{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T15:18:02Z","timestamp":1791299882065,"version":"4.1.0"},"reference-count":92,"publisher":"Rockefeller University Press","issue":"7","content-domain":{"domain":["rupress.org"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2016,6,27]]},"abstract":"<jats:p>Acute myocardial infarction (MI) is a severe ischemic disease responsible for heart failure and sudden death. Inflammatory cells orchestrate postischemic cardiac remodeling after MI. Studies using mice with defective mast\/stem cell growth factor receptor c-Kit have suggested key roles for mast cells (MCs) in postischemic cardiac remodeling. Because c-Kit mutations affect multiple cell types of both immune and nonimmune origin, we addressed the impact of MCs on cardiac function after MI, using the c-Kit\u2013independent MC-deficient (Cpa3Cre\/+) mice. In response to MI, MC progenitors originated primarily from white adipose tissue, infiltrated the heart, and differentiated into mature MCs. MC deficiency led to reduced postischemic cardiac function and depressed cardiomyocyte contractility caused by myofilament Ca2+ desensitization. This effect correlated with increased protein kinase A (PKA) activity and hyperphosphorylation of its targets, troponin I and myosin-binding protein C. MC-specific tryptase was identified to regulate PKA activity in cardiomyocytes via protease-activated receptor 2 proteolysis. This work reveals a novel function for cardiac MCs modulating cardiomyocyte contractility via alteration of PKA-regulated force\u2013Ca2+ interactions in response to MI. Identification of this MC-cardiomyocyte cross-talk provides new insights on the cellular and molecular mechanisms regulating the cardiac contractile machinery and a novel platform for therapeutically addressable regulators.<\/jats:p>","DOI":"10.1084\/jem.20160081","type":"journal-article","created":{"date-parts":[[2016,6,27]],"date-time":"2016-06-27T13:10:35Z","timestamp":1467033035000},"page":"1353-1374","update-policy":"https:\/\/doi.org\/10.1084\/jem.crossmarkpolicy","source":"Crossref","is-referenced-by-count":132,"title":["Mast cells regulate myofilament calcium sensitization and heart function after myocardial infarction"],"prefix":"10.1084","volume":"213","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0016-887X","authenticated-orcid":false,"given":"Anta","family":"Ngkelo","sequence":"first","affiliation":[{"name":"Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale (INSERM), UMRS-970, Centre de Recherche Cardiovasculaire, Universit\u00e9 Paris Descartes, Sorbonne Paris Cit\u00e9, F-75015 Paris, France 1"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ad\u00e8le","family":"Richart","sequence":"additional","affiliation":[{"name":"Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale (INSERM), UMRS-970, Centre de Recherche Cardiovasculaire, Universit\u00e9 Paris Descartes, Sorbonne Paris Cit\u00e9, F-75015 Paris, France 1"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5192-2860","authenticated-orcid":false,"given":"Jonathan A.","family":"Kirk","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Johns Hopkins Medical Institutions, Baltimore, MD 212015 2"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3184-3740","authenticated-orcid":false,"given":"Philippe","family":"Bonnin","sequence":"additional","affiliation":[{"name":"INSERM, U965, H\u00f4pital Lariboisi\u00e8re\u2013Fernand-Widal, Assistance Publique H\u00f4pitaux de Paris, F-75010 Paris, France 3"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jose","family":"Vilar","sequence":"additional","affiliation":[{"name":"Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale (INSERM), UMRS-970, Centre de Recherche Cardiovasculaire, Universit\u00e9 Paris Descartes, Sorbonne Paris Cit\u00e9, F-75015 Paris, France 1"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mathilde","family":"Lemitre","sequence":"additional","affiliation":[{"name":"Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale (INSERM), UMRS-970, Centre de Recherche Cardiovasculaire, Universit\u00e9 Paris Descartes, Sorbonne Paris Cit\u00e9, F-75015 Paris, France 1"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pauline","family":"Marck","sequence":"additional","affiliation":[{"name":"INSERM, UMR-1048, Institut des Maladies M\u00e9taboliques et Cardiovasculaires, F-31004 Toulouse, France 4"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maxime","family":"Branchereau","sequence":"additional","affiliation":[{"name":"INSERM, UMR-1048, Institut des Maladies M\u00e9taboliques et Cardiovasculaires, F-31004 Toulouse, France 4"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5268-0584","authenticated-orcid":false,"given":"Sylvain","family":"Le Gall","sequence":"additional","affiliation":[{"name":"Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale (INSERM), UMRS-970, Centre de Recherche Cardiovasculaire, Universit\u00e9 Paris Descartes, Sorbonne Paris Cit\u00e9, F-75015 Paris, France 1"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1559-0774","authenticated-orcid":false,"given":"Nisa","family":"Renault","sequence":"additional","affiliation":[{"name":"Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale (INSERM), UMRS-970, Centre de Recherche Cardiovasculaire, Universit\u00e9 Paris Descartes, Sorbonne Paris Cit\u00e9, F-75015 Paris, France 1"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Coralie","family":"Guerin","sequence":"additional","affiliation":[{"name":"National Cytometry Platform, Department of Infection and Immunity, Luxembourg Institute of Health, L-4354 Esch-sur-Alzette, Luxembourg 5"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4970-8988","authenticated-orcid":false,"given":"Mark J.","family":"Ranek","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Johns Hopkins Medical Institutions, Baltimore, MD 212015 2"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8081-8296","authenticated-orcid":false,"given":"Ana\u00efs","family":"Kervadec","sequence":"additional","affiliation":[{"name":"Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale (INSERM), UMRS-970, Centre de Recherche Cardiovasculaire, Universit\u00e9 Paris Descartes, Sorbonne Paris Cit\u00e9, F-75015 Paris, France 1"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1222-0732","authenticated-orcid":false,"given":"Luca","family":"Danelli","sequence":"additional","affiliation":[{"name":"Laboratoire d\u2019Excellence INFLAMEX, Universit\u00e9 Paris Diderot, Sorbonne Paris Cit\u00e9, F-75018 Paris, France 6"},{"name":"INSERM, U1149, F-75018 Paris, France 7"},{"name":"Centre National de la Recherche Scientifique (CNRS) ERL 8252, F-75018 Paris, France 8"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gregory","family":"Gautier","sequence":"additional","affiliation":[{"name":"Laboratoire d\u2019Excellence INFLAMEX, Universit\u00e9 Paris Diderot, Sorbonne Paris Cit\u00e9, F-75018 Paris, France 6"},{"name":"INSERM, U1149, F-75018 Paris, France 7"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ulrich","family":"Blank","sequence":"additional","affiliation":[{"name":"Laboratoire d\u2019Excellence INFLAMEX, Universit\u00e9 Paris Diderot, Sorbonne Paris Cit\u00e9, F-75018 Paris, France 6"},{"name":"INSERM, U1149, F-75018 Paris, France 7"},{"name":"Centre National de la Recherche Scientifique (CNRS) ERL 8252, F-75018 Paris, France 8"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3560-1389","authenticated-orcid":false,"given":"Pierre","family":"Launay","sequence":"additional","affiliation":[{"name":"Laboratoire d\u2019Excellence INFLAMEX, Universit\u00e9 Paris Diderot, Sorbonne Paris Cit\u00e9, F-75018 Paris, France 6"},{"name":"INSERM, U1149, F-75018 Paris, France 7"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6271-7125","authenticated-orcid":false,"given":"Eric","family":"Camerer","sequence":"additional","affiliation":[{"name":"Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale (INSERM), UMRS-970, Centre de Recherche Cardiovasculaire, Universit\u00e9 Paris Descartes, Sorbonne Paris Cit\u00e9, F-75015 Paris, France 1"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2350-2914","authenticated-orcid":false,"given":"Patrick","family":"Bruneval","sequence":"additional","affiliation":[{"name":"Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale (INSERM), UMRS-970, Centre de Recherche Cardiovasculaire, Universit\u00e9 Paris Descartes, Sorbonne Paris Cit\u00e9, F-75015 Paris, France 1"},{"name":"H\u00f4pital European George Pompidou, Assistance Publique H\u00f4pitaux de Paris, F-75015 Paris, France 9"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9845-4064","authenticated-orcid":false,"given":"Philippe","family":"Menasche","sequence":"additional","affiliation":[{"name":"Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale (INSERM), UMRS-970, Centre de Recherche Cardiovasculaire, Universit\u00e9 Paris Descartes, Sorbonne Paris Cit\u00e9, F-75015 Paris, France 1"},{"name":"H\u00f4pital European George Pompidou, Assistance Publique H\u00f4pitaux de Paris, F-75015 Paris, France 9"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christophe","family":"Heymes","sequence":"additional","affiliation":[{"name":"INSERM, UMR-1048, Institut des Maladies M\u00e9taboliques et Cardiovasculaires, F-31004 Toulouse, France 4"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elodie","family":"Luche","sequence":"additional","affiliation":[{"name":"STROMALab, Etablissement Fran\u00e7ais du Sang, INSERM U1031, CNRS ERL 5311, Universit\u00e9 de Toulouse, F-31004 Toulouse, France 10"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9647-3248","authenticated-orcid":false,"given":"Louis","family":"Casteilla","sequence":"additional","affiliation":[{"name":"STROMALab, Etablissement Fran\u00e7ais du Sang, INSERM U1031, CNRS ERL 5311, Universit\u00e9 de Toulouse, F-31004 Toulouse, France 10"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B\u00e9atrice","family":"Cousin","sequence":"additional","affiliation":[{"name":"STROMALab, Etablissement Fran\u00e7ais du Sang, INSERM U1031, CNRS ERL 5311, Universit\u00e9 de Toulouse, F-31004 Toulouse, France 10"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hans-Reimer","family":"Rodewald","sequence":"additional","affiliation":[{"name":"Division of Cellular Immunology, German Cancer Research Center, D-69120 Heidelberg, Germany 