{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T14:00:11Z","timestamp":1790690411742,"version":"4.1.0"},"reference-count":52,"publisher":"Rockefeller University Press","issue":"9","license":[{"start":{"date-parts":[[2019,6,25]],"date-time":"2019-06-25T00:00:00Z","timestamp":1561420800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/www.rupress.org\/terms\/"},{"start":{"date-parts":[[2020,3,1]],"date-time":"2020-03-01T00:00:00Z","timestamp":1583020800000},"content-version":"vor","delay-in-days":250,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-sa\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["CA084488"],"award-info":[{"award-number":["CA084488"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["CA140043"],"award-info":[{"award-number":["CA140043"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Wistar Institute Animal and Bioinformatics","award":["P30 CA010815"],"award-info":[{"award-number":["P30 CA010815"]}]}],"content-domain":{"domain":["rupress.org"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2019,9,2]]},"abstract":"<jats:p>We have identified a precursor that differentiates into granulocytes in vitro and in vivo yet belongs to the monocytic lineage. We have termed these cells monocyte-like precursors of granulocytes (MLPGs). Under steady state conditions, MLPGs were absent in the spleen and barely detectable in the bone marrow (BM). In contrast, these cells significantly expanded in tumor-bearing mice and differentiated to polymorphonuclear myeloid-derived suppressor cells (PMN-MDSCs). Selective depletion of monocytic cells had no effect on the number of granulocytes in naive mice but decreased the population of PMN-MDSCs in tumor-bearing mice by 50%. The expansion of MLPGs was found to be controlled by the down-regulation of Rb1, but not IRF8, which is known to regulate the expansion of PMN-MDSCs from classic granulocyte precursors. In cancer patients, putative MLPGs were found within the population of CXCR1+CD15\u2212CD14+HLA-DR\u2212\/lo monocytic cells. These findings describe a mechanism of abnormal myelopoiesis in cancer and suggest potential new approaches for selective targeting of MDSCs.<\/jats:p>","DOI":"10.1084\/jem.20181952","type":"journal-article","created":{"date-parts":[[2019,6,25]],"date-time":"2019-06-25T18:55:13Z","timestamp":1561488913000},"page":"2150-2169","update-policy":"https:\/\/doi.org\/10.1084\/jem.crossmarkpolicy","source":"Crossref","is-referenced-by-count":117,"title":["Identification of monocyte-like precursors of granulocytes in cancer as a mechanism for accumulation of PMN-MDSCs"],"prefix":"10.1084","volume":"216","author":[{"given":"J\u00e9r\u00f4me","family":"Mastio","sequence":"first","affiliation":[{"name":"Immunology, Microenvironment and Metastasis Program, The Wistar Institute, Philadelphia, PA 1"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9450-2762","authenticated-orcid":true,"given":"Thomas","family":"Condamine","sequence":"additional","affiliation":[{"name":"Immunology, Microenvironment and Metastasis Program, The Wistar Institute, Philadelphia, PA 1"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"George","family":"Dominguez","sequence":"additional","affiliation":[{"name":"Immunology, Microenvironment and Metastasis Program, The Wistar Institute, Philadelphia, PA 1"},{"name":"Anixa Diagnostic Corporation, San Jose, CA 2"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1536-0418","authenticated-orcid":true,"given":"Andrew V.","family":"Kossenkov","sequence":"additional","affiliation":[{"name":"Immunology, Microenvironment and Metastasis Program, The Wistar Institute, Philadelphia, PA 1"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laxminarasimha","family":"Donthireddy","sequence":"additional","affiliation":[{"name":"Immunology, Microenvironment