{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,27]],"date-time":"2026-10-27T13:37:58Z","timestamp":1793108278203,"version":"4.5.0"},"reference-count":61,"publisher":"Rockefeller University Press","issue":"11","license":[{"start":{"date-parts":[[2018,10,3]],"date-time":"2018-10-03T00:00:00Z","timestamp":1538524800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/www.rupress.org\/terms\/"},{"start":{"date-parts":[[2019,5,6]],"date-time":"2019-05-06T00:00:00Z","timestamp":1557100800000},"content-version":"vor","delay-in-days":215,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-sa\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","award":["CRC914-B08"],"award-info":[{"award-number":["CRC914-B08"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","award":["CRC1123-B04"],"award-info":[{"award-number":["CRC1123-B04"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100014440","name":"MCIU","doi-asserted-by":"crossref","award":["SAF2012-31142"],"award-info":[{"award-number":["SAF2012-31142"]}],"id":[{"id":"10.13039\/100014440","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100012818","name":"Comunidad de Madrid","doi-asserted-by":"publisher","award":["S2010\/BMD-2314"],"award-info":[{"award-number":["S2010\/BMD-2314"]}],"id":[{"id":"10.13039\/100012818","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100012818","name":"Comunidad de Madrid","doi-asserted-by":"publisher","award":["SAF2013-49662-EXP"],"award-info":[{"award-number":["SAF2013-49662-EXP"]}],"id":[{"id":"10.13039\/100012818","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100014440","name":"MCIU","doi-asserted-by":"crossref","award":["2010-032828"],"award-info":[{"award-number":["2010-032828"]}],"id":[{"id":"10.13039\/100014440","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100014440","name":"MCIU","doi-asserted-by":"crossref","award":["SVP-2014-068595"],"award-info":[{"award-number":["SVP-2014-068595"]}],"id":[{"id":"10.13039\/100014440","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100014440","name":"MCIU","doi-asserted-by":"crossref","award":["BES-2013\u2013065550"],"award-info":[{"award-number":["BES-2013\u2013065550"]}],"id":[{"id":"10.13039\/100014440","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100014440","name":"MCIU","doi-asserted-by":"crossref","award":["JCI-2012-14147"],"award-info":[{"award-number":["JCI-2012-14147"]}],"id":[{"id":"10.13039\/100014440","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100014440","name":"MCIU","doi-asserted-by":"crossref","award":["JCI-2012-12659"],"award-info":[{"award-number":["JCI-2012-12659"]}],"id":[{"id":"10.13039\/100014440","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100014440","name":"MCIU","doi-asserted-by":"crossref","award":["MSCA-IF-EF-748381"],"award-info":[{"award-number":["MSCA-IF-EF-748381"]}],"id":[{"id":"10.13039\/100014440","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100000024","name":"Canadian Institutes of Health Research","doi-asserted-by":"publisher","award":["CIHR 388337"],"award-info":[{"award-number":["CIHR 388337"]}],"id":[{"id":"10.13039\/501100000024","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005884","name":"CNIC","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100005884","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100014440","name":"MCIU","doi-asserted-by":"crossref","award":["SEV-2015-0505"],"award-info":[{"award-number":["SEV-2015-0505"]}],"id":[{"id":"10.13039\/100014440","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100001348","name":"A*STAR","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001348","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100010663","name":"H2020 Program from the EU","doi-asserted-by":"publisher","award":["MSCA-IF-EF-74838"],"award-info":[{"award-number":["MSCA-IF-EF-74838"]}],"id":[{"id":"10.13039\/100010663","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["rupress.org"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2018,11,5]]},"abstract":"<jats:p>Immune