{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,10]],"date-time":"2026-11-10T02:48:19Z","timestamp":1794278899182,"version":"4.9.0"},"reference-count":155,"publisher":"Rockefeller University Press","issue":"2","license":[{"start":{"date-parts":[[2021,1,8]],"date-time":"2021-01-08T00:00:00Z","timestamp":1610064000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/www.rupress.org\/terms\/"},{"start":{"date-parts":[[2021,8,2]],"date-time":"2021-08-02T00:00:00Z","timestamp":1627862400000},"content-version":"vor","delay-in-days":206,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-sa\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000065","name":"National Institute of Neurological Disorders and Stroke","doi-asserted-by":"publisher","award":["R01 NS102633-01"],"award-info":[{"award-number":["R01 NS102633-01"]}],"id":[{"id":"10.13039\/100000065","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Office of the Assistant Secretary of Defense for Health Affairs","id":[{"id":"https:\/\/ror.org\/03b7pda13","id-type":"ROR","asserted-by":"crossref"}]},{"name":"Multiple Sclerosis Research Program","award":["W81XWH-14-1-0156"],"award-info":[{"award-number":["W81XWH-14-1-0156"]}]},{"DOI":"10.13039\/100007366","name":"Fondazione Italiana Sclerosi Multipla","doi-asserted-by":"publisher","award":["FISM 2014\/R\/15"],"award-info":[{"award-number":["FISM 2014\/R\/15"]}],"id":[{"id":"10.13039\/100007366","id-type":"DOI","asserted-by":"publisher"}]},{"name":"\u201c5 per mille\u201d"},{"DOI":"10.13039\/501100000925","name":"National Health and Medical Research Council","doi-asserted-by":"publisher","award":["APP1177797"],"award-info":[{"award-number":["APP1177797"]}],"id":[{"id":"10.13039\/501100000925","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100023281","name":"Australian Youth and Health Foundation","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100023281","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100019371","name":"Bakewell Foundation","doi-asserted-by":"crossref","id":[{"id":"10.13039\/100019371","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100007366","name":"Fondazione Italiana Sclerosi Multipla","doi-asserted-by":"publisher","award":["FISM 2018\/B\/1"],"award-info":[{"award-number":["FISM 2018\/B\/1"]}],"id":[{"id":"10.13039\/100007366","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000890","name":"National Multiple Sclerosis Society","doi-asserted-by":"publisher","award":["FG-1907-34474"],"award-info":[{"award-number":["FG-1907-34474"]}],"id":[{"id":"10.13039\/100000890","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Leon and Harriet Felman Fund for Human MS Research"}],"content-domain":{"domain":["rupress.org"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2021,2,1]]},"abstract":"<jats:p>Recent and accumulating work in experimental animal models and humans shows that diet has a much more pervasive and prominent role than previously thought in modulating neuroinflammatory and neurodegenerative mechanisms leading to some of the most common chronic central nervous system (CNS) diseases. Chronic or intermittent food restriction has profound effects in shaping brain and peripheral metabolism, immunity, and gut microbiome biology. Interactions among calorie intake, meal frequency, diet quality, and the gut microbiome modulate specific metabolic and molecular pathways that regulate cellular, tissue, and organ homeostasis as well as inflammation during normal brain aging and CNS neurodegenerative diseases, including Alzheimer\u2019s disease, Parkinson\u2019s disease, amyotrophic lateral sclerosis, and multiple sclerosis, among others. This review discusses these findings and their potential application to the prevention and treatment of CNS neuroinflammatory diseases and the promotion of healthy brain aging.<\/jats:p>","DOI":"10.1084\/jem.20190086","type":"journal-article","created":{"date-parts":[[2020,12,1]],"date-time":"2020-12-01T02:21:33Z","timestamp":1606789293000},"update-policy":"https:\/\/doi.org\/10.1084\/jem.crossmarkpolicy","source":"Crossref","is-referenced-by-count":112,"title":["Effects of dietary restriction on neuroinflammation in neurodegenerative diseases"],"prefix":"10.1084","volume":"218","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8500-5537","authenticated-orcid":true,"given":"Luigi","family":"Fontana","sequence":"first","affiliation":[{"name":"Charles Perkins Center, Faculty of Medicine and Health, University of Sydney, Sydney, New South Wales, Australia 1"},{"name":"Department of Endocrinology, Royal Prince Alfred Hospital, Sydney, Australia 2"},{"name":"Department of Clinical and Experimental Sciences, Brescia University, Brescia, Italy 3"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8180-9730","authenticated-orcid":true,"given":"Laura","family":"Ghezzi","sequence":"additional","affiliation":[{"name":"Department of Neurology, Washington University in St. Louis, St. Louis, MO 4"},{"name":"University of Milan, Milan, Italy 5"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0829-7569","authenticated-orcid":true,"given":"Anne H.","family":"Cross","sequence":"additional","affiliation":[{"name":"Department of Neurology, Washington University in St. Louis, St. Louis, MO 4"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8760-109X","authenticated-orcid":true,"given":"Laura","family":"Piccio","sequence":"additional","affiliation":[{"name":"Department of Neurology, Washington University in St. Louis, St. Louis, MO 4"},{"name":"Brain and Mind Centre, School of Medical Sciences, University of Sydney, Sydney, New South Wales, Australia 6"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"291","published-online":{"date-parts":[[2021,1,8]]},"reference":[{"key":"2023072716042273100_bib1","doi-asserted-by":"publisher","first-page":"383","DOI":"10.1016\/S0197-4580(00)00124-X","article-title":"Inflammation and Alzheimer\u2019s disease","volume":"21","author":"Akiyama","year":"2000","journal-title":"Neurobiol. Aging."},{"key":"2023072716042273100_bib2","doi-asserted-by":"publisher","first-page":"1830","DOI":"10.1016\/j.jmb.2019.03.006","article-title":"Microglia-Specific Metabolic Changes in Neurodegeneration","volume":"431","author":"Aldana","year":"2019","journal-title":"J. Mol. Biol."},{"key":"2023072716042273100_bib3","doi-asserted-by":"publisher","first-page":"1117","DOI":"10.1056\/NEJM199704173361601","article-title":"A clinical trial of the effects of dietary patterns on blood pressure","volume":"336","author":"Appel","year":"1997","journal-title":"N. Engl. J. Med."},{"key":"2023072716042273100_bib4","doi-asserted-by":"publisher","first-page":"548","DOI":"10.1016\/j.expneurol.2008.04.006","article-title":"Dietary restriction does not prevent nigrostriatal degeneration in the 6-hydroxydopamine model of Parkinson\u2019s disease","volume":"212","author":"Armentero","year":"2008","journal-title":"Exp. Neurol."