{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,17]],"date-time":"2026-07-17T22:51:01Z","timestamp":1784328661047,"version":"3.55.0"},"reference-count":65,"publisher":"Rockefeller University Press","issue":"11","funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["91339201"],"award-info":[{"award-number":["91339201"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81422002"],"award-info":[{"award-number":["81422002"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["31571193"],"award-info":[{"award-number":["31571193"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["31271227"],"award-info":[{"award-number":["31271227"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["rupress.org"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2016,10,17]]},"abstract":"<jats:p>Abdominal aortic aneurysm (AAA), characterized by a localized dilation of the abdominal aorta, is a life-threatening vascular pathology. Because of the current lack of effective treatment for AAA rupture, prevention is of prime importance for AAA management. Calorie restriction (CR) is a nonpharmacological intervention that delays the aging process and provides various health benefits. However, whether CR prevents AAA formation remains untested. In this study, we subjected Apoe\u2212\/\u2212 mice to 12 wk of CR and then examined the incidence of angiotensin II (AngII)\u2013induced AAA formation. We found that CR markedly reduced the incidence of AAA formation and attenuated aortic elastin degradation in Apoe\u2212\/\u2212 mice. The expression and activity of Sirtuin 1 (SIRT1), a key metabolism\/energy sensor, were up-regulated in vascular smooth muscle cells (VSMCs) upon CR. Importantly, the specific ablation of SIRT1 in smooth muscle cells abolished the preventive effect of CR on AAA formation in Apoe\u2212\/\u2212 mice. Mechanistically, VSMC-SIRT1\u2013dependent deacetylation of histone H3 lysine 9 on the matrix metallopeptidase 2 (Mmp2) promoter was required for CR-mediated suppression of AngII-induced MMP2 expression. Together, our findings suggest that CR may be an effective intervention that protects against AAA formation.<\/jats:p>","DOI":"10.1084\/jem.20151794","type":"journal-article","created":{"date-parts":[[2016,9,26]],"date-time":"2016-09-26T14:13:30Z","timestamp":1474899210000},"page":"2473-2488","update-policy":"https:\/\/doi.org\/10.1084\/jem.crossmarkpolicy","source":"Crossref","is-referenced-by-count":72,"title":["Calorie restriction protects against experimental abdominal aortic aneurysms in mice"],"prefix":"10.1084","volume":"213","author":[{"given":"Yue","family":"Liu","sequence":"first","affiliation":[{"name":"State Key Laboratory of Medical Molecular Biology, Department of Biochemistry and Molecular Biology, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100730, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ting-Ting","family":"Wang","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Medical Molecular Biology, Department of Biochemistry and Molecular Biology, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100730, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ran","family":"Zhang","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Medical Molecular Biology, Department of Biochemistry and Molecular Biology, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100730, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8895-2038","authenticated-orcid":false,"given":"Wen-Yan","family":"Fu","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Medical Molecular Biology, Department of Biochemistry and Molecular Biology, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100730, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xu","family":"Wang","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Medical Molecular Biology, Department of Biochemistry and Molecular