protection relies on the capacity of neutrophils to infiltrate challenged tissues. Naive tissues, in contrast, are believed to remain free of these cells and protected from their toxic cargo. Here, we show that neutrophils are endowed with the capacity to infiltrate multiple tissues in the steady-state, a process that follows tissue-specific dynamics. By focusing in two particular tissues, the intestine and the lungs, we find that neutrophils infiltrating the intestine are engulfed by resident macrophages, resulting in repression of Il23 transcription, reduced G-CSF in plasma, and reinforced activity of distant bone marrow niches. In contrast, diurnal accumulation of neutrophils within the pulmonary vasculature influenced circadian transcription in the lungs. Neutrophil-influenced transcripts in this organ were associated with carcinogenesis and migration. Consistently, we found that neutrophils dictated the diurnal patterns of lung invasion by melanoma cells. Homeostatic infiltration of tissues unveils a facet of neutrophil biology that supports organ function, but can also instigate pathological states.<\/jats:p>","DOI":"10.1084\/jem.20181468","type":"journal-article","created":{"date-parts":[[2018,10,3]],"date-time":"2018-10-03T09:56:08Z","timestamp":1538560568000},"page":"2778-2795","update-policy":"https:\/\/doi.org\/10.1084\/jem.crossmarkpolicy","source":"Crossref","is-referenced-by-count":319,"title":["Neutrophils instruct homeostatic and pathological states in naive tissues"],"prefix":"10.1084","volume":"215","author":[{"given":"Maria","family":"Casanova-Acebes","sequence":"first","affiliation":[{"name":"Area of Developmental and Cell Biology, Centro Nacional de Investigaciones Cardiovasculares Carlos III (CNIC), Madrid, Spain 1"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jos\u00e9 A.","family":"Nicol\u00e1s-\u00c1vila","sequence":"additional","affiliation":[{"name":"Area of Developmental and Cell Biology, Centro Nacional de Investigaciones Cardiovasculares Carlos III (CNIC), Madrid, Spain 1"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5197-193X","authenticated-orcid":true,"given":"Jackson LiangYao","family":"Li","sequence":"additional","affiliation":[{"name":"Area of Developmental and Cell Biology, Centro Nacional de Investigaciones Cardiovasculares Carlos III (CNIC), Madrid, Spain 1"},{"name":"Singapore Immunology Nework (SIgN), A*STAR, Biopolis, Singapore 2"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1065-0245","authenticated-orcid":true,"given":"Susana","family":"Garc\u00eda-Silva","sequence":"additional","affiliation":[{"name":"Department of Molecular Oncology, Spanish National Cancer Research Center (CNIO), Madrid, Spain 3"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2168-0063","authenticated-orcid":true,"given":"Akhila","family":"Balachander","sequence":"additional","affiliation":[{"name":"Singapore Immunology Nework (SIgN), A*STAR, Biopolis, Singapore 2"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrea","family":"Rubio-Ponce","sequence":"additional","affiliation":[{"name":"Area of Developmental and Cell Biology, Centro Nacional de Investigaciones Cardiovasculares Carlos III (CNIC), Madrid, Spain 1"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Linnea A.","family":"Weiss","sequence":"additional","affiliation":[{"name":"Area of Developmental and Cell Biology, Centro Nacional de Investigaciones Cardiovasculares Carlos III (CNIC), Madrid, Spain 1"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jos\u00e9 M.","family":"Adrover","sequence":"additional","affiliation":[{"name":"Area of Developmental and Cell Biology, Centro Nacional de Investigaciones Cardiovasculares Carlos III (CNIC), Madrid, Spain 1"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kyle","family":"Burrows","sequence":"additional","affiliation":[{"name":"Department