and Metastasis Program, The Wistar Institute, Philadelphia, PA 1"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Filippo","family":"Veglia","sequence":"additional","affiliation":[{"name":"Immunology, Microenvironment and Metastasis Program, The Wistar Institute, Philadelphia, PA 1"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9930-0411","authenticated-orcid":true,"given":"Cindy","family":"Lin","sequence":"additional","affiliation":[{"name":"Immunology, Microenvironment and Metastasis Program, The Wistar Institute, Philadelphia, PA 1"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fang","family":"Wang","sequence":"additional","affiliation":[{"name":"Immunology, Microenvironment and Metastasis Program, The Wistar Institute, Philadelphia, PA 1"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuyu","family":"Fu","sequence":"additional","affiliation":[{"name":"Immunology, Microenvironment and Metastasis Program, The Wistar Institute, Philadelphia, PA 1"},{"name":"Institute of Human Virology, Zhongshan School of Medicine, Sun Yat-Sen University, Guangzhou, China 3"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5964-1599","authenticated-orcid":true,"given":"Jie","family":"Zhou","sequence":"additional","affiliation":[{"name":"Institute of Human Virology, Zhongshan School of Medicine, Sun Yat-Sen University, Guangzhou, China 3"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3642-0096","authenticated-orcid":true,"given":"Patrick","family":"Viatour","sequence":"additional","affiliation":[{"name":"Department of Pathology and Laboratory Medicine, University of Pennsylvania School of Medicine, Philadelphia, PA 4"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sergio","family":"Lavilla-Alonso","sequence":"additional","affiliation":[{"name":"Immunology, Microenvironment and Metastasis Program, The Wistar Institute, Philadelphia, PA 1"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexander T.","family":"Polo","sequence":"additional","affiliation":[{"name":"Anixa Diagnostic Corporation, San Jose, CA 2"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8605-7291","authenticated-orcid":true,"given":"Evgenii N.","family":"Tcyganov","sequence":"additional","affiliation":[{"name":"Immunology, Microenvironment and Metastasis Program, The Wistar Institute, Philadelphia, PA 1"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"suffix":"Jr.","given":"Charles","family":"Mulligan","sequence":"additional","affiliation":[{"name":"Helen F Graham Cancer Center at Christiana Care Health System, Newark, DE 5"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brian","family":"Nam","sequence":"additional","affiliation":[{"name":"Helen F Graham Cancer Center at Christiana Care Health System, Newark, DE 5"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0030-797X","authenticated-orcid":true,"given":"Joseph","family":"Bennett","sequence":"additional","affiliation":[{"name":"Helen F Graham Cancer Center at Christiana Care Health System, Newark, DE 5"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gregory","family":"Masters","sequence":"additional","affiliation":[{"name":"Helen F Graham Cancer Center at Christiana Care Health System, Newark, DE 5"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Guarino","sequence":"additional","affiliation":[{"name":"Helen F Graham Cancer Center at Christiana Care Health System, Newark, DE 5"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amit","family":"Kumar","sequence":"additional","affiliation":[{"name":"Anixa Diagnostic Corporation, San Jose, CA 2"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yulia","family":"Nefedova","sequence":"additional","affiliation":[{"name":"Immunology, Microenvironment