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Investigation of conventional CD4+ T cells (Th17 cells) has yielded invaluable insights into IL-17 function and its regulation. More recently, we and others reported production of IL-17 from innate \u03b1\u03b2+ T cell populations, which was shown to occur primarily via IL-23R signaling through the transcription factor STAT-3. In our current study, we identify promyelocytic leukemia zinc finger (PLZF)\u2013expressing iNKT, CD4\u2212\/CD8+, and CD4\u2212\/CD8\u2212 (DN) \u03b1\u03b2+T cells, which produce IL-17 in response to TCR and IL-1 receptor ligation independently of STAT-3 signaling. Notably, this noncanonical pathway of IL-17 production may be important in mucosal defense and is by itself sufficient to control pathogenic Staphylococcus aureus infection at the ocular surface.<\/jats:p>","DOI":"10.1084\/jem.20170369","type":"journal-article","created":{"date-parts":[[2018,2,28]],"date-time":"2018-02-28T09:10:07Z","timestamp":1519809007000},"page":"1079-1090","update-policy":"https:\/\/doi.org\/10.1084\/jem.crossmarkpolicy","source":"Crossref","is-referenced-by-count":28,"title":["STAT-3\u2013independent production of IL-17 by mouse innate-like \u03b1\u03b2 T cells controls ocular infection"],"prefix":"10.1084","volume":"215","author":[{"given":"Anthony J.","family":"St. Leger","sequence":"first","affiliation":[{"name":"Laboratory of Immunology, National Eye Institute, National Institutes of Health, Bethesda, MD 1"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1192-9435","authenticated-orcid":true,"given":"Anna M.","family":"Hansen","sequence":"additional","affiliation":[{"name":"Laboratory of Immunology, National Eye Institute, National Institutes of Health, Bethesda, MD 1"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hatice","family":"Karauzum","sequence":"additional","affiliation":[{"name":"Laboratory of Clinical Infectious Diseases, National Institutes of Health, Bethesda, MD 2"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Reiko","family":"Horai","sequence":"additional","affiliation":[{"name":"Laboratory of Immunology, National Eye Institute, National Institutes of Health, Bethesda, MD 1"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cheng-Rong","family":"Yu","sequence":"additional","affiliation":[{"name":"Laboratory of Immunology, National Eye Institute, National Institutes of Health, Bethesda, MD 1"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arian","family":"Laurence","sequence":"additional","affiliation":[{"name":"Molecular Immunology and Inflammation Branch, National Institute of Arthritis, Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, MD 3"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katrin D.","family":"Mayer-Barber","sequence":"additional","affiliation":[{"name":"Laboratory of Clinical Immunology and Microbiology, Inflammation and Innate Immunity, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 4"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Phyllis","family":"Silver","sequence":"additional","affiliation":[{"name":"Laboratory of Immunology, National Eye Institute, National Institutes of Health, Bethesda, MD 1"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rafael","family":"Villasmil","sequence":"additional","affiliation":[{"name":"Laboratory of Immunology, National Eye Institute, National Institutes of Health, Bethesda, MD 1"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Charles","family":"Egwuagu","sequence":"additional","affiliation":[{"name":"Laboratory of Immunology, National Eye Institute, National Institutes of Health, Bethesda, MD 1"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sandip K.","family":"Datta","sequence":"additional","affiliation":[{"name":"Laboratory of Clinical Infectious Diseases, National Institutes of Health, Bethesda, MD 2"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7140-7671","authenticated-orcid":true,"given":"Rachel R.","family":"Caspi","sequence":"additional","affiliation":[{"name":"Laboratory of Immunology, National Eye Institute, National Institutes of Health, Bethesda, MD 1"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"291","published-online":{"date-parts":[[2018,2,28]]},"reference":[{"key":"2023072604293906200_bib1","doi-asserted-by":"publisher","first-page":"626","DOI":"10.1016\/j.jaci.2014.11.001","article-title":"The 3 major types of innate and adaptive cell-mediated effector immunity","volume":"135","author":"Annunziato","year":"2015","journal-title":"J. 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