of Immunology, University of Toronto, Canada 4"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Noelia","family":"A-Gonz\u00e1lez","sequence":"additional","affiliation":[{"name":"Area of Developmental and Cell Biology, Centro Nacional de Investigaciones Cardiovasculares Carlos III (CNIC), Madrid, Spain 1"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ivan","family":"Ballesteros","sequence":"additional","affiliation":[{"name":"Area of Developmental and Cell Biology, Centro Nacional de Investigaciones Cardiovasculares Carlos III (CNIC), Madrid, Spain 1"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sapna","family":"Devi","sequence":"additional","affiliation":[{"name":"Singapore Immunology Nework (SIgN), A*STAR, Biopolis, Singapore 2"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juan A.","family":"Quintana","sequence":"additional","affiliation":[{"name":"Area of Developmental and Cell Biology, Centro Nacional de Investigaciones Cardiovasculares Carlos III (CNIC), Madrid, Spain 1"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Georgiana","family":"Crainiciuc","sequence":"additional","affiliation":[{"name":"Area of Developmental and Cell Biology, Centro Nacional de Investigaciones Cardiovasculares Carlos III (CNIC), Madrid, Spain 1"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Magdalena","family":"Leiva","sequence":"additional","affiliation":[{"name":"Area of Developmental and Cell Biology, Centro Nacional de Investigaciones Cardiovasculares Carlos III (CNIC), Madrid, Spain 1"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthias","family":"Gunzer","sequence":"additional","affiliation":[{"name":"University Duisburg-Essen, University Hospital, Institute for Experimental Immunology and Imaging, Essen, Germany 5"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christian","family":"Weber","sequence":"additional","affiliation":[{"name":"Institute for Cardiovascular Prevention, Ludwig-Maximilians University, Munich, Germany 6"},{"name":"Dept. of Biochemistry, Cardiovascular Research Institute Maastricht (CARIM), Maastricht University, Maastricht, Netherlands 7"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takashi","family":"Nagasawa","sequence":"additional","affiliation":[{"name":"Laboratory of Stem Cell Biology and Developmental Immunology, Graduate School of Frontier Biosciences and Graduate School of Medicine, Osaka University, Osaka, Japan 8"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Oliver","family":"Soehnlein","sequence":"additional","affiliation":[{"name":"Institute for Cardiovascular Prevention, Ludwig-Maximilians University, Munich, Germany 6"},{"name":"German Centre for Cardiovascular Research (DZHK), Partner Site Munich Heart Alliance, Munich, Germany 9"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4481-7827","authenticated-orcid":true,"given":"Miriam","family":"Merad","sequence":"additional","affiliation":[{"name":"Tisch Cancer Institute and Immunology Institute, Icahn School of Medicine at Mount Sinai, New York, NY 10"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2673-0485","authenticated-orcid":true,"given":"Arthur","family":"Mortha","sequence":"additional","affiliation":[{"name":"Department of Immunology, University of Toronto, Canada 4"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1905-3586","authenticated-orcid":true,"given":"Lai Guan","family":"Ng","sequence":"additional","affiliation":[{"name":"Singapore Immunology Nework (SIgN), A*STAR, Biopolis, Singapore 2"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4256-3413","authenticated-orcid":true,"given":"Hector","family":"Peinado","sequence":"additional","affiliation":[{"name":"Department of Molecular Oncology, Spanish National Cancer Research Center (CNIO), Madrid, Spain 3"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5513-555X","authenticated-orcid":true,"given":"Andr\u00e9s","family":"Hidalgo","sequence":"additional","affiliation":[{"name":"Area