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Here, we are aimed at developing molecular imaging tools for visualizing \u03b3-secretase. We used our recently developed \u03b3-secretase modulators (GSMs) and synthesized our GSM-based imaging agent, [11C]SGSM-15606. We subsequently performed molecular imaging in rodents, including AD transgenic animals, and macaques, which revealed that our probe displayed good brain uptake and selectivity, stable metabolism, and appropriate kinetics and distribution for imaging \u03b3-secretase in the brain. Interestingly, rodents and macaques shared certain brain areas with high \u03b3-secretase expression, suggesting a functional conservation of \u03b3-secretase. Collectively, we have provided the first molecular brain imaging of \u03b3-secretase, which may not only accelerate our drug discovery for AD but also advance our understanding of AD.<\/jats:p>","DOI":"10.1084\/jem.20182266","type":"journal-article","created":{"date-parts":[[2020,9,16]],"date-time":"2020-09-16T15:42:47Z","timestamp":1600270967000},"update-policy":"https:\/\/doi.org\/10.1084\/jem.crossmarkpolicy","source":"Crossref","is-referenced-by-count":15,"title":["Molecular imaging of Alzheimer\u2019s disease\u2013related gamma-secretase in mice and nonhuman primates"],"prefix":"10.1084","volume":"217","author":[{"given":"Yulong","family":"Xu","sequence":"first","affiliation":[{"name":"Athinoula A. 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