Biology, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100730, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fang","family":"Wang","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Medical Molecular Biology, Department of Biochemistry and Molecular Biology, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100730, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peng","family":"Gao","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Medical Molecular Biology, Department of Biochemistry and Molecular Biology, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100730, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3907-6147","authenticated-orcid":false,"given":"Yang-Nan","family":"Ding","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Medical Molecular Biology, Department of Biochemistry and Molecular Biology, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100730, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan","family":"Xie","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Medical Molecular Biology, Department of Biochemistry and Molecular Biology, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100730, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"De-Long","family":"Hao","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Medical Molecular Biology, Department of Biochemistry and Molecular Biology, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100730, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hou-Zao","family":"Chen","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Medical Molecular Biology, Department of Biochemistry and Molecular Biology, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100730, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"De-Pei","family":"Liu","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Medical Molecular Biology, Department of Biochemistry and Molecular Biology, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100730, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"291","published-online":{"date-parts":[[2016,9,26]]},"reference":[{"key":"2023072603222745800_bib1","doi-asserted-by":"publisher","first-page":"485","DOI":"10.1042\/bj20020707","article-title":"A functional activating protein 1 (AP-1) site regulates matrix metalloproteinase 2 (MMP-2) transcription by cardiac cells through interactions with JunB-Fra1 and JunB-FosB heterodimers","volume":"369","author":"Bergman","year":"2003","journal-title":"Biochem. J."},{"key":"2023072603222745800_bib2","doi-asserted-by":"publisher","first-page":"683","DOI":"10.4161\/cc.9.4.10766","article-title":"Calorie restriction: decelerating mTOR-driven aging from cells to organisms (including humans)","volume":"9","author":"Blagosklonny","year":"2010","journal-title":"Cell Cycle."},{"key":"2023072603222745800_bib3","doi-asserted-by":"publisher","first-page":"e1759","DOI":"10.1371\/journal.pone.0001759","article-title":"SirT1 regulates energy metabolism and response to caloric restriction in mice","volume":"3","author":"Boily","year":"2008","journal-title":"PLoS One."},{"key":"2023072603222745800_bib4","doi-asserted-by":"publisher","first-page":"806","DOI":"10.1001\/jama.2013.950","article-title":"Surveillance intervals for small abdominal aortic aneurysms: a meta-analysis","volume":"309","author":"Bown","year":"2013","journal-title":"JAMA."},{"key":"2023072603222745800_bib5","doi-asserted-by":"publisher","first-page":"214","DOI":"10.1152\/physiol.00010.2011","article-title":"Calorie restriction: is AMPK a key sensor and effector?","volume":"26","author":"Cant\u00f3","year":"2011","journal-title":"Physiology (Bethesda)."},{"key":"2023072603222745800_bib6","doi-asserted-by":"publisher","first-page":"515","DOI":"10.1016\/j.stem.2012.04.002","article-title":"Short-term calorie restriction enhances skeletal muscle stem cell function","volume":"10","author":"Cerletti","year":"2012","journal-title":"Cell Stem Cell."