},{"key":"2023072716042273100_bib5","doi-asserted-by":"publisher","first-page":"897","DOI":"10.1002\/iub.1450","article-title":"Recent advances in detection of AGEs: Immunochemical, bioanalytical and biochemical approaches","volume":"67","author":"Ashraf","year":"2015","journal-title":"IUBMB Life."},{"key":"2023072716042273100_bib6","doi-asserted-by":"publisher","DOI":"10.1111\/acel.12861","article-title":"Trends in age-related disease burden and healthcare utilization","volume":"18","author":"Atella","year":"2019","journal-title":"Aging Cell."},{"key":"2023072716042273100_bib7","doi-asserted-by":"publisher","first-page":"9","DOI":"10.1016\/j.atherosclerosis.2007.07.025","article-title":"Receptor for advanced glycation endproducts and atherosclerosis: From basic mechanisms to clinical implications","volume":"196","author":"Basta","year":"2008","journal-title":"Atherosclerosis."},{"key":"2023072716042273100_bib8","doi-asserted-by":"publisher","first-page":"3049","DOI":"10.1523\/JNEUROSCI.4373-15.2016","article-title":"Ghrelin-AMPK Signaling Mediates the Neuroprotective Effects of Calorie Restriction in Parkinson\u2019s Disease","volume":"36","author":"Bayliss","year":"2016","journal-title":"J. Neurosci."},{"key":"2023072716042273100_bib9","doi-asserted-by":"publisher","first-page":"126","DOI":"10.1001\/archinternmed.2009.470","article-title":"Effects of the DASH diet alone and in combination with exercise and weight loss on blood pressure and cardiovascular biomarkers in men and women with high blood pressure: the ENCORE study","volume":"170","author":"Blumenthal","year":"2010","journal-title":"Arch. Intern. Med."},{"key":"2023072716042273100_bib10","doi-asserted-by":"publisher","first-page":"1389","DOI":"10.1126\/science.1123511","article-title":"Onset and progression in inherited ALS determined by motor neurons and microglia","volume":"312","author":"Boill\u00e9e","year":"2006","journal-title":"Science."},{"key":"2023072716042273100_bib11","doi-asserted-by":"publisher","first-page":"464","DOI":"10.3390\/ijms20030464","article-title":"Dietary Restriction and Neuroinflammation: A Potential Mechanistic Link","volume":"20","author":"Bok","year":"2019","journal-title":"Int. J. Mol. Sci."},{"key":"2023072716042273100_bib12","doi-asserted-by":"publisher","first-page":"777","DOI":"10.1016\/j.tcb.2020.07.002","article-title":"A Senescence-Centric View of Aging: Implications for Longevity and Disease","volume":"30","author":"Borghesan","year":"2020","journal-title":"Trends Cell Biol."},{"key":"2023072716042273100_bib13","doi-asserted-by":"publisher","first-page":"458","DOI":"10.1038\/35013070","article-title":"Vagus nerve stimulation attenuates the systemic inflammatory response to endotoxin","volume":"405","author":"Borovikova","year":"2000","journal-title":"Nature."},{"key":"2023072716042273100_bib14","doi-asserted-by":"publisher","first-page":"517","DOI":"10.1007\/s00702-002-0808-2","article-title":"Idiopathic Parkinson\u2019s disease: possible routes by which vulnerable neuronal types may be subject to neuroinvasion by an unknown pathogen","volume":"110","author":"Braak","year":"2003","journal-title":"J. Neural Transm. (Vienna)."},{"key":"2023072716042273100_bib15","doi-asserted-by":"publisher","first-page":"79","DOI":"10.1016\/j.bbr.2014.06.001","article-title":"Partial rescue of memory deficits induced by calorie restriction in a mouse model of tau deposition","volume":"271","author":"Brownlow","year":"2014","journal-title":"Behav. Brain Res."},{"key":"2023072716042273100_bib16","doi-asserted-by":"publisher","first-page":"578","DOI":"10.1038\/s41586-018-0543-y","article-title":"Clearance of senescent glial cells prevents tau-dependent pathology and cognitive decline","volume":"562","author":"Bussian","year":"2018","journal-title":"Nature."},{"key":"2023072716042273100_bib17","doi-asserted-by":"publisher","first-page":"B337","DOI":"10.1093\/gerona\/50A.6.B337","article-title":"Caloric restriction decreases age-dependent accumulation of the glycoxidation products, N epsilon-(carboxymethyl)lysine and pentosidine, in rat skin collagen","volume":"50","author":"Cefalu","year":"1995","journal-title":"J. Gerontol. A Biol. Sci. Med. Sci."},{"key":"2023072716042273100_bib18","doi-asserted-by":"publisher","first-page":"3","DOI":"10.1016\/j.exger.2014.09.018","article-title":"Cellular senescence and the aging brain","volume":"68","author":"Chinta","year":"2015","journal-title":"Exp. Gerontol."},{"key":"2023072716042273100_bib19","doi-asserted-by":"publisher","first-page":"2136","DOI":"10.1016\/j.celrep.2016.05.009","article-title":"A Diet Mimicking Fasting Promotes Regeneration and Reduces Autoimmunity and Multiple Sclerosis Symptoms","volume":"15","author":"Choi","year":"2016","journal-title":"Cell Rep."},{"key":"2023072716042273100_bib20","doi-asserted-by":"publisher","first-page":"806","DOI":"10.1016\/j.freeradbiomed.2004.12.008","article-title":"Enhanced susceptibility to 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine neurotoxicity in high-fat diet-induced obesity","volume":"38","author":"Choi","year":"2005","journal-title":"Free Radic. Biol. Med."},{"key":"2023072716042273100_bib21","doi-asserted-by":"publisher","first-page":"366","DOI":"10.1016\/j.cmet.2020.06.018","article-title":"Effects of 4- and 6-h Time-Restricted Feeding on Weight and Cardiometabolic Health: A Randomized Controlled Trial in Adults with Obesity","volume":"32","author":"Cienfuegos","year":"2020","journal-title":"Cell Metab."},{"key":"2023072716042273100_bib22","doi-asserted-by":"publisher","first-page":"1222","DOI":"10.1016\/j.cmet.2018.05.006","article-title":"Intermittent Fasting Confers Protection in CNS Autoimmunity by Altering the Gut Microbiota","volume":"27","author":"Cignarella","year":"2018","journal-title":"Cell Metab."},{"key":"2023072716042273100_bib23","doi-asserted-by":"publisher","first-page":"201","DOI":"10.1126\/science.1173635","article-title":"Caloric restriction delays disease onset and mortality in rhesus monkeys","volume":"325","author":"Colman","year":"2009","journal-title":"Science."},{"key":"2023072716042273100_bib24","doi-asserted-by":"publisher","first-page":"99","DOI":"10.1146\/annurev-pathol-121808-102144","article-title":"The senescence-associated secretory phenotype: the dark side of tumor suppression","volume":"5","author":"Copp\u00e9","year":"2010","journal-title":"Annu. Rev. Pathol."},{"key":"2023072716042273100_bib25","doi-asserted-by":"publisher","first-page":"585","DOI":"10.1038\/nature12480","article-title":"Dietary intervention impact on gut microbial gene richness","volume":"500","author":"Cotillard","year":"2013","journal-title":"Nature."},{"key":"2023072716042273100_bib26","doi-asserted-by":"publisher","first-page":"169","DOI":"10.1016\/S1474-4422(04)00681-7","article-title":"Insulin and neurodegenerative disease: shared and specific mechanisms","volume":"3","author":"Craft","year":"2004","journal-title":"Lancet Neurol."