of Developmental and Cell Biology, Centro Nacional de Investigaciones Cardiovasculares Carlos III (CNIC), Madrid, Spain 1"},{"name":"Institute for Cardiovascular Prevention, Ludwig-Maximilians University, Munich, Germany 6"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"291","published-online":{"date-parts":[[2018,10,3]]},"reference":[{"key":"2023072609293729800_bib1","doi-asserted-by":"publisher","first-page":"334","DOI":"10.1016\/j.it.2016.03.005","article-title":"Aging: A Temporal Dimension for Neutrophils","volume":"37","author":"Adrover","year":"2016","journal-title":"Trends Immunol."},{"key":"2023072609293729800_bib2","doi-asserted-by":"publisher","first-page":"1281","DOI":"10.1084\/jem.20161375","article-title":"Phagocytosis imprints heterogeneity in tissue-resident macrophages","volume":"214","author":"A-Gonz\u00e1lez","year":"2017","journal-title":"J. Exp. Med."},{"key":"2023072609293729800_bib3","doi-asserted-by":"publisher","first-page":"7802","DOI":"10.1038\/ncomms8802","article-title":"Intestinal CD169(+) macrophages initiate mucosal inflammation by secreting CCL8 that recruits inflammatory monocytes","volume":"6","author":"Asano","year":"2015","journal-title":"Nat. Commun."},{"key":"2023072609293729800_bib4","doi-asserted-by":"publisher","first-page":"666","DOI":"10.1126\/science.1142883","article-title":"Monitoring of blood vessels and tissues by a population of monocytes with patrolling behavior","volume":"317","author":"Auffray","year":"2007","journal-title":"Science."},{"key":"2023072609293729800_bib5","doi-asserted-by":"publisher","first-page":"514","DOI":"10.1038\/ni.2569","article-title":"Trypanosoma cruzi trans-sialidase initiates a program independent of the transcription factors ROR\u03b3t and Ahr that leads to IL-17 production by activated B cells","volume":"14","author":"Bermejo","year":"2013","journal-title":"Nat. Immunol."},{"key":"2023072609293729800_bib6","doi-asserted-by":"publisher","first-page":"419","DOI":"10.1038\/nmeth762","article-title":"A Cre-inducible diphtheria toxin receptor mediates cell lineage ablation after toxin administration","volume":"2","author":"Buch","year":"2005","journal-title":"Nat. Methods."},{"key":"2023072609293729800_bib7","doi-asserted-by":"publisher","first-page":"1025","DOI":"10.1016\/j.cell.2013.04.040","article-title":"Rhythmic modulation of the hematopoietic niche through neutrophil clearance","volume":"153","author":"Casanova-Acebes","year":"2013","journal-title":"Cell."},{"key":"2023072609293729800_bib8","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1152\/ajplegacy.1968.215.2.353","article-title":"Quantitative studies of blood and bone marrow neutrophils in normal mice","volume":"215","author":"Chervenick","year":"1968","journal-title":"Am. J. Physiol."},{"key":"2023072609293729800_bib9","first-page":"G1195","article-title":"Neutrophil margination and extravasation in sinusoids and venules of liver during endotoxin-induced injury","volume":"272","author":"Chosay","year":"1997","journal-title":"Am. J. Physiol."},{"key":"2023072609293729800_bib10","doi-asserted-by":"publisher","first-page":"261","DOI":"10.1084\/jem.20101688","article-title":"Bone marrow CD169+ macrophages promote the retention of hematopoietic stem and progenitor cells in the mesenchymal stem cell niche","volume":"208","author":"Chow","year":"2011","journal-title":"J. Exp. Med."},{"key":"2023072609293729800_bib11","doi-asserted-by":"publisher","first-page":"1331","DOI":"10.1182\/blood-2008-10-184754","article-title":"Suppression of CXCL12 production by bone marrow osteoblasts is a common and critical pathway for cytokine-induced mobilization","volume":"114","author":"Christopher","year":"2009","journal-title":"Blood."},{"key":"2023072609293729800_bib12","doi-asserted-by":"publisher","first-page":"431","DOI":"10.1038\/nrc.2016.52","article-title":"Neutrophils in cancer: neutral no more","volume":"16","author":"Coffelt","year":"2016","journal-title":"Nat. Rev. Cancer."