},{"key":"2023072603222745800_bib7","doi-asserted-by":"publisher","first-page":"390","DOI":"10.1126\/science.1099196","article-title":"Calorie restriction promotes mammalian cell survival by inducing the SIRT1 deacetylase","volume":"305","author":"Cohen","year":"2004","journal-title":"Science."},{"key":"2023072603222745800_bib8","doi-asserted-by":"publisher","first-page":"881","DOI":"10.3390\/metabo3040881","article-title":"Transcriptomics and metabonomics identify essential metabolic signatures in calorie restriction (CR) regulation across multiple mouse strains","volume":"3","author":"Collino","year":"2013","journal-title":"Metabolites."},{"key":"2023072603222745800_bib9","doi-asserted-by":"publisher","first-page":"201","DOI":"10.1126\/science.1173635","article-title":"Caloric restriction delays disease onset and mortality in rhesus monkeys","volume":"325","author":"Colman","year":"2009","journal-title":"Science."},{"key":"2023072603222745800_bib10","doi-asserted-by":"publisher","first-page":"3557","DOI":"10.1038\/ncomms4557","article-title":"Caloric restriction reduces age-related and all-cause mortality in rhesus monkeys","volume":"5","author":"Colman","year":"2014","journal-title":"Nat. Commun."},{"key":"2023072603222745800_bib11","doi-asserted-by":"publisher","first-page":"518","DOI":"10.1016\/j.mad.2009.06.004","article-title":"Anti-oxidative and anti-inflammatory vasoprotective effects of caloric restriction in aging: role of circulating factors and SIRT1","volume":"130","author":"Csiszar","year":"2009","journal-title":"Mech. Ageing Dev."},{"key":"2023072603222745800_bib12","doi-asserted-by":"publisher","first-page":"429","DOI":"10.1161\/01.ATV.0000118013.72016.ea","article-title":"Mouse models of abdominal aortic aneurysms","volume":"24","author":"Daugherty","year":"2004","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"key":"2023072603222745800_bib13","doi-asserted-by":"publisher","first-page":"1605","DOI":"10.1172\/JCI7818","article-title":"Angiotensin II promotes atherosclerotic lesions and aneurysms in apolipoprotein E-deficient mice","volume":"105","author":"Daugherty","year":"2000","journal-title":"J. Clin. Invest."},{"key":"2023072603222745800_bib14","doi-asserted-by":"publisher","first-page":"681","DOI":"10.1042\/CS20090372","article-title":"Angiotensin II infusion promotes ascending aortic aneurysms: attenuation by CCR2 deficiency in apoE\u2212\/\u2212 mice","volume":"118","author":"Daugherty","year":"2010","journal-title":"Clin. Sci."},{"key":"2023072603222745800_bib15","doi-asserted-by":"publisher","first-page":"1006","DOI":"10.2337\/db09-1187","article-title":"Downregulation of the longevity-associated protein sirtuin 1 in insulin resistance and metabolic syndrome: potential biochemical mechanisms","volume":"59","author":"de Kreutzenberg","year":"2010","journal-title":"Diabetes."},{"key":"2023072603222745800_bib16","doi-asserted-by":"publisher","first-page":"6659","DOI":"10.1073\/pnas.0308291101","article-title":"Long-term calorie restriction is highly effective in reducing the risk for atherosclerosis in humans","volume":"101","author":"Fontana","year":"2004","journal-title":"Proc. Natl. Acad. Sci. USA."},{"key":"2023072603222745800_bib17","doi-asserted-by":"publisher","first-page":"E197","DOI":"10.1152\/ajpendo.00102.2007","article-title":"Calorie restriction or exercise: effects on coronary heart disease risk factors. A randomized, controlled trial","volume":"293","author":"Fontana","year":"2007","journal-title":"Am. J. Physiol. Endocrinol. Metab."},{"key":"2023072603222745800_bib18","doi-asserted-by":"publisher","first-page":"321","DOI":"10.1126\/science.1172539","article-title":"Extending healthy life span\u2014from yeast to humans","volume":"328","author":"Fontana","year":"2010","journal-title":"Science."