11"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1596-2299","authenticated-orcid":false,"given":"David A.","family":"Kass","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Johns Hopkins Medical Institutions, Baltimore, MD 212015 2"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean-S\u00e9bastien","family":"Silvestre","sequence":"additional","affiliation":[{"name":"Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale (INSERM), UMRS-970, Centre de Recherche Cardiovasculaire, Universit\u00e9 Paris Descartes, Sorbonne Paris Cit\u00e9, F-75015 Paris, France 1"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"291","published-online":{"date-parts":[[2016,6,27]]},"reference":[{"key":"2023072603323427300_bib1","doi-asserted-by":"crossref","first-page":"L193","DOI":"10.1152\/ajplung.2000.278.1.L193","article-title":"Mast cell tryptase stimulates human lung fibroblast proliferation via protease-activated receptor-2","volume":"278","author":"Akers","year":"2000","journal-title":"Am. J. Physiol. Lung Cell. Mol. Physiol."},{"key":"2023072603323427300_bib2","doi-asserted-by":"publisher","first-page":"2136","DOI":"10.1161\/ATVBAHA.110.213280","article-title":"Protease-activated receptor 2 deficiency reduces cardiac ischemia\/reperfusion injury","volume":"30","author":"Antoniak","year":"2010","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"key":"2023072603323427300_bib3","doi-asserted-by":"publisher","first-page":"6147","DOI":"10.4049\/jimmunol.1301350","article-title":"Mast cells are dispensable for normal and activin-promoted wound healing and skin carcinogenesis","volume":"191","author":"Antsiferova","year":"2013","journal-title":"J. Immunol."},{"key":"2023072603323427300_bib4","doi-asserted-by":"publisher","first-page":"H2183","DOI":"10.1152\/ajpheart.00520.2005","article-title":"Specific enhancement of sarcomeric response to Ca2+ protects murine myocardium against ischemia-reperfusion dysfunction","volume":"289","author":"Arteaga","year":"2005","journal-title":"Am. J. Physiol. Heart Circ. Physiol."},{"key":"2023072603323427300_bib5","doi-asserted-by":"publisher","first-page":"1806","DOI":"10.1093\/jnci\/djj498","article-title":"Effect of cromolyn on S100P interactions with RAGE and pancreatic cancer growth and invasion in mouse models","volume":"98","author":"Arumugam","year":"2006","journal-title":"J. Natl. Cancer Inst."},{"key":"2023072603323427300_bib6","doi-asserted-by":"publisher","first-page":"866","DOI":"10.1016\/j.yjmcc.2009.11.014","article-title":"Phosphorylation and function of cardiac myosin binding protein-C in health and disease","volume":"48","author":"Barefield","year":"2010","journal-title":"J. Mol. Cell. Cardiol."},{"key":"2023072603323427300_bib7","doi-asserted-by":"crossref","first-page":"1372","DOI":"10.1152\/jappl.2001.91.3.1372","article-title":"Tryptase and agonists of PAR-2 induce the proliferation of human airway smooth muscle cells","volume":"91","author":"Berger","year":"2001","journal-title":"J. Appl. Physiol."},{"key":"2023072603323427300_bib8","doi-asserted-by":"publisher","first-page":"3063","DOI":"10.1172\/JCI80055","article-title":"T lymphocytes and fractalkine contribute to myocardial ischemia\/reperfusion injury in patients","volume":"125","author":"Boag","year":"2015","journal-title":"J. Clin. Invest."},{"key":"2023072603323427300_bib9","doi-asserted-by":"publisher","first-page":"11408","DOI":"10.1073\/pnas.0504197102","article-title":"Identification of mast cell progenitors in adult mice","volume":"102","author":"Chen","year":"2005","journal-title":"Proc. Natl. Acad. Sci. USA."},{"key":"2023072603323427300_bib10","doi-asserted-by":"publisher","first-page":"615","DOI":"10.1085\/jgp.201010448","article-title":"Protein kinase A-induced myofilament desensitization to Ca2+ as a result of phosphorylation of cardiac myosin-binding protein C","volume":"136","author":"Chen","year":"2010","journal-title":"J. Gen. Physiol."},{"key":"2023072603323427300_bib11","doi-asserted-by":"publisher","first-page":"1383","DOI":"10.1172\/JCI119658","article-title":"Mast cell tryptase regulates rat colonic myocytes through proteinase-activated receptor 2","volume":"100","author":"Corvera","year":"1997","journal-title":"J. Clin. Invest."},{"key":"2023072603323427300_bib12","doi-asserted-by":"publisher","first-page":"1016","DOI":"10.1016\/S0006-291X(03)00061-5","article-title":"Reconstitution of lethally irradiated mice by cells isolated from adipose tissue","volume":"301","author":"Cousin","year":"2003","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"2023072603323427300_bib13","doi-asserted-by":"publisher","first-page":"4577","DOI":"10.1172\/JCI75212","article-title":"Mast cells aggravate sepsis by inhibiting peritoneal macrophage phagocytosis","volume":"124","author":"Dahdah","year":"2014","journal-title":"J. Clin. Invest."},{"key":"2023072603323427300_bib14","doi-asserted-by":"publisher","first-page":"3147","DOI":"10.1172\/JCI81321","article-title":"Macrophages mediate cardioprotective cellular postconditioning in acute myocardial infarction","volume":"125","author":"de Couto","year":"2015","journal-title":"J. Clin. Invest."