},{"key":"2023072609293729800_bib13","doi-asserted-by":"publisher","first-page":"378","DOI":"10.1038\/nri.2016.49","article-title":"Neutrophil migration in infection and wound repair: going forward in reverse","volume":"16","author":"de Oliveira","year":"2016","journal-title":"Nat. Rev. Immunol."},{"key":"2023072609293729800_bib14","doi-asserted-by":"publisher","first-page":"231","DOI":"10.1038\/nature11885","article-title":"Haematopoietic stem cells and early lymphoid progenitors occupy distinct bone marrow niches","volume":"495","author":"Ding","year":"2013","journal-title":"Nature."},{"key":"2023072609293729800_bib15","doi-asserted-by":"publisher","first-page":"1620","DOI":"10.1182\/blood-2006-03-013771","article-title":"The antiapoptotic protein Mcl-1 is essential for the survival of neutrophils but not macrophages","volume":"109","author":"Dzhagalov","year":"2007","journal-title":"Blood."},{"key":"2023072609293729800_bib16","doi-asserted-by":"publisher","first-page":"64","DOI":"10.1038\/ni1022","article-title":"An essential function for the nuclear receptor RORgamma(t) in the generation of fetal lymphoid tissue inducer cells","volume":"5","author":"Eberl","year":"2004","journal-title":"Nat. Immunol."},{"key":"2023072609293729800_bib17","doi-asserted-by":"publisher","first-page":"514","DOI":"10.1038\/nature10228","article-title":"Control of TH17 cells occurs in the small intestine","volume":"475","author":"Esplugues","year":"2011","journal-title":"Nature."},{"key":"2023072609293729800_bib18","doi-asserted-by":"crossref","first-page":"719","DOI":"10.1182\/blood.V96.2.719","article-title":"Insertion of enhanced green fluorescent protein into the lysozyme gene creates mice with green fluorescent granulocytes and macrophages","volume":"96","author":"Faust","year":"2000","journal-title":"Blood."},{"key":"2023072609293729800_bib19","doi-asserted-by":"publisher","first-page":"7879","DOI":"10.1158\/0008-5472.CAN-04-0674","article-title":"Effects of chronic jet lag on tumor progression in mice","volume":"64","author":"Filipski","year":"2004","journal-title":"Cancer Res."},{"key":"2023072609293729800_bib20","doi-asserted-by":"publisher","first-page":"563","DOI":"10.1016\/S0092-8674(00)81032-6","article-title":"Susceptibility to infection and altered hematopoiesis in mice deficient in both P- and E-selectins","volume":"84","author":"Frenette","year":"1996","journal-title":"Cell."},{"key":"2023072609293729800_bib21","doi-asserted-by":"publisher","first-page":"3111","DOI":"10.1096\/fj.08-109876","article-title":"The role of the bone marrow in neutrophil clearance under homeostatic conditions in the mouse","volume":"22","author":"Furze","year":"2008","journal-title":"FASEB J."},{"key":"2023072609293729800_bib22","doi-asserted-by":"publisher","first-page":"493","DOI":"10.1152\/jappl.1995.79.2.493","article-title":"Sites of leukocyte sequestration in the pulmonary microcirculation","volume":"79","author":"Gebb","year":"1995","journal-title":"J. Appl. Physiol."},{"key":"2023072609293729800_bib23","doi-asserted-by":"publisher","first-page":"445","DOI":"10.1038\/nmeth.3322","article-title":"Catchup: a mouse model for imaging-based tracking and modulation of neutrophil granulocytes","volume":"12","author":"Hasenberg","year":"2015","journal-title":"Nat. Methods."},{"key":"2023072609293729800_bib24","doi-asserted-by":"publisher","first-page":"365","DOI":"10.1002\/(SICI)1097-0215(19991029)83:3&lt;365::AID-IJC12&gt;3.0.CO;2-4","article-title":"Circadian coordination of cancer growth and metastatic spread","volume":"83","author":"Hrushesky","year":"1999","journal-title":"Int. J. Cancer."},{"key":"2023072609293729800_bib25","first-page":"2662","article-title":"Augmentation of tumor metastasis by platelet-activating factor","volume":"56","author":"Im","year":"1996","journal-title":"Cancer Res."