and Metastasis Program, The Wistar Institute, Philadelphia, PA 1"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert H.","family":"Vonderheide","sequence":"additional","affiliation":[{"name":"Department of Medicine, University of Pennsylvania School of Medicine, Philadelphia, PA 6"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lucia R.","family":"Languino","sequence":"additional","affiliation":[{"name":"Thomas Jefferson University, Philadelphia, PA 7"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Scott I.","family":"Abrams","sequence":"additional","affiliation":[{"name":"Department of Immunology, Roswell Park Comprehensive Cancer Center, Buffalo, NY 8"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9913-6407","authenticated-orcid":true,"given":"Dmitry I.","family":"Gabrilovich","sequence":"additional","affiliation":[{"name":"Immunology, Microenvironment and Metastasis Program, The Wistar Institute, Philadelphia, PA 1"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"291","published-online":{"date-parts":[[2019,6,25]]},"reference":[{"key":"2023072822284116900_bib1","doi-asserted-by":"publisher","first-page":"193","DOI":"10.1038\/35004599","article-title":"A clonogenic common myeloid progenitor that gives rise to all myeloid lineages","volume":"404","author":"Akashi","year":"2000","journal-title":"Nature."},{"key":"2023072822284116900_bib2","doi-asserted-by":"publisher","first-page":"105","DOI":"10.1007\/978-3-319-67577-0_8","article-title":"Targeting Myeloid-Derived Suppressor Cells in Cancer","volume":"1036","author":"Anani","year":"2017","journal-title":"Adv. Exp. Med. Biol."},{"key":"2023072822284116900_bib3","doi-asserted-by":"publisher","first-page":"1421","DOI":"10.1007\/s00262-013-1447-1","article-title":"Increase in CD14+HLA-DR -\/low myeloid-derived suppressor cells in hepatocellular carcinoma patients and its impact on prognosis","volume":"62","author":"Arihara","year":"2013","journal-title":"Cancer Immunol. Immunother."},{"key":"2023072822284116900_bib4","doi-asserted-by":"publisher","first-page":"822","DOI":"10.1016\/j.ccr.2012.04.025","article-title":"Tumor-derived granulocyte-macrophage colony-stimulating factor regulates myeloid inflammation and T cell immunity in pancreatic cancer","volume":"21","author":"Bayne","year":"2012","journal-title":"Cancer Cell."},{"key":"2023072822284116900_bib5","doi-asserted-by":"publisher","first-page":"12150","DOI":"10.1038\/ncomms12150","article-title":"Recommendations for myeloid-derived suppressor cell nomenclature and characterization standards","volume":"7","author":"Bronte","year":"2016","journal-title":"Nat. Commun."},{"key":"2023072822284116900_bib6","doi-asserted-by":"publisher","first-page":"1729","DOI":"10.1128\/MCB.00952-09","article-title":"Regulation of RB transcription in vivo by RB family members","volume":"30","author":"Burkhart","year":"2010","journal-title":"Mol. Cell. Biol."},{"key":"2023072822284116900_bib7","doi-asserted-by":"publisher","first-page":"5034","DOI":"10.1158\/1078-0432.CCR-16-3016","article-title":"Immune Correlates of GM-CSF and Melanoma Peptide Vaccination in a Randomized Trial for the Adjuvant Therapy of Resected High-Risk Melanoma (E4697)","volume":"23","author":"Butterfield","year":"2017","journal-title":"Clin. Cancer Res."},{"key":"2023072822284116900_bib8","doi-asserted-by":"publisher","first-page":"1110","DOI":"10.1038\/nature09264","article-title":"Rb regulates fate choice and lineage commitment in vivo","volume":"466","author":"Calo","year":"2010","journal-title":"Nature."},{"key":"2023072822284116900_bib9","doi-asserted-by":"publisher","first-page":"E566","DOI":"10.1073\/pnas.1424927112","article-title":"Invasive breast cancer reprograms early myeloid differentiation in the bone marrow to generate immunosuppressive neutrophils","volume":"112","author":"Casbon","year":"2015","journal-title":"Proc. Natl. Acad. Sci. USA."