},{"key":"2023072603222745800_bib19","doi-asserted-by":"publisher","first-page":"347","DOI":"10.1007\/s00109-013-1111-4","article-title":"Overexpression of SIRT1 in vascular smooth muscle cells attenuates angiotensin II-induced vascular remodeling and hypertension in mice","volume":"92","author":"Gao","year":"2014","journal-title":"J. Mol. Med."},{"key":"2023072603222745800_bib20","doi-asserted-by":"publisher","first-page":"2275","DOI":"10.1161\/CIRCULATIONAHA.107.717926","article-title":"Obesity, adipokines, and abdominal aortic aneurysm: Health in men study","volume":"116","author":"Golledge","year":"2007","journal-title":"Circulation."},{"key":"2023072603222745800_bib21","doi-asserted-by":"publisher","first-page":"386","DOI":"10.1161\/CIRCULATIONAHA.112.124404","article-title":"Vascular smooth muscle cell sirtuin 1 protects against DNA damage and inhibits atherosclerosis","volume":"127","author":"Gorenne","year":"2013","journal-title":"Circulation."},{"key":"2023072603222745800_bib22","doi-asserted-by":"publisher","first-page":"2072","DOI":"10.1101\/gad.227439.113","article-title":"Calorie restriction and sirtuins revisited","volume":"27","author":"Guarente","year":"2013","journal-title":"Genes Dev."},{"key":"2023072603222745800_bib23","doi-asserted-by":"publisher","first-page":"1121","DOI":"10.1016\/S0047-6374(02)00008-8","article-title":"Dietary restriction reduces atherosclerosis and oxidative stress in the aorta of apolipoprotein E-deficient mice","volume":"123","author":"Guo","year":"2002","journal-title":"Mech. Ageing Dev."},{"key":"2023072603222745800_bib24","doi-asserted-by":"publisher","first-page":"139","DOI":"10.1016\/j.molcel.2011.01.002","article-title":"Sirt3 promotes the urea cycle and fatty acid oxidation during dietary restriction","volume":"41","author":"Hallows","year":"2011","journal-title":"Mol. Cell."},{"key":"2023072603222745800_bib25","doi-asserted-by":"publisher","first-page":"257","DOI":"10.1007\/978-1-60327-299-5_16","article-title":"Zymography and reverse zymography for detecting MMPs and TIMPs","volume":"622","author":"Hawkes","year":"2010","journal-title":"Methods Mol. Biol."},{"key":"2023072603222745800_bib26","doi-asserted-by":"publisher","first-page":"887","DOI":"10.1038\/nm.3882","article-title":"Nicotinamide N-methyltransferase regulates hepatic nutrient metabolism through Sirt1 protein stabilization","volume":"21","author":"Hong","year":"2015","journal-title":"Nat. Med."},{"key":"2023072603222745800_bib27","doi-asserted-by":"publisher","first-page":"789","DOI":"10.1172\/JCI4189","article-title":"Agonist-stimulated cytoskeletal reorganization and signal transduction at focal adhesions in vascular smooth muscle cells require c-Src","volume":"103","author":"Ishida","year":"1999","journal-title":"J. Clin. Invest."},{"key":"2023072603222745800_bib28","doi-asserted-by":"publisher","first-page":"452","DOI":"10.1067\/mva.1991.26737","article-title":"Suggested standards for reporting on arterial aneurysms","volume":"13","author":"Johnston","year":"1991","journal-title":"J. Vasc. Surg."},{"key":"2023072603222745800_bib29","doi-asserted-by":"publisher","first-page":"852","DOI":"10.7326\/0003-4819-159-12-201312170-00012","article-title":"Abdominal aortic aneurysm: still no pill","volume":"159","author":"Lederle","year":"2013","journal-title":"Ann. Intern. Med."},{"key":"2023072603222745800_bib30","doi-asserted-by":"publisher","first-page":"1390","DOI":"10.1126\/science.285.5432.1390","article-title":"Gene expression profile of aging and its retardation by caloric restriction","volume":"285","author":"Lee","year":"1999","journal-title":"Science."},{"key":"2023072603222745800_bib31","doi-asserted-by":"publisher","first-page":"206","DOI":"10.1016\/j.atherosclerosis.2008.05.036","article-title":"Caloric restriction alone and with exercise improves CVD risk in healthy non-obese individuals","volume":"203","author":"Lefevre","year":"2009","journal-title":"Atherosclerosis."