},{"key":"2023072609293729800_bib26","doi-asserted-by":"publisher","first-page":"e1004651","DOI":"10.1371\/journal.ppat.1004651","article-title":"Neutrophils: Between host defence, immune modulation, and tissue injury","volume":"11","author":"Kruger","year":"2015","journal-title":"PLoS Pathog."},{"key":"2023072609293729800_bib27","doi-asserted-by":"publisher","first-page":"331","DOI":"10.1172\/JCI38702","article-title":"IL-17 produced by neutrophils regulates IFN-gamma-mediated neutrophil migration in mouse kidney ischemia-reperfusion injury","volume":"120","author":"Li","year":"2010","journal-title":"J. Clin. Invest."},{"key":"2023072609293729800_bib28","doi-asserted-by":"publisher","first-page":"643","DOI":"10.1016\/S0092-8674(00)80137-3","article-title":"The alpha(1,3)fucosyltransferase Fuc-TVII controls leukocyte trafficking through an essential role in L-, E-, and P-selectin ligand biosynthesis","volume":"86","author":"Mal\u00fd","year":"1996","journal-title":"Cell."},{"key":"2023072609293729800_bib29","doi-asserted-by":"publisher","first-page":"442","DOI":"10.1038\/nature06685","article-title":"Haematopoietic stem cell release is regulated by circadian oscillations","volume":"452","author":"M\u00e9ndez-Ferrer","year":"2008","journal-title":"Nature."},{"key":"2023072609293729800_bib30","doi-asserted-by":"publisher","first-page":"829","DOI":"10.1038\/nature09262","article-title":"Mesenchymal and haematopoietic stem cells form a unique bone marrow niche","volume":"466","author":"M\u00e9ndez-Ferrer","year":"2010","journal-title":"Nature."},{"key":"2023072609293729800_bib31","doi-asserted-by":"publisher","first-page":"2268","DOI":"10.1172\/JCI31990","article-title":"Critical role of macrophages in the marginal zone in the suppression of immune responses to apoptotic cell-associated antigens","volume":"117","author":"Miyake","year":"2007","journal-title":"J. Clin. Invest."},{"key":"2023072609293729800_bib32","doi-asserted-by":"publisher","first-page":"1249288","DOI":"10.1126\/science.1249288","article-title":"Microbiota-dependent crosstalk between macrophages and ILC3 promotes intestinal homeostasis","volume":"343","author":"Mortha","year":"2014","journal-title":"Science."},{"key":"2023072609293729800_bib33","first-page":"305","article-title":"Methods for cosinor-rhythmometry","volume":"6","author":"Nelson","year":"1979","journal-title":"Chronobiologia."},{"key":"2023072609293729800_bib34","doi-asserted-by":"publisher","first-page":"15","DOI":"10.1016\/j.immuni.2016.12.012","article-title":"Neutrophils in Homeostasis, Immunity, and Cancer","volume":"46","author":"Nicol\u00e1s-\u00c1vila","year":"2017","journal-title":"Immunity."},{"key":"2023072609293729800_bib35","doi-asserted-by":"publisher","first-page":"1145","DOI":"10.1084\/jem.20041185","article-title":"The role of CXCR4 in maintaining peripheral B cell compartments and humoral immunity","volume":"200","author":"Nie","year":"2004","journal-title":"J. Exp. Med."},{"key":"2023072609293729800_bib36","doi-asserted-by":"publisher","first-page":"204","DOI":"10.1016\/j.devcel.2013.06.017","article-title":"Molecular signatures of tissue-specific microvascular endothelial cell heterogeneity in organ maintenance and regeneration","volume":"26","author":"Nolan","year":"2013","journal-title":"Dev. Cell."},{"key":"2023072609293729800_bib37","doi-asserted-by":"publisher","first-page":"324","DOI":"10.1016\/j.cmet.2016.07.001","article-title":"Circadian Rhythm Disruption Promotes Lung Tumorigenesis","volume":"24","author":"Papagiannakopoulos","year":"2016","journal-title":"Cell Metab."},{"key":"2023072609293729800_bib38","doi-asserted-by":"publisher","first-page":"431","DOI":"10.1016\/j.cell.2004.10.010","article-title":"JunB deficiency leads to a myeloproliferative disorder arising from hematopoietic stem cells","volume":"119","author":"Passegu\u00e9","year":"2004","journal-title":"Cell."