},{"key":"2023072603323427300_bib15","doi-asserted-by":"publisher","first-page":"E1677","DOI":"10.1210\/jc.2012-1532","article-title":"Mast cells in human adipose tissue: link with morbid obesity, inflammatory status, and diabetes","volume":"97","author":"Divoux","year":"2012","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"2023072603323427300_bib16","doi-asserted-by":"publisher","first-page":"390","DOI":"10.2353\/ajpath.2009.080513","article-title":"Role of stem cell factor and bone marrow-derived fibroblasts in airway remodeling","volume":"174","author":"Dolgachev","year":"2009","journal-title":"Am. J. Pathol."},{"key":"2023072603323427300_bib17","doi-asserted-by":"publisher","first-page":"848","DOI":"10.1074\/jbc.M111.293258","article-title":"Augmented phosphorylation of cardiac troponin I in hypertensive heart failure","volume":"287","author":"Dong","year":"2012","journal-title":"J. Biol. Chem."},{"key":"2023072603323427300_bib18","doi-asserted-by":"publisher","first-page":"e000411","DOI":"10.1161\/JAHA.113.000411","article-title":"Prokineticin receptor-1 is a new regulator of endothelial insulin uptake and capillary formation to control insulin sensitivity and cardiovascular and kidney functions","volume":"2","author":"Dormishian","year":"2013","journal-title":"J. Am. Heart Assoc."},{"key":"2023072603323427300_bib19","doi-asserted-by":"publisher","first-page":"39","DOI":"10.1016\/j.imlet.2003.11.019","article-title":"Regulation of mast cell activation by complement-derived peptides","volume":"92","author":"Erdei","year":"2004","journal-title":"Immunol. Lett."},{"key":"2023072603323427300_bib20","doi-asserted-by":"publisher","first-page":"1559","DOI":"10.1073\/pnas.0908540107","article-title":"Leaky RyR2 trigger ventricular arrhythmias in Duchenne muscular dystrophy","volume":"107","author":"Fauconnier","year":"2010","journal-title":"Proc. Natl. Acad. Sci. USA."},{"key":"2023072603323427300_bib21","doi-asserted-by":"publisher","first-page":"1865","DOI":"10.1172\/JCI27019","article-title":"Cardioprotective c-kit+ cells are from the bone marrow and regulate the myocardial balance of angiogenic cytokines","volume":"116","author":"Fazel","year":"2006","journal-title":"J. Clin. Invest."},{"key":"2023072603323427300_bib22","doi-asserted-by":"publisher","first-page":"832","DOI":"10.1016\/j.immuni.2011.09.015","article-title":"Cre-mediated cell ablation contests mast cell contribution in models of antibody- and T cell-mediated autoimmunity","volume":"35","author":"Feyerabend","year":"2011","journal-title":"Immunity."},{"key":"2023072603323427300_bib23","doi-asserted-by":"publisher","first-page":"107","DOI":"10.1016\/S0014-5793(99)00693-6","article-title":"NMR analysis of cardiac troponin C-troponin I complexes: effects of phosphorylation","volume":"453","author":"Finley","year":"1999","journal-title":"FEBS Lett."},{"key":"2023072603323427300_bib24","doi-asserted-by":"publisher","first-page":"408","DOI":"10.1007\/s00011-006-6016-z","article-title":"Rat cardiac mast cell maturation and differentiation following acute ventricular volume overload","volume":"55","author":"Forman","year":"2006","journal-title":"Inflamm. Res."},{"key":"2023072603323427300_bib25","doi-asserted-by":"publisher","first-page":"361","DOI":"10.1016\/j.stem.2010.02.013","article-title":"Distinguishing mast cell and granulocyte differentiation at the single-cell level","volume":"6","author":"Franco","year":"2010","journal-title":"Cell Stem Cell."},{"key":"2023072603323427300_bib26","doi-asserted-by":"publisher","first-page":"687","DOI":"10.1161\/01.CIR.98.7.687","article-title":"Stem cell factor induction is associated with mast cell accumulation after canine myocardial ischemia and reperfusion","volume":"98","author":"Frangogiannis","year":"1998","journal-title":"Circulation."},{"key":"2023072603323427300_bib27","doi-asserted-by":"publisher","first-page":"183","DOI":"10.1016\/j.cmet.2015.01.005","article-title":"Altered myocardial calcium cycling and energetics in heart failure--a rational approach for disease treatment","volume":"21","author":"Gorski","year":"2015","journal-title":"Cell Metab."},{"key":"2023072603323427300_bib28","doi-asserted-by":"publisher","first-page":"835","DOI":"10.1016\/S0002-9440(10)62055-X","article-title":"Mast cell-deficient W-sash c-kit mutant Kit W-sh\/W-sh mice as a model for investigating mast cell biology in vivo","volume":"167","author":"Grimbaldeston","year":"2005","journal-title":"Am. J. Pathol."},{"key":"2023072603323427300_bib29","doi-asserted-by":"publisher","first-page":"254","DOI":"10.1016\/S0014-5793(99)00727-9","article-title":"cAPK-phosphorylation controls the interaction of the regulatory domain of cardiac myosin binding protein C with myosin-S2 in an on-off fashion","volume":"453","author":"Gruen","year":"1999","journal-title":"FEBS Lett."},{"key":"2023072603323427300_bib30","doi-asserted-by":"publisher","first-page":"355","DOI":"10.1111\/j.1365-2613.2009.00659.x","article-title":"Ischaemia\/reperfusion induced cardiac stem cell homing to the injured myocardium by stimulating stem cell factor expression via NF-\u03baB pathway","volume":"90","author":"Guo","year":"2009","journal-title":"Int. J. Exp. Pathol."