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The mechanisms regulating ILC2, however, are not fully understood. Here, we found that ICAM-1 is required for the development and function of ILC2. ICAM-1\u2013deficient (ICAM-1\u2212\/\u2212) mice displayed significantly lower levels of ILC2s in the bone marrow and peripheral tissues than wild-type controls. CLP transfer and in vitro culture assays revealed that the regulation of ILC2 by ICAM-1 is cell intrinsic. Furthermore, ILC2s from ICAM-1\u2212\/\u2212 mice were functionally impaired, as indicated by the diminished production of type-2 cytokines in response to IL-33 challenge. The reduction in lung ILC2s caused a clear remission of airway inflammation in ICAM-1\u2212\/\u2212 mice after administration of papain or Alternaria alternata. We further demonstrate that ILC2 defects caused by ICAM-1 deficiency are due to ERK signaling-dependent down-regulation of GATA3 protein. Collectively, these observations identify ICAM-1 as a novel regulator of ILC2.<\/jats:p>","DOI":"10.1084\/jem.20172359","type":"journal-article","created":{"date-parts":[[2018,7,26]],"date-time":"2018-07-26T09:54:42Z","timestamp":1532598882000},"page":"2157-2174","update-policy":"https:\/\/doi.org\/10.1084\/jem.crossmarkpolicy","source":"Crossref","is-referenced-by-count":71,"title":["ICAM-1 controls development and function of ILC2"],"prefix":"10.1084","volume":"215","author":[{"given":"Ai-Hua","family":"Lei","sequence":"first","affiliation":[{"name":"Joint Program in Immunology, Department of Internal Medicine, Affiliated Guangzhou Women and Children's Medical Center, Zhongshan School of Medicine, Sun Yat-sen University, Guangzhou, China 1"},{"name":"Institute of Human Virology, Zhongshan School of Medicine, Sun Yat-sen University, Guangzhou, China 2"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qiang","family":"Xiao","sequence":"additional","affiliation":[{"name":"Joint Program in Immunology, Department of Internal Medicine, Affiliated Guangzhou Women and Children's Medical Center, Zhongshan School of Medicine, Sun Yat-sen University, Guangzhou, China 1"},{"name":"Institute of Human Virology, Zhongshan School of Medicine, Sun Yat-sen University, Guangzhou, China 2"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gao-Yu","family":"Liu","sequence":"additional","affiliation":[{"name":"Institute of Human Virology, Zhongshan School of Medicine, Sun Yat-sen University, Guangzhou, China 2"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kun","family":"Shi","sequence":"additional","affiliation":[{"name":"Department of Gynecology, Guangzhou Women and Children\u2019s Medical Center, Guangzhou, China 3"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qiong","family":"Yang","sequence":"additional","affiliation":[{"name":"Institute of Human Virology, Zhongshan School of Medicine, Sun Yat-sen University, Guangzhou, China 2"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xing","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Medical Oncology and Guangdong Key Laboratory of Liver Disease, the Third Affiliated Hospital of Sun Yat-sen University, Guangzhou, China 4"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu-Feng","family":"Liu","sequence":"additional","affiliation":[{"name":"Institute of Human Virology, Zhongshan School of Medicine, Sun Yat-sen University, Guangzhou, China 2"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hai-Kun","family":"Wang","sequence":"additional","affiliation":[{"name":"CAS Key Laboratory of Molecular Virology and Immunology, Institut Pasteur of Shanghai, Chinese Academy of Sciences, Shanghai, China 5"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei-Ping","family":"Cai","sequence":"additional","affiliation":[{"name":"Guangzhou No.8 Hospital, Guangzhou, China 6"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu-Juan","family":"Guan","sequence":"additional","affiliation":[{"name":"Guangzhou No.8 Hospital, Guangzhou, China 6"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9913-6407","authenticated-orcid":true,"given":"Dmitry I.","family":"Gabrilovich","sequence":"additional","affiliation":[{"name":"Institute of Human Virology, Zhongshan School of Medicine, Sun Yat-sen University, Guangzhou, China 2"},{"name":"The Wistar Institute, Philadelphia, PA 7"},{"name":"Key Laboratory of Tropical Disease Control, Chinese Ministry of Education, Sun Yat-sen University, Guangzhou, China 8"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5964-1599","authenticated-orcid":true,"given":"Jie","family":"Zhou","sequence":"additional","affiliation":[{"name":"Joint Program in Immunology, Department of Internal Medicine, Affiliated Guangzhou Women and Children's Medical Center, Zhongshan School of Medicine, Sun Yat-sen University, Guangzhou, China 1"},{"name":"Institute of Human Virology, Zhongshan School of Medicine, Sun Yat-sen University, Guangzhou, China 2"},{"name":"Key Laboratory of Tropical Disease Control, Chinese Ministry of Education, Sun Yat-sen University, Guangzhou, China 8"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"291","published-online":{"date-parts":[[2018,7,26]]},"reference":[{"key":"2025062415012058600_bib1","doi-asserted-by":"publisher","first-page":"1153","DOI":"10.1084\/jem.20151646","article-title":"G9a regulates group 2 innate lymphoid cell development by repressing the group 3 innate lymphoid cell program","volume":"213","author":"Antignano","year":"2016","journal-title":"J. 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