},{"key":"2023072609293729800_bib39","doi-asserted-by":"publisher","first-page":"289","DOI":"10.1016\/j.it.2012.04.004","article-title":"Lymphoid microenvironments and innate lymphoid cells in the gut","volume":"33","author":"Pearson","year":"2012","journal-title":"Trends Immunol."},{"key":"2023072609293729800_bib40","doi-asserted-by":"publisher","first-page":"883","DOI":"10.1038\/nm.2753","article-title":"Melanoma exosomes educate bone marrow progenitor cells toward a pro-metastatic phenotype through MET","volume":"18","author":"Peinado","year":"2012","journal-title":"Nat. Med."},{"key":"2023072609293729800_bib41","doi-asserted-by":"publisher","first-page":"1381","DOI":"10.1038\/nm.2514","article-title":"The neutrophil in vascular inflammation","volume":"17","author":"Phillipson","year":"2011","journal-title":"Nat. Med."},{"key":"2023072609293729800_bib42","doi-asserted-by":"publisher","first-page":"1463","DOI":"10.1093\/bioinformatics\/btp184","article-title":"Globally optimal stitching of tiled 3D microscopic image acquisitions","volume":"25","author":"Preibisch","year":"2009","journal-title":"Bioinformatics."},{"key":"2023072609293729800_bib43","doi-asserted-by":"publisher","first-page":"170","DOI":"10.1038\/ni.2194","article-title":"B cell-helper neutrophils stimulate the diversification and production of immunoglobulin in the marginal zone of the spleen","volume":"13","author":"Puga","year":"2012","journal-title":"Nat. Immunol."},{"key":"2023072609293729800_bib44","doi-asserted-by":"publisher","first-page":"746","DOI":"10.1038\/90795","article-title":"Diphtheria toxin receptor-mediated conditional and targeted cell ablation in transgenic mice","volume":"19","author":"Saito","year":"2001","journal-title":"Nat. Biotechnol."},{"key":"2023072609293729800_bib45","doi-asserted-by":"publisher","first-page":"675","DOI":"10.1111\/j.1365-2141.1985.tb02882.x","article-title":"The kinetics of 111indium distribution following injection of 111indium labelled autologous granulocytes in man","volume":"61","author":"Saverymuttu","year":"1985","journal-title":"Br. J. Haematol."},{"key":"2023072609293729800_bib46","doi-asserted-by":"publisher","first-page":"290","DOI":"10.1016\/j.immuni.2012.05.021","article-title":"Adrenergic nerves govern circadian leukocyte recruitment to tissues","volume":"37","author":"Scheiermann","year":"2012","journal-title":"Immunity."},{"key":"2023072609293729800_bib47","doi-asserted-by":"publisher","first-page":"190","DOI":"10.1038\/nri3386","article-title":"Circadian control of the immune system","volume":"13","author":"Scheiermann","year":"2013","journal-title":"Nat. Rev. Immunol."},{"key":"2023072609293729800_bib48","doi-asserted-by":"publisher","first-page":"676","DOI":"10.1038\/nmeth.2019","article-title":"Fiji: an open-source platform for biological-image analysis","volume":"9","author":"Schindelin","year":"2012","journal-title":"Nat. Methods."},{"key":"2023072609293729800_bib49","doi-asserted-by":"publisher","first-page":"e3","DOI":"10.2202\/1544-6115.1027","article-title":"Linear models and empirical bayes methods for assessing differential expression in microarray experiments","volume":"3","author":"Smyth","year":"2004","journal-title":"Stat. Appl. Genet. Mol. Biol."},{"key":"2023072609293729800_bib50","doi-asserted-by":"publisher","first-page":"285","DOI":"10.1016\/j.immuni.2005.01.011","article-title":"Phagocytosis of apoptotic neutrophils regulates granulopoiesis via IL-23 and IL-17","volume":"22","author":"Stark","year":"2005","journal-title":"Immunity."},{"key":"2023072609293729800_bib51","doi-asserted-by":"publisher","first-page":"977","DOI":"10.1016\/j.immuni.2006.10.016","article-title":"Maintenance of the hematopoietic stem cell pool by CXCL12-CXCR4 chemokine signaling in bone marrow stromal cell niches","volume":"25","author":"Sugiyama","year":"2006","journal-title":"Immunity."