},{"key":"2023072603323427300_bib31","doi-asserted-by":"crossref","first-page":"678","DOI":"10.1016\/j.cmet.2015.04.013","article-title":"Hematopoietic Kit deficiency, rather than lack of mast cells, protects mice from obesity and insulin resistance","volume":"21","author":"Gutierrez","year":"2015","journal-title":"Cell Metab."},{"key":"2023072603323427300_bib32","doi-asserted-by":"publisher","first-page":"957","DOI":"10.1182\/blood-2009-05-219923","article-title":"Adipose tissue is an extramedullary reservoir for functional hematopoietic stem and progenitor cells","volume":"115","author":"Han","year":"2010","journal-title":"Blood."},{"key":"2023072603323427300_bib33","doi-asserted-by":"publisher","first-page":"1114","DOI":"10.2174\/1381612811319060012","article-title":"Mast cell chymase and tryptase as targets for cardiovascular and metabolic diseases","volume":"19","author":"He","year":"2013","journal-title":"Curr. Pharm. Des."},{"key":"2023072603323427300_bib34","doi-asserted-by":"publisher","first-page":"1184","DOI":"10.1161\/hh2401.101908","article-title":"Power output is increased after phosphorylation of myofibrillar proteins in rat skinned cardiac myocytes","volume":"89","author":"Herron","year":"2001","journal-title":"Circ. Res."},{"key":"2023072603323427300_bib35","doi-asserted-by":"publisher","first-page":"121","DOI":"10.1007\/978-1-4939-1568-2_8","article-title":"The emerging prominence of the cardiac mast cell as a potent mediator of adverse myocardial remodeling","volume":"1220","author":"Janicki","year":"2015","journal-title":"Methods Mol. Biol."},{"key":"2023072603323427300_bib36","doi-asserted-by":"publisher","first-page":"H2845","DOI":"10.1152\/ajpheart.00209.2007","article-title":"PAR-2 activation at the time of reperfusion salvages myocardium via an ERK1\/2 pathway in in vivo rat hearts","volume":"293","author":"Jiang","year":"2007","journal-title":"Am. J. Physiol. Heart Circ. Physiol."},{"key":"2023072603323427300_bib37","doi-asserted-by":"publisher","first-page":"668","DOI":"10.1016\/j.immuni.2011.11.004","article-title":"Mast cell deficiency, a game of kit and mouse","volume":"35","author":"Katz","year":"2011","journal-title":"Immunity."},{"key":"2023072603323427300_bib38","doi-asserted-by":"publisher","first-page":"129","DOI":"10.1172\/JCI69253","article-title":"Cardiac resynchronization sensitizes the sarcomere to calcium by reactivating GSK-3\u03b2","volume":"124","author":"Kirk","year":"2014","journal-title":"J. Clin. Invest."},{"key":"2023072603323427300_bib39","doi-asserted-by":"crossref","first-page":"772","DOI":"10.4049\/jimmunol.148.3.772","article-title":"Effect of IL-3 and stem cell factor on the appearance of human basophils and mast cells from CD34+ pluripotent progenitor cells","volume":"148","author":"Kirshenbaum","year":"1992","journal-title":"J. Immunol."},{"key":"2023072603323427300_bib40","doi-asserted-by":"crossref","first-page":"447","DOI":"10.1182\/blood.V52.2.447.447","article-title":"Decrease of mast cells in W\/Wv mice and their increase by bone marrow transplantation","volume":"52","author":"Kitamura","year":"1978","journal-title":"Blood."},{"key":"2023072603323427300_bib41","doi-asserted-by":"publisher","first-page":"214","DOI":"10.1007\/s11883-009-0033-7","article-title":"Mast cells in atherogenesis: actions and reactions","volume":"11","author":"Kovanen","year":"2009","journal-title":"Curr. Atheroscler. Rep."},{"key":"2023072603323427300_bib42","doi-asserted-by":"publisher","first-page":"103","DOI":"10.1016\/j.ejphar.2015.04.050","article-title":"The impact of mast cells on cardiovascular diseases","volume":"778","author":"Kritikou","year":"2016","journal-title":"Eur. J. Pharmacol."},{"key":"2023072603323427300_bib43","doi-asserted-by":"publisher","first-page":"H857","DOI":"10.1152\/ajpheart.00841.2002","article-title":"Effect of extraction of myosin binding protein C on contractility of rat heart","volume":"285","author":"Kulikovskaya","year":"2003","journal-title":"Am. J. Physiol. Heart Circ. Physiol."},{"key":"2023072603323427300_bib44","doi-asserted-by":"publisher","first-page":"41","DOI":"10.1097\/00019501-200502000-00008","article-title":"Distinct mouse coronary anatomy and myocardial infarction consequent to ligation","volume":"16","author":"Kumar","year":"2005","journal-title":"Coron. Artery Dis."},{"key":"2023072603323427300_bib45","doi-asserted-by":"publisher","first-page":"12","DOI":"10.1016\/j.cardiores.2004.12.022","article-title":"Regulation of cardiac contractile function by troponin I phosphorylation","volume":"66","author":"Layland","year":"2005","journal-title":"Cardiovasc. Res."},{"key":"2023072603323427300_bib46","doi-asserted-by":"publisher","first-page":"1070","DOI":"10.1016\/S0006-3495(01)75764-5","article-title":"Multiple structures of thick filaments in resting cardiac muscle and their influence on cross-bridge interactions","volume":"81","author":"Levine","year":"2001","journal-title":"Biophys. J."},{"key":"2023072603323427300_bib47","doi-asserted-by":"publisher","first-page":"559","DOI":"10.1007\/s10974-004-5879-2","article-title":"Structural based insights into the role of troponin in cardiac muscle pathophysiology","volume":"25","author":"Li","year":"2004","journal-title":"J. Muscle Res. Cell Motil."