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Chronic high-fat diet (HFD) results in the accumulation of a monocyte-derived CD11c+CD64+ double-positive (DP) macrophage eWAT population with a predominant anti-inflammatory\/detoxifying gene profile, but reduced endocytic function. In contrast, fasting rapidly and reversibly leads to VAM depletion, while acute inflammatory stress induced by pathogens transiently depletes VAMs and simultaneously boosts DP macrophage accumulation. Our results indicate that ATM populations dynamically adapt to metabolic stress and inflammation, suggesting an important role for these cells in maintaining tissue homeostasis.<\/jats:p>","DOI":"10.1084\/jem.20181049","type":"journal-article","created":{"date-parts":[[2019,3,12]],"date-time":"2019-03-12T14:55:12Z","timestamp":1552402512000},"page":"786-806","update-policy":"https:\/\/doi.org\/10.1084\/jem.crossmarkpolicy","source":"Crossref","is-referenced-by-count":161,"title":["Vasculature-associated fat macrophages readily adapt to inflammatory and metabolic challenges"],"prefix":"10.1084","volume":"216","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8338-8626","authenticated-orcid":true,"given":"Hernandez Moura","family":"Silva","sequence":"first","affiliation":[{"name":"Kimmel Center for Biology and Medicine at the Skirball Institute, New York University School of Medicine, New York, NY 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