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Using longitudinal intravital multiphoton microscopy of DCGFP\/MCRFP reporter mice, we herein provide in vivo evidence that migratory DCs execute targeted cell-to-cell interactions with stationary MCs before leaving the inflamed skin to draining lymph nodes. During initial stages of skin inflammation, DCs dynamically scan MCs, whereas at a later stage, long-lasting interactions predominate. These innate-to-innate synapse-like contacts ultimately culminate in DC-to-MC molecule transfers including major histocompatibility complex class II (MHCII) proteins enabling subsequent ex vivo priming of allogeneic T cells with a specific cytokine signature. The extent of MHCII transfer to MCs correlates with their T cell priming efficiency. Importantly, preventing the cross talk by preceding DC depletion decreases MC antigen presenting capacity and T cell\u2013driven inflammation. Consequently, we identify an innate intercellular communication arming resident MCs with key DC functions that might contribute to the acute defense potential during critical periods of migration-based DC absence.<\/jats:p>","DOI":"10.1084\/jem.20160783","type":"journal-article","created":{"date-parts":[[2017,10,30]],"date-time":"2017-10-30T10:00:08Z","timestamp":1509357608000},"page":"3791-3811","update-policy":"https:\/\/doi.org\/10.1084\/jem.crossmarkpolicy","source":"Crossref","is-referenced-by-count":69,"title":["Mast cells acquire MHCII from dendritic cells during skin inflammation"],"prefix":"10.1084","volume":"214","author":[{"given":"Jan","family":"Dudeck","sequence":"first","affiliation":[{"name":"Institute for Molecular and Clinical Immunology, Medical Faculty, Otto-von-Guericke University Magdeburg, Magdeburg, Germany 1"},{"name":"Institute for Immunology, Medical Faculty Carl-Gustav Carus, Technische Universit\u00e4t Dresden, Dresden, Germany 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