},{"key":"2023072716042273100_bib27","doi-asserted-by":"publisher","first-page":"609","DOI":"10.1038\/s41573-020-0072-x","article-title":"Brain energy rescue: an emerging therapeutic concept for neurodegenerative disorders of ageing","volume":"19","author":"Cunnane","year":"2020","journal-title":"Nat. Rev. Drug Discov."},{"key":"2023072716042273100_bib28","doi-asserted-by":"publisher","first-page":"913","DOI":"10.3945\/ajcn.116.137232","article-title":"Body-composition changes in the Comprehensive Assessment of Long-term Effects of Reducing Intake of Energy (CALERIE)-2 study: a 2-y randomized controlled trial of calorie restriction in nonobese humans","volume":"105","author":"Das","year":"2017","journal-title":"Am. J. Clin. Nutr."},{"key":"2023072716042273100_bib29","doi-asserted-by":"publisher","first-page":"461","DOI":"10.1212\/WNL.0b013e318227b227","article-title":"Midlife vascular risk factor exposure accelerates structural brain aging and cognitive decline","volume":"77","author":"Debette","year":"2011","journal-title":"Neurology."},{"key":"2023072716042273100_bib30","doi-asserted-by":"publisher","first-page":"114","DOI":"10.1016\/j.neubiorev.2017.01.044","article-title":"Contribution of neuroinflammation and immunity to brain aging and the mitigating effects of physical and cognitive interventions","volume":"75","author":"Di Benedetto","year":"2017","journal-title":"Neurosci. Biobehav. Rev."},{"key":"2023072716042273100_bib31","doi-asserted-by":"publisher","first-page":"61","DOI":"10.1016\/S1474-4422(19)30393-X","article-title":"Antihypertensive medications and risk for incident dementia and Alzheimer\u2019s disease: a meta-analysis of individual participant data from prospective cohort studies","volume":"19","author":"Ding","year":"2020","journal-title":"Lancet Neurol."},{"key":"2023072716042273100_bib32","doi-asserted-by":"publisher","first-page":"57","DOI":"10.1172\/JCI200421134","article-title":"Ghrelin inhibits leptin- and activation-induced proinflammatory cytokine expression by human monocytes and T cells","volume":"114","author":"Dixit","year":"2004","journal-title":"J. Clin. Invest."},{"key":"2023072716042273100_bib33","doi-asserted-by":"publisher","first-page":"195","DOI":"10.1002\/(SICI)1097-4547(19990715)57:2&lt;195::AID-JNR5&gt;3.0.CO;2-P","article-title":"Dietary restriction and 2-deoxyglucose administration improve behavioral outcome and reduce degeneration of dopaminergic neurons in models of Parkinson\u2019s disease","volume":"57","author":"Duan","year":"1999","journal-title":"J. Neurosci. Res."},{"key":"2023072716042273100_bib34","doi-asserted-by":"publisher","first-page":"245","DOI":"10.1007\/BF03167069","article-title":"Experimental allergic encephalomyelitis in male Lewis rats subjected to calorie restriction","volume":"60","author":"Esquifino","year":"2004","journal-title":"J. Physiol. Biochem."},{"key":"2023072716042273100_bib35","doi-asserted-by":"publisher","first-page":"6","DOI":"10.1186\/1742-2094-4-6","article-title":"Immune response after experimental allergic encephalomyelitis in rats subjected to calorie restriction","volume":"4","author":"Esquifino","year":"2007","journal-title":"J. Neuroinflammation."},{"key":"2023072716042273100_bib36","doi-asserted-by":"publisher","first-page":"1076","DOI":"10.3390\/nu11051076","article-title":"Nutritional Modulation of Immune and Central Nervous System Homeostasis: The Role of Diet in Development of Neuroinflammation and Neurological Disease","volume":"11","author":"Estrada","year":"2019","journal-title":"Nutrients."},{"key":"2023072716042273100_bib37","doi-asserted-by":"publisher","first-page":"929","DOI":"10.1007\/s10072-016-2518-9","article-title":"Effects of prolonged fasting on fatigue and quality of life in patients with multiple sclerosis","volume":"37","author":"Etemadifar","year":"2016","journal-title":"Neurol. Sci."},{"key":"2023072716042273100_bib38","doi-asserted-by":"publisher","first-page":"230","DOI":"10.1111\/j.1600-0404.2009.01185.x","article-title":"Leptin and ghrelin concentrations and weight loss in Parkinson\u2019s disease","volume":"121","author":"Fiszer","year":"2010","journal-title":"Acta Neurol. Scand."},{"key":"2023072716042273100_bib39","doi-asserted-by":"publisher","first-page":"12","DOI":"10.1016\/j.msard.2018.02.019","article-title":"A survey of dietary characteristics in a large population of people with multiple sclerosis","volume":"22","author":"Fitzgerald","year":"2018","journal-title":"Mult. Scler. Relat. Disord."},{"key":"2023072716042273100_bib40","doi-asserted-by":"publisher","first-page":"566","DOI":"10.1038\/s41569-018-0026-8","article-title":"Interventions to promote cardiometabolic health and slow cardiovascular ageing","volume":"15","author":"Fontana","year":"2018","journal-title":"Nat. Rev. Cardiol."},{"key":"2023072716042273100_bib41","doi-asserted-by":"publisher","first-page":"106","DOI":"10.1016\/j.cell.2015.02.020","article-title":"Promoting health and longevity through diet: from model organisms to humans","volume":"161","author":"Fontana","year":"2015","journal-title":"Cell."},{"key":"2023072716042273100_bib42","doi-asserted-by":"publisher","first-page":"1010","DOI":"10.2337\/db06-1656","article-title":"Visceral fat adipokine secretion is associated with systemic inflammation in obese humans","volume":"56","author":"Fontana","year":"2007","journal-title":"Diabetes."},{"key":"2023072716042273100_bib43","doi-asserted-by":"publisher","first-page":"97","DOI":"10.1007\/s11357-009-9118-z","article-title":"Effects of long-term calorie restriction and endurance exercise on glucose tolerance, insulin action, and adipokine production","volume":"32","author":"Fontana","year":"2010","journal-title":"Age (Dordr.)."},{"key":"2023072716042273100_bib44","doi-asserted-by":"publisher","first-page":"321","DOI":"10.1126\/science.1172539","article-title":"Extending healthy life span--from yeast to humans","volume":"328","author":"Fontana","year":"2010","journal-title":"Science."},{"key":"2023072716042273100_bib45","doi-asserted-by":"publisher","first-page":"22","DOI":"10.1111\/acel.12400","article-title":"Effects of 2-year calorie restriction on circulating levels of IGF-1, IGF-binding proteins and cortisol in nonobese men and women: a randomized clinical trial","volume":"15","author":"Fontana","year":"2016","journal-title":"Aging Cell."},{"key":"2023072716042273100_bib46","doi-asserted-by":"publisher","first-page":"576","DOI":"10.1038\/s41574-018-0059-4","article-title":"Inflammaging: a new immune-metabolic viewpoint for age-related diseases","volume":"14","author":"Franceschi","year":"2018","journal-title":"Nat. Rev. Endocrinol."},{"key":"2023072716042273100_bib47","doi-asserted-by":"publisher","first-page":"609","DOI":"10.1146\/annurev-immunol-032713-120236","article-title":"Metabolic regulation of immune responses","volume":"32","author":"Ganeshan","year":"2014","journal-title":"Annu. Rev. Immunol."