{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,17]],"date-time":"2026-07-17T15:29:31Z","timestamp":1784302171295,"version":"3.55.0"},"reference-count":44,"publisher":"Rockefeller University Press","issue":"9","license":[{"start":{"date-parts":[[2019,7,11]],"date-time":"2019-07-11T00:00:00Z","timestamp":1562803200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/www.rupress.org\/terms\/"},{"start":{"date-parts":[[2020,3,1]],"date-time":"2020-03-01T00:00:00Z","timestamp":1583020800000},"content-version":"vor","delay-in-days":234,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-sa\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100007229","name":"Bijzonder Onderzoeksfonds","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100007229","id-type":"DOI","asserted-by":"publisher"}]},{"name":"University of Ghent"},{"DOI":"10.13039\/100010663","name":"European Research Council","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100010663","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100010663","name":"ERC","doi-asserted-by":"publisher","award":["G0G7318N"],"award-info":[{"award-number":["G0G7318N"]}],"id":[{"id":"10.13039\/100010663","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003130","name":"Research Foundation Flanders","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003130","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100010663","name":"ERC","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100010663","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100010663","name":"H2020 European Research Council","doi-asserted-by":"publisher","award":["694502"],"award-info":[{"award-number":["694502"]}],"id":[{"id":"10.13039\/100010663","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001665","name":"Agence Nationale de la Recherche","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001665","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004099","name":"Ligue Contre le Cancer","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004099","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100016913","name":"MSDAvenir","doi-asserted-by":"crossref","id":[{"id":"10.13039\/100016913","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100020986","name":"Innate Pharma","doi-asserted-by":"crossref","id":[{"id":"10.13039\/100020986","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100001677","name":"INSERM","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001677","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004794","name":"Centre National de la Recherche Scientifique","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004794","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007586","name":"Aix-Marseille Universit\u00e9","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100007586","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Methusalem","award":["BOF16\/MET_V\/007"],"award-info":[{"award-number":["BOF16\/MET_V\/007"]}]}],"content-domain":{"domain":["rupress.org"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2019,9,2]]},"abstract":"<jats:p>The ubiquitin-editing enzyme A20 is a well-known regulator of immune cell function and homeostasis. In addition, A20 protects cells from death in an ill-defined manner. While most studies focus on its role in the TNF-receptor complex, we here identify a novel component in the A20-mediated decision between life and death. Loss of A20 in NK cells led to spontaneous NK cell death and severe NK cell lymphopenia. The few remaining NK cells showed an immature, hyperactivated phenotype, hallmarked by the basal release of cytokines and cytotoxic molecules. NK-A20\u2212\/\u2212 cells were hypersensitive to TNF-induced cell death and could be rescued, at least partially, by a combined deficiency with TNF. Unexpectedly, rapamycin, a well-established inhibitor of mTOR, also strongly protected NK-A20\u2212\/\u2212 cells from death, and further studies revealed that A20 restricts mTOR activation in NK cells. This study therefore maps A20 as a crucial regulator of mTOR signaling and underscores the need for a tightly balanced mTOR pathway in NK cell homeostasis.