},{"key":"2023072822284116900_bib10","doi-asserted-by":"publisher","first-page":"2507","DOI":"10.1056\/NEJMoa1103782","article-title":"Improved survival with vemurafenib in melanoma with BRAF V600E mutation","volume":"364","author":"Chapman","year":"2011","journal-title":"N. Engl. J. Med."},{"key":"2023072822284116900_bib11","doi-asserted-by":"publisher","first-page":"8716","DOI":"10.18632\/oncotarget.2368","article-title":"IL-6-stimulated CD11b+ CD14+ HLA-DR- myeloid-derived suppressor cells, are associated with progression and poor prognosis in squamous cell carcinoma of the esophagus","volume":"5","author":"Chen","year":"2014","journal-title":"Oncotarget."},{"key":"2023072822284116900_bib12","doi-asserted-by":"publisher","first-page":"97","DOI":"10.1146\/annurev-med-051013-052304","article-title":"Regulation of tumor metastasis by myeloid-derived suppressor cells","volume":"66","author":"Condamine","year":"2015","journal-title":"Annu. Rev. Med."},{"key":"2023072822284116900_bib13","doi-asserted-by":"publisher","DOI":"10.1101\/cshperspect.a003285","article-title":"Leukocytes in mammary development and cancer","volume":"3","author":"Coussens","year":"2011","journal-title":"Cold Spring Harb. Perspect. Biol."},{"key":"2023072822284116900_bib14","doi-asserted-by":"publisher","first-page":"21539","DOI":"10.18632\/oncotarget.15368","article-title":"Ipilimumab treatment decreases monocytic MDSCs and increases CD8 effector memory T cells in long-term survivors with advanced melanoma","volume":"8","author":"de Coa\u00f1a","year":"2017","journal-title":"Oncotarget."},{"key":"2023072822284116900_bib15","doi-asserted-by":"publisher","first-page":"49","DOI":"10.1007\/s00262-008-0523-4","article-title":"Increased circulating myeloid-derived suppressor cells correlate with clinical cancer stage, metastatic tumor burden, and doxorubicin-cyclophosphamide chemotherapy","volume":"58","author":"Diaz-Montero","year":"2009","journal-title":"Cancer Immunol. Immunother."},{"key":"2023072822284116900_bib16","doi-asserted-by":"publisher","first-page":"364","DOI":"10.1016\/j.immuni.2018.02.002","article-title":"Developmental Analysis of Bone Marrow Neutrophils Reveals Populations Specialized in Expansion, Trafficking, and Effector Functions","volume":"48","author":"Evrard","year":"2018","journal-title":"Immunity."},{"key":"2023072822284116900_bib17","doi-asserted-by":"publisher","first-page":"253","DOI":"10.1038\/nri3175","article-title":"Coordinated regulation of myeloid cells by tumours","volume":"12","author":"Gabrilovich","year":"2012","journal-title":"Nat. Rev. Immunol."},{"key":"2023072822284116900_bib18","doi-asserted-by":"publisher","first-page":"1404","DOI":"10.1002\/jcp.24260","article-title":"Tumor associated macrophages and neutrophils in tumor progression","volume":"228","author":"Galdiero","year":"2013","journal-title":"J. Cell. Physiol."},{"key":"2023072822284116900_bib19","doi-asserted-by":"publisher","first-page":"3439","DOI":"10.1073\/pnas.92.8.3439","article-title":"Prostate cancer in a transgenic mouse","volume":"92","author":"Greenberg","year":"1995","journal-title":"Proc. Natl. Acad. Sci. USA."},{"key":"2023072822284116900_bib20","doi-asserted-by":"publisher","first-page":"307","DOI":"10.1016\/S0092-8674(00)81348-3","article-title":"Immunodeficiency and chronic myelogenous leukemia-like syndrome in mice with a targeted mutation of the ICSBP gene","volume":"87","author":"Holtschke","year":"1996","journal-title":"Cell."