},{"key":"2023072603323427300_bib48","doi-asserted-by":"publisher","first-page":"940","DOI":"10.1038\/nm.1994","article-title":"Genetic deficiency and pharmacological stabilization of mast cells reduce diet-induced obesity and diabetes in mice","volume":"15","author":"Liu","year":"2009","journal-title":"Nat. Med."},{"key":"2023072603323427300_bib49","doi-asserted-by":"publisher","first-page":"18592","DOI":"10.1074\/jbc.M310836200","article-title":"Regulated shedding of PAR1 N-terminal exodomain from endothelial cells","volume":"279","author":"Ludeman","year":"2004","journal-title":"J. Biol. Chem."},{"key":"2023072603323427300_bib50","doi-asserted-by":"publisher","first-page":"24145","DOI":"10.1074\/jbc.M802278200","article-title":"Phosphorylation of the cAMP-dependent protein kinase (PKA) regulatory subunit modulates PKA-AKAP interaction, substrate phosphorylation, and calcium signaling in cardiac cells","volume":"283","author":"Manni","year":"2008","journal-title":"J. Biol. Chem."},{"key":"2023072603323427300_bib51","doi-asserted-by":"publisher","first-page":"3461","DOI":"10.4049\/jimmunol.170.7.3461","article-title":"IL-9 enhances the growth of human mast cell progenitors under stimulation with stem cell factor","volume":"170","author":"Matsuzawa","year":"2003","journal-title":"J. Immunol."},{"key":"2023072603323427300_bib52","doi-asserted-by":"publisher","first-page":"264","DOI":"10.1161\/HYPERTENSIONAHA.111.169417","article-title":"Tryptase\/protease-activated receptor 2 interactions induce selective mitogen-activated protein kinase signaling and collagen synthesis by cardiac fibroblasts","volume":"58","author":"McLarty","year":"2011","journal-title":"Hypertension."},{"key":"2023072603323427300_bib53","doi-asserted-by":"publisher","first-page":"465","DOI":"10.1161\/hh0402.105372","article-title":"Protease-activated receptor-2 activation causes EDHF-like coronary vasodilation: selective preservation in ischemia\/reperfusion injury: involvement of lipoxygenase products, VR1 receptors, and C-fibers","volume":"90","author":"McLean","year":"2002","journal-title":"Circ. Res."},{"key":"2023072603323427300_bib54","doi-asserted-by":"publisher","first-page":"285","DOI":"10.1097\/HCO.0000000000000165","article-title":"New pharmacologic interventions to increase cardiac contractility: challenges and opportunities","volume":"30","author":"Movsesian","year":"2015","journal-title":"Curr. Opin. Cardiol."},{"key":"2023072603323427300_bib55","doi-asserted-by":"publisher","first-page":"45","DOI":"10.1007\/s12079-011-0146-y","article-title":"Tryptase activates isolated adult cardiac fibroblasts via protease activated receptor-2 (PAR-2)","volume":"6","author":"Murray","year":"2012","journal-title":"J. Cell Commun. Signal."},{"key":"2023072603323427300_bib56","doi-asserted-by":"publisher","first-page":"3678","DOI":"10.1073\/pnas.97.7.3678","article-title":"Protease-activated receptor-2 modulates myocardial ischemia-reperfusion injury in the rat heart","volume":"97","author":"Napoli","year":"2000","journal-title":"Proc. Natl. Acad. Sci. USA."},{"key":"2023072603323427300_bib57","doi-asserted-by":"publisher","first-page":"177","DOI":"10.1016\/j.yjmcc.2014.03.010","article-title":"Combined troponin I Ser-150 and Ser-23\/24 phosphorylation sustains thin filament Ca2+ sensitivity and accelerates deactivation in an acidic environment","volume":"72","author":"Nixon","year":"2014","journal-title":"J. Mol. Cell. Cardiol."},{"key":"2023072603323427300_bib58","doi-asserted-by":"publisher","first-page":"1472","DOI":"10.1038\/labinvest.2012.116","article-title":"Evidence questioning cromolyn\u2019s effectiveness and selectivity as a \u2018mast cell stabilizer\u2019 in mice","volume":"92","author":"Oka","year":"2012","journal-title":"Lab. Invest."},{"key":"2023072603323427300_bib59","doi-asserted-by":"publisher","first-page":"1023","DOI":"10.1006\/bbrc.2002.6761","article-title":"Interaction of S100 proteins with the antiallergic drugs, olopatadine, amlexanox, and cromolyn: identification of putative drug binding sites on S100A1 protein","volume":"292","author":"Okada","year":"2002","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"2023072603323427300_bib60","doi-asserted-by":"publisher","first-page":"433","DOI":"10.1042\/bj20030351","article-title":"Hsp90 is a direct target of the anti-allergic drugs disodium cromoglycate and amlexanox","volume":"374","author":"Okada","year":"2003","journal-title":"Biochem. J."},{"key":"2023072603323427300_bib61","doi-asserted-by":"publisher","first-page":"4291","DOI":"10.1182\/blood.V100.13.4291","article-title":"Stem cell factor induces eosinophil activation and degranulation: mediator release and gene array analysis","volume":"100","author":"Oliveira","year":"2002","journal-title":"Blood."},{"key":"2023072603323427300_bib62","doi-asserted-by":"publisher","first-page":"2065","DOI":"10.1002\/stem.523","article-title":"Adipose tissue as a dedicated reservoir of functional mast cell progenitors","volume":"28","author":"Poglio","year":"2010","journal-title":"Stem Cells."