<\/jats:p>","DOI":"10.1084\/jem.20182164","type":"journal-article","created":{"date-parts":[[2019,7,11]],"date-time":"2019-07-11T18:45:13Z","timestamp":1562870713000},"page":"2010-2023","update-policy":"https:\/\/doi.org\/10.1084\/jem.crossmarkpolicy","source":"Crossref","is-referenced-by-count":24,"title":["The ubiquitin-editing enzyme A20 controls NK cell homeostasis through regulation of mTOR activity and TNF"],"prefix":"10.1084","volume":"216","author":[{"given":"Jessica","family":"Vetters","sequence":"first","affiliation":[{"name":"Laboratory of Immunoregulation and Mucosal Immunology, VIB Center for Inflammation Research, Ghent, Belgium 1"},{"name":"Laboratory for Endoplasmic Reticulum Stress and Inflammation, VIB Center for Inflammation Research, Ghent, Belgium 2"},{"name":"GROUP-ID Consortium, Ghent University and Ghent University Hospital, Ghent, Belgium 3"},{"name":"Department of Internal Medicine and Pediatrics, Ghent University, Ghent, Belgium 4"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mary J.","family":"van Helden","sequence":"additional","affiliation":[{"name":"Laboratory of Immunoregulation and Mucosal Immunology, VIB Center for Inflammation Research, Ghent, Belgium 1"},{"name":"Department of Internal Medicine and Pediatrics, Ghent University, Ghent, Belgium 4"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sigrid","family":"Wahlen","sequence":"additional","affiliation":[{"name":"Department of Diagnostic Sciences, Ghent University, Ghent, Belgium 5"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2514-5655","authenticated-orcid":true,"given":"Simon J.","family":"Tavernier","sequence":"additional","affiliation":[{"name":"Laboratory of Immunoregulation and Mucosal Immunology, VIB Center for Inflammation Research, Ghent, Belgium 1"},{"name":"Department of Internal Medicine and Pediatrics, Ghent University, Ghent, Belgium 4"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arne","family":"Martens","sequence":"additional","affiliation":[{"name":"Department of Biomedical Molecular Biology, Ghent University, Ghent, Belgium 6"},{"name":"Cellular and Molecular (Patho)physiology, VIB Center for Inflammation Research, Ghent, Belgium 9"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Farzaneh","family":"Fayazpour","sequence":"additional","affiliation":[{"name":"Laboratory for Endoplasmic Reticulum Stress and Inflammation, VIB Center for Inflammation Research, Ghent, Belgium 2"},{"name":"GROUP-ID Consortium, Ghent University and Ghent University Hospital, Ghent, Belgium 3"},{"name":"Department of Internal Medicine and Pediatrics, Ghent University, Ghent, Belgium 4"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karl","family":"Vergote","sequence":"additional","affiliation":[{"name":"Laboratory of Immunoregulation and Mucosal Immunology, VIB Center for Inflammation Research, Ghent, Belgium 1"},{"name":"Department of Internal Medicine and Pediatrics, Ghent University, Ghent, Belgium 4"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manon","family":"Vanheerswynghels","sequence":"additional","affiliation":[{"name":"Laboratory of Immunoregulation and Mucosal Immunology, VIB Center for Inflammation Research, Ghent, Belgium 1"},{"name":"Department of Internal Medicine and Pediatrics, Ghent University, Ghent, Belgium 4"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kim","family":"Deswarte","sequence":"additional","affiliation":[{"name":"Laboratory of Immunoregulation and Mucosal Immunology, VIB Center for Inflammation Research, Ghent, Belgium 1"},{"name":"Department of Internal Medicine and Pediatrics, Ghent University, Ghent, Belgium 4"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Justine","family":"Van Moorleghem","sequence":"additional","affiliation":[{"name":"Laboratory of Immunoregulation and Mucosal Immunology, VIB Center for Inflammation Research, Ghent, Belgium 1"},{"name":"Department of Internal Medicine and Pediatrics, Ghent University, Ghent, Belgium 4"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sofie","family":"De Prijck","sequence":"additional","affiliation":[{"name":"Laboratory of Immunoregulation and Mucosal Immunology, VIB Center for Inflammation Research, Ghent, Belgium 1"},{"name":"Department of Internal Medicine and Pediatrics, Ghent University, Ghent, Belgium 4"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nozomi","family":"Takahashi","sequence":"additional","affiliation":[{"name":"Department of Biomedical Molecular Biology, Ghent University, Ghent, Belgium 