},{"key":"2023072716042273100_bib48","doi-asserted-by":"publisher","first-page":"84","DOI":"10.1016\/j.chom.2016.12.006","article-title":"Prior Dietary Practices and Connections to a Human Gut Microbial Metacommunity Alter Responses to Diet Interventions","volume":"21","author":"Griffin","year":"2017","journal-title":"Cell Host Microbe."},{"key":"2023072716042273100_bib49","doi-asserted-by":"publisher","first-page":"928","DOI":"10.1016\/j.neurobiolaging.2012.07.008","article-title":"Dietary energy intake modifies brainstem autonomic dysfunction caused by mutant \u03b1-synuclein","volume":"34","author":"Griffioen","year":"2013","journal-title":"Neurobiol. Aging."},{"key":"2023072716042273100_bib50","doi-asserted-by":"publisher","first-page":"1524","DOI":"10.1001\/archinte.163.13.1524","article-title":"An 18-year follow-up of overweight and risk of Alzheimer disease","volume":"163","author":"Gustafson","year":"2003","journal-title":"Arch. Intern. Med."},{"key":"2023072716042273100_bib51","doi-asserted-by":"publisher","first-page":"123","DOI":"10.1016\/j.jchemneu.2017.10.001","article-title":"Beneficial effects of dietary restriction in aging brain","volume":"95","author":"Hadem","year":"2019","journal-title":"J. Chem. Neuroanat."},{"key":"2023072716042273100_bib52","doi-asserted-by":"publisher","first-page":"212","DOI":"10.1016\/j.nbd.2006.12.019","article-title":"Intermittent fasting and caloric restriction ameliorate age-related behavioral deficits in the triple-transgenic mouse model of Alzheimer\u2019s disease","volume":"26","author":"Halagappa","year":"2007","journal-title":"Neurobiol. Dis."},{"key":"2023072716042273100_bib53","doi-asserted-by":"publisher","first-page":"214","DOI":"10.1002\/mus.20255","article-title":"Caloric restriction transiently improves motor performance but hastens clinical onset of disease in the Cu\/Zn-superoxide dismutase mutant G93A mouse","volume":"31","author":"Hamadeh","year":"2005","journal-title":"Muscle Nerve."},{"key":"2023072716042273100_bib54","doi-asserted-by":"publisher","first-page":"1334","DOI":"10.1177\/1352458512436596","article-title":"High body mass index before age 20 is associated with increased risk for multiple sclerosis in both men and women","volume":"18","author":"Hedstr\u00f6m","year":"2012","journal-title":"Mult. Scler."},{"key":"2023072716042273100_bib55","doi-asserted-by":"publisher","first-page":"388","DOI":"10.1016\/S1474-4422(15)70016-5","article-title":"Neuroinflammation in Alzheimer\u2019s disease","volume":"14","author":"Heneka","year":"2015","journal-title":"Lancet Neurol."},{"key":"2023072716042273100_bib56","doi-asserted-by":"publisher","first-page":"358","DOI":"10.1038\/nrn3880","article-title":"Immune attack: the role of inflammation in Alzheimer disease","volume":"16","author":"Heppner","year":"2015","journal-title":"Nat. Rev. Neurosci."},{"key":"2023072716042273100_bib57","doi-asserted-by":"publisher","first-page":"415","DOI":"10.1096\/fj.03-0678fje","article-title":"Adipose tissue energy metabolism: altered gene expression profile of mice subjected to long-term caloric restriction","volume":"18","author":"Higami","year":"2004","journal-title":"FASEB J."},{"key":"2023072716042273100_bib58","doi-asserted-by":"publisher","first-page":"381","DOI":"10.1001\/jama.1920.02620060015005","article-title":"The effects of food restriction during war on mortality in Copenhagen","volume":"74","author":"Hindhede","year":"1920","journal-title":"JAMA."},{"key":"2023072716042273100_bib59","doi-asserted-by":"publisher","first-page":"1380","DOI":"10.1016\/j.clnu.2016.03.011","article-title":"Changes in hunger and fullness in relation to gut peptides before and after 8 weeks of alternate day fasting","volume":"35","author":"Hoddy","year":"2016","journal-title":"Clin. Nutr."},{"key":"2023072716042273100_bib60","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0162717","article-title":"Alpha-Synuclein Proteins Promote Pro-Inflammatory Cascades in Microglia: Stronger Effects of the A53T Mutant","volume":"11","author":"Hoenen","year":"2016","journal-title":"PLoS One."},{"key":"2023072716042273100_bib61","doi-asserted-by":"publisher","first-page":"881","DOI":"10.1016\/j.bbrc.2016.09.109","article-title":"Alpha-synuclein activates BV2 microglia dependent on its aggregation state","volume":"479","author":"Hoffmann","year":"2016","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"2023072716042273100_bib62","doi-asserted-by":"publisher","first-page":"1104","DOI":"10.1210\/jc.2015-2315","article-title":"Cognitive Effects of Intentional Weight Loss in Elderly Obese Individuals With Mild Cognitive Impairment","volume":"101","author":"Horie","year":"2016","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"2023072716042273100_bib63","doi-asserted-by":"publisher","first-page":"1955","DOI":"10.1212\/01.wnl.0000247052.18422.e5","article-title":"Body mass index and the risk of Parkinson disease","volume":"67","author":"Hu","year":"2006","journal-title":"Neurology."},{"key":"2023072716042273100_bib64","doi-asserted-by":"publisher","first-page":"47","DOI":"10.1186\/1471-2318-11-47","article-title":"Recent trends in chronic disease, impairment and disability among older adults in the United States","volume":"11","author":"Hung","year":"2011","journal-title":"BMC Geriatr."},{"key":"2023072716042273100_bib65","doi-asserted-by":"publisher","first-page":"1157","DOI":"10.1001\/jamaneurol.2019.1997","article-title":"Association of Obesity With Multiple Sclerosis Risk and Response to First-line Disease Modifying Drugs in Children","volume":"76","author":"Huppke","year":"2019","journal-title":"JAMA Neurol."},{"key":"2023072716042273100_bib66","doi-asserted-by":"publisher","DOI":"10.1111\/acel.12719","article-title":"Effects of 2\u00a0years of caloric restriction on oxidative status assessed by urinary F2-isoprostanes: The CALERIE 2 randomized clinical trial","volume":"17","author":"Il\u2019yasova","year":"2018","journal-title":"Aging Cell."},{"key":"2023072716042273100_bib67","doi-asserted-by":"publisher","first-page":"236","DOI":"10.1002\/mds.27922","article-title":"Body mass index, diabetes, and the risk of Parkinson\u2019s disease","volume":"35","author":"Jeong","year":"2020","journal-title":"Mov. Disord."},{"key":"2023072716042273100_bib68","doi-asserted-by":"publisher","first-page":"65","DOI":"10.1016\/j.neulet.2018.02.049","article-title":"RAGE and its emerging role in the pathogenesis of Parkinson\u2019s disease","volume":"672","author":"Jiang","year":"2018","journal-title":"Neurosci. Lett."},{"key":"2023072716042273100_bib69","doi-asserted-by":"publisher","first-page":"1102","DOI":"10.1016\/j.cell.2019.07.050","article-title":"Dietary Intake Regulates the Circulating Inflammatory Monocyte Pool","volume":"178","author":"Jordan","year":"2019","journal-title":"Cell."