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Cnbp-deficient macrophages induced canonical NF-\u03baB\/Rel signaling normally but were impaired in their ability to control the activation of c-Rel, a key driver of IL-12\u03b2 gene transcription. The nuclear translocation and DNA-binding activity of c-Rel required CNBP. Lastly, Cnbp-deficient mice were more susceptible to acute toxoplasmosis associated with reduced production of IL-12\u03b2, as well as a reduced T helper type 1 (Th1) cell IFN-\u03b3 response essential to controlling parasite replication. Collectively, these findings identify CNBP as important regulator of c-Rel\u2013dependent IL-12\u03b2 gene transcription and Th1 immunity.<\/jats:p>","DOI":"10.1084\/jem.20181031","type":"journal-article","created":{"date-parts":[[2018,11,15]],"date-time":"2018-11-15T14:31:14Z","timestamp":1542292274000},"page":"3136-3150","update-policy":"https:\/\/doi.org\/10.1084\/jem.crossmarkpolicy","source":"Crossref","is-referenced-by-count":45,"title":["CNBP controls IL-12 gene transcription and Th1 immunity"],"prefix":"10.1084","volume":"215","author":[{"given":"Yongzhi","family":"Chen","sequence":"first","affiliation":[{"name":"Program in Innate Immunity, Department of Medicine, University of Massachusetts Medical School, Worcester, MA 1"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shruti","family":"Sharma","sequence":"additional","affiliation":[{"name":"Program in Innate Immunity, Department of Medicine, University of Massachusetts Medical School, Worcester, MA 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