6"},{"name":"Molecular Signaling and Cell Death, VIB Center for Inflammation Research, Ghent, Belgium 7"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6669-8822","authenticated-orcid":true,"given":"Peter","family":"Vandenabeele","sequence":"additional","affiliation":[{"name":"Department of Biomedical Molecular Biology, Ghent University, Ghent, Belgium 6"},{"name":"Molecular Signaling and Cell Death, VIB Center for Inflammation Research, Ghent, Belgium 7"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0937-9171","authenticated-orcid":true,"given":"Louis","family":"Boon","sequence":"additional","affiliation":[{"name":"Bioceros BV, Utrecht, Netherlands 8"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8427-4775","authenticated-orcid":true,"given":"Geert","family":"van Loo","sequence":"additional","affiliation":[{"name":"Department of Biomedical Molecular Biology, Ghent University, Ghent, Belgium 6"},{"name":"Cellular and Molecular (Patho)physiology, VIB Center for Inflammation Research, Ghent, Belgium 9"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7022-8287","authenticated-orcid":true,"given":"Eric","family":"Vivier","sequence":"additional","affiliation":[{"name":"Innate Pharma Research Laboratories, Innate Pharma, Marseille, France 10"},{"name":"Aix-Marseille University, Assistance Publique\u2013H\u00f4pitaux de Marseille, Centre d'Immunologie de Marseille-Luminy, H\u00f4pital de la Timone, Marseille Immunop\u00f4le, Marseille, France 11"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4376-6834","authenticated-orcid":true,"given":"Bart N.","family":"Lambrecht","sequence":"additional","affiliation":[{"name":"Laboratory of Immunoregulation and Mucosal Immunology, VIB Center for Inflammation Research, Ghent, Belgium 1"},{"name":"GROUP-ID Consortium, Ghent University and Ghent University Hospital, Ghent, Belgium 3"},{"name":"Department of Internal Medicine and Pediatrics, Ghent University, Ghent, Belgium 4"},{"name":"Department of Pulmonary Medicine, Erasmus University Medical Center, Rotterdam, Netherlands 12"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1702-1636","authenticated-orcid":true,"given":"Sophie","family":"Janssens","sequence":"additional","affiliation":[{"name":"Laboratory for Endoplasmic Reticulum Stress and Inflammation, VIB Center for Inflammation Research, Ghent, Belgium 2"},{"name":"GROUP-ID Consortium, Ghent University and Ghent University Hospital, Ghent, Belgium 3"},{"name":"Department of Internal Medicine and Pediatrics, Ghent University, Ghent, Belgium 4"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"291","published-online":{"date-parts":[[2019,7,11]]},"reference":[{"key":"2023072822224533600_bib1","doi-asserted-by":"publisher","first-page":"272","DOI":"10.1038\/nature12599","article-title":"Paneth cells as a site of origin for intestinal inflammation","volume":"503","author":"Adolph","year":"2013","journal-title":"Nature."},{"key":"2023072822224533600_bib2","doi-asserted-by":"publisher","first-page":"15","DOI":"10.1016\/j.jim.2004.08.008","article-title":"CD107a as a functional marker for the identification of natural killer cell activity","volume":"294","author":"Alter","year":"2004","journal-title":"J. Immunol. Methods."},{"key":"2023072822224533600_bib3","doi-asserted-by":"publisher","first-page":"22","DOI":"10.1016\/j.it.2013.10.005","article-title":"A20 in inflammation and autoimmunity","volume":"35","author":"Catrysse","year":"2014","journal-title":"Trends Immunol."},{"key":"2023072822224533600_bib4","doi-asserted-by":"publisher","DOI":"10.1038\/cddis.2016.154","article-title":"A20 prevents chronic liver inflammation and cancer by protecting hepatocytes from death","volume":"7","author":"Catrysse","year":"2016","journal-title":"Cell Death Dis."},{"key":"2023072822224533600_bib5","doi-asserted-by":"publisher","first-page":"5488","DOI":"10.1182\/blood-2008-10-187179","article-title":"Maturation of mouse NK cells is a 4-stage developmental program","volume":"113","author":"Chiossone","year":"2009","journal-title":"Blood."},{"key":"2023072822224533600_bib6","doi-asserted-by":"publisher","first-page":"2227","DOI":"10.1182\/blood-2010-09-306019","article-title":"B cells lacking the tumor suppressor TNFAIP3\/A20 display impaired differentiation and hyperactivation and cause inflammation and autoimmunity in aged mice","volume":"117","author":"Chu","year":"2011","journal-title":"Blood."