},{"key":"2023072716042273100_bib70","first-page":"47","article-title":"Intermittent feeding attenuates clinical course of experimental autoimmune encephalomyelitis in C57BL\/6 mice","volume":"2","author":"Kafami","year":"2010","journal-title":"Avicenna J. Med. Biotechnol."},{"key":"2023072716042273100_bib71","doi-asserted-by":"publisher","first-page":"11897","DOI":"10.1523\/JNEUROSCI.2553-12.2012","article-title":"A calorie-restricted diet decreases brain iron accumulation and preserves motor performance in old rhesus monkeys","volume":"32","author":"Kastman","year":"2012","journal-title":"J. Neurosci."},{"key":"2023072716042273100_bib72","doi-asserted-by":"publisher","first-page":"441","DOI":"10.1007\/s10522-008-9168-0","article-title":"Age-related impairments in neuronal plasticity markers and astrocytic GFAP and their reversal by late-onset short term dietary restriction","volume":"9","author":"Kaur","year":"2008","journal-title":"Biogerontology."},{"key":"2023072716042273100_bib73","doi-asserted-by":"publisher","first-page":"627","DOI":"10.1016\/j.neuron.2019.05.035","article-title":"Transneuronal Propagation of Pathologic \u03b1-Synuclein from the Gut to the Brain Models Parkinson\u2019s Disease","volume":"103","author":"Kim","year":"2019","journal-title":"Neuron."},{"key":"2023072716042273100_bib74","doi-asserted-by":"publisher","first-page":"521","DOI":"10.1016\/S1474-4422(05)70150-2","article-title":"Statin therapy in Alzheimer\u2019s disease","volume":"4","author":"Kivipelto","year":"2005","journal-title":"Lancet Neurol."},{"key":"2023072716042273100_bib75","doi-asserted-by":"publisher","first-page":"673","DOI":"10.1016\/S2213-8587(19)30151-2","article-title":"2 years of calorie restriction and cardiometabolic risk (CALERIE): exploratory outcomes of a multicentre, phase 2, randomised controlled trial","volume":"7","author":"Kraus","year":"2019","journal-title":"Lancet Diabetes Endocrinol."},{"key":"2023072716042273100_bib76","doi-asserted-by":"publisher","first-page":"1169","DOI":"10.1152\/physrev.00032.2015","article-title":"Brain Insulin Resistance at the Crossroads of Metabolic and Cognitive Disorders in Humans","volume":"96","author":"Kullmann","year":"2016","journal-title":"Physiol. Rev."},{"key":"2023072716042273100_bib77","doi-asserted-by":"publisher","first-page":"194","DOI":"10.1002\/ana.25396","article-title":"Visceral obesity relates to deep white matter hyperintensities via inflammation","volume":"85","author":"Lampe","year":"2019","journal-title":"Ann. Neurol."},{"key":"2023072716042273100_bib78","doi-asserted-by":"publisher","first-page":"548","DOI":"10.1212\/WNL.0b013e31828154f3","article-title":"Childhood obesity and risk of pediatric multiple sclerosis and clinically isolated syndrome","volume":"80","author":"Langer-Gould","year":"2013","journal-title":"Neurology."},{"key":"2023072716042273100_bib79","doi-asserted-by":"publisher","first-page":"541","DOI":"10.1038\/nature12506","article-title":"Richness of human gut microbiome correlates with metabolic markers","volume":"500","author":"Le Chatelier","year":"2013","journal-title":"Nature."},{"key":"2023072716042273100_bib80","doi-asserted-by":"publisher","first-page":"2","DOI":"10.1017\/S1092852918001566","article-title":"The effect of caloric restriction on working memory in healthy non-obese adults","volume":"25","author":"Leclerc","year":"2020","journal-title":"CNS Spectr."},{"key":"2023072716042273100_bib81","doi-asserted-by":"publisher","first-page":"294","DOI":"10.1038\/77046","article-title":"Gene-expression profile of the ageing brain in mice","volume":"25","author":"Lee","year":"2000","journal-title":"Nat. Genet."},{"key":"2023072716042273100_bib82","doi-asserted-by":"publisher","first-page":"3","DOI":"10.1007\/s00401-013-1190-x","article-title":"The neuropathology of obesity: insights from human disease","volume":"127","author":"Lee","year":"2014","journal-title":"Acta Neuropathol."},{"key":"2023072716042273100_bib83","doi-asserted-by":"publisher","first-page":"5638","DOI":"10.3390\/ijms20225638","article-title":"The Novel Perspectives of Adipokines on Brain Health","volume":"20","author":"Lee","year":"2019","journal-title":"Int. J. Mol. Sci."},{"key":"2023072716042273100_bib84","doi-asserted-by":"publisher","first-page":"672","DOI":"10.1016\/j.cmet.2017.08.019","article-title":"Intermittent Fasting Promotes White Adipose Browning and Decreases Obesity by Shaping the Gut\u00a0Microbiota","volume":"26","author":"Li","year":"2017","journal-title":"Cell Metab."},{"key":"2023072716042273100_bib85","doi-asserted-by":"publisher","DOI":"10.1111\/jnc.15105","article-title":"Intermittent fasting promotes adult hippocampal neuronal differentiation by activating GSK-3\u03b2 in 3xTg-AD mice","author":"Li","year":"2020","journal-title":"J. Neurochem."},{"key":"2023072716042273100_bib86","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0227887","article-title":"Astrocyte senescence promotes glutamate toxicity in cortical neurons","volume":"15","author":"Limbad","year":"2020","journal-title":"PLoS One."},{"key":"2023072716042273100_bib87","doi-asserted-by":"publisher","first-page":"1258","DOI":"10.1001\/archneur.59.8.1258","article-title":"Caloric intake and the risk of Alzheimer disease","volume":"59","author":"Luchsinger","year":"2002","journal-title":"Arch. Neurol."},{"key":"2023072716042273100_bib88","doi-asserted-by":"publisher","first-page":"984","DOI":"10.1016\/j.cell.2020.02.008","article-title":"Caloric Restriction Reprograms the Single-Cell Transcriptional Landscape of Rattus Norvegicus Aging","volume":"180","author":"Ma","year":"2020","journal-title":"Cell."},{"key":"2023072716042273100_bib89","doi-asserted-by":"publisher","first-page":"631","DOI":"10.1096\/fj.05-5263com","article-title":"Caloric restriction and intermittent fasting alter spectral measures of heart rate and blood pressure variability in rats","volume":"20","author":"Mager","year":"2006","journal-title":"FASEB J."},{"key":"2023072716042273100_bib90","doi-asserted-by":"publisher","first-page":"B20","DOI":"10.1093\/geronj\/44.1.B20","article-title":"Evidence for the glycation hypothesis of aging from the food-restricted rodent model","volume":"44","author":"Masoro","year":"1989","journal-title":"J. Gerontol."},{"key":"2023072716042273100_bib91","doi-asserted-by":"publisher","first-page":"18171","DOI":"10.1073\/pnas.0405831102","article-title":"Caloric restriction increases neurotrophic factor levels and attenuates neurochemical and behavioral deficits in a primate model of Parkinson\u2019s disease","volume":"101","author":"Maswood","year":"2004","journal-title":"Proc. Natl. Acad. Sci. USA."},{"key":"2023072716042273100_bib92","doi-asserted-by":"publisher","first-page":"59","DOI":"10.3389\/fnagi.2019.00059","article-title":"Astrocyte Heterogeneity: Impact to Brain Aging and Disease","volume":"11","author":"Matias","year":"2019","journal-title":"Front. Aging Neurosci."