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Although it is appreciated that distinct functional and phenotypic CD8+ T cell subsets persist, it is unclear whether there is plasticity among subsets and what mechanisms maintain subset-specific differences. Here, we show that continued Id2 regulation of E-protein activity is required to maintain the KLRG1hi CD8+ T cell population after lymphocytic choriomeningitis virus infection. Induced deletion of Id2 phenotypically and transcriptionally transformed the KLRG1hi \u201cterminal\u201d effector\/effector-memory CD8+ T cell population into a KLRG1lo memory-like population, promoting a gene-expression program that resembled that of central memory T cells. Our results question the idea that KLRG1hi CD8+ T cells are necessarily terminally programmed and suggest that sustained regulation is required to maintain distinct CD8+ T cell states.<\/jats:p>","DOI":"10.1084\/jem.20171584","type":"journal-article","created":{"date-parts":[[2018,2,12]],"date-time":"2018-02-12T10:07:27Z","timestamp":1518430047000},"page":"773-783","update-policy":"https:\/\/doi.org\/10.1084\/jem.crossmarkpolicy","source":"Crossref","is-referenced-by-count":90,"title":["Sustained Id2 regulation of E proteins is required for terminal differentiation of effector CD8+ T cells"],"prefix":"10.1084","volume":"215","author":[{"given":"Kyla D.","family":"Omilusik","sequence":"first","affiliation":[{"name":"Department of Biological Sciences, University of California, San Diego, La Jolla, CA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6632-8381","authenticated-orcid":true,"given":"Marija S.","family":"Nadjsombati","sequence":"additional","affiliation":[{"name":"Department of Biological Sciences, University of California, San Diego, La Jolla, CA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura A.","family":"Shaw","sequence":"additional","affiliation":[{"name":"Department of Biological Sciences, University of California, San Diego, La Jolla, CA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5550-6701","authenticated-orcid":true,"given":"Bingfei","family":"Yu","sequence":"additional","affiliation":[{"name":"Department of Biological Sciences, University of California, San Diego, La Jolla, CA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J. 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