},{"key":"2023072822224533600_bib7","doi-asserted-by":"publisher","first-page":"3633","DOI":"10.1182\/blood-2001-12-0293","article-title":"In vivo evidence for a dependence on interleukin 15 for survival of natural killer cells","volume":"100","author":"Cooper","year":"2002","journal-title":"Blood."},{"key":"2023072822224533600_bib8","doi-asserted-by":"publisher","first-page":"313","DOI":"10.1038\/nchembio.83","article-title":"Identification of RIP1 kinase as a specific cellular target of necrostatins","volume":"4","author":"Degterev","year":"2008","journal-title":"Nat. Chem. Biol."},{"key":"2023072822224533600_bib9","doi-asserted-by":"crossref","first-page":"2272","DOI":"10.1182\/blood.V91.7.2272","article-title":"Systemic overexpression of BCL-2 in the hematopoietic system protects transgenic mice from the consequences of lethal irradiation","volume":"91","author":"Domen","year":"1998","journal-title":"Blood."},{"key":"2023072822224533600_bib10","doi-asserted-by":"publisher","first-page":"253","DOI":"10.1084\/jem.191.2.253","article-title":"The role of apoptosis in the regulation of hematopoietic stem cells: Overexpression of Bcl-2 increases both their number and repopulation potential","volume":"191","author":"Domen","year":"2000","journal-title":"J. Exp. Med."},{"key":"2023072822224533600_bib11","doi-asserted-by":"publisher","first-page":"1973","DOI":"10.1084\/jem.20151065","article-title":"NKT sublineage specification and survival requires the ubiquitin-modifying enzyme TNFAIP3\/A20","volume":"213","author":"Drennan","year":"2016","journal-title":"J. Exp. Med."},{"key":"2023072822224533600_bib12","doi-asserted-by":"publisher","first-page":"1565","DOI":"10.1182\/blood-2010-06-291633","article-title":"A novel Ncr1-Cre mouse reveals the essential role of STAT5 for NK-cell survival and development","volume":"117","author":"Eckelhart","year":"2011","journal-title":"Blood."},{"key":"2023072822224533600_bib13","doi-asserted-by":"publisher","first-page":"2092","DOI":"10.1091\/mbc.e07-12-1257","article-title":"The Atg16L complex specifies the site of LC3 lipidation for membrane biogenesis in autophagy","volume":"19","author":"Fujita","year":"2008","journal-title":"Mol. Biol. Cell."},{"key":"2023072822224533600_bib14","doi-asserted-by":"publisher","first-page":"481","DOI":"10.1038\/ncb2738","article-title":"ER-stress-induced transcriptional regulation increases protein synthesis leading to cell\u00a0death","volume":"15","author":"Han","year":"2013","journal-title":"Nat. Cell Biol."},{"key":"2023072822224533600_bib15","doi-asserted-by":"publisher","first-page":"1517","DOI":"10.4049\/jimmunol.176.3.1517","article-title":"CD27 dissects mature NK cells into two subsets with distinct responsiveness and migratory capacity","volume":"176","author":"Hayakawa","year":"2006","journal-title":"J. Immunol."},{"key":"2023072822224533600_bib16","doi-asserted-by":"publisher","first-page":"856","DOI":"10.1038\/ni1487","article-title":"Interleukin 15-mediated survival of natural killer cells is determined by interactions among Bim, Noxa and Mcl-1","volume":"8","author":"Huntington","year":"2007","journal-title":"Nat. Immunol."},{"key":"2023072822224533600_bib17","doi-asserted-by":"publisher","first-page":"1219","DOI":"10.1038\/ni.2740","article-title":"Pathogen signatures activate a ubiquitination pathway that modulates the function of the metabolic checkpoint kinase mTOR","volume":"14","author":"Ivanov","year":"2013","journal-title":"Nat. Immunol."},{"key":"2023072822224533600_bib18","doi-asserted-by":"publisher","first-page":"523","DOI":"10.1038\/ni796","article-title":"In vivo developmental stages in murine natural killer cell maturation","volume":"3","author":"Kim","year":"2002","journal-title":"Nat. Immunol."},{"key":"2023072822224533600_bib19","doi-asserted-by":"publisher","first-page":"82","DOI":"10.1016\/j.immuni.2011.05.013","article-title":"The ubiquitin-editing protein A20 prevents dendritic cell activation, recognition of apoptotic cells, and systemic autoimmunity","volume":"35","author":"Kool","year":"2011","journal-title":"Immunity."},{"key":"2023072822224533600_bib20","doi-asserted-by":"publisher","first-page":"2350","DOI":"10.1126\/science.289.5488.2350","article-title":"Failure to regulate TNF-induced NF-kappaB and cell death responses in A20-deficient mice","volume":"289","author":"Lee","year":"2000","journal-title":"Science."