},{"key":"2023072603222745800_bib32","doi-asserted-by":"publisher","first-page":"1180","DOI":"10.1161\/CIRCRESAHA.110.237875","article-title":"SIRT1 acts as a modulator of neointima formation following vascular injury in mice","volume":"108","author":"Li","year":"2011","journal-title":"Circ. Res."},{"key":"2023072603222745800_bib33","doi-asserted-by":"publisher","first-page":"98","DOI":"10.1186\/1741-7015-9-98","article-title":"Epigenetic regulation of caloric restriction in aging","volume":"9","author":"Li","year":"2011","journal-title":"BMC Med."},{"key":"2023072603222745800_bib34","doi-asserted-by":"publisher","first-page":"783","DOI":"10.1002\/mc.20652","article-title":"Down-regulation of MMP-2 through the p38 MAPK-NF-\u03baB-dependent pathway by aloe-emodin leads to inhibition of nasopharyngeal carcinoma cell invasion","volume":"49","author":"Lin","year":"2010","journal-title":"Mol. Carcinog."},{"key":"2023072603222745800_bib35","doi-asserted-by":"publisher","first-page":"742","DOI":"10.1007\/s11427-014-4709-z","article-title":"Mechanistic perspectives of calorie restriction on vascular homeostasis","volume":"57","author":"Liu","year":"2014","journal-title":"Sci. China Life Sci."},{"key":"2023072603222745800_bib36","doi-asserted-by":"crossref","first-page":"966","DOI":"10.1046\/j.1365-2168.2000.01481-4.x","article-title":"Mortality from ruptured abdominal aortic aneurysm in Wales","volume":"87","author":"Logan","year":"2000","journal-title":"Br. J. Surg."},{"key":"2023072603222745800_bib37","doi-asserted-by":"publisher","first-page":"625","DOI":"10.1172\/JCI0215334","article-title":"Matrix metalloproteinases 2 and 9 work in concert to produce aortic aneurysms","volume":"110","author":"Longo","year":"2002","journal-title":"J. Clin. Invest."},{"key":"2023072603222745800_bib38","first-page":"993","article-title":"Decreased vascular smooth muscle cell density in medial degeneration of human abdominal aortic aneurysms","volume":"150","author":"L\u00f3pez-Candales","year":"1997","journal-title":"Am. J. Pathol."},{"key":"2023072603222745800_bib39","doi-asserted-by":"publisher","first-page":"1349","DOI":"10.2337\/diabetes.54.5.1349","article-title":"Akt2 is essential for the full effect of calorie restriction on insulin-stimulated glucose uptake in skeletal muscle","volume":"54","author":"McCurdy","year":"2005","journal-title":"Diabetes."},{"key":"2023072603222745800_bib40","doi-asserted-by":"publisher","first-page":"II329","DOI":"10.1161\/01.cir.0000087660.82721.15","article-title":"Abnormal extracellular matrix protein transport associated with increased apoptosis of vascular smooth muscle cells in marfan syndrome and bicuspid aortic valve thoracic aortic aneurysm","volume":"108","author":"Nataatmadja","year":"2003","journal-title":"Circulation."},{"key":"2023072603222745800_bib41","doi-asserted-by":"publisher","first-page":"92","DOI":"10.1038\/nrcardio.2010.180","article-title":"Pathophysiology and epidemiology of abdominal aortic aneurysms","volume":"8","author":"Nordon","year":"2011","journal-title":"Nat. Rev. Cardiol."},{"key":"2023072603222745800_bib42","doi-asserted-by":"publisher","first-page":"99","DOI":"10.1016\/j.cmet.2008.06.012","article-title":"Diet and aging","volume":"8","author":"Piper","year":"2008","journal-title":"Cell Metab."},{"key":"2023072603222745800_bib43","doi-asserted-by":"publisher","first-page":"1458","DOI":"10.1161\/ATVBAHA.109.192658","article-title":"Obesity promotes inflammation in periaortic adipose tissue and angiotensin II-induced abdominal aortic aneurysm formation","volume":"29","author":"Police","year":"2009","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"key":"2023072603222745800_bib44","doi-asserted-by":"publisher","first-page":"H1932","DOI":"10.1152\/ajpheart.00961.2009","article-title":"Weight loss in obese C57BL\/6 mice limits adventitial expansion of established angiotensin II-induced abdominal aortic aneurysms","volume":"298","author":"Police","year":"2010","journal-title":"Am. J. Physiol. Heart Circ. Physiol."