},{"key":"2023072716042273100_bib93","doi-asserted-by":"publisher","first-page":"1176","DOI":"10.1016\/j.cmet.2018.05.011","article-title":"Hallmarks of Brain Aging: Adaptive and Pathological Modification by Metabolic States","volume":"27","author":"Mattson","year":"2018","journal-title":"Cell Metab."},{"key":"2023072716042273100_bib94","doi-asserted-by":"publisher","first-page":"16647","DOI":"10.1073\/pnas.1413965111","article-title":"Meal frequency and timing in health and disease","volume":"111","author":"Mattson","year":"2014","journal-title":"Proc. Natl. Acad. Sci. USA."},{"key":"2023072716042273100_bib95","doi-asserted-by":"publisher","first-page":"1285","DOI":"10.1212\/WNL.38.8.1285","article-title":"Reactive microglia are positive for HLA-DR in the substantia nigra of Parkinson\u2019s and Alzheimer\u2019s disease brains","volume":"38","author":"McGeer","year":"1988","journal-title":"Neurology."},{"key":"2023072716042273100_bib96","doi-asserted-by":"publisher","first-page":"65","DOI":"10.1083\/jcb.201708092","article-title":"Senescence and aging: Causes, consequences, and therapeutic avenues","volume":"217","author":"McHugh","year":"2018","journal-title":"J. Cell Biol."},{"key":"2023072716042273100_bib97","doi-asserted-by":"publisher","first-page":"363","DOI":"10.3389\/fneur.2019.00363","article-title":"Autonomic Dysfunction in \u03b1-Synucleinopathies","volume":"10","author":"Mendoza-Vel\u00e1squez","year":"2019","journal-title":"Front. Neurol."},{"key":"2023072716042273100_bib98","doi-asserted-by":"publisher","first-page":"1416","DOI":"10.18632\/aging.100994","article-title":"Long-term moderate calorie restriction inhibits inflammation without impairing cell-mediated immunity: a randomized controlled trial in non-obese humans","volume":"8","author":"Meydani","year":"2016","journal-title":"Aging (Albany NY)."},{"key":"2023072716042273100_bib99","doi-asserted-by":"publisher","first-page":"687","DOI":"10.1016\/S0306-4522(98)00334-0","article-title":"The mosaic of brain glial hyperactivity during normal ageing and its attenuation by food restriction","volume":"89","author":"Morgan","year":"1999","journal-title":"Neuroscience."},{"key":"2023072716042273100_bib100","doi-asserted-by":"publisher","first-page":"36","DOI":"10.1016\/j.arr.2016.08.005","article-title":"Calorie restriction in humans: An update","volume":"39","author":"Most","year":"2017","journal-title":"Ageing Res. Rev."},{"key":"2023072716042273100_bib101","doi-asserted-by":"publisher","first-page":"1323","DOI":"10.1177\/1352458513483889","article-title":"Childhood body mass index and multiple sclerosis risk: a long-term cohort study","volume":"19","author":"Munger","year":"2013","journal-title":"Mult. Scler."},{"key":"2023072716042273100_bib102","doi-asserted-by":"publisher","first-page":"1543","DOI":"10.1212\/WNL.0b013e3181c0d6e0","article-title":"Body size and risk of MS in two cohorts of US women","volume":"73","author":"Munger","year":"2009","journal-title":"Neurology."},{"key":"2023072716042273100_bib103","doi-asserted-by":"publisher","DOI":"10.1111\/acel.12840","article-title":"Tau protein aggregation is associated with cellular senescence in the brain","volume":"17","author":"Musi","year":"2018","journal-title":"Aging Cell."},{"key":"2023072716042273100_bib104","doi-asserted-by":"publisher","first-page":"500","DOI":"10.1016\/S1474-4422(08)70092-9","article-title":"The ketogenic diet for the treatment of childhood epilepsy: a randomised controlled trial","volume":"7","author":"Neal","year":"2008","journal-title":"Lancet Neurol."},{"key":"2023072716042273100_bib105","doi-asserted-by":"publisher","first-page":"627","DOI":"10.1007\/s10522-014-9529-9","article-title":"Senescent cells: SASPected drivers of age-related pathologies","volume":"15","author":"Ovadya","year":"2014","journal-title":"Biogerontology."},{"key":"2023072716042273100_bib106","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0009386","article-title":"Caloric restriction shortens lifespan through an increase in lipid peroxidation, inflammation and apoptosis in the G93A mouse, an animal model of ALS","volume":"5","author":"Patel","year":"2010","journal-title":"PLoS One."},{"key":"2023072716042273100_bib107","doi-asserted-by":"publisher","first-page":"995","DOI":"10.1016\/j.neurobiolaging.2004.09.014","article-title":"Caloric restriction attenuates Abeta-deposition in Alzheimer transgenic models","volume":"26","author":"Patel","year":"2005","journal-title":"Neurobiol. Aging."},{"key":"2023072716042273100_bib108","doi-asserted-by":"publisher","first-page":"1203","DOI":"10.1016\/j.jand.2015.02.018","article-title":"Intermittent Fasting and Human Metabolic Health","volume":"115","author":"Patterson","year":"2015","journal-title":"J. Acad. Nutr. Diet."},{"key":"2023072716042273100_bib109","doi-asserted-by":"publisher","first-page":"743","DOI":"10.1038\/nrendo.2012.189","article-title":"The vagus nerve and the inflammatory reflex--linking immunity and metabolism","volume":"8","author":"Pavlov","year":"2012","journal-title":"Nat. Rev. Endocrinol."},{"key":"2023072716042273100_bib110","doi-asserted-by":"publisher","first-page":"117","DOI":"10.1016\/S0006-8993(99)01471-7","article-title":"No benefit of dietary restriction on disease onset or progression in amyotrophic lateral sclerosis Cu\/Zn-superoxide dismutase mutant mice","volume":"833","author":"Pedersen","year":"1999","journal-title":"Brain Res."},{"key":"2023072716042273100_bib111","doi-asserted-by":"publisher","first-page":"1243","DOI":"10.3233\/JAD-200145","article-title":"Association of Peripheral Insulin Resistance and Other Markers of Type 2 Diabetes Mellitus with Brain Amyloid Deposition in Healthy Individuals at Risk of Dementia","volume":"76","author":"Pekkala","year":"2020","journal-title":"J. Alzheimers Dis."},{"key":"2023072716042273100_bib112","doi-asserted-by":"publisher","first-page":"940","DOI":"10.1189\/jlb.0208133","article-title":"Chronic calorie restriction attenuates experimental autoimmune encephalomyelitis","volume":"84","author":"Piccio","year":"2008","journal-title":"J. Leukoc. Biol."},{"key":"2023072716042273100_bib113","doi-asserted-by":"publisher","first-page":"417","DOI":"10.3233\/JAD-2006-10411","article-title":"Calorie restriction attenuates Alzheimer\u2019s disease type brain amyloidosis in Squirrel monkeys (Saimiri sciureus)","volume":"10","author":"Qin","year":"2006","journal-title":"J. Alzheimers Dis."},{"key":"2023072716042273100_bib114","doi-asserted-by":"publisher","first-page":"2398","DOI":"10.1016\/j.neurobiolaging.2011.11.025","article-title":"Neuroprotection provided by dietary restriction in rats is further enhanced by reducing glucocortocoids","volume":"33","author":"Qiu","year":"2012","journal-title":"Neurobiol. Aging."