},{"key":"2023072822224533600_bib21","doi-asserted-by":"publisher","first-page":"749","DOI":"10.1038\/ni.2936","article-title":"The metabolic checkpoint kinase mTOR is essential for IL-15 signaling during the development and activation of NK cells","volume":"15","author":"Mar\u00e7ais","year":"2014","journal-title":"Nat. Immunol."},{"key":"2023072822224533600_bib22","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.26423","article-title":"High mTOR activity is a hallmark of reactive natural killer cells and amplifies early signaling through activating receptors","volume":"6","author":"Mar\u00e7ais","year":"2017","journal-title":"eLife."},{"key":"2023072822224533600_bib23","doi-asserted-by":"publisher","first-page":"1052","DOI":"10.1080\/15548627.2015.1055439","article-title":"TNFAIP3 promotes survival of CD4 T cells by restricting MTOR and promoting autophagy","volume":"11","author":"Matsuzawa","year":"2015","journal-title":"Autophagy."},{"key":"2023072822224533600_bib24","doi-asserted-by":"publisher","first-page":"4153","DOI":"10.4049\/jimmunol.169.8.4153","article-title":"Enforced expression of Bcl-2 restores the number of NK cells, but does not rescue the impaired development of NKT cells or intraepithelial lymphocytes, in IL-2\/IL-15 receptor beta-chain-deficient mice","volume":"169","author":"Minagawa","year":"2002","journal-title":"J. Immunol."},{"key":"2023072822224533600_bib25","doi-asserted-by":"publisher","first-page":"18324","DOI":"10.1073\/pnas.1112064108","article-title":"Fate mapping analysis of lymphoid cells expressing the NKp46 cell surface receptor","volume":"108","author":"Narni-Mancinelli","year":"2011","journal-title":"Proc. Natl. Acad. Sci. USA."},{"key":"2023072822224533600_bib26","doi-asserted-by":"publisher","first-page":"1464","DOI":"10.1128\/MCB.24.4.1464-1469.2004","article-title":"Kinase RIP3 is dispensable for normal NF-\u03baBs, signaling by the B-cell and T-cell receptors, tumor necrosis factor receptor 1, and toll-like receptors 2 and 4","volume":"24","author":"Newton","year":"2004","journal-title":"Mol. Cell. Biol."},{"key":"2023072822224533600_bib27","doi-asserted-by":"publisher","first-page":"618","DOI":"10.1038\/ni.3172","article-title":"The ubiquitin-modifying enzyme A20 restricts ubiquitination of the kinase RIPK3 and protects cells from necroptosis","volume":"16","author":"Onizawa","year":"2015","journal-title":"Nat. Immunol."},{"key":"2023072822224533600_bib28","doi-asserted-by":"crossref","first-page":"12424","DOI":"10.1016\/S0021-9258(18)42292-2","article-title":"The A20 zinc finger protein protects cells from tumor necrosis factor cytotoxicity","volume":"267","author":"Opipari","year":"1992","journal-title":"J. Biol. Chem."},{"key":"2023072822224533600_bib29","doi-asserted-by":"publisher","first-page":"1910","DOI":"10.1016\/j.celrep.2016.04.082","article-title":"Atg5 is essential for the development and survival of innate lymphocytes","volume":"15","author":"O'Sullivan","year":"2016","journal-title":"Cell Rep."},{"key":"2023072822224533600_bib30","doi-asserted-by":"publisher","first-page":"1397","DOI":"10.1084\/jem.184.4.1397","article-title":"Immune and inflammatory responses in TNF alpha-deficient mice: a critical requirement for TNF alpha in the formation of primary B cell follicles, follicular dendritic cell networks and germinal centers, and in the maturation of the humoral immune response","volume":"184","author":"Pasparakis","year":"1996","journal-title":"J. Exp. Med."},{"key":"2023072822224533600_bib31","doi-asserted-by":"publisher","first-page":"731","DOI":"10.1038\/s41556-019-0324-3","article-title":"A20 prevents inflammasome-dependent arthritis by inhibiting macrophage necroptosis through its ZnF7 ubiquitin-binding domain","volume":"21","author":"Polykratis","year":"2019","journal-title":"Nat. Cell Biol."},{"key":"2023072822224533600_bib32","doi-asserted-by":"publisher","first-page":"568","DOI":"10.1038\/nri2604","article-title":"Oncogenic stress sensed by the immune system: role of natural killer cell receptors","volume":"9","author":"Raulet","year":"2009","journal-title":"Nat. Rev. Immunol."