},{"key":"2023072603222745800_bib45","doi-asserted-by":"publisher","first-page":"157","DOI":"10.1016\/S0197-4580(99)00043-3","article-title":"Controlling caloric consumption: protocols for rodents and rhesus monkeys","volume":"20","author":"Pugh","year":"1999","journal-title":"Neurobiol. Aging."},{"key":"2023072603222745800_bib46","doi-asserted-by":"publisher","first-page":"e88584","DOI":"10.1371\/journal.pone.0088584","article-title":"Effect of diet on expression of genes involved in lipid metabolism, oxidative stress, and inflammation in mouse liver-insights into mechanisms of hepatic steatosis","volume":"9","author":"Renaud","year":"2014","journal-title":"PLoS One."},{"key":"2023072603222745800_bib47","doi-asserted-by":"publisher","first-page":"171","DOI":"10.1016\/j.stem.2014.12.004","article-title":"The NAD+-dependent SIRT1 deacetylase translates a metabolic switch into regulatory epigenetics in skeletal muscle stem cells","volume":"16","author":"Ryall","year":"2015","journal-title":"Cell Stem Cell."},{"key":"2023072603222745800_bib48","doi-asserted-by":"publisher","first-page":"649","DOI":"10.1038\/nm.1958","article-title":"Cyclophilin A enhances vascular oxidative stress and the development of angiotensin II-induced aortic aneurysms","volume":"15","author":"Satoh","year":"2009","journal-title":"Nat. Med."},{"key":"2023072603222745800_bib49","doi-asserted-by":"publisher","first-page":"360","DOI":"10.1002\/bjs.8983","article-title":"Obesity and abdominal aortic aneurysm","volume":"100","author":"Stackelberg","year":"2013","journal-title":"Br. J. Surg."},{"key":"2023072603222745800_bib50","doi-asserted-by":"publisher","first-page":"126","DOI":"10.1016\/S0140-6736(51)91210-X","article-title":"Mortality from circulatory diseases in Norway 1940-1945","volume":"1","author":"Strom","year":"1951","journal-title":"Lancet."},{"key":"2023072603222745800_bib51","doi-asserted-by":"publisher","first-page":"291","DOI":"10.1007\/s00109-010-0703-5","article-title":"Improved cardiac metabolism and activation of the RISK pathway contributes to improved post-ischemic recovery in calorie restricted mice","volume":"89","author":"Sung","year":"2011","journal-title":"J. Mol. Med."},{"key":"2023072603222745800_bib52","doi-asserted-by":"publisher","first-page":"2053","DOI":"10.1101\/gr.155028.113","article-title":"H4K16 acetylation marks active genes and enhancers of embryonic stem cells, but does not alter chromatin compaction","volume":"23","author":"Taylor","year":"2013","journal-title":"Genome Res."},{"key":"2023072603222745800_bib53","doi-asserted-by":"publisher","first-page":"1219","DOI":"10.1161\/CIRCRESAHA.112.280399","article-title":"\u03b2-Arrestin-2 deficiency attenuates abdominal aortic aneurysm formation in mice","volume":"112","author":"Trivedi","year":"2013","journal-title":"Circ. Res."},{"key":"2023072603222745800_bib54","doi-asserted-by":"publisher","first-page":"93","DOI":"10.1016\/j.molcel.2004.08.031","article-title":"Human SirT1 interacts with histone H1 and promotes formation of facultative heterochromatin","volume":"16","author":"Vaquero","year":"2004","journal-title":"Mol. Cell."},{"key":"2023072603222745800_bib55","doi-asserted-by":"publisher","first-page":"1396","DOI":"10.1016\/j.jvs.2008.07.054","article-title":"Mortality of ruptured abdominal aortic aneurysm treated with open or endovascular repair","volume":"48","author":"Verhoeven","year":"2008","journal-title":"J. Vasc. Surg."},{"key":"2023072603222745800_bib56","doi-asserted-by":"publisher","first-page":"890","DOI":"10.1111\/acel.12247","article-title":"SIRT1-mediated epigenetic downregulation of plasminogen activator inhibitor-1 prevents vascular endothelial replicative senescence","volume":"13","author":"Wan","year":"2014","journal-title":"Aging Cell."