},{"key":"2023072822284116900_bib21","doi-asserted-by":"publisher","first-page":"1885","DOI":"10.1038\/sj.onc.1202077","article-title":"Transgenic mouse model for skin malignant melanoma","volume":"17","author":"Kato","year":"1998","journal-title":"Oncogene."},{"key":"2023072822284116900_bib22","doi-asserted-by":"publisher","first-page":"18217","DOI":"10.1038\/srep18217","article-title":"The significance of G-CSF expression and myeloid-derived suppressor cells in the chemoresistance of uterine cervical cancer","volume":"5","author":"Kawano","year":"2015","journal-title":"Sci. Rep."},{"key":"2023072822284116900_bib23","doi-asserted-by":"publisher","first-page":"907","DOI":"10.1080\/17460441.2016.1201057","article-title":"The discovery of vemurafenib for the treatment of BRAF-mutated metastatic melanoma","volume":"11","author":"Kim","year":"2016","journal-title":"Expert Opin. Drug Discov."},{"key":"2023072822284116900_bib24","doi-asserted-by":"publisher","first-page":"18","DOI":"10.1158\/1940-6207.CAPR-12-0275","article-title":"MUC1 vaccine for individuals with advanced adenoma of the colon: a cancer immunoprevention feasibility study","volume":"6","author":"Kimura","year":"2013","journal-title":"Cancer Prev. Res. (Phila.)."},{"key":"2023072822284116900_bib25","doi-asserted-by":"publisher","first-page":"4978","DOI":"10.1038\/ncomms5978","article-title":"IRF8 inhibits C\/EBP\u03b1 activity to restrain mononuclear phagocyte progenitors from differentiating into neutrophils","volume":"5","author":"Kurotaki","year":"2014","journal-title":"Nat. Commun."},{"key":"2023072822284116900_bib26","doi-asserted-by":"publisher","first-page":"2801","DOI":"10.4049\/jimmunol.0804007","article-title":"P2X1 ion channels promote neutrophil chemotaxis through Rho kinase activation","volume":"183","author":"Lecut","year":"2009","journal-title":"J. Immunol."},{"key":"2023072822284116900_bib27","doi-asserted-by":"publisher","first-page":"983","DOI":"10.1007\/s00262-016-1861-2","article-title":"Circulating immune cell phenotype can predict the outcome of lenalidomide plus low-dose dexamethasone treatment in patients with refractory\/relapsed multiple myeloma","volume":"65","author":"Lee","year":"2016","journal-title":"Cancer Immunol. Immunother."},{"key":"2023072822284116900_bib28","doi-asserted-by":"publisher","DOI":"10.1080\/2162402X.2014.998469","article-title":"Splenectomy inhibits non-small cell lung cancer growth by modulating anti-tumor adaptive and innate immune response","volume":"4","author":"Levy","year":"2015","journal-title":"OncoImmunology."},{"key":"2023072822284116900_bib29","doi-asserted-by":"publisher","first-page":"323","DOI":"10.1186\/1471-2105-12-323","article-title":"RSEM: accurate transcript quantification from RNA-Seq data with or without a reference genome","volume":"12","author":"Li","year":"2011","journal-title":"BMC Bioinformatics."},{"key":"2023072822284116900_bib30","doi-asserted-by":"publisher","first-page":"550","DOI":"10.1186\/s13059-014-0550-8","article-title":"Moderated estimation of fold change and dispersion for RNA-seq data with DESeq2","volume":"15","author":"Love","year":"2014","journal-title":"Genome Biol."},{"key":"2023072822284116900_bib31","doi-asserted-by":"publisher","first-page":"2908","DOI":"10.1158\/1078-0432.CCR-15-2412","article-title":"Baseline Peripheral Blood Biomarkers Associated with Clinical Outcome of Advanced Melanoma Patients Treated with Ipilimumab","volume":"22","author":"Martens","year":"2016","journal-title":"Clin. Cancer Res."},{"key":"2023072822284116900_bib32","doi-asserted-by":"publisher","first-page":"4129","DOI":"10.4049\/jimmunol.1601722","article-title":"The Granulocyte Progenitor Stage Is a Key Target of IRF8-Mediated Regulation of Myeloid-Derived Suppressor Cell Production","volume":"198","author":"Netherby","year":"2017","journal-title":"J. Immunol."