},{"key":"2023072822224533600_bib33","doi-asserted-by":"publisher","first-page":"128","DOI":"10.1016\/j.tibs.2008.12.003","article-title":"Autoregulatory feedback loops terminating the NF-kappaB response","volume":"34","author":"Renner","year":"2009","journal-title":"Trends Biochem. Sci."},{"key":"2023072822224533600_bib34","doi-asserted-by":"publisher","first-page":"4539","DOI":"10.1038\/ncomms5539","article-title":"Innate immunodeficiency following genetic ablation of Mcl1 in natural killer cells","volume":"5","author":"Sathe","year":"2014","journal-title":"Nat. Commun."},{"key":"2023072822224533600_bib35","doi-asserted-by":"publisher","first-page":"49","DOI":"10.1038\/nature13035","article-title":"Haematopoietic stem cells require a highly regulated protein synthesis rate","volume":"509","author":"Signer","year":"2014","journal-title":"Nature."},{"key":"2023072822224533600_bib36","doi-asserted-by":"publisher","first-page":"181","DOI":"10.1016\/j.immuni.2010.07.017","article-title":"The ubiquitin modifying enzyme A20 restricts B cell survival and prevents autoimmunity","volume":"33","author":"Tavares","year":"2010","journal-title":"Immunity."},{"key":"2023072822224533600_bib37","doi-asserted-by":"publisher","first-page":"698","DOI":"10.1038\/ncb3518","article-title":"Regulated IRE1-dependent mRNA decay sets the threshold for dendritic cell survival","volume":"19","author":"Tavernier","year":"2017","journal-title":"Nat. Cell Biol."},{"key":"2023072822224533600_bib38","doi-asserted-by":"publisher","first-page":"1513","DOI":"10.1084\/jem.20092474","article-title":"Enterocyte-specific A20 deficiency sensitizes to tumor necrosis factor-induced toxicity and experimental colitis","volume":"207","author":"Vereecke","year":"2010","journal-title":"J. Exp. Med."},{"key":"2023072822224533600_bib39","doi-asserted-by":"publisher","first-page":"5103","DOI":"10.1038\/ncomms6103","article-title":"A20 controls intestinal homeostasis through cell-specific activities","volume":"5","author":"Vereecke","year":"2014","journal-title":"Nat. Commun."},{"key":"2023072822224533600_bib40","doi-asserted-by":"publisher","first-page":"503","DOI":"10.1038\/ni1582","article-title":"Functions of natural killer cells","volume":"9","author":"Vivier","year":"2008","journal-title":"Nat. Immunol."},{"key":"2023072822224533600_bib41","doi-asserted-by":"publisher","first-page":"239","DOI":"10.1038\/nri3174","article-title":"Targeting natural killer cells and natural killer T cells in cancer","volume":"12","author":"Vivier","year":"2012","journal-title":"Nat. Rev. Immunol."},{"key":"2023072822224533600_bib42","doi-asserted-by":"publisher","first-page":"1054","DOI":"10.1016\/j.cell.2018.07.017","article-title":"Innate Lymphoid Cells: 10 Years On","volume":"174","author":"Vivier","year":"2018","journal-title":"Cell."},{"key":"2023072822224533600_bib43","doi-asserted-by":"publisher","first-page":"1213","DOI":"10.4049\/jimmunol.174.3.1213","article-title":"Roles for common cytokine receptor gamma-chain-dependent cytokines in the generation, differentiation, and maturation of NK cell precursors and peripheral NK cells in vivo","volume":"174","author":"Vosshenrich","year":"2005","journal-title":"J. Immunol."},{"key":"2023072822224533600_bib44","doi-asserted-by":"publisher","first-page":"15","DOI":"10.1016\/j.coviro.2015.10.008","article-title":"Roles of natural killer cells in antiviral immunity","volume":"16","author":"Waggoner","year":"2016","journal-title":"Curr. Opin. Virol."}],"container-title":["Journal of Experimental Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/rupress.org\/jem\/article-pdf\/216\/9\/2010\/1841509\/jem_20182164.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/rupress.org\/jem\/article-pdf\/216\/9\/2010\/1841509\/jem_20182164.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,7,28]],"date-time":"2023-07-28T22:23:22Z","timestamp":1690583002000},"score":1,"resource":{"primary":{"URL":"https:\/\/rupress.org\/jem\/article\/216\/9\/2010\/120707\/The-ubiquitin-editing-enzyme-A20-controls-NK-cell"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,7,11]]},"references-count":44,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2019,9,2]]}},"URL":"https:\/\/doi.org\/10.1084\/jem.20182164","relation":{},"ISSN":["0022-1007","1540-9538"],"issn-type":[{"value":"0022-1007","type":"print"},{"value":"1540-9538","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,7,11]]}}}