},{"key":"2023072716042273100_bib115","doi-asserted-by":"publisher","first-page":"943","DOI":"10.1093\/gerona\/61.9.943","article-title":"One year of caloric restriction in humans: feasibility and effects on body composition and abdominal adipose tissue","volume":"61","author":"Racette","year":"2006","journal-title":"J. Gerontol. A Biol. Sci. Med. Sci."},{"key":"2023072716042273100_bib116","doi-asserted-by":"publisher","first-page":"341","DOI":"10.1038\/nri.2016.42","article-title":"Gut microbiota, metabolites and host immunity","volume":"16","author":"Rooks","year":"2016","journal-title":"Nat. Rev. Immunol."},{"key":"2023072716042273100_bib117","doi-asserted-by":"publisher","first-page":"e1413","DOI":"10.1212\/WNL.0000000000005328","article-title":"Body mass index, sitting time, and risk of Parkinson disease","volume":"90","author":"Roos","year":"2018","journal-title":"Neurology."},{"key":"2023072716042273100_bib118","doi-asserted-by":"publisher","first-page":"59","DOI":"10.1038\/362059a0","article-title":"Mutations in Cu\/Zn superoxide dismutase gene are associated with familial amyotrophic lateral sclerosis","volume":"362","author":"Rosen","year":"1993","journal-title":"Nature."},{"key":"2023072716042273100_bib119","doi-asserted-by":"publisher","first-page":"230","DOI":"10.1159\/000197108","article-title":"Short-term effects of prolonged fasting on multiple sclerosis","volume":"61","author":"Saadatnia","year":"2009","journal-title":"Eur. Neurol."},{"key":"2023072716042273100_bib120","doi-asserted-by":"publisher","first-page":"3167","DOI":"10.1007\/s00268-020-05543-w","article-title":"Transcutaneous Stimulation of Auricular Branch of the Vagus Nerve Attenuates the Acute Inflammatory Response After Lung Lobectomy","volume":"44","author":"Salama","year":"2020","journal-title":"World J. Surg."},{"key":"2023072716042273100_bib121","doi-asserted-by":"publisher","first-page":"1469","DOI":"10.1016\/j.cell.2016.11.018","article-title":"Gut Microbiota Regulate Motor Deficits and Neuroinflammation in a Model of Parkinson\u2019s Disease","volume":"167","author":"Sampson","year":"2016","journal-title":"Cell."},{"key":"2023072716042273100_bib122","doi-asserted-by":"publisher","first-page":"136","DOI":"10.4049\/jimmunol.1301158","article-title":"Leptin metabolically licenses T cells for activation to link nutrition and immunity","volume":"192","author":"Saucillo","year":"2014","journal-title":"J. Immunol."},{"key":"2023072716042273100_bib123","doi-asserted-by":"publisher","first-page":"1293","DOI":"10.1016\/j.neurobiolaging.2014.10.043","article-title":"Reduction of \u03b2-amyloid and \u03b3-secretase by calorie restriction in female Tg2576 mice","volume":"36","author":"Schafer","year":"2015","journal-title":"Neurobiol. Aging."},{"key":"2023072716042273100_bib124","doi-asserted-by":"publisher","first-page":"1982","DOI":"10.1212\/WNL.0b013e3181ffe4f6","article-title":"Insulin metabolism and the risk of Alzheimer disease: the Rotterdam Study","volume":"75","author":"Schrijvers","year":"2010","journal-title":"Neurology."},{"key":"2023072716042273100_bib125","doi-asserted-by":"publisher","first-page":"917","DOI":"10.1007\/s11357-011-9289-2","article-title":"Late-onset intermittent fasting dietary restriction as a potential intervention to retard age-associated brain function impairments in male rats","volume":"34","author":"Singh","year":"2012","journal-title":"Age (Dordr.)."},{"key":"2023072716042273100_bib126","doi-asserted-by":"publisher","first-page":"1331","DOI":"10.1161\/HYPERTENSIONAHA.109.146795","article-title":"Effects of the dietary approaches to stop hypertension diet, exercise, and caloric restriction on neurocognition in overweight adults with high blood pressure","volume":"55","author":"Smith","year":"2010","journal-title":"Hypertension."},{"key":"2023072716042273100_bib127","doi-asserted-by":"publisher","first-page":"553","DOI":"10.1001\/jama.2018.21442","article-title":"Effect of Intensive vs Standard Blood Pressure Control on Probable Dementia: A Randomized Clinical Trial","volume":"321","author":"Williamson","year":"2019","journal-title":"JAMA."},{"key":"2023072716042273100_bib128","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.brainres.2013.02.046","article-title":"Calorie restriction attenuates astrogliosis but not amyloid plaque load in aged rhesus macaques: a preliminary quantitative imaging study","volume":"1508","author":"Sridharan","year":"2013","journal-title":"Brain Res."},{"key":"2023072716042273100_bib129","doi-asserted-by":"publisher","first-page":"31","DOI":"10.3389\/fnagi.2012.00031","article-title":"Brain volumetric and microstructural correlates of executive and motor performance in aged rhesus monkeys","volume":"4","author":"Sridharan","year":"2012","journal-title":"Front. Aging Neurosci."},{"key":"2023072716042273100_bib130","doi-asserted-by":"publisher","first-page":"644","DOI":"10.1111\/j.1474-9726.2012.00825.x","article-title":"Caloric restriction may reverse age-related autonomic decline in humans","volume":"11","author":"Stein","year":"2012","journal-title":"Aging Cell."},{"key":"2023072716042273100_bib131","doi-asserted-by":"publisher","first-page":"204","DOI":"10.1111\/imm.12922","article-title":"Inflammation in CNS neurodegenerative diseases","volume":"154","author":"Stephenson","year":"2018","journal-title":"Immunology."},{"key":"2023072716042273100_bib132","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1002\/jnr.20093","article-title":"Microglia and Alzheimer\u2019s disease pathogenesis","volume":"77","author":"Streit","year":"2004","journal-title":"J. Neurosci. Res."},{"key":"2023072716042273100_bib133","doi-asserted-by":"publisher","first-page":"126","DOI":"10.1016\/S0140-6736(51)91210-X","article-title":"Mortality from circulatory diseases in Norway 1940-1945","volume":"1","author":"Strom","year":"1951","journal-title":"Lancet."},{"key":"2023072716042273100_bib134","doi-asserted-by":"publisher","first-page":"922","DOI":"10.1016\/j.cmet.2018.08.003","article-title":"Insulin Receptor-Mediated Stimulation Boosts T Cell Immunity during Inflammation and Infection","volume":"28","author":"Tsai","year":"2018","journal-title":"Cell Metab."},{"key":"2023072716042273100_bib135","doi-asserted-by":"publisher","first-page":"741","DOI":"10.1002\/cphy.c160015","article-title":"Central Regulation of Glucose Homeostasis","volume":"7","author":"Tups","year":"2017","journal-title":"Compr. Physiol."},{"key":"2023072716042273100_bib136","doi-asserted-by":"publisher","first-page":"535","DOI":"10.1007\/s00401-019-02040-w","article-title":"Evidence for bidirectional and trans-synaptic parasympathetic and sympathetic propagation of alpha-synuclein in rats","volume":"138","author":"Van Den Berge","year":"2019","journal-title":"Acta Neuropathol."