},{"key":"2023072603323427300_bib63","doi-asserted-by":"publisher","first-page":"4952","DOI":"10.1182\/blood-2012-01-406959","article-title":"In situ production of innate immune cells in murine white adipose tissue","volume":"120","author":"Poglio","year":"2012","journal-title":"Blood."},{"key":"2023072603323427300_bib64","doi-asserted-by":"publisher","first-page":"218","DOI":"10.3390\/ijms16010218","article-title":"Compartmentalization role of A-kinase anchoring proteins (AKAPs) in mediating protein kinase A (PKA) signaling and cardiomyocyte hypertrophy","volume":"16","author":"Rababa\u2019h","year":"2015","journal-title":"Int. J. Mol. Sci."},{"key":"2023072603323427300_bib65","doi-asserted-by":"publisher","first-page":"373","DOI":"10.1038\/nrd3024","article-title":"Teaching old receptors new tricks: biasing seven-transmembrane receptors","volume":"9","author":"Rajagopal","year":"2010","journal-title":"Nat. Rev. Drug Discov."},{"key":"2023072603323427300_bib66","doi-asserted-by":"publisher","first-page":"943","DOI":"10.1016\/j.yjmcc.2010.01.004","article-title":"Calcium sensitivity, force frequency relationship and cardiac troponin I: critical role of PKA and PKC phosphorylation sites","volume":"48","author":"Ramirez-Correa","year":"2010","journal-title":"J. Mol. Cell. Cardiol."},{"key":"2023072603323427300_bib67","doi-asserted-by":"publisher","first-page":"3744","DOI":"10.2174\/138161211798357908","article-title":"Targeting cardiac mast cells: pharmacological modulation of the local renin-angiotensin system","volume":"17","author":"Reid","year":"2011","journal-title":"Curr. Pharm. Des."},{"key":"2023072603323427300_bib68","doi-asserted-by":"publisher","first-page":"2","DOI":"10.1016\/j.ejphar.2015.07.016","article-title":"Murine and human mast cell progenitors","volume":"778","author":"Schmetzer","year":"2016","journal-title":"Eur. J. Pharmacol."},{"key":"2023072603323427300_bib69","doi-asserted-by":"publisher","first-page":"380","DOI":"10.1046\/j.0022-202x.2001.01658.x","article-title":"Agonists of proteinase-activated receptor 2 induce cytokine release and activation of nuclear transcription factor kappaB in human dermal microvascular endothelial cells","volume":"118","author":"Shpacovitch","year":"2002","journal-title":"J. Invest. Dermatol."},{"key":"2023072603323427300_bib70","doi-asserted-by":"publisher","first-page":"191","DOI":"10.1007\/978-4-431-38453-3_17","article-title":"Heart failure, ischemia\/reperfusion injury and cardiac troponin","volume":"592","author":"Solaro","year":"2007","journal-title":"Adv. Exp. Med. Biol."},{"key":"2023072603323427300_bib71","doi-asserted-by":"publisher","first-page":"102","DOI":"10.1002\/path.1690","article-title":"Mast cell tryptase may modulate endothelial cell phenotype in healing myocardial infarcts","volume":"205","author":"Somasundaram","year":"2005","journal-title":"J. Pathol."},{"key":"2023072603323427300_bib72","doi-asserted-by":"publisher","first-page":"e66743","DOI":"10.1371\/journal.pone.0066743","article-title":"Distinctive G protein-dependent signaling by protease-activated receptor 2 (PAR2) in smooth muscle: Feedback inhibition of RhoA by cAMP-independent PKA","volume":"8","author":"Sriwai","year":"2013","journal-title":"PLoS One."},{"key":"2023072603323427300_bib73","doi-asserted-by":"publisher","first-page":"503","DOI":"10.1161\/CIRCRESAHA.107.153650","article-title":"Differential roles of cardiac myosin-binding protein C and cardiac troponin I in the myofibrillar force responses to protein kinase A phosphorylation","volume":"101","author":"Stelzer","year":"2007","journal-title":"Circ. Res."},{"key":"2023072603323427300_bib74","doi-asserted-by":"publisher","first-page":"530","DOI":"10.1074\/jbc.M110.148684","article-title":"Cardiac troponin T, a sarcomeric AKAP, tethers protein kinase A at the myofilaments","volume":"286","author":"Sumandea","year":"2011","journal-title":"J. Biol. Chem."},{"key":"2023072603323427300_bib75","doi-asserted-by":"publisher","first-page":"588","DOI":"10.1038\/nsb0803-588","article-title":"Pulling the calcium trigger","volume":"10","author":"Sykes","year":"2003","journal-title":"Nat. Struct. Biol."},{"key":"2023072603323427300_bib76","doi-asserted-by":"publisher","first-page":"1808","DOI":"10.1073\/pnas.0808920106","article-title":"c-kit expression identifies cardiovascular precursors in the neonatal heart","volume":"106","author":"Tallini","year":"2009","journal-title":"Proc. Natl. Acad. Sci. USA."},{"key":"2023072603323427300_bib77","doi-asserted-by":"publisher","first-page":"66","DOI":"10.1016\/j.jim.2013.11.020","article-title":"Characterization and validation of new tools for measuring site-specific cardiac troponin I phosphorylation","volume":"403","author":"Thoemmes","year":"2014","journal-title":"J. Immunol. Methods."},{"key":"2023072603323427300_bib78","doi-asserted-by":"publisher","first-page":"1686","DOI":"10.1016\/j.athoracsur.2013.06.063","article-title":"Injectable small intestine submucosal extracellular matrix in an acute myocardial infarction model","volume":"96","author":"Toeg","year":"2013","journal-title":"Ann. Thorac. Surg."},{"key":"2023072603323427300_bib79","doi-asserted-by":"publisher","first-page":"195","DOI":"10.1038\/nrendo.2010.20","article-title":"Transplantation of adipose tissue and stem cells: role in metabolism and disease","volume":"6","author":"Tran","year":"2010","journal-title":"Nat. Rev. Endocrinol."