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However, the neuronal function of VRK3 is still unknown despite its etiological potential in human autism spectrum disorder (ASD). Here, we report that VRK3-deficient mice exhibit typical symptoms of autism-like behavior, including hyperactivity, stereotyped behaviors, reduced social interaction, and impaired context-dependent spatial memory. A significant decrease in dendritic spine number and arborization were identified in the hippocampus CA1 of VRK3-deficient mice. These mice also exhibited a reduced rectification of AMPA receptor\u2013mediated current and changes in expression of synaptic and signaling proteins, including tyrosine receptor kinase B (TrkB), Arc, and CaMKII\u03b1. Notably, TrkB stimulation with 7,8-dihydroxyflavone reversed the altered synaptic structure and function and successfully restored autism-like behavior in VRK3-deficient mice. These results reveal that VRK3 plays a critical role in neurodevelopmental disorders and suggest a potential therapeutic strategy for ASD.<\/jats:p>","DOI":"10.1084\/jem.20160974","type":"journal-article","created":{"date-parts":[[2017,9,12]],"date-time":"2017-09-12T14:10:17Z","timestamp":1505225417000},"page":"2947-2966","update-policy":"https:\/\/doi.org\/10.1084\/jem.crossmarkpolicy","source":"Crossref","is-referenced-by-count":31,"title":["Autism-like behavior caused by deletion of vaccinia-related kinase 3 is improved by TrkB stimulation"],"prefix":"10.1084","volume":"214","author":[{"given":"Myung-Su","family":"Kang","sequence":"first","affiliation":[{"name":"Department of Life Sciences, Pohang University of Science and Technology, Pohang, Republic of Korea 1"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4439-6222","authenticated-orcid":true,"given":"Tae-Yong","family":"Choi","sequence":"additional","affiliation":[{"name":"Department of Physiology, Dental Research Institute, Seoul National University School of Dentistry, Seoul, Republic of Korea 3"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5901-1316","authenticated-orcid":true,"given":"Hye Guk","family":"Ryu","sequence":"additional","affiliation":[{"name":"Department of Life Sciences, Pohang University of Science and Technology, Pohang, Republic of Korea 1"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dohyun","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Life Sciences, Pohang University of Science and Technology, Pohang, Republic of Korea 1"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seung-Hyun","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Physiology, Dental Research Institute, Seoul National University School of Dentistry, Seoul, Republic of Korea 3"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7534-5167","authenticated-orcid":true,"given":"Se-Young","family":"Choi","sequence":"additional","affiliation":[{"name":"Department of Physiology, Dental Research Institute, Seoul National University School of Dentistry, Seoul, Republic of Korea 3"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7292-2627","authenticated-orcid":true,"given":"Kyong-Tai","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Life Sciences, Pohang University of Science and Technology, Pohang, Republic of Korea 1"},{"name":"Division of Integrative Biosciences and Biotechnology, Pohang University of Science and Technology, Pohang, Republic of Korea 2"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"291","published-online":{"date-parts":[[2017,9,12]]},"reference":[{"key":"2023072603381553400_bib1","doi-asserted-by":"publisher","first-page":"461","DOI":"10.1016\/j.conb.2011.12.006","article-title":"Regulation of AMPA receptor trafficking and synaptic plasticity","volume":"22","author":"Anggono","year":"2012","journal-title":"Curr. 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