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While lymphatic vessels facilitate T cell priming, they also exert immune suppressive effects in lymph nodes at steady-state. Therefore, we hypothesized that peripheral lymphatic vessels acquire suppressive mechanisms to limit local effector CD8+ T cell accumulation in murine skin. We demonstrate that nonhematopoietic PD-L1 is largely expressed by lymphatic and blood endothelial cells and limits CD8+ T cell accumulation in tumor microenvironments. IFN\u03b3 produced by tissue-infiltrating, antigen-specific CD8+ T cells, which are in close proximity to tumor-associated lymphatic vessels, is sufficient to induce lymphatic vessel PD-L1 expression. Disruption of IFN\u03b3-dependent crosstalk through lymphatic-specific loss of IFN\u03b3R boosts T cell accumulation in infected and malignant skin leading to increased viral pathology and tumor control, respectively. Consequently, we identify IFN\u03b3R as an immunological switch in lymphatic vessels that balances protective immunity and immunopathology leading to adaptive immune resistance in melanoma.<\/jats:p>","DOI":"10.1084\/jem.20180654","type":"journal-article","created":{"date-parts":[[2018,10,31]],"date-time":"2018-10-31T09:45:13Z","timestamp":1540979113000},"page":"3057-3074","update-policy":"https:\/\/doi.org\/10.1084\/jem.crossmarkpolicy","source":"Crossref","is-referenced-by-count":167,"title":["IFN\u03b3-activated dermal lymphatic vessels inhibit cytotoxic T cells in melanoma and inflamed skin"],"prefix":"10.1084","volume":"215","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6788-3560","authenticated-orcid":true,"given":"Ryan S.","family":"Lane","sequence":"first","affiliation":[{"name":"Department of Cell, Developmental and Cancer Biology, Oregon Health and Science University, Portland, OR 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