},{"key":"2023072609293729800_bib52","doi-asserted-by":"publisher","first-page":"L913","DOI":"10.1152\/ajplung.2001.281.4.L913","article-title":"Neutrophil maturation and activation determine anatomic site of clearance from circulation","volume":"281","author":"Suratt","year":"2001","journal-title":"Am. J. Physiol. Lung Cell. Mol. Physiol."},{"key":"2023072609293729800_bib53","doi-asserted-by":"publisher","first-page":"1755","DOI":"10.1084\/jem.20080588","article-title":"IL-17 produced by Paneth cells drives TNF-induced shock","volume":"205","author":"Takahashi","year":"2008","journal-title":"J. Exp. Med."},{"key":"2023072609293729800_bib54","doi-asserted-by":"publisher","first-page":"1407","DOI":"10.1038\/nm.2885","article-title":"Neutrophils mediate insulin resistance in mice fed a high-fat diet through secreted elastase","volume":"18","author":"Talukdar","year":"2012","journal-title":"Nat. Med."},{"key":"2023072609293729800_bib55","doi-asserted-by":"publisher","first-page":"241","DOI":"10.1002\/gene.20095","article-title":"Mouse in red: red fluorescent protein expression in mouse ES cells, embryos, and adult animals","volume":"40","author":"Vintersten","year":"2004","journal-title":"Genesis."},{"key":"2023072609293729800_bib56","doi-asserted-by":"publisher","first-page":"413","DOI":"10.1038\/nature16140","article-title":"Neutrophils support lung colonization of metastasis-initiating breast cancer cells","volume":"528","author":"Wculek","year":"2015","journal-title":"Nature."},{"key":"2023072609293729800_bib57","doi-asserted-by":"publisher","first-page":"183","DOI":"10.1126\/science.2749255","article-title":"Mechanics of stimulated neutrophils: cell stiffening induces retention in capillaries","volume":"245","author":"Worthen","year":"1989","journal-title":"Science."},{"key":"2023072609293729800_bib58","doi-asserted-by":"publisher","first-page":"445","DOI":"10.1038\/nature12034","article-title":"Macrophage biology in development, homeostasis and disease","volume":"496","author":"Wynn","year":"2013","journal-title":"Nature."},{"key":"2023072609293729800_bib59","doi-asserted-by":"publisher","first-page":"eaam8929","DOI":"10.1126\/sciimmunol.aam8929","article-title":"The Lung is a Host Defense Niche for Immediate Neutrophil-Mediated Vascular Protection","volume":"2","author":"Yipp","year":"2017","journal-title":"Sci. Immunol."},{"key":"2023072609293729800_bib60","doi-asserted-by":"publisher","first-page":"e0150606","DOI":"10.1371\/journal.pone.0150606","article-title":"A Protocol for the Comprehensive Flow Cytometric Analysis of Immune Cells in Normal and Inflamed Murine Non-Lymphoid Tissues","volume":"11","author":"Yu","year":"2016","journal-title":"PLoS One."},{"key":"2023072609293729800_bib61","doi-asserted-by":"publisher","first-page":"16219","DOI":"10.1073\/pnas.1408886111","article-title":"A circadian gene expression atlas in mammals: implications for biology and medicine","volume":"111","author":"Zhang","year":"2014","journal-title":"Proc. Natl. Acad. Sci. USA."}],"container-title":["Journal of Experimental Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/rupress.org\/jem\/article-pdf\/215\/11\/2778\/1765210\/jem_20181468.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/rupress.org\/jem\/article-pdf\/215\/11\/2778\/1765210\/jem_20181468.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,7,26]],"date-time":"2023-07-26T05:32:06Z","timestamp":1690349526000},"score":1,"resource":{"primary":{"URL":"https:\/\/rupress.org\/jem\/article\/215\/11\/2778\/120272\/Neutrophils-instruct-homeostatic-and-pathological"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,10,3]]},"references-count":61,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2018,11,5]]}},"URL":"https:\/\/doi.org\/10.1084\/jem.20181468","relation":{"has-review":[{"id-type":"doi","id":"10.3410\/f.734145820.793557412","asserted-by":"object"}]},"ISSN":["0022-1007","1540-9538"],"issn-type":[{"value":"0022-1007","type":"print"},{"value":"1540-9538","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,10,3]]}}}