"2023072603160339700_bib53","doi-asserted-by":"publisher","first-page":"424","DOI":"10.1046\/j.1523-1747.2002.01847.x","article-title":"Human keratinocytes express functional CD14 and toll-like receptor 4","volume":"119","author":"Song","year":"2002","journal-title":"J. Invest.                        Dermatol."},{"key":"2023072603160339700_bib54","doi-asserted-by":"publisher","first-page":"1321","DOI":"10.1126\/science.1222551","article-title":"Innate lymphoid cells promote anatomical containment of lymphoid-resident commensal bacteria","volume":"336","author":"Sonnenberg","year":"2012","journal-title":"Science."},{"key":"2023072603160339700_bib55","doi-asserted-by":"crossref","first-page":"673","DOI":"10.1038\/ni805","article-title":"Human epithelial cells trigger dendritic cell mediated allergic inflammation by producing TSLP","volume":"3","author":"Soumelis","year":"2002","journal-title":"Nat. Immunol."},{"key":"2023072603160339700_bib56","doi-asserted-by":"publisher","first-page":"5948","DOI":"10.4049\/jimmunol.181.9.5948","article-title":"IL-23 promotes maintenance but not commitment to the Th17 lineage","volume":"181","author":"Stritesky","year":"2008","journal-title":"J. Immunol."},{"key":"2023072603160339700_bib57","doi-asserted-by":"publisher","first-page":"898","DOI":"10.1111\/j.0022-202X.2005.23697.x","article-title":"Hyaluronan synthase induction and hyaluronan accumulation in mouse epidermis following skin injury","volume":"124","author":"Tammi","year":"2005","journal-title":"J. Invest. Dermatol."},{"key":"2023072603160339700_bib58","doi-asserted-by":"publisher","first-page":"5688","DOI":"10.4049\/jimmunol.1001538","article-title":"Cutting edge: A critical functional role for IL-23 in psoriasis","volume":"185","author":"Tonel","year":"2010","journal-title":"J. Immunol."},{"key":"2023072603160339700_bib59","doi-asserted-by":"publisher","first-page":"4965","DOI":"10.1172\/JCI75660","article-title":"Skin exposure promotes a Th2-dependent sensitization to peanut allergens","volume":"124","author":"Tordesillas","year":"2014","journal-title":"J. Clin.                        Invest."},{"key":"2023072603160339700_bib60","doi-asserted-by":"publisher","first-page":"2602","DOI":"10.4049\/jimmunol.171.5.2602","article-title":"Blockade of S100A8 and S100A9 suppresses neutrophil migration in response to lipopolysaccharide","volume":"171","author":"Vandal","year":"2003","journal-title":"J. Immunol."},{"key":"2023072603160339700_bib61","doi-asserted-by":"publisher","first-page":"13","DOI":"10.1016\/j.imlet.2007.01.007","article-title":"Initiation of adaptive immune responses by transcutaneous immunization","volume":"109","author":"Warger","year":"2007","journal-title":"Immunol. Lett."},{"key":"2023072603160339700_bib62","doi-asserted-by":"publisher","first-page":"241","DOI":"10.1016\/j.immuni.2004.07.007","article-title":"IL-22 increases the innate immunity of tissues","volume":"21","author":"Wolk","year":"2004","journal-title":"Immunity."},{"key":"2023072603160339700_bib63","doi-asserted-by":"publisher","first-page":"359","DOI":"10.1067\/mai.2001.112695","article-title":"An obligate role for T-cell receptor alphabeta+ T cells but not T-cell receptor gammadelta+ T cells, B cells, or CD40\/CD40L interactions in a mouse model of atopic dermatitis","volume":"107","author":"Woodward","year":"2001","journal-title":"J. Allergy Clin. Immunol."},{"key":"2023072603160339700_bib64","doi-asserted-by":"publisher","first-page":"513","DOI":"10.1038\/nature11984","article-title":"Induction of pathogenic TH17 cells by inducible salt-sensing kinase SGK1","volume":"496","author":"Wu","year":"2013","journal-title":"Nature."},{"key":"2023072603160339700_bib65","doi-asserted-by":"publisher","first-page":"31335","DOI":"10.1074\/jbc.M005304200","article-title":"Interleukin (IL)-22, a novel human cytokine that signals through the interferon receptor-related proteins CRF2-4 and IL-22R","volume":"275","author":"Xie","year":"2000","journal-title":"J. Biol. Chem."},{"key":"2023072603160339700_bib66","doi-asserted-by":"publisher","first-page":"3753","DOI":"10.1038\/ncomms4753","article-title":"IL-21 induces IL-22 production in CD4+ T cells","volume":"5","author":"Yeste","year":"2014","journal-title":"Nat. Commun."},{"key":"2023072603160339700_bib67","doi-asserted-by":"publisher","first-page":"2592","DOI":"10.1111\/j.1582-4934.2010.01127.x","article-title":"Endogenous toll-like receptor ligands and their biological significance","volume":"14","author":"Yu","year":"2010","journal-title":"J. Cell. Mol. Med."},{"key":"2023072603160339700_bib68","doi-asserted-by":"publisher","first-page":"e40797","DOI":"10.1371\/journal.pone.0040797","article-title":"The pro-inflammatory cytokine IL-22 up-regulates keratin 17 expression in keratinocytes via STAT3 and ERK1\/2","volume":"7","author":"Zhang","year":"2012","journal-title":"PLoS One."},{"key":"2023072603160339700_bib69","doi-asserted-by":"publisher","first-page":"648","DOI":"10.1038\/nature05505","article-title":"Interleukin-22, a T(H)17 cytokine,                        mediates IL-23-induced dermal inflammation and acanthosis","volume":"445","author":"Zheng","year":"2007","journal-title":"Nature."},{"key":"2023072603160339700_bib70","doi-asserted-by":"publisher","first-page":"282","DOI":"10.1038\/nm1720","article-title":"Interleukin-22 mediates early host defense against attaching and effacing bacterial pathogens","volume":"14","author":"Zheng","year":"2008","journal-title":"Nat. Med."},{"key":"2023072603160339700_bib71","doi-asserted-by":"publisher","first-page":"12768","DOI":"10.1073\/pnas.1300318110","article-title":"IL-22-producing neutrophils contribute to antimicrobial defense and restitution of colonic epithelial integrity during colitis","volume":"110","author":"Zindl","year":"2013","journal-title":"Proc. Natl. Acad. Sci. USA."}],"container-title":["Journal of Experimental Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/rupress.org\/jem\/article-pdf\/213\/10\/2147\/1754777\/jem_20150376.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/rupress.org\/jem\/article-pdf\/213\/10\/2147\/1754777\/jem_20150376.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,7,26]],"date-time":"2023-07-26T03:16:39Z","timestamp":1690341399000},"score":1,"resource":{"primary":{"URL":"https:\/\/rupress.org\/jem\/article\/213\/10\/2147\/42026\/IL-23-induced-in-keratinocytes-by-endogenous-TLR4"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,8,22]]},"references-count":71,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2016,9,19]]}},"URL":"https:\/\/doi.org\/10.1084\/jem.20150376","relation":{},"ISSN":["0022-1007","1540-9538"],"issn-type":[{"value":"0022-1007","type":"print"},{"value":"1540-9538","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,8,22]]}}}