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New research approaches have highlighted host as well as parasite molecules or pathways that could be targeted for interventions. In this study, we discuss host\u2013parasite interactions at the different stages of the Plasmodium life cycle within the mammalian host and the potential for therapeutics that prevent parasite migration, invasion, intracellular growth, or egress from host cells, as well as parasite-induced pathology.<\/jats:p>","DOI":"10.1084\/jem.20151677","type":"journal-article","created":{"date-parts":[[2016,2,2]],"date-time":"2016-02-02T03:24:12Z","timestamp":1454383452000},"page":"143-153","update-policy":"https:\/\/doi.org\/10.1084\/jem.crossmarkpolicy","source":"Crossref","is-referenced-by-count":19,"title":["Expanding the antimalarial toolkit: Targeting host\u2013parasite interactions"],"prefix":"10.1084","volume":"213","author":[{"given":"Jean","family":"Langhorne","sequence":"first","affiliation":[{"name":"Mill Hill Laboratory, The Francis Crick Institute, London NW7 1AA, England, UK 1"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Patrick E.","family":"Duffy","sequence":"additional","affiliation":[{"name":"Laboratory of Malaria Immunology and Vaccinology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rockville, MD 20852 2"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"291","published-online":{"date-parts":[[2016,2,1]]},"reference":[{"key":"2023072603131150900_bib1","doi-asserted-by":"publisher","first-page":"5467","DOI":"10.4049\/jimmunol.1102223","article-title":"Strong impact of CD4+ Foxp3+ regulatory T cells and limited effect of T cell-derived IL-10 on pathogen clearance during Plasmodium yoelii infection","volume":"188","author":"Abel","year":"2012","journal-title":"J. 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