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The relative strength of phosphoinositide 3-kinase (PI3K) signaling early in the T cell response can dramatically influence downstream effector and memory T cell differentiation. We show that initial PI3K signaling during T cell activation results in up-regulation of the signaling scaffold B cell adaptor for PI3K (BCAP), which further potentiates PI3K signaling and promotes the accumulation of CD8+ T cells with a terminally differentiated effector phenotype. Accordingly, BCAP-deficient CD8+ T cells have attenuated clonal expansion and altered effector and memory T cell development following infection with Listeria monocytogenes. Thus, induction of BCAP serves as a positive feedback circuit to enhance PI3K signaling in activated CD8+ T cells, thereby acting as a molecular checkpoint regulating effector and memory T cell development.<\/jats:p>","DOI":"10.1084\/jem.20171820","type":"journal-article","created":{"date-parts":[[2018,8,9]],"date-time":"2018-08-09T09:25:23Z","timestamp":1533806723000},"page":"2429-2443","update-policy":"https:\/\/doi.org\/10.1084\/jem.crossmarkpolicy","source":"Crossref","is-referenced-by-count":38,"title":["B cell adaptor for PI3-kinase (BCAP) modulates CD8+ effector and memory T cell differentiation"],"prefix":"10.1084","volume":"215","author":[{"given":"Mark D.","family":"Singh","sequence":"first","affiliation":[{"name":"Immunology Program, Benaroya Research Institute, Seattle, WA 1"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Minjian","family":"Ni","sequence":"additional","affiliation":[{"name":"Immunology Program, Benaroya Research Institute, Seattle, WA 1"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5265-6082","authenticated-orcid":true,"given":"Jenna M.","family":"Sullivan","sequence":"additional","affiliation":[{"name":"Immunology Program, Benaroya Research Institute, Seattle, WA 1"},{"name":"Department of Immunology, University of Washington School of Medicine, Seattle, WA 2"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jessica A.","family":"Hamerman","sequence":"additional","affiliation":[{"name":"Immunology Program, Benaroya Research Institute, Seattle, WA 1"},{"name":"Department of Immunology, University of Washington School of Medicine, Seattle, WA 2"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9652-7178","authenticated-orcid":true,"given":"Daniel J.","family":"Campbell","sequence":"additional","affiliation":[{"name":"Immunology Program, Benaroya Research Institute, Seattle, WA 1"},{"name":"Department of Immunology, University of Washington School of Medicine, Seattle, WA 2"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"291","published-online":{"date-parts":[[2018,8,9]]},"reference":[{"key":"2023072604275286300_bib1","doi-asserted-by":"publisher","first-page":"555","DOI":"10.1093\/intimm\/dxf022","article-title":"A co-stimulatory molecule on activated T cells, H4\/ICOS, delivers specific signals in T(h) cells and regulates their responses","volume":"14","author":"Arimura","year":"2002","journal-title":"Int. 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