},{"key":"2023072716042273100_bib137","doi-asserted-by":"publisher","first-page":"15596","DOI":"10.1073\/pnas.242407999","article-title":"Inflammatory mediators are induced by dietary glycotoxins, a major risk factor for diabetic angiopathy","volume":"99","author":"Vlassara","year":"2002","journal-title":"Proc. Natl. Acad. Sci. USA."},{"key":"2023072716042273100_bib138","doi-asserted-by":"publisher","first-page":"e1029","DOI":"10.1212\/WNL.0000000000007035","article-title":"The prevalence of MS in the United States: A population-based estimate using health claims data","volume":"92","author":"Wallin","year":"2019","journal-title":"Neurology."},{"key":"2023072716042273100_bib139","doi-asserted-by":"publisher","first-page":"384","DOI":"10.1038\/nature01339","article-title":"Nicotinic acetylcholine receptor alpha7 subunit is an essential regulator of inflammation","volume":"421","author":"Wang","year":"2003","journal-title":"Nature."},{"key":"2023072716042273100_bib140","doi-asserted-by":"publisher","first-page":"659","DOI":"10.1096\/fj.04-3182fje","article-title":"Caloric restriction attenuates beta-amyloid neuropathology in a mouse model of Alzheimer\u2019s disease","volume":"19","author":"Wang","year":"2005","journal-title":"FASEB J."},{"key":"2023072716042273100_bib141","doi-asserted-by":"publisher","first-page":"353","DOI":"10.3389\/fnins.2020.00353","article-title":"RAGE Silencing Ameliorates Neuroinflammation by Inhibition of p38-NF-\u03baB Signaling Pathway in Mouse Model of Parkinson\u2019s Disease","volume":"14","author":"Wang","year":"2020","journal-title":"Front. Neurosci."},{"key":"2023072716042273100_bib142","doi-asserted-by":"publisher","first-page":"1033","DOI":"10.1093\/ajcn\/84.5.1033","article-title":"Improvements in glucose tolerance and insulin action induced by increasing energy expenditure or decreasing energy intake: a randomized controlled trial","volume":"84","author":"Weiss","year":"2006","journal-title":"Am. J. Clin. Nutr."},{"key":"2023072716042273100_bib143","doi-asserted-by":"publisher","first-page":"388","DOI":"10.1177\/1352458514546785","article-title":"Body size and the risk of multiple sclerosis in Norway and Italy: the EnvIMS study","volume":"21","author":"Wesnes","year":"2015","journal-title":"Mult. Scler."},{"key":"2023072716042273100_bib144","doi-asserted-by":"publisher","first-page":"987","DOI":"10.1016\/j.neuroimage.2010.03.015","article-title":"Age-related changes in neural volume and microstructure associated with interleukin-6 are ameliorated by a calorie-restricted diet in old rhesus monkeys","volume":"51","author":"Willette","year":"2010","journal-title":"Neuroimage."},{"key":"2023072716042273100_bib145","doi-asserted-by":"publisher","first-page":"1036","DOI":"10.2337\/db11-1187","article-title":"Calorie restriction reduces the influence of glucoregulatory dysfunction on regional brain volume in aged rhesus monkeys","volume":"61","author":"Willette","year":"2012","journal-title":"Diabetes."},{"key":"2023072716042273100_bib146","doi-asserted-by":"publisher","first-page":"2215","DOI":"10.1007\/s11357-013-9518-y","article-title":"Interleukin-8 and interleukin-10, brain volume and microstructure, and the influence of calorie restriction in old rhesus macaques","volume":"35","author":"Willette","year":"2013","journal-title":"Age (Dordr.)."},{"key":"2023072716042273100_bib147","doi-asserted-by":"publisher","first-page":"1255","DOI":"10.1073\/pnas.0808587106","article-title":"Caloric restriction improves memory in elderly humans","volume":"106","author":"Witte","year":"2009","journal-title":"Proc. Natl. Acad. Sci. USA."},{"key":"2023072716042273100_bib148","doi-asserted-by":"publisher","first-page":"619","DOI":"10.1146\/annurev-physiol-022516-034406","article-title":"Microglia in Physiology and Disease","volume":"79","author":"Wolf","year":"2017","journal-title":"Annu. Rev. Physiol."},{"key":"2023072716042273100_bib149","doi-asserted-by":"publisher","first-page":"22","DOI":"10.3389\/fncel.2013.00022","article-title":"Microglial aging in the healthy CNS: phenotypes, drivers, and rejuvenation","volume":"7","author":"Wong","year":"2013","journal-title":"Front. Cell. Neurosci."},{"key":"2023072716042273100_bib150","doi-asserted-by":"publisher","first-page":"1502","DOI":"10.1016\/j.neurobiolaging.2007.03.028","article-title":"Calorie restriction ameliorates neurodegenerative phenotypes in forebrain-specific presenilin-1 and presenilin-2 double knockout mice","volume":"29","author":"Wu","year":"2008","journal-title":"Neurobiol. Aging."},{"key":"2023072716042273100_bib151","doi-asserted-by":"publisher","first-page":"422","DOI":"10.1016\/j.celrep.2015.12.042","article-title":"Long-Term Calorie Restriction Enhances Cellular Quality-Control Processes in Human Skeletal Muscle","volume":"14","author":"Yang","year":"2016","journal-title":"Cell Rep."},{"key":"2023072716042273100_bib152","doi-asserted-by":"publisher","first-page":"65","DOI":"10.3389\/fnmol.2018.00065","article-title":"Low-Fat Diet With Caloric Restriction Reduces White Matter Microglia Activation During Aging","volume":"11","author":"Yin","year":"2018","journal-title":"Front. Mol. Neurosci."},{"key":"2023072716042273100_bib153","doi-asserted-by":"publisher","first-page":"721","DOI":"10.1056\/NEJMoa2003697","article-title":"Effects of Diet versus Gastric Bypass on Metabolic Function in Diabetes","volume":"383","author":"Yoshino","year":"2020","journal-title":"N. Engl. J. Med."},{"key":"2023072716042273100_bib154","doi-asserted-by":"publisher","first-page":"2163","DOI":"10.1038\/ncomms3163","article-title":"Structural modulation of gut microbiota in life-long calorie-restricted mice","volume":"4","author":"Zhang","year":"2013","journal-title":"Nat. Commun."},{"key":"2023072716042273100_bib155","doi-asserted-by":"publisher","first-page":"2217","DOI":"10.1002\/jnr.24064","article-title":"The vicious circle of hypometabolism in neurodegenerative diseases: Ways and mechanisms of metabolic correction","volume":"95","author":"Zilberter","year":"2017","journal-title":"J. Neurosci. Res."}],"container-title":["Journal of Experimental Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/rupress.org\/jem\/article-pdf\/doi\/10.1084\/jem.20190086\/1816336\/jem_20190086.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/rupress.org\/jem\/article-pdf\/doi\/10.1084\/jem.20190086\/1816336\/jem_20190086.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,7,27]],"date-time":"2023-07-27T12:05:47Z","timestamp":1690459547000},"score":1,"resource":{"primary":{"URL":"https:\/\/rupress.org\/jem\/article\/218\/2\/e20190086\/211666\/Effects-of-dietary-restriction-on"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,1,8]]},"references-count":155,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2021,2,1]]}},"URL":"https:\/\/doi.org\/10.1084\/jem.20190086","relation":{},"ISSN":["0022-1007","1540-9538"],"issn-type":[{"value":"0022-1007","type":"print"},{"value":"1540-9538","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,1,8]]},"article-number":"e20190086"}}