},{"key":"2023072603222745800_bib57","doi-asserted-by":"publisher","first-page":"11","DOI":"10.1016\/j.molcel.2008.09.011","article-title":"Interplay among BRCA1, SIRT1, and Survivin during BRCA1-associated tumorigenesis","volume":"32","author":"Wang","year":"2008","journal-title":"Mol. Cell."},{"key":"2023072603222745800_bib58","doi-asserted-by":"publisher","first-page":"422","DOI":"10.1172\/JCI38136","article-title":"TGF-\u03b2 activity protects against inflammatory aortic aneurysm progression and complications in angiotensin II\u2013infused mice","volume":"120","author":"Wang","year":"2010","journal-title":"J. Clin. Invest."},{"key":"2023072603222745800_bib59","doi-asserted-by":"crossref","first-page":"1087","DOI":"10.1093\/jn\/137.4.1087","article-title":"Improvements in body composition, glucose tolerance, and insulin action induced by increasing energy expenditure or decreasing energy intake","volume":"137","author":"Weiss","year":"2007","journal-title":"J. Nutr."},{"key":"2023072603222745800_bib60","doi-asserted-by":"crossref","first-page":"1033","DOI":"10.1093\/ajcn\/84.5.1033","article-title":"Improvements in glucose tolerance and insulin action induced by increasing energy expenditure or decreasing energy intake: a randomized controlled trial","volume":"84","author":"Weiss","year":"2006","journal-title":"Am. J. Clin. Nutr."},{"key":"2023072603222745800_bib61","doi-asserted-by":"publisher","first-page":"434","DOI":"10.1196\/annals.1396.037","article-title":"Caloric restriction, the traditional Okinawan diet, and healthy aging: the diet of the world\u2019s longest-lived people and its potential impact on morbidity and life span","volume":"1114","author":"Willcox","year":"2007","journal-title":"Ann. N. Y. Acad. Sci."},{"key":"2023072603222745800_bib62","doi-asserted-by":"publisher","first-page":"2369","DOI":"10.1038\/sj.emboj.7600244","article-title":"Modulation of NF-\u03baB-dependent transcription and cell survival by the SIRT1 deacetylase","volume":"23","author":"Yeung","year":"2004","journal-title":"EMBO J."},{"key":"2023072603222745800_bib63","doi-asserted-by":"publisher","first-page":"7097","DOI":"10.1074\/jbc.M109.038604","article-title":"SIRT1 suppresses activator protein-1 transcriptional activity and cyclooxygenase-2 expression in macrophages","volume":"285","author":"Zhang","year":"2010","journal-title":"J. Biol. Chem."},{"key":"2023072603222745800_bib64","doi-asserted-by":"publisher","first-page":"E1201","DOI":"10.1073\/pnas.1119304109","article-title":"Midlife gene expressions identify modulators of aging through dietary interventions","volume":"109","author":"Zhou","year":"2012","journal-title":"Proc. Natl. Acad. Sci. USA."},{"key":"2023072603222745800_bib65","doi-asserted-by":"publisher","first-page":"639","DOI":"10.1161\/CIRCRESAHA.111.243592","article-title":"Repression of P66Shc expression by SIRT1 contributes to the prevention of hyperglycemia-induced endothelial dysfunction","volume":"109","author":"Zhou","year":"2011","journal-title":"Circ. Res."}],"container-title":["Journal of Experimental Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/rupress.org\/jem\/article-pdf\/213\/11\/2473\/1755239\/jem_20151794.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/rupress.org\/jem\/article-pdf\/213\/11\/2473\/1755239\/jem_20151794.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,7,26]],"date-time":"2023-07-26T03:23:28Z","timestamp":1690341808000},"score":1,"resource":{"primary":{"URL":"https:\/\/rupress.org\/jem\/article\/213\/11\/2473\/41990\/Calorie-restriction-protects-against-experimental"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,9,26]]},"references-count":65,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2016,10,17]]}},"URL":"https:\/\/doi.org\/10.1084\/jem.20151794","relation":{},"ISSN":["0022-1007","1540-9538"],"issn-type":[{"value":"0022-1007","type":"print"},{"value":"1540-9538","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,9,26]]}}}