},{"key":"2023072822284116900_bib33","doi-asserted-by":"publisher","first-page":"2369","DOI":"10.4049\/jimmunol.1402412","article-title":"IFN regulatory factor 8 represses GM-CSF expression in T cells to affect myeloid cell lineage differentiation","volume":"194","author":"Paschall","year":"2015","journal-title":"J. Immunol."},{"key":"2023072822284116900_bib34","doi-asserted-by":"publisher","first-page":"689","DOI":"10.1111\/bjh.13198","article-title":"Circulating myeloid-derived suppressor cells correlate with clinical outcome in Hodgkin Lymphoma patients treated up-front with a risk-adapted strategy","volume":"168","author":"Romano","year":"2015","journal-title":"Br. J. Haematol."},{"key":"2023072822284116900_bib35","doi-asserted-by":"publisher","first-page":"5661","DOI":"10.1158\/1078-0432.CCR-15-3104","article-title":"Clinical Significance of Circulating CD33+CD11b+HLA-DR- Myeloid Cells in Patients with Stage IV Melanoma Treated with Ipilimumab","volume":"22","author":"Sade-Feldman","year":"2016","journal-title":"Clin. Cancer Res."},{"key":"2023072822284116900_bib36","doi-asserted-by":"publisher","first-page":"57","DOI":"10.1016\/j.ccell.2014.12.002","article-title":"Acetyl-CoA synthetase 2 promotes acetate utilization and maintains cancer cell growth under metabolic stress","volume":"27","author":"Schug","year":"2015","journal-title":"Cancer Cell."},{"issue":"9b","key":"2023072822284116900_bib37","doi-asserted-by":"publisher","first-page":"3939","DOI":"10.1111\/j.1582-4934.2009.00685.x","article-title":"Interferon regulatory factor-8 modulates the development of tumour-induced CD11b+Gr-1+ myeloid cells","volume":"13","author":"Stewart","year":"2009","journal-title":"J. Cell. Mol. Med."},{"key":"2023072822284116900_bib38","doi-asserted-by":"publisher","first-page":"273","DOI":"10.1016\/j.cell.2017.09.021","article-title":"Ferroptosis: A Regulated Cell Death Nexus Linking Metabolism, Redox Biology, and Disease","volume":"171","author":"Stockwell","year":"2017","journal-title":"Cell."},{"key":"2023072822284116900_bib39","doi-asserted-by":"publisher","first-page":"9440","DOI":"10.1073\/pnas.1530509100","article-title":"Statistical significance for genomewide studies","volume":"100","author":"Storey","year":"2003","journal-title":"Proc. Natl. Acad. Sci. USA."},{"key":"2023072822284116900_bib40","doi-asserted-by":"publisher","first-page":"592","DOI":"10.1158\/2326-6066.CIR-15-0298","article-title":"Pretreatment Immune Status Correlates with Progression-Free Survival in Chemotherapy-Treated Metastatic Colorectal Cancer Patients","volume":"4","author":"Tada","year":"2016","journal-title":"Cancer Immunol. Res."},{"key":"2023072822284116900_bib41","doi-asserted-by":"publisher","first-page":"416","DOI":"10.1016\/j.stem.2008.07.009","article-title":"Hematopoietic stem cell quiescence is maintained by compound contributions of the retinoblastoma gene family","volume":"3","author":"Viatour","year":"2008","journal-title":"Cell Stem Cell."},{"key":"2023072822284116900_bib42","doi-asserted-by":"publisher","first-page":"4464","DOI":"10.1172\/JCI68189","article-title":"Myeloid-derived suppressor cell development is regulated by a STAT\/IRF-8 axis","volume":"123","author":"Waight","year":"2013","journal-title":"J. Clin. Invest."},{"key":"2023072822284116900_bib43","doi-asserted-by":"publisher","first-page":"855","DOI":"10.1016\/S0092-8674(04)00215-6","article-title":"Mechanism of activation of the RAF-ERK signaling pathway by oncogenic mutations of B-RAF","volume":"116","author":"Wan","year":"2004","journal-title":"Cell."},{"key":"2023072822284116900_bib44","doi-asserted-by":"publisher","first-page":"208","DOI":"10.3892\/br.2016.694","article-title":"Identification of CD4+CD25+CD127- regulatory T cells and CD14+HLA-DR-\/low myeloid-derived suppressor cells and their roles in the prognosis of breast cancer","volume":"5","author":"Wang","year":"2016","journal-title":"Biomed. Rep."