},{"key":"2023072603323427300_bib80","doi-asserted-by":"publisher","first-page":"21536","DOI":"10.1074\/jbc.271.35.21536","article-title":"The cloned thrombin receptor is necessary and sufficient for activation of mitogen-activated protein kinase and mitogenesis in mouse lung fibroblasts. Loss of responses in fibroblasts from receptor knockout mice","volume":"271","author":"Trejo","year":"1996","journal-title":"J. Biol. Chem."},{"key":"2023072603323427300_bib81","doi-asserted-by":"publisher","first-page":"10324","DOI":"10.1021\/bi034495r","article-title":"A cross-linking study of the N-terminal extension of human cardiac troponin I","volume":"42","author":"Ward","year":"2003","journal-title":"Biochemistry."},{"key":"2023072603323427300_bib82","doi-asserted-by":"publisher","first-page":"249","DOI":"10.1016\/j.tcm.2014.06.004","article-title":"Role of protease-activated receptors for the innate immune response of the heart","volume":"24","author":"Weithauser","year":"2014","journal-title":"Trends Cardiovasc. Med."},{"key":"2023072603323427300_bib83","doi-asserted-by":"publisher","first-page":"44","DOI":"10.1046\/j.1523-1747.2000.00827.x","article-title":"Mast cell and myeloid marker expression during early in vitro mast cell differentiation from human peripheral blood mononuclear cells","volume":"114","author":"Welker","year":"2000","journal-title":"J. Invest. Dermatol."},{"key":"2023072603323427300_bib84","doi-asserted-by":"publisher","first-page":"478","DOI":"10.1038\/nri3690","article-title":"Mast cell secretory granules: armed for battle","volume":"14","author":"Wernersson","year":"2014","journal-title":"Nat. Rev. Immunol."},{"key":"2023072603323427300_bib85","doi-asserted-by":"publisher","first-page":"570","DOI":"10.1016\/S0140-6736(08)61237-4","article-title":"Acute myocardial infarction","volume":"372","author":"White","year":"2008","journal-title":"Lancet."},{"key":"2023072603323427300_bib86","doi-asserted-by":"publisher","first-page":"502","DOI":"10.1136\/postgradmedj-2012-302976rep","article-title":"Republished: clinical implications of the third universal definition of myocardial infarction","volume":"90","author":"White","year":"2014","journal-title":"Postgrad. Med. J."},{"key":"2023072603323427300_bib87","doi-asserted-by":"publisher","first-page":"222","DOI":"10.1111\/j.1398-9995.1991.tb00575.x","article-title":"Identification of mast cells in bronchoalveolar lavage fluid. Comparison between different fixation and staining methods","volume":"46","author":"Xaubet","year":"1991","journal-title":"Allergy."},{"key":"2023072603323427300_bib88","doi-asserted-by":"publisher","first-page":"3486","DOI":"10.1016\/j.ijcard.2013.04.165","article-title":"Cardiomyocyte-specific overexpression of human stem cell factor protects against myocardial ischemia and reperfusion injury","volume":"168","author":"Xiang","year":"2013","journal-title":"Int. J. Cardiol."},{"key":"2023072603323427300_bib89","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1159\/000314164","article-title":"G-protein-coupled receptor 35 is a target of the asthma drugs cromolyn disodium and nedocromil sodium","volume":"86","author":"Yang","year":"2010","journal-title":"Pharmacology."},{"key":"2023072603323427300_bib90","doi-asserted-by":"publisher","first-page":"158","DOI":"10.1016\/j.ejphar.2015.05.071","article-title":"Mast cell stabilisers","volume":"778","author":"Zhang","year":"2016","journal-title":"Eur. J. Pharmacol."},{"key":"2023072603323427300_bib91","doi-asserted-by":"publisher","first-page":"R1681","DOI":"10.1152\/ajpregu.90746.2008","article-title":"Protease-activated receptor 2-mediated protection of myocardial ischemia-reperfusion injury: role of transient receptor potential vanilloid receptors","volume":"297","author":"Zhong","year":"2009","journal-title":"Am. J. Physiol. Regul. Integr. Comp. Physiol."},{"key":"2023072603323427300_bib92","doi-asserted-by":"publisher","first-page":"1273","DOI":"10.1038\/nm.3284","article-title":"B lymphocytes trigger monocyte mobilization and impair heart function after acute myocardial infarction","volume":"19","author":"Zouggari","year":"2013","journal-title":"Nat. Med."}],"container-title":["Journal of Experimental Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/rupress.org\/jem\/article-pdf\/213\/7\/1353\/1756024\/jem_20160081.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/rupress.org\/jem\/article-pdf\/213\/7\/1353\/1756024\/jem_20160081.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,7,25]],"date-time":"2023-07-25T23:33:15Z","timestamp":1690327995000},"score":1,"resource":{"primary":{"URL":"https:\/\/rupress.org\/jem\/article\/213\/7\/1353\/42180\/Mast-cells-regulate-myofilament-calcium"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,6,27]]},"references-count":92,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2016,6,27]]}},"URL":"https:\/\/doi.org\/10.1084\/jem.20160081","relation":{},"ISSN":["0022-1007","1540-9538"],"issn-type":[{"value":"0022-1007","type":"print"},{"value":"1540-9538","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,6,27]]}}}