},{"key":"2023072822284116900_bib45","doi-asserted-by":"publisher","first-page":"10427","DOI":"10.1007\/s13277-016-4916-2","article-title":"The clinical and prognostic significance of CD14(+)HLA-DR(-\/low) myeloid-derived suppressor cells in hepatocellular carcinoma patients receiving radiotherapy","volume":"37","author":"Wang","year":"2016","journal-title":"Tumour Biol."},{"key":"2023072822284116900_bib46","doi-asserted-by":"publisher","first-page":"1766","DOI":"10.4049\/jimmunol.1301939","article-title":"A reporter mouse reveals lineage-specific and heterogeneous expression of IRF8 during lymphoid and myeloid cell differentiation","volume":"193","author":"Wang","year":"2014","journal-title":"J. Immunol."},{"key":"2023072822284116900_bib47","doi-asserted-by":"publisher","first-page":"345","DOI":"10.1158\/2326-6066.CIR-15-0193","article-title":"Phase I\/II Study of Metastatic Melanoma Patients Treated with Nivolumab Who Had Progressed after Ipilimumab","volume":"4","author":"Weber","year":"2016","journal-title":"Cancer Immunol. Res."},{"key":"2023072822284116900_bib48","doi-asserted-by":"publisher","first-page":"1452","DOI":"10.1182\/blood-2014-09-600833","article-title":"IRF8 acts in lineage-committed rather than oligopotent progenitors to control neutrophil vs monocyte production","volume":"125","author":"Y\u00e1\u00f1ez","year":"2015","journal-title":"Blood."},{"key":"2023072822284116900_bib49","doi-asserted-by":"publisher","first-page":"890","DOI":"10.1016\/j.immuni.2017.10.021","article-title":"Granulocyte-Monocyte Progenitors and Monocyte-Dendritic Cell Progenitors Independently Produce Functionally Distinct Monocytes","volume":"47","author":"Y\u00e1\u00f1ez","year":"2017","journal-title":"Immunity."},{"key":"2023072822284116900_bib50","doi-asserted-by":"publisher","first-page":"167","DOI":"10.1189\/jlb.0311177","article-title":"Characterization of the nature of granulocytic myeloid-derived suppressor cells in tumor-bearing mice","volume":"91","author":"Youn","year":"2012","journal-title":"J. Leukoc. Biol."},{"key":"2023072822284116900_bib51","doi-asserted-by":"publisher","first-page":"211","DOI":"10.1038\/ni.2526","article-title":"Epigenetic silencing of retinoblastoma gene regulates pathologic differentiation of myeloid cells in cancer","volume":"14","author":"Youn","year":"2013","journal-title":"Nat. Immunol."},{"key":"2023072822284116900_bib52","doi-asserted-by":"publisher","first-page":"230","DOI":"10.1186\/1471-2105-8-230","article-title":"A comprehensive evaluation of SAM, the SAM R-package and a simple modification to improve its performance","volume":"8","author":"Zhang","year":"2007","journal-title":"BMC Bioinformatics."}],"container-title":["Journal of Experimental Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/rupress.org\/jem\/article-pdf\/216\/9\/2150\/1841964\/jem_20181952.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/rupress.org\/jem\/article-pdf\/216\/9\/2150\/1841964\/jem_20181952.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,7,28]],"date-time":"2023-07-28T22:29:18Z","timestamp":1690583358000},"score":1,"resource":{"primary":{"URL":"https:\/\/rupress.org\/jem\/article\/216\/9\/2150\/120713\/Identification-of-monocyte-like-precursors-of"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,6,25]]},"references-count":52,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2019,9,2]]}},"URL":"https:\/\/doi.org\/10.1084\/jem.20181952","relation":{},"ISSN":["0022-1007","1540-9538"],"issn-type":[{